scholarly journals PROFILE OF KERATOMYCOSIS IN A TERTIARY CARE TEACHING HOSPITAL IN WESTERN UTTAR PRADESH, INDIA

2021 ◽  
pp. 1-4
Author(s):  
Vandana Sardana ◽  
Sameer R Verma

Introduction- Fungal keratitis or keratomycosis refers to an infective process of the cornea caused by fungi capable of invading the ocular surface. Aims & Objectives-i) To determine the frequency of fungal keratitis in clinically diagnosed cases ii)To identify the aetiological agents of keratomycosis. iii) To assess the precipitating factors associated with it. Method- A retrospective data of 2 years was analyzed to study the number of cases of fungal keratitis, from among the corneal scrapings submitted to the Department of Microbiology, examined for the presence of fungal elements by direct microscopic methods and for the fungal growth in culture. Results-The frequency of fungal keratitis in clinically diagnosed cases was 28.6 %. Among the positive cases, males outnumbered females with the ratio of 1.67:1. The maximum number of positive cases were seen in the age group of 21-30 years, followed by the age groups of 31-40 years and 11-20 years. The most common cause of fungal keratitis was Aspergillus flavus (31.25 %), followed by Aspergillus fumigatus (18.75 %), Fusarium solani and Candida albicans (12.5 % each ), and Cladophialophora bantiana, Curvularia, Mucor and Candida tropicalis (6.25 % each ). Aspergillus species were found to be isolated from 50% of cases of keratomycosis. Filamentous fungi were predominantly associated with mycotic keratitis, accounting for 81.25% of cases, as compared to yeasts which had caused keratitis in 18.75% of cases. Amongst the cases of keratomycosis, all were positive for fungal growth on culture, out of which 81.25% cases were also positive for the presence of fungal elements on direct microscopy. Discussion: Keratomycosis is the leading cause of ocular morbidity worldwide, including India. Fungal agents causing keratitis should receive special attention due to their opportunistic behaviour and indolent course of disease. Lack of early diagnosis and treatment prelude the onset of complications, which may compromise the patient’s vision and thereby the quality of life. Conclusion: Regular surveillance and scrutiny of mycotic keratitis is important and essential to understand the pattern of fungi, existing or emerging, so as to prevent the unnecessary and irrational usage of antibiotics.

2020 ◽  
Vol 09 (02) ◽  
pp. 036-041
Author(s):  
Mukesh Kumar Prajapati ◽  
Deepak Dwivedi ◽  
Naresh Bajaj

Abstract Objective The main aim of this study was to assess quality of life in children with epilepsy. Materials and Methods A prospective observational study was conducted in Regional Early Intervention Centre of the Department of Pediatrics Tertiary Care Hospital in central India. This study included 120 children with epilepsy aged between 2 and 18 years. In this study, we assessed the quality of life in children with epilepsy with the help of Pediatric Quality of Life Inventory (PedsQL). We further analyzed the quality of life in various dimensions. For the statistical analyses for SPSS version, 20 was used, chi-squared and Fisher's exact test was used for categorical variables, and Student's t-test was used for quantitative variables. Linear regression analysis was done for multivariate analysis. Result Mean total PedsQL score for total cohort was 70.96. The cognitive dimension of epileptic children was more affected than physical, social, and emotional dimensions. Factors associated with lower PedsQL scores in epilepsy patients were associated with long duration of epilepsy, polytherapy, male gender, low head circumference, presence of intellectual disability, and refractory epilepsy. Conclusion Epilepsy affects the quality of life in children across all age groups. Among epilepsy indicators, polytherapy, refractory epilepsy, and duration of epilepsy were the most important factors associated with poor quality of life. We can conclude that every effort should be made to decrease the duration of treatment and minimize the number of drugs for improving the quality of life in this patient cohort.


