Faculty Opinions recommendation of Clinical presentation of atopic dermatitis by filaggrin gene mutation status during the first 7 years of life in a prospective cohort study.

2013 ◽  
Author(s):  
Akemi Ishida-Yamamoto
Keyword(s):  
Atopic Dermatitis ◽  
Cohort Study ◽  
Gene Mutation ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Clinical Presentation ◽  
Mutation Status

scholarly journals Clinical Presentation of Atopic Dermatitis by Filaggrin Gene Mutation Status during the First 7 Years of Life in a Prospective Cohort Study

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e48678 ◽  
Author(s):  
Charlotte Giwercman Carson ◽  
Morten Arendt Rasmussen ◽  
Jacob P. Thyssen ◽  
Torkil Menné ◽  
Hans Bisgaard
Keyword(s):  
Atopic Dermatitis ◽  
Cohort Study ◽  
Gene Mutation ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Clinical Presentation ◽  
Mutation Status

A Prospective Cohort Study of Fecal miR-223 and miR-451a as Noninvasive and Specific Biomarkers for Diagnosis of Necrotizing Enterocolitis in Preterm Infants

Neonatology ◽  
2020 ◽  
pp. 1-7
Author(s):  
Pak Cheung Ng ◽  
Kathy Yuen Yee Chan ◽  
Hugh Simon Lam ◽  
Raymond Pui On Wong ◽  
Terence Ping Yuen Ma ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Clinical Presentation ◽  
Fecal Calprotectin ◽  
Controlled Study ◽  
Clinical Value ◽  
Predictive Values

<b><i>Objective:</i></b> The objective of this study is to evaluate the usefulness of fecal microRNA (miR)-223 and miR-451a, as novel noninvasive biomarkers for early diagnosis of necrotizing enterocolitis (NEC) in preterm infants. <b><i>Methods:</i></b> Among the top-listed target miRNAs in our previous differential microarray analysis, miR-223 and miR-451a were quantified in a pilot validation case-controlled study (NEC vs. non-NEC/nonsepsis infants; <i>n</i> = 6 in each group). A definitive prospective cohort study (<i>n</i> = 218) further assessed their clinical usefulness as noninvasive and specific diagnostic biomarkers. Fecal calprotectin was quantified in parallel for comparison. <b><i>Results:</i></b> Of 43 proven NEC cases in the cohort study, 24 (55.8%) had fecal samples recovered within the first 3 days of clinical presentation. Fecal miRNA-223 (10.5 fold), miR-451a (4.5 fold), and calprotectin (2.1 fold) concentrations were significant higher in NEC compared with the non-NEC group (<i>p</i> &#x3c; 0.009). Accepting a minimum sensitivity of 0.75, the positive predictive values (PPVs) ranged between 0.19 and 0.20. Combining fecal biomarkers and CRP (Day 1) could marginally increase the PPVs (0.31–0.34) but adversely lowered the sensitivity (0.54–0.63). <b><i>Conclusions:</i></b> Although fecal miRNA biomarkers and calprotectin concentrations were significantly higher in the NEC group, the considerable overlapping of concentrations between groups and low recovery of stool specimens within 72 h of clinical presentation rendered fecal noninvasive tests of limited clinical value in guiding diagnosis of NEC during the acute phase. A further study is underway to evaluate their roles in surveillance for predicting high-risk premature infants developing NEC.

Infant feeding practices and physician diagnosed atopic dermatitis: a prospective cohort study in Taiwan

2011 ◽  
Vol 22 (1-Part-I) ◽  
pp. 43-49 ◽  
Author(s):  
Chao-Hua Chuang ◽  
Wu-Shiun Hsieh ◽  
Yi-Chun Chen ◽  
Pei-Jen Chang ◽  
Baai-Shyun Hurng ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Cohort Study ◽  
Infant Feeding ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Feeding Practices ◽  
Infant Feeding Practices

Do young adults with atopic dermatitis avoid harmful workplace exposure at their first job? A prospective cohort study

2015 ◽  
Vol 89 (3) ◽  
pp. 397-406 ◽  
Author(s):  
Junxiang Wei ◽  
Jessica Gerlich ◽  
Christian Vogelberg ◽  
Erika von Mutius ◽  
Doris Windstetter ◽  
...  
Keyword(s):  
Young Adults ◽  
Atopic Dermatitis ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Workplace Exposure ◽  
First Job
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