Faculty Opinions recommendation of Long-term mortality and causes of death in isolated GHD, ISS, and SGA patients treated with recombinant growth hormone during childhood in Belgium, The Netherlands, and Sweden: preliminary report of 3 countries participating in the EU SAGhE study.

Author(s):  
Gianluca Aimaretti ◽  
Flavia Prodam
2011 ◽  
pp. LB-5-LB-5 ◽  
Author(s):  
Jean-Claude Carel ◽  
Emmanuel Ecosse ◽  
Fabienne Landier ◽  
Djamila Meguellati-Hakkas ◽  
Florentia Kaguelidou ◽  
...  

2021 ◽  
Vol 6 (2) ◽  
pp. 185-193
Author(s):  
Jamie I Verhoeven ◽  
Marco Pasi ◽  
Barbara Casolla ◽  
Hilde Hénon ◽  
Frank-Erik de Leeuw ◽  
...  

Introduction Intracerebral haemorrhage (ICH) in young adults is rare but has devastating consequences. We investigated long-term mortality rates, causes of death and predictors of long-term mortality in young spontaneous ICH survivors. Patients and methods We included consecutive patients aged 18–55 years from the Prognosis of Intracerebral Haemorrhage cohort (PITCH), a prospective observational cohort of patients admitted to Lille University Hospital (2004–2009), who survived at least 30 days after spontaneous ICH. We studied long-term mortality with Kaplan-Meier analyses, collected causes of death, performed uni-/multivariable Cox-regression analyses for the association of baseline characteristics with long-term mortality. Results Of 560 patients enrolled in the PITCH, 75 patients (75% men) met our inclusion criteria (median age 50 years, interquartile range [IQR] 44–53 years). During a median follow-up of 8.2 years (IQR 5.0–10.1), 26 patients died (35%), with a standardized mortality ratio of 13.0 (95% confidence interval [95% CI] 8.5–18.0) compared to peers from the general population. Causes of death were vascular in 7 (27%) patients, non-vascular in 13 (50%) and unknown in 6 (23%). Global cerebral atrophy (hazard ratio [HR] 3.0, 95% CI 1.1–8.6), modified Rankin Score >2 before ICH (HR 3.4, 95% CI 1.0–11.0), and excessive alcohol consumption (HR 3.3, 95% CI 1.1–10.2) were independently associated with long-term mortality. Discussion We found a 13-fold higher mortality risk for young ICH survivors compared to the general French population. Predictors of long-term mortality were pre-existing conditions, not ICH-characteristics. Conclusion Young ICH survivors remain at increased mortality risk of vascular and non-vascular death for years after ICH.


2000 ◽  
Vol 85 (10) ◽  
pp. 3720-3725 ◽  
Author(s):  
Giovanni Amato ◽  
Gherardo Mazziotti ◽  
Carolina Di Somma ◽  
Eleonora Lalli ◽  
Giuseppina De Felice ◽  
...  

Brain Injury ◽  
2020 ◽  
Vol 34 (4) ◽  
pp. 556-566 ◽  
Author(s):  
Erica Sercy ◽  
Alessandro Orlando ◽  
Matthew Carrick ◽  
Mark Lieser ◽  
Robert Madayag ◽  
...  

2019 ◽  
Vol 57 (1) ◽  
pp. 21-28 ◽  
Author(s):  
S. Lahtinen ◽  
P. Koivunen ◽  
T. Ala-Kokko ◽  
O. Kaarela ◽  
P. Ohtonen ◽  
...  

2013 ◽  
Vol 43 (1) ◽  
pp. 166-177 ◽  
Author(s):  
D. N. Podlekareva ◽  
A. M. Panteleev ◽  
D. Grint ◽  
F. A. Post ◽  
J. M. Miro ◽  
...  

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