DIABETIC STRIATOPATHY: A RARE PRESENTATION OF NONKETOTIC HYPERGLYCEMIA

2021 ◽  
pp. 108-109
Author(s):  
Ranjan Mallick ◽  
Shyam Sunder Hembram ◽  
Ram Chandra Bhadra Chandra Bhadra
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type Ii Diabetes ◽  
Western Europe ◽  
Rare Complication ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Rare Presentation ◽  
Acute Hyperglycaemia

Type II Diabetes Mellitus is one of the most common non-communicable diseases with innumerable & potentially life threatening complications. In 2017, approximately 462 million individuals were affected by type 2 diabetes corresponding to 6.28% of the world's population (4.4% of those aged 15-49 years, 15% of those aged 50-69, and 22% of those aged 70+), or a prevalence rate of 6059 cases per 100,000. Over 1 million deaths per year can be attributed to diabetes alone, making it the ninth leading cause of mortality. The burden of diabetes mellitus is rising globally, and at a much faster rate in developed regions, such as Western Europe. The gender distribution is equal, and the incidence peaks at around 55 years of age. Global prevalence of type 2 diabetes is projected to increase to 7079 individuals per 100,000 by 2030, reecting a continued rise across all regions of the world.[¹] . Two of the common complications due to acute hyperglycaemia are Diabetic Ketocidosis & Non ketotic hyperosmolar coma which are considered a spectrum of the same complication due to low circulating levels of insulin leading to impaired glucose metabolism by insulin dependant tissues with rising levels of anti-insulin hormones like glucagon, cortisol & catecholamines due to intracellular starvation resulting in hypergylcemia & fatty acid breakdown & ketonemia. Amongst the numerous complications of Type II Diabetes Mellitus, here we present a rare complication of acute hyperglycaemia and its radiological picture in the central nervous system. A 56 year old female patient with a history of Type II Diabetes Mellitus with Hypertension under long term medication came for a private consultation with a complaint of Right sided involuntary, random, irregular, inging and ailing, rapid, non-patterned movements for past 7 days. The patient was advised for an urgent MRI of Brain which demonstrated high T1 signal & low T2/FLAIR intensity with no diffusion restriction of DWI & ADC map in left sided putamen & head of caudate nucleus. We illustrated a rare classical nding of acute hyperglycemic effect on brain in a case of long standing Type II Diabetes Mellitus despite being on medications

scholarly journals Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

2017 ◽  
Vol 2 (2) ◽  
pp. 26-34
Author(s):  
Hridaya Parajuli ◽  
Jyotsna Shakya ◽  
Bashu Dev Pardhe ◽  
Puspa Raj Khanal ◽  
Narayan Prasad Parajuli ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type Ii ◽  
Significant Difference

Background: Hyperuricemia is associated with type 2 diabetes, which is a metabolic disorder of multiple etiologies resulting from defects in insulin action. The present study wascarried out to look for any association between uric acid and Type II Diabetes Mellitus and also status of triacylglycerol level among those patients.Methods: The blood samples were collected 100 diabetic and 100 non-diabetic individuals in the department of biochemistry and then analyzed for estimation of blood glucose, Uric Acid and Triacylglycerol level.Results: The average level of serum uric acid in diabetic patients was higher (5.706±1.617) in comparison to non diabetic subjects (4.322±0.784) with statistically significant difference (p≤0.05). For female the result indicate there was a positive correlation between (FBS and triglycerides) and (triglycerides and uric acids) which was statistically significant (r =-0.465, n = 41, p = 0.002) and(r =-0.370, n = 41, p = 0.017) respectively.Conclusions: This study documents that hyperuricemia is associated with type 2 diabetes mellitus. Furthermore, the serum triacylglycerol and serum uric acid is also found to be associated risk factors for diabetic complications. Hence, timely diagnosis and management of diabetes is vital to control the complications related to diabetes.Ann. Clin. Chem. Lab. Med. 2016:2(1); 26-34

scholarly journals Influence of Glycated Haemoglobin Levels on Intraocular Pressure in patients with Type –II Diabetes Mellitus

