Faculty Opinions recommendation of RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels.

2015 ◽  
Author(s):  
Hugues Abriel
Keyword(s):  
Sodium Channels ◽  
Ring Finger ◽  
Membrane Localization ◽  
Ring Finger Protein ◽  
Voltage Gated ◽  
Finger Protein ◽  
Voltage Gated Sodium Channels

scholarly journals RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels

2015 ◽  
Vol 112 (9) ◽  
pp. 2859-2864 ◽  
Author(s):  
Kazutoyo Ogino ◽  
Sean E. Low ◽  
Kenta Yamada ◽  
Louis Saint-Amant ◽  
Weibin Zhou ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Ring Finger ◽  
Membrane Localization ◽  
Ring Finger Protein ◽  
Excitable Cells ◽  
Gene Encoding ◽  
Voltage Gated ◽  
Finger Protein ◽  
Voltage Gated Sodium Channels ◽  
New Gene

Following their synthesis in the endoplasmic reticulum (ER), voltage-gated sodium channels (NaV) are transported to the membranes of excitable cells, where they often cluster, such as at the axon initial segment of neurons. Although the mechanisms by which NaV channels form and maintain clusters have been extensively examined, the processes that govern their transport and degradation have received less attention. Our entry into the study of these processes began with the isolation of a new allele of the zebrafish mutant alligator, which we found to be caused by mutations in the gene encoding really interesting new gene (RING) finger protein 121 (RNF121), an E3-ubiquitin ligase present in the ER and cis-Golgi compartments. Here we demonstrate that RNF121 facilitates two opposing fates of NaV channels: (i) ubiquitin-mediated proteasome degradation and (ii) membrane localization when coexpressed with auxiliary NaVβ subunits. Collectively, these results indicate that RNF121 participates in the quality control of NaV channels during their synthesis and subsequent transport to the membrane.

scholarly journals Erratum to: Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?

2020 ◽  
Author(s):  
Zhi-mei Li ◽  
Li-xia Chen ◽  
Hua Li
Keyword(s):  
Open Access ◽  
Sodium Channels ◽  
Voltage Gated ◽  
Internet Portal ◽  
Creative Commons ◽  
Link Type ◽  
Voltage Gated Sodium Channels

The article “Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?”, written by Zhi-mei LI, Li-xia CHEN, Hua LI, was originally published electronically on the publisher’s internet portal on December 2019 without open access. With the author(s)’ decision to opt for Open Choice, the copyright of the article is changed to © The Author(s) 2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The original article has been corrected.Corresponding authors: Li-xia CHEN, Hua LI

scholarly journals A novel RING finger protein interacts with the cytoplasmic domain of CD40.

1994 ◽  
Vol 269 (48) ◽  
pp. 30069-30072
Author(s):  
H.M. Hu ◽  
K O'Rourke ◽  
M.S. Boguski ◽  
V.M. Dixit
Keyword(s):  
Ring Finger ◽  
Cytoplasmic Domain ◽  
Ring Finger Protein ◽  
Finger Protein
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