Faculty Opinions recommendation of Induction Chemotherapy plus Concurrent Chemoradiotherapy in Endemic Nasopharyngeal Carcinoma: Individual Patient Data Pooled Analysis of Four Randomized Trials.

2018 ◽  
Author(s):  
Jason Chan
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Induction Chemotherapy ◽  
Randomized Trials ◽  
Concurrent Chemoradiotherapy ◽  
Individual Patient Data ◽  
Pooled Analysis ◽  
Patient Data

Taxane-Cisplatin-Fluorouracil As Induction Chemotherapy in Locally Advanced Head and Neck Cancers: An Individual Patient Data Meta-Analysis of the Meta-Analysis of Chemotherapy in Head and Neck Cancer Group

2013 ◽  
Vol 31 (23) ◽  
pp. 2854-2860 ◽  
Author(s):  
Pierre Blanchard ◽  
Jean Bourhis ◽  
Benjamin Lacas ◽  
Marshall R. Posner ◽  
Jan B. Vermorken ◽  
...  
Keyword(s):  
Head And Neck ◽  
Induction Chemotherapy ◽  
Randomized Trials ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Locally Advanced ◽  
Patient Data ◽  
Head And Neck Cancers ◽  
Rank Test ◽  
Advanced Head

Purpose Cisplatin plus fluorouracil (PF) induction chemotherapy has been compared with taxane (docetaxel or paclitaxel), cisplatin, and fluorouracil (Tax-PF) in randomized trials in locoregionally advanced head and neck cancers (LAHNCs). The aim of this meta-analysis was to study the efficacy and toxicity of Tax-PF and PF and identify differences in outcomes in subsets of patients. Methods Five randomized trials representing 1,772 patients were identified. Updated individual patient data (IPD) were retrieved for all trials. The log-rank test, stratified by trial, was used for comparison. Interaction or trend tests were used to study the interaction between covariates and treatment. Results Median follow-up was 4.9 years. The hazard ratio (HR) of death was 0.79 (95% CI, 0.70 to 0.89; P < .001; absolute benefit at 5 years: 7.4%) in favor of Tax-PF. Heterogeneity was significant (P = .08, I2 = 51%) and related to one trial. There was no more heterogeneity after exclusion of this trial (P = .99, I2 = 0%), and HR of death was 0.72 (95% CI, 0.63 to 0.83) in favor of Tax-PF. There was no interaction between treatment effect and the following patient covariates: age, sex, performance status, tumor stage, or site. Tax-PF was associated with significant reductions of progression, locoregional failure, and distant failure compared with PF, with HRs of 0.78 (95% CI, 0.69 to 0.87; P < .001), 0.79 (95% CI, 0.66 to 0.94; P = .007), and 0.63 (95% CI, 0.45 to 0.89; P = .009) respectively. Conclusion This IPD meta-analysis shows the superiority of Tax-PF over PF as induction chemotherapy. Its precise role in the management of LAHNC remains to be determined.

scholarly journals Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data

2019 ◽  
Vol 4 (11) ◽  
pp. e553-e564 ◽  
Author(s):  
Dongshan Zhu ◽  
Hsin-Fang Chung ◽  
Annette J Dobson ◽  
Nirmala Pandeya ◽  
Graham G Giles ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Individual Patient Data ◽  
Pooled Analysis ◽  
Patient Data ◽  
Natural Menopause ◽  
Incident Cardiovascular Disease
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