2019 ◽  
Vol 11 (1) ◽  
pp. 19-23
Author(s):  
Ajai Agrawal ◽  
Shubham Ahuja ◽  
Anupam Singh ◽  
Ramanuj Samanta ◽  
Sanjeev Kumar Mittal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Intraocular Pressure ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Group I ◽  
Hba1c Levels

Introduction: Patients with diabetes mellitus are at a higher risk of developing primary open angle glaucoma (POAG) as compared to non-diabetic patients. Objectives: To determine whether there is a correlation between hyperglycemic levels and intraocular pressure (IOP) and to identify patients of Type II diabetes mellitus who are at a higher risk of developing glaucoma. Materials and Methods: This was a hospital based, cross sectional study performed on patients with type II diabetes mellitus, at a tertiary health care center in Uttarakhand, India between July, 2018 and September, 2018. 318 eyes of 159 patients with Type2 diabetes mellitus were included in the study. IOP was measured by Goldmannappla nation to no meter and central corneal thickness was measured with specula microscope in all patients, in addition to glycated hemoglobin levels (HbA1c) and fasting and post-prandial blood glucose levels. The data was analysed using SPSS 22 software. Results: Mean IOP was found to be 15.75 ± 3.18 mm Hg in patients with HbA1c levels between 6.5%-12% (Group I) and 17.42 ± 2.67 mm Hg in patients with HbA1c levels more than 12 % (Group II). The difference between the two groups was statistically significant (P =0.013). Out of 159 patients with Type 2 Diabetes mellitus, a total of 11 patients had IOP more than 21mm Hg in one or both the eyes. Conclusion: Hyperglycaemic levels as determined by raised HbA1c levels are associated with higher intraocular pressures in patients with type 2 diabetes mellitus.

scholarly journals Clinical evaluation of an Ayurvedic Formulation in the management of Avaranajanya Madhumeha (Type 2 Diabetes Mellitus)

2019 ◽  
Vol 1 ◽  
pp. 50-64
Author(s):  
DEVASHISH BHARDWAJ ◽  
VEENIT K. AGNIHOTRI ◽  
PRANAV PANDYA
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Research Plan ◽  
Urine Sugar ◽  
Diabetes Patients

A research plan has been developed in the present study to address the problems associated with Avaranajanya Madhumeha (type 2 diabetes). This research plan is based on the treatment methods of Ayurveda (ancient Indian medicine) and utilization of modern scientific methods as research tools. A specific ayurvedic herbo-mineral formulation has been prepared in Ghansatt (solid extract) form; the selected eight herbs and one herbo-mineral have anti-hyperglycemic (PRAMEHA HARA) and antihypercholestermic (MEDOHARA) properties with rejuvenative (RASAYANA) effects as described in classical ayurvedic methods. 15 diagnosed type II diabetes mellitus patients were selected through accidental sampling. Ayurvedic formulation was prescribed to type II diabetes patients for one year along with dietary restrictions. Diabetic diagnostic parameters of these patients like Fasting Blood Sugar (FBS), Post Patrum Blood Sugar (PPBS), Glycocylated Hemoglobin (HbA1C) and Urine Sugar Fasting were monitored every three months; these were measured before and after intervention. The obtained data were statistically analyzed through paired t-test. There was significant reduction in FBS level, PPBS level, HbA1C level and urine fasting sugar level in type 2 diabetes patients who completed the clinical trial successfully. Thus, ayurvedic formulation treatment lead to an overall significant reduction in blood sugar and urine sugar levels in type II diabetes patients. No side effects were noted during the study period. This study suggests that the ayurvedic formulation had very good hypoglycemic effects proved by clinical improvement and bio-chemical analysis of diabetes parameters in the treatment of type II diabetes mellitus.

scholarly journals FREQUENCY OF MICROALBUMINURIA IN ABNORMAL LIPID METABOLISM AND SUFFERING FROM TYPE II DIABETES MELLITUS

2021 ◽  
Vol 71 (4) ◽  
pp. 1126-29
Author(s):  
Ejaz Ali ◽  
Abdul Latif Khattak ◽  
Andaleeb Khan ◽  
Kamil Rehman Butt ◽  
Raheel Akhtar Yousafzai ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Metabolism ◽  
Type Ii Diabetes ◽  
General Medicine ◽  
Type Ii Diabetes Mellitus ◽  
Military Hospital ◽  
Type Ii ◽  
Abnormal Lipid Metabolism

