Faculty Opinions recommendation of Determinants of corneal biomechanical properties in an adult Chinese population.

Author(s):  
Renato Ambrosio ◽  
Bruno Valbon
Author(s):  
Arun Narayanaswamy ◽  
Ronald S. Chung ◽  
Ren-Yi Wu ◽  
Judy Park ◽  
Wan-Ling Wong ◽  
...  

The Eye ◽  
2019 ◽  
Vol 21 (128) ◽  
pp. 15-19
Author(s):  
Irina Bubnova ◽  
Veronica Averich ◽  
Elena Belousova

Purpose: Evaluation of corneal biomechanical prop¬erties and their influence on IOP indices in patients with keratoconus. Material and methods. The study included 194 eyes with keratoconus (113 patients aged from 23 to 36 years old). Corneal refraction in central zone varied from 48.25 to 56.75 D, values of corneal thickness ranged from 279 to 558 μm. Patients were divided into 4 groups according to Amsler classification: I stage – 40 eyes; II stage – 78 eyes; III stage – 54 eyes and IV stage – 22 eyes. Standard ophthal¬mological examination was carried out including pneumo¬tonometry. IOP indices and values of biomechanical prop¬erties were evaluated by dynamic bidirectional pneumatic applanation and pneumatic impression. Results. Study of corneal biomechanical properties in patients with keratoconus showed a decrease of such biomechanical indices as corneal hysteresis (CH) on aver¬age to 8.42±1.12 mm Hg, corneal resistance factor (CRF) – to 7.45±0.96 mm Hg, coefficient of elasticity (CE) – 5.35± 0.87 mm Hg. Values of these indices strongly depended on the stage of keratoconus. In the whole sample, the aver¬age corneal compensated IOP (IOPcc) amounted to 15.08± 2.43 mm Hg, Goldman IOP (IOPg) was 11.61±2.37 mm Hg and pneumatic tonometry IOP (IOPp) was 10.13±2.94 mm Hg. IOPcc indices didn’t have any statistically significant differ¬ence in dependence on the stage of keratoconus (р>0.473), while in process of disease progression IOPg and IOPp indi¬ces showed statistically significant decrease of mean values. Conclusion. Progression of keratoconus led to a de¬crease in corneal biomechanical properties which deter¬mine reduction of such indices as IOPg and IOPp in contrast to IOPcc.


2013 ◽  
Vol 72 (2) ◽  
pp. 99-102 ◽  
Author(s):  
Renato Ambrósio Jr ◽  
Isaac Ramos ◽  
Allan Luz ◽  
Fernando Correa Faria ◽  
Andreas Steinmueller ◽  
...  

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207189 ◽  
Author(s):  
Byung Soo Kang ◽  
Li-Ke Wang ◽  
Yong-Ping Zheng ◽  
Jeremy A. Guggenheim ◽  
William K. Stell ◽  
...  

2020 ◽  
Author(s):  
Na Wu ◽  
Yuhong Chen ◽  
Yaping Yang ◽  
Xinghuai Sun

Abstract Background: To investigate the corneal biomechanical changes in primary open angle glaucoma (POAG) patients treated with long-term prostaglandin analogue (PGA). Methods: 111 newly diagnosed POAG patients, including 43 high tension glaucoma (HTG) and 68 normal tension glaucoma (NTG), were measured by Corvis ST to obtain intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanical parameters at baseline and at each follow-up visit after initiation of PGA treatment. The follow-up measurements were analyzed by the generalized estimate equation model with an exchangeable correlation structure. Restricted cubic spline was employed to estimate the dose-response relation between follow-up time and corneal biomechanics.Results: The mean follow-up time was 10.3 ± 7.02 months. Deformation amplitude (β=-0.0015, P=0.016), the first applanation velocity (AV1, β=-0.0004, P=0.00058) decreased and the first applanation time (AT1, β=0.0089, P<0.000001) increased statistically significantly with PGA therapy over time after adjusting for age, gender, axial length, corneal curvature, IOP and CCT. In addition, AT1 was lower (7.2950 ± 0.2707 in NTG and 7.5889 ± 0.2873 in HTG, P=0.00011) and AV1 was greater (0.1478 ± 0.0187 in NTG and 0.1314 ± 0.0191 in HTG, P=0.00002) in NTG than in HTG after adjusting for confounding factors.Conclusions: Chronic use of PGA probably influences the corneal biomechanical properties directly, which is to make cornea less deformable. Besides, corneas in NTG tended to be more deformable compared to those in HTG with long-term treatment of PGA.


Author(s):  
D.D. Sibakin ◽  
◽  
V.A. Breev ◽  
E.G. Solodkova ◽  
◽  
...  

Purpose. To analyse keratopographic and biomechanical corneal indicators with the diagnostic results assessment of the influence on the treatment tactics of myopic refraction patient. Materials and methods. Keratotopographic and biomechanical parameters of the cornea in a patient with mild myopia were evaluated. Results. The Belin/Ambrosio (Enchanced Ectasia Display) - BAD keratoconus screening program was used on Pentacam HR, which did not reveal corneal pathology. According to the results of CBI (Corvis biomechanical index) on Corvis ST (OD - 0.61, OS - 0.48), that was indicating poor corneal biomechanical properties and a high risk of keratectasia development. Conclusion. Ophthalmic examination, using The Corvis ST (Oculus, Germany) biomechanical measurements, makes possible to reveal with greater sensitivity subclinical signs of a keratectatic process at the pre-clinical stage of development. Key words: keratotopography, corneal biomechanics, keratoconus.


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