Faculty Opinions recommendation of An unexpected partnership: MHC class II molecules as ligands for NK cells.

2021 ◽  
Author(s):  
Fadi Issa
Keyword(s):  
Nk Cells ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Mhc Class Ii Molecules

scholarly journals FcγRIIIA-mediated activation of NK cells by IgG heavy chain complexed with MHC class II molecules

2019 ◽  
Vol 31 (5) ◽  
pp. 303-314 ◽  
Author(s):  
Yuta Shimizu ◽  
Masako Kohyama ◽  
Hideki Yorifuji ◽  
Hui Jin ◽  
Noriko Arase ◽  
...  
Keyword(s):  
Nk Cells ◽  
Mhc Class Ii ◽  
Heavy Chain ◽  
Class Ii ◽  
Mhc Class Ii Molecules

scholarly journals Synaptic Clusters of MHC Class II Molecules Induced on DCs by Adhesion Molecule–mediated Initial T-Cell Scanning

2005 ◽  
Vol 16 (7) ◽  
pp. 3314-3322 ◽  
Author(s):  
Hortensia de la Fuente ◽  
María Mittelbrunn ◽  
Lorena Sánchez-Martín ◽  
Miguel Vicente-Manzanares ◽  
Amalia Lamana ◽  
...  
Keyword(s):  
T Cells ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Regulatory Pathway ◽  
Immune Synapse ◽  
Mhc Ii ◽  
Cytoskeleton Reorganization ◽  
Adhesive Contacts ◽  
Enhance Antigen Presentation ◽  
Mhc Class Ii Molecules

Initial adhesive contacts between T lymphocytes and dendritic cells (DCs) facilitate recognition of peptide-MHC complexes by the TCR. In this report, we studied the dynamic behavior of adhesion and Ag receptors on DCs during initial contacts with T-cells. Adhesion molecules LFA-1- and ICAM-1,3-GFP as well as MHC class II-GFP molecules were very rapidly concentrated at the DC contact area. Binding of ICAM-3, and ICAM-1 to a lesser extent, to LFA-1 expressed by mature but not immature DC, induced MHC-II clustering into the immune synapse. Also, ICAM-3 binding to DC induced the activation of the Vav1-Rac1 axis, a regulatory pathway involved in actin cytoskeleton reorganization, which was essential for MHC-II clustering on DCs. Our results support a model in which ICAM-mediated MHC-II clustering on DC constitutes a priming mechanism to enhance antigen presentation to T-cells.

scholarly journals Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules

2007 ◽  
Vol 104 (14) ◽  
pp. 5989-5994 ◽  
Author(s):  
A. M. Keller ◽  
T. A. Groothuis ◽  
E. A. M. Veraar ◽  
M. Marsman ◽  
L. M. de Buy Wenniger ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
Intracellular Trafficking ◽  
Immunological Synapse ◽  
Class Ii ◽  
Mhc Class Ii Molecules
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