Objective: To determine the frequency of dyslipidaemia in type-2 diabetic patients and to compare the frequency of dyslipidaemia in patients with and without microalbuminuria in type 2 diabetes. Study Design: cross-sectional study. Place and Duration of Study: Department of General Medicine, Combined Military Hospital Quetta Pakistan, from Dec 2018 to Jun 2019. Methodology: All patients who fulfilled the inclusion criteria and visited General Medicine department of Combined Military Hospital Quetta with type II diabetes mellitus were included in the study. Blood sample following an 8-12 hours fasting over the last night and 24 hour urine sample for microalbuminuria was collected to assess the outcome i.e. frequency of dyslipidaemia and also its frequency with and without microalbuminuria. Result: A total of 165 patients with type 2 diabetes mellitus were included. Ninety nine (60%) were males and 66 (40%) were females with the mean age of 48.08 ± 7.63 years. Overall, dyslipidaemia was found in 48 (29.1%) patients, dyslipidaemia was noted in 29 (17.6%) with microalbuminuria and 19 (11.5%) without microalbuminuria. Chi-square test revealed that dyslipidaemia was significantly more in patients of diabetes mellites having microalbuminuria than those not having it (p-value=0.01). Conclusion: Abnormal lipid metabolism was present in significantly more in patients with microalbuminuria as compared to those without microalbuminuria suffering from type II diabetes mellitus.

ROLE OF HS-CRP AND IRISIN IN OBESITY AND TYPE II DIABETES MELLITUS

2021 ◽  
pp. 46-47
Author(s):  
Pankaj Kambale ◽  
Sandip Lambe ◽  
Kanchan Lambe
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Control Group ◽  
Case Group ◽  
Type Ii ◽  
Hs Crp

Background: Overweight and type of II diabetes is emerging as important disease and the prevalence of these diseases is also increasing signicantly. Studies had proposed that irisin is having a role to play in pathophysiology of obesity and other metabolic diseases. The patients who are having type 2 diabetes are found to have higher irisin levels. The study on the association of irisin and hs-CRP with obesity and type 2 diabetes is increasing. Aim: The aim of the present study is to identify the role of irisin and HS-CRP in obesity and type II diabetes mellitus. Material and Methods: This was a community based cross-sectional study which is conducted on the medical OPD visitors of a tertiary care centre. For conducting this study 50 participants ageing between 10-50 years were selected and both male and female participants were included in this research study. In this study 25 patients belong to the case group and 25 patients were of the control group. Results: In the present study the mean of the HS-CRP was found to be 1.45±0.56 for case group and for the control group it was found to be 0.83±0.49. In the present study the mean irisin value for the case group was found to be 8.27±3.21 and for the control group it was found to be 7.47±2.54. Conclusion: In the current study it was found that the hs-CRP and the irisin level of the patients with type 2 diabetes and obesity are higher as compared with the normal individuals. It can be said that both the hs-CRP and the irisin level are positively associated with the obesity and type II diabetes mellitus.

scholarly journals 340. Prevalence of Type II Diabetes Mellitus Among Patients Living with HIV in the United States

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S180-S181
Author(s):  
Morgan Birabaharan ◽  
Andrew Strunk ◽  
Amit Garg ◽  
Stefan Hagmann
Keyword(s):  
Diabetes Mellitus ◽  
United States ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
The United States ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Living With Hiv