Author(s):  
Gajendra V. Singh ◽  
Antriksh Srivastava ◽  
Vinisha Chandra ◽  
Santosh Kumar ◽  
Rishabh Goel

Background: Pulmonary tuberculosis (TB) is a unique infectious disease that more often results in permanent structural changes in the lung parenchyma. It is by virtue of these changes that the patients even after bacteriological cure continue to suffer the after effects of the disease. Objective of study was to assess the clinico-physiological profile of patients of pulmonary impairment after tuberculosis (PIAT) attending S. N. Medical College, Agra, Uttar Pradesh, India.Methods: Over the time period of 2 years, 350 patients of healed pulmonary tuberculosis were identified and studied about their clinico-physiological profile. This profile included age, sex, category of treatment, pulmonary function test pattern, exercising capacity, exercise tolerance and quality of life.Results: It was found that majority of the patients were males, >60 years of age and had taken Category-II treatment. Most of the patients were having an obstructive pattern on PFT, poor exercise tolerance and exercise capacity and a poor quality of life.Conclusions: Patients of healed pulmonary TB continue to experience respiratory symptoms owing to the permanent anatomical changes in the lung conferred by the disease.


Author(s):  
Ruby Kumari ◽  
Lata Shukla Dwivedy ◽  
Sweta Gupta ◽  
Surabhi . ◽  
Madhuri Choudhary ◽  
...  

Background: AUB has significant impact on quality of life of women related to health specially in developing countries including India. FIGO AUB systems are universally accepted. Aim was to study the clinical spectrum of AUB according to the FIGO AUB systems and women’s attitude towards its management.Methods: Cross sectional prospective study was carried out in the department of Obstetrics and Gynaecology, ANMMCH, Gaya, a tertiary care center, among women of 15-55 years age groups having complain related to abnormal uterine bleeding, for 1 year from 1st May 2019 to 30th April 2020 on 1000 patients. Data was collected and analyzed by percentage and proportions.Results: Prevalence of AUB was maximum among 15-30 years age group of patients (46.80%). Most of the patients belong to lower (62.5%) class, rural area (68%) and were anaemic (62.5%). Ovulatory dysfunction (55%) was most common cause for AUB, maximum patients choose surgical management (hysterectomy) but after counselling, most of them shifted to medical management.Conclusions: This study suggests more conservative approach for management of AUB and emphasizes the importance of awareness for clinical spectrum of AUB among women so that they can be self-motivated for early treatment and unnecessary hysterectomy can be avoided.


2015 ◽  
Vol 22 (10) ◽  
pp. 1345-1350
Author(s):  
Muhammad Saad Ullah ◽  
Sohail Safdar ◽  
Muhammad Nabeel Ahmad

Objective: The main objective of the present study was to find out visual outcomeof Low Vision Devices among patients suffering from different diseases causing reduced visualacuity in the area of Dera Ghazi Khan, Southern Punjab, Pakistan. Setting: OphthalmologyDepartment, Dera Ghazi Khan which is a tertiary care hospital. Period: 10th February, 2014 to31st December, 2014. Material and Methods: Patients (n=55) presented for their low visionassessment included two groups age wise as patients equal or more than 18 years age (n=22)and patients less than 18 years (n=33). LOG MAR VA charts, contrast sensitivity test, visualfields through arc perimeters, color vision with color pencils hue 16 test along with objective andsubjective refractions were applied. All the data were entered and analyzed using SPSS version16.00. Results: Patients (n=55) aged 7-90 years presented for their low vision assessment hadmean age 23.73+ 2.9 years. The patients were divided into two age groups. First group was22 (40%) patients equal or more than 18 years age and second consisted of 33(60%) patientsless than 18 years age group. Among the patients examined, 40 (72.7%) were males and 15(27.3%) were females. Our study results revealed that the low vision devices provision wasassociated with a statistically significant improvement in both near and distance visual acuitiesand with patients’ fulfillment. Conclusion: There was a significant improvement in far and nearvisual acuity of the patients suffering from a multiplicity of blindness caused diseases by whichpatients are able to improve their quality of life and able to do their tasks without getting helpfrom others.


Author(s):  
Amir Nazarian ◽  
Kirles Bishay ◽  
Reza Gholami ◽  
Michael A Scaffidi ◽  
Rishad Khan ◽  
...  

