Faculty Opinions recommendation of Lack of detectable platelet autoantibodies is correlated with nonresponsiveness to rituximab treatment in ITP patients.

2018 ◽  
Author(s):  
Ravindra Sarode
Keyword(s):  
Platelet Autoantibodies

Interference of IgG, IgG aggregates and immune complexes in tests for platelet autoantibodies

1983 ◽  
Vol 55 (3) ◽  
pp. 533-545 ◽  
Author(s):  
F. M. Helmerhorst ◽  
R. J. T. Smeenk ◽  
C. E. Hack ◽  
C. P. Engelfriet ◽  
A. E. G. Kr. von dem Borne
Keyword(s):  
Immune Complexes ◽  
Platelet Autoantibodies

Familial Chronic Thrombocytopenia with Platelet Autoantibodies

1965 ◽  
Vol 34 (1) ◽  
pp. 30-35 ◽  
Author(s):  
D. Harms ◽  
V. Sachs
Keyword(s):  
Platelet Autoantibodies

scholarly journals Antibodies to platelets in patients with anti-phospholipid antibodies

Blood ◽  
1991 ◽  
Vol 77 (12) ◽  
pp. 2655-2659 ◽  
Author(s):  
HJ Out ◽  
PG de Groot ◽  
M van Vliet ◽  
GC de Gast ◽  
HK Nieuwenhuis ◽  
...  
Keyword(s):  
Platelet Activation ◽  
Lysosomal Membrane ◽  
Immunofluorescence Method ◽  
Exact Role ◽  
Flow Cytofluorometry ◽  
Healthy Donors ◽  
Lysosomal Membrane Proteins ◽  
Lysosomal Membrane Protein ◽  
Platelet Autoantibodies

Abstract Binding of anti-phospholipid antibodies to circulating platelets and its consequences on platelet activation and aggregation was investigated in 11 patients with anti-phospholipid antibodies. Seven patients had mild thrombocytopenia. Nine healthy donors served as controls. Binding to platelets was investigated by performing enzyme- linked immunosorbent assays (ELISAs) with phospholipids as antigen on platelet eluates. Platelet activation was measured by flow cytofluorometry using monoclonal antibodies to an activation-specific lysosomal membrane protein. Findings in ELISA were compared with results of a conventional immunofluorescence method to detect platelet autoantibodies. In seven patients antibodies to negatively charged phospholipids were present in platelet eluates. In all thrombocytopenic patients and controls the platelets were not activated and aggregation was not impaired. There was a positive concordance of 50% between the results of immunofluorescence and ELISA. No apparent relation was found between the results of ELISA or immunofluorescence and platelet counts. It is concluded that anti-phospholipid antibodies can bind to circulating platelets. This binding is not associated with measurable aggregation abnormalities nor with platelet activation characterized by exposure of lysosomal membrane proteins. More studies are necessary to determine the exact role of anti-phospholipid antibodies in the pathogenesis of thrombocytopenia and thrombosis.

Platelet-associated IgM elevated in patients with chronic hepatitis C contains no anti-platelet autoantibodies

2008 ◽  
Vol 17 (5) ◽  
pp. 230-237 ◽  
Author(s):  
S. Kosugi ◽  
Y. Imai ◽  
Y. Kurata ◽  
Y. Tomiyama ◽  
M. Shiraga ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Platelet Autoantibodies

Blind Verification of Elevated Platelet Autoantibodies in Serum of Schizophrenic Patients – Part II: Adult Subjects

2009 ◽  
Vol 60 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Baruch Spivak ◽  
Mila Schechtman ◽  
Yael Schönherz-Pine ◽  
Rachel Blumensohn ◽  
Susanna Mostovoy ◽  
...  
Keyword(s):  
Schizophrenic Patients ◽  
Platelet Autoantibodies

Aplastic Anemia by Platelet Autoantibodies in a Patient After Taking Methazolamide

1990 ◽  
Vol 110 (5) ◽  
pp. 570-571 ◽  
Author(s):  
Sayoko E. Moroi-Fetters ◽  
Earl N. Metz ◽  
Robert B. Chambers ◽  
Frederick H. Davidorf
Keyword(s):  
Aplastic Anemia ◽  
Platelet Autoantibodies

The Problem of Platelet Autoantibodies

Vox Sanguinis ◽  
1977 ◽  
Vol 33 (4) ◽  
pp. 234-245 ◽  
Author(s):  
C. Mueller-Eckhardt ◽  
Bettina Mayser ◽  
D. Heinrich
Keyword(s):  
Platelet Autoantibodies
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