Abstract Background An aging HIV-infected population has growing recognition for its increasing prevalence of type 2 diabetes mellitus (T2DM). Most studies of T2DM prevalence among patients living with HIV involve selected samples and/or small cohorts which limit generalizability. We sought to evaluate the overall prevalence of T2DM among patients living with HIV in the United States as well as within specific demographic subgroups. Methods A cross-sectional analysis was performed using a large, multi-institutional database (Explorys), where clinical information across 27 healthcare networks are matched and standardized to create longitudinal records for each unique patient. At present, the database contains 63 million unique lives, representing 18% of the population across all 4 census regions of the United States. Patients with all types of insurance as well as those who are self-pay are represented. The analysis included adult patients with an active status in the database during April 2014- April 2019 who, not missing data on age, gender, race, and body mass index. The Systematized Nomenclature of Medicine—Clinical Terms (SNOMED-CT) of “Human Immunodeficiency Virus,” “diabetes mellitus type 2,” “disorder due to type 2 diabetes mellitus,” and “Type II diabetes mellitus uncontrolled” were used to identify patients with HIV and T2DM. Results We identified 90,900 patients with HIV. The overall prevalence of T2DM among patients with HIV was 22.1% (20,080/90,900) compared with 14.9% (2,679,490/17,946,580) in the general population. In subgroup analysis, the prevalence of T2DM was highest among patients with HIV who were female, older, other race, obese, hypertensive, hyperlipidemic, smokers, alcoholics, and those with a history of hepatitis C infection. Patients with no exposure to antiretroviral therapy (ART) had higher prevalence of T2DM than those with exposure (24.9% vs. 17.6%). Conclusion In this US population-based study, we found 1 in 5 people living with HIV had prevalent T2DM. In addition, we observed that HIV-associated T2DM may not depend on chronic ART exposure. Physicians caring for patients with HIV should be aware of the association and should monitor for signs and symptoms of T2DM. Disclosures All authors: No reported disclosures.

scholarly journals The Description of Sexual Dysfunction in Patients of Type II Diabetes Mellitus in Poly Disease In Mardi Hospital Waluyo City Blitar

2015 ◽  
Vol 2 (3) ◽  
pp. 216-221
Author(s):  
Sukma Puji Rahayu ◽  
Tri Cahyo Sepdianto ◽  
Arif Mulyadi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Sexual Dysfunction ◽  
Type Ii Diabetes ◽  
Sampling Technique ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Chronic Complications

Chronic complications of diabetes mellitus was the most common autonomic neuropathyresulted in sexual dysfunction. The aim of research was to described the sexual dysfunction in patientswith type 2 diabetes mellitus at Poli Penyakit Dalam Mardi Waluyo Hospital Blitar. The researchmethod used descriptive design. The population in this study were patients with type 2 diabetes mellituswho visited in poli penyakit dalam in Mardi Waluyo Hospital Blitar in April as many as 856 people, anda sample of 86 people were taken using purposive sampling technique. Collecting data used the FSFIquestionnaire for womens and IIEF for mens. These results indicate that the majority of patients withtype 2 diabetes mellitus sexual dysfunction. In patients 75% of women experience sexual dysfunction. At74% of men with erectile dysfunction, 88% experienced orgasm dysfunction, 85% experienced sexualdesire dysfunction, 86% experienced a satisfying sexual dysfunction, 89% overall satisfaction dysfunction.The suggestion in this research was expected FSFI and IIEF questionnaire could be used as a toolto monitor the presence of sexual dysfunction in Blitar.

scholarly journals Echocardiographic evaluation of diastolic dysfunction in type 2 diabetes mellitus without cardiac manifestations in rural hospital

2020 ◽  
Vol 7 (11) ◽  
pp. 1658
Author(s):  
Sachinkumar K Khade ◽  
Sudeep Kumar ◽  
Digvijay S. Hodgar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Informed Consent ◽  
Diastolic Dysfunction ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Cardiac Manifestations

Background: Diabetes is the commonest metabolic disorder affecting the people all over the world. Objective of the study was to identify the diastolic dysfunction in type 2 diabetes mellitus patient to recognize the early involvement of heart.Methods: This cross sectional study was conducted in tertiary care hospital cases of type II diabetes mellitus coming to our hospital and giving informed consent. Period of study was from September 2016 to February 2018. Consecutive type of non-probability sampling was used for the selection of study subjects. A total of 54 diagnosed patients of type II diabetes mellitus coming to our hospital and giving informed consent were included in the study.Results: Prevalence of diastolic dysfunction was observed to be 44.4% in patients of type 2 diabetes mellitus without cardiac manifestations. Prevalence of diastolic dysfunction was seen in 47.4% males in comparison to 42.9% females. Prevalence of diastolic dysfunction was 11.1%, 77.3% and 80% in cases with disease duration of 0-5 years, 6-10 years and more than 10 years respectively. Prevalence of diastolic dysfunction was more in cases with poor glycaemic control i.e. hemoglobin A1c (HbA1c) value >8% as compared to cases with good glycemic control.Conclusions: There was an association between the prevalence of diastolic dysfunction with the increasing age. We had higher percentage of patients with diastolic dysfunction as duration of diabetes increased. Diastolic dysfunction was seen in 55.2% patients receiving oral hypoglycaemic agents (OHAs) as compared to 23.5% patients who were on insulin and 50% patients who were on both insulin and OHAs.