Abstract Background Health-related quality of life (QoL) is often adversely affected in patients with inflammatory bowel disease (IBD). We aimed to identify factors associated with poor QoL among Canadian patients with IBD in clinical remission. Methods We enrolled patients at a single academic tertiary care center with inactive IBD. All eligible patients completed a series of questionnaires that included questions on demographics, disease activity, anxiety, depression and the presence of irritable bowel syndrome (IBS) symptoms. Stool sample for fecal calprotectin (FC) was also collected to assess for subclinical inflammation. The primary outcome measure was QoL assessed by the short inflammatory bowel disease questionnaire (SIBDQ), with planned subgroup comparisons for fatigue, anxiety, depression and IBS symptoms. Results Ninety-three patients were eligible for inclusion in this study. The median SIBDQ scores were lower in patients with anxiety (P < 0.001), depression (P = 0.004), IBS symptoms (P < 0.001) and fatigue (P = 0.018). Elevated FC in patients in clinical remission did not impact QoL. These findings were consistent on multivariate linear regression. Conclusions Anxiety, depression, fatigue and IBS symptoms are all independently associated with lower QoL in patients with inactive IBD. Clinicians are encouraged to screen for these important factors as they may detrimentally impact QoL in IBD patients even in clinical remission.


2020 ◽  
pp. 1-2
Author(s):  
Arer AR ◽  
Hulagbali M

A study was conducted on 90 children suffering with thalassemia who are attending thalassemia unit of KLES Dr. Prabhakar Kore Charitable Hospital Belagavi. To assess the health related quality of life of children with thalassemia and to find out the association between health related quality of life of children with Thalassemia and selected demographic variables. Purposive sampling technique was used to select the samples. Data was collected using standardized paediatric inventory quality of life (PedsQL 4.0 Generic Core Scales) tool. Data obtained was tabulated and analysed in terms of objectives of the study using descriptive and inferential statistics. The study revealed that Majority 70 (77.78%) of thalassemia children had average level of quality of life where as minimum 10 (11.11%) of thalassemia children had low and high level of quality of life. The association between age groups and levels of QOL is found to be not statistically significant (Chi-square= 6.3530, p=0.1740) and the association between religions and levels of QOL is found to be not statistically significant.


Author(s):  
Ajai K. Singh ◽  
Poonam Chaturvedi ◽  
Pradeep K. Maurya ◽  
Dinkar Kulshreshtha ◽  
Abdul Qavi ◽  
...  

Background: Early rehabilitation plays a very important role in stroke outcome. In India people from rural areas get primary treatment from district hospitals, where the rehabilitation facilities are not available, and then referred to the tertiary care hospital (after 2-3weeks) hence the rehabilitation process is delayed. It may delay the improvement in functional outcome and quality of life. These factors should be evaluated. To evaluate effects of PNF intervention in urban and rural population in Uttar Pradesh.Methods: Total 90 patients were recruited in this study and divided into rural (coming from rural areas of Uttar Pradesh) and urban (coming from urban areas) groups. Patients were given rehabilitation for 4weeks and improvement in functional activities was assessed by Barthel's-Index (BI), Quality of Life was assessed by Stroke Specific Quality of Life Scale (SSQOL) and sensory motor improvement was assessed by Fugl- Meyer Assessment before and after the intervention. Patients were again assessed at 6months.Results: 41 patients in experimental and 49 patients in control group completed the 6 months follow up and were available for analysis. On analysis urban group showed better (<0.05) improvement in functional activities, sensory motor improvement (FMA) and quality of life (SSQOL) as well. People who directly admitted to our multispecialty and tertiary care hospital and received early rehabilitation showed better improvement than the patients who received late rehabilitation.Conclusions: Early rehabilitation leads to early improvement in functional activities. PNF exercises are very effective in improving motor function and should be given from the first day after stroke.


Author(s):  
Arup Chakraborty ◽  
Mousumi Datta ◽  
Debjani Guchhait ◽  
Shibaji Gupta

Background: Japanese encephalitis (JE) vaccination in India started in 2006 with SA-14-14-2 live attenuated JE vaccine (JEV) following large outbreaks of JE in some districts of Eastern Uttar Pradesh and Bihar in 2005. Age groups 1-15 yrs are first vaccinated with a single dose of JEV in a campaign mode followed by integration of this vaccine in routine immunization. It is beyond doubt that added to vaccination campaigns, proper awareness on JE can play significant role in controlling the disease.Methods: An observational study with cross sectional design was conducted in Kolkata Medical College and Hospital, Kolkata during JE Vaccination campaign during January, 2018 among 85 respondents, to assess the awareness on JE, among care-givers who brought their children for vaccination at the immunization clinic.Results: It was found that only 37.6% the respondents attending the campaign knew the name of the disease; 17.6% respondents were aware about disease transmission, and 5.9% could state two or more clinical features that might be associated with Japanese Encephalitis. 69.4% had no knowledge of up to what age JE vaccines can be administered; 23.5% said it can be administered till the beneficiaries attain fifteen years of age.Conclusions: IEC activities during JE vaccination campaign was not able raise awareness on JE to the desired level. However beneficiaries were informed about service availability and could be mobilised to come for vaccination.


