'Ionic' liquid salts can bypass skin and treat skin infections better

2019 ◽  
Author(s):  
Editage Insights
Keyword(s):  
Ionic Liquid ◽  
Skin Infections ◽  
Liquid Salts

scholarly journals Probing the Local Structure of Pure Ionic Liquid Salts with Solid- and Liquid-State NMR

ChemPhysChem ◽  
2010 ◽  
Vol 11 (1) ◽  
pp. 260-268 ◽  
Author(s):  
Peter G. Gordon ◽  
Darren H. Brouwer ◽  
John A. Ripmeester
Keyword(s):  
Ionic Liquid ◽  
Local Structure ◽  
Liquid State ◽  
Liquid Salts

Application of Hydroxylamine Ionic Liquid Salts in Hydroxylation of Benzene to Phenol with Ammonium Molybdate–Copper Chloride–Ionic Liquid System

2017 ◽  
Vol 46 (3) ◽  
pp. 289-292 ◽  
Author(s):  
Zhihui Li ◽  
Xudong Qi ◽  
Liya Gao ◽  
Yuanyuan Xu ◽  
Dongsheng Zhang ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Copper Chloride ◽  
Liquid System ◽  
Ammonium Molybdate ◽  
Hydroxylation Of Benzene ◽  
Liquid Salts

SYNTHESIS AND EVALUATION OF TASTE-MASKED IONIC LIQUID SALTS OF LORATADINE

2020 ◽  
pp. 71-79
Author(s):  
PRADNYA GONDANE ◽  
NIDHI P. SAPKAL ◽  
NIDHI JAISWAL
Keyword(s):  
Ionic Liquid ◽  
Melting Point ◽  
Uv Spectroscopy ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Drug Products ◽  
Dsc Studies ◽  
Counter Ions ◽  
Liquid Salts ◽  
Salt Forms

Objective: To synthesize and evaluate taste-masked ionic liquid (IL) salts of loratadine. Methods: In the present work, pharmaceutically active IL salts of loratadine using selected counter-ions were synthesized. The synthesized IL salts were characterized using melting point, Ultraviolet (UV) spectroscopy, Fourier Transform Infra-Red (FTIR) spectroscopy, Differential Scanning Calorimetry (DSC), and X-ray Diffraction (XRD). These salts were also evaluated for solubility, dissolution, and palatability studies. Results: All synthesized IL salts of loratadine exhibited melting points below 100 °C. UV spectral data and FTIR data confirmed the formation of new salt forms with selected counter-ions. The absence of sharp melting point peaks during DSC studies revealed the amorphous nature of new salt forms. During XRD studies, loratadine-indomethacin IL salt yields completely amorphous compound while the intensity of characteristic peaks of loratadine was found to be reduced with other counter-ions. Solubility studies revealed that the solubility of loratadine is reduced from 35.85 mg/ml to 3.63 mg/ml, 15.39 mg/ml, 5.31 mg/ml, and 3.71 mg/ml in case of IL-1, IL-2, IL-3, and IL-4, respectively. Dissolution studies further confirmed this finding. Except for oleate, all the IL salts were found to be palatable by subjects with the score ranging from 2.5 to 2.8, which is the standard range for palatability. Conclusion: Results obtained in the present work indicated that IL salts of loratadine can be synthesized successfully using selected counter-ions. This approach can be used to mask the bitter taste of pure loratadine and thus can be used for the development of drug products intended for children.

Reactivity of hydroxylamine ionic liquid salts in the direct synthesis of caprolactam from cyclohexanone under mild conditions

RSC Advances ◽  
2016 ◽  
Vol 6 (87) ◽  
pp. 83619-83625 ◽  
Author(s):  
Zhihui Li ◽  
Qiusheng Yang ◽  
Liya Gao ◽  
Yuanyuan Xu ◽  
Dongsheng Zhang ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Direct Synthesis ◽  
Mild Conditions ◽  
Liquid Salts

Several novel hydroxylamine ionic liquid salts were prepared and employed in the direct synthesis of caprolactam from cyclohexanone under mild conditions.

Stabilising disproportionation of lipophilic ionic liquid salts in lipid-based formulations

2021 ◽  
Vol 597 ◽  
pp. 120292
Author(s):  
Anthony Lai ◽  
Yasemin Sahbaz ◽  
Leigh Ford ◽  
Tri-Hung Nguyen ◽  
Shadabul Haque ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Liquid Salts
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