scholarly journals Fibrinogen levels in type II diabetes mellitus patients with microvascular complications

2018 ◽  
Vol 5 (6) ◽  
pp. 1428
Author(s):  
Vijayalakshmi Chikkamath ◽  
Arathi Darshan ◽  
Jayaprakash S. Appajigol ◽  
Naveen Angadi ◽  
Abhishek T. G.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Type Ii Diabetes ◽  
Microvascular Complications ◽  
Type Ii Diabetes Mellitus ◽  
Plasma Fibrinogen ◽  
Type Ii

Background: Diabetes increases the morbidity and mortality due to its propensity to develop micro and macrovascular complications. Recently the role of haemostatic factors, particularly fibrinogen, in atherosclerosis and its complications has invited considerable attention. The present study was conducted to study plasma fibrinogen levels in type II diabetes mellitus patients with microvascular complications.Methods: One hundred patients aged 18years to 60years with type 2 diabetes mellitus with microvascular complications were included in the study. HBA1c, plasma fibrinogen, urine routine examination, fundoscopy, monofilament testing, FBS, PPBS were done. Descriptive statistics was used to analyse data.Results: Out of 100 diabetes patients with microvascular complication studies, 88 patients were found to have hyperfibrinogenaemia. Out of 100 patients 67 patients had HbA1c of more than 8%, and all of them had elevated fibrinogen levels (p <0.0001). The prevalence of hyperfibrinogenemia was higher in patients with diabetic retinopathy (90%), when compared to those without diabetic retinopathy (83.33%) although it was statistically not significant (p=0.266).Conclusions: Hyperfibrinogenemia among type 2 diabetes mellitus patients with microvascular complications was high. Glycaemic control has a significant impact on the fibrinogen levels. Longer the duration of diabetes, there was a higher prevalence of hyperfibrinogenemia.

scholarly journals Clinical and psychopathological features of patients with type II diabetes mellitus

2021 ◽  
Vol 11 (11) ◽  
pp. 182-187
Author(s):  
A. Kondratenko
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Emotional Disorders ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Visual Modality ◽  
Type Ii ◽  
Duration Of Diabetes

Today, type II diabetes mellitus (T2DM) is considered to be the most important nosological cause of decreased cognitive functions. A number of studies have found that hyperglycemia and duration of diabetes are associated with cognitive deficits, with the prevalence of cognitive impairment in type 2 diabetes mellitus being 20% in men and 18% in women over 60 years of age. To achieve this goal, it was conducted a comprehensive clinical-psychopathological and psychodiagnostic examination of 82 patients with moderate type 2 diabetes mellitus (46 women and 36 men) aged 35.9±10.1 years in accordance with the principles of bioethics and deontology. The mean duration of diabetes was 7.9±5.2 years. The severity of diabetes in most cases was defined as moderate (84.1%), and in 15.9% of cases corresponded to severe. 30.2% of patients used insulin as a basic hypoglycemic therapy, 69.8% - tablets. According to the analysis of the emotional state of patients with T2DM were characterized by complaints of low, depressed mood (69.5% of examined patients), uncontrolled emotional reactions (46.2%), feelings of anxiety, constant internal tension (44.7%), paresthesias (29.1%), sleep-wake cycle disorders (56.2%), general weakness, lethargy and fatigue (58.2%), fatigue (90.0%), frequent mood swings, with a predominance of decreased mood background (23.3%), emotional lability with excessive vulnerability and sensitivity (16.6%), irritability (16.6%). The clinical and psychopathological structure of emotional disorders is represented by anxious (43.4%), depressive (26.6%), astheno-hypochondriac (19.8%), hysteroform (10.2%) syndromes. Clinical examination of patients with DM showed that more often (in 95.0% of cases) in patients with T2DM there is a decrease in memory of auditory and visual modality, impaired intellectual abilities, slow thinking, lack of attention and information processing.

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