2021 ◽  
Vol 8 (20) ◽  
pp. 1505-1509
Author(s):  
Bindu Madhavi R ◽  
Manjula Y.M ◽  
Suma C ◽  
Soumya Basanth ◽  
Nibedita Acharya

BACKGROUND Treatment of fungal ulcers is one of the most challenging tasks. Various topical antifungal drugs have poor corneal stromal penetration. Voriconazole is a broad spectrum drug and is an effective agent for the treatment of fungal keratitis as a topical preparation. It is potent against a broad range of clinically significant fungal infections both in the eye as well systemically. In tropical climatic conditions filamentous fungi commonly cause eye infections and are associated with poor visual outcomes. The treatment options for mycotic ulcers are limited, therefore direct intrastromal injections are helpful in the management of these deep mycotic keratitis. We wanted to evaluate the role of intrastromal injection of voriconazole in the management of deep fungal keratitis not responding to conventional therapy. METHODS This an interventional case series study done at a tertiary care centre in south India from the year April 2019 to August 2020. Eight eyes of eight patients with microbiologically proven deep stromal recalcitrant mycotic keratitis not responding to topical antifungal medications were evaluated. Voriconazole 50 microgram / 0.1 ml was injected around the infiltrate in the corneal stroma as an adjunctive to the topical antifungal treatment. Main outcome measure was a reduction of the size of the infiltrate and ulcer and decrease in infection on regular follow ups. RESULTS Before injecting voriconazole, all the cases were of either gradually worsening of lesions on topical treatment, or not responding to topical treatment. After the injection a rapid decrease in the size of corneal ulcer, hypopyon, and infiltration was seen within 3 weeks. CONCLUSIONS Targeted delivery of intrastromal voriconazole may be a safe and effective way in the management of deep seated fungal ulcers which respond poorly to conventional treatment procedures, thus reducing the need for further surgical treatment. KEYWORDS Intrastromal Injection, Voriconazole, Fungal Keratitis, Deep Mycotic Keratitis


Author(s):  
Sumit Saxena ◽  
Kuldeep Srivastava ◽  
Anurag Srivastava ◽  
Anju Saxena

Introduction: Satisfaction of the patient play a very important decisive factor for pay-for-performance metrics and it also replicates the type of care being provided. One of the major parameters to establish patient satisfaction is to measure success of services provided in hospital. Aim: To assess the quality of care in terms of patient’s satisfaction in a tertiary care hospital of Uttar Pradesh. Materials and Methods: A community based cross-sectional study was carried out among patients attending the Outpatient Department (OPD) at Varunarjun Medical College and Rohilkhand Hospital, Uttar Pradesh, India. Total 88 people (patients or attendants) were interviewed by using a predesigned and pretested semi-structured proforma, in Hindi language. The questionnaire contained questions related to an individual’s experience with the staff and environment of health system at the end of their outpatient visit. Data were analysed using Statistical Package for the Social Sciences (SPSS) version 20.0. Results: The majority 37 (42.0%) belonged to age group of 34-49 years, 58 (66%) were males, 36 (40.9%) educated upto high school and 45 (51.2%) belonged to general category. In the present study, regarding hospital informatory, 28 (31.8%) respondent found good direction indicators. Waiting period was less than half-an-hour reported by 47 (53.4%) patients. Sixty-three (71.5%) patients had opportunity to ask questions about their disease and treatment. Most of the respondent 50 (56.8%) said that hospital staff listened to their questions and problems. Statistically significant association was found in- between patient satisfaction and socio-demographic variable like age, gender, education and socio-economic status (p-value <0.05). Around 68 (77.2%) respondent were not satisfied with behaviour of hospital staff (nurses and paramedical staff) whereas only 35 (39.8%) respondent were satisfied with the behaviour of treating doctor. Conclusion: Among the different domains of measurements of patient satisfaction, only few were satisfied with doctor’s and paramedical staff. Doctor's time, behaviour of paramedical staff and poor quality of services were the main reasons for dissatisfaction among dissatisfied patients.


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