Faculty Opinions recommendation of Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling.

2010 ◽  
Author(s):  
Arturo Alvarez-Buylla ◽  
Cheuk Ka Tong
Keyword(s):  
Cxcr4 Signaling ◽  
Vascular Niche ◽  
Differential Responses

scholarly journals Adult SVZ Lineage Cells Home to and Leave the Vascular Niche via Differential Responses to SDF1/CXCR4 Signaling

2010 ◽  
Vol 7 (2) ◽  
pp. 163-173 ◽  
Author(s):  
Erzsebet Kokovay ◽  
Susan Goderie ◽  
Yue Wang ◽  
Steve Lotz ◽  
Gang Lin ◽  
...  
Keyword(s):  
Cxcr4 Signaling ◽  
Vascular Niche ◽  
Differential Responses

Differential Responses of Guinea Grass Populations to Drought Stress 1

Crop Science ◽  
1978 ◽  
Vol 18 (5) ◽  
pp. 853-857 ◽  
Author(s):  
A. E. Klar ◽  
J. A. Usberti ◽  
D. W. Henderson
Keyword(s):  
Drought Stress ◽  
Guinea Grass ◽  
Differential Responses

Differential Responses of Texas Convicts

1932 ◽  
Vol 38 (1) ◽  
pp. 10-21 ◽  
Author(s):  
Carl M. Rosenquist
Keyword(s):  
Differential Responses

scholarly journals Differential responses of needle and branch order-based root decay to nitrogen addition: dominant effects of acid-unhydrolyzable residue and microbial enzymes

2015 ◽  
Vol 394 (1-2) ◽  
pp. 315-327 ◽  
Author(s):  
Liang Kou ◽  
Weiwei Chen ◽  
Xinyu Zhang ◽  
Wenlong Gao ◽  
Hao Yang ◽  
...  
Keyword(s):  
Nitrogen Addition ◽  
Microbial Enzymes ◽  
Branch Order ◽  
Root Decay ◽  
Differential Responses

CXCR4 signaling at the fetal–maternal interface may drive inflammation and syncytia formation during ovine pregnancy†

2020 ◽  
Author(s):  
Stacia Z McIntosh ◽  
Marlie M Maestas ◽  
Jordyn R Dobson ◽  
Kelsey E Quinn ◽  
Cheyenne L Runyan ◽  
...  
Keyword(s):  
Intracellular Signaling ◽  
Placental Development ◽  
Cxcr4 Signaling ◽  
Proinflammatory Mediators ◽  
Placental Angiogenesis ◽  
Precise Understanding ◽  
Chemokine Ligand ◽  
Syncytia Formation ◽  
Complex Signaling ◽  
Surface Remodeling

Abstract Early pregnancy features complex signaling between fetal trophoblast cells and maternal endometrium directing major peri-implantation events including localized inflammation and remodeling to establish proper placental development. Proinflammatory mediators are important for conceptus attachment, but a more precise understanding of molecular pathways regulating this process is needed to understand how the endometrium becomes receptive to implantation. Both chemokine ligand 12 (CXCL12) and its receptor CXCR4 are expressed by fetal and maternal tissues. We identified this pair as a critical driver of placental angiogenesis, but their additional importance to inflammation and trophoblast cell survival, proliferation, and invasion imply a role in syncytia formation at the fetal–maternal microenvironment. We hypothesized that CXCL12 encourages both endometrial inflammation and conceptus attachment during implantation. We employed separate ovine studies to (1) characterize endometrial inflammation during early gestation in the ewe, and (2) establish functional implications of CXCL12 at the fetal–maternal interface through targeted intrauterine infusion of the CXCR4 inhibitor AMD3100. Endometrial tissues were evaluated for inflammatory mediators, intracellular signaling events, endometrial modifications, and trophoblast syncytialization using western blotting and immunohistochemistry. Endometrial tissue from ewes receiving CXCR4 inhibitor demonstrated dysregulated inflammation and reduced AKT and NFKB, paired with elevated autophagic activity compared to control. Immunohistochemical observation revealed an impairment in endometrial surface remodeling and diminished trophoblast syncytialization following localized CXCR4 inhibition. These data suggest CXCL12–CXCR4 regulates endometrial inflammation and remodeling for embryonic implantation, and provide insight regarding mechanisms that, when dysregulated, lead to pregnancy pathologies such as intrauterine growth restriction and preeclampsia.

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