scholarly journals ROLE OF PROPHYLACTIC ANTI COAGULANTS AND ANTI PLATELETS TO REDUCE THE INCIDENCE OF THROMBOSIS, STROKE, MYOCARDIAL INFARCTION IN ASYMPTOMATIC PATIENTS OF COVID19

2021 ◽  
pp. 14-16
Author(s):  
J Mariano Anto Brunomascarenhas
Keyword(s):  
Myocardial Infarction ◽  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
The Body ◽  
Vein Thrombosis ◽  
Asymptomatic Patients ◽  
Embolism And Thrombosis ◽  
Deep Vein ◽  
Serial Evaluation

BACKGROUND: As we are in the middle of the second year of the COVID19 Pandemic,we are observing an increased incidence of conditions like Cerebrovascular Accidents, Ischemic Heart Disease, Myocardial Infarction, Deep Vein Thrombosis,Pulmonary Embolism,and Thrombosis of Other Vessels. MATERIALS AND METHODS: Literature Review and Analysis of Coagulation Profiles of Patients in the past 1 year treated by the author was done. RESULTS AND CONCLUSIONS: 1. COVID19 is not just an infectious disease, but also an Immune Disease. The Immune Part can also happen in Asymptomatic Patients and those who got the vaccine. 2. Most of the disease processes in the body start after the virus has been cleared from the throat. The vigil against complications must not stop when the Throat Swab becomes negative or even when the patient is discharged but must continue for months till all the disease processes stop. 3.It is recommended that: a.Initial Evaluation with PT, aPTT, INR is done for: I.Those suffering from COVID 19 who have not undergone D Dimer evaluation ii.Those recovering from COVID 19. iii.Those likely to have had COVID 19 (based on the symptoms),but the infection was not documented. iv.Those likely to have had asymptomatic COVID 19 (contacts of COVID19 infected patients) v.Those planning to take Vaccines for COVID19. b.An Abnormal Value in PT,aPTT,INR may be managed with appropriate Drugs like Aspirin,Clopidogrel,Dipyridamole, Ticlopidine, Rivaroxaban, Dabigatran, Apixaban, Edoxaban, Heparin, Low Molecular Weight Heparin, Warfarin, and other drugs. c. Serial Evaluation of PT, aPTT, INR be done after 1 month, 3 months, 6 months (and even at more frequent intervals if indicated) and the drugs are added or removed,the dosage of the drugs is increased or reduced based on the results. d.Standard Indication of IVC Filter may be followed. 4.It is the knowledge of the pathogenesis of Thrombosis that is crucial in the prevention and management of Stroke, Heart Attack, Deep Vein Thrombosis, and Pulmonary Embolism rather than fancy gadgets, expensive tests, and exotic drugs.

scholarly journals Estimating the risk of thrombotic events in people with congenital hemophilia A using US claims data

2021 ◽  
Author(s):  
Imi Faghmous ◽  
Francis Nissen ◽  
Peter Kuebler ◽  
Carlos Flores ◽  
Anisha M Patel ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Ischemic Stroke ◽  
Hemophilia A ◽  
Incidence Rates ◽  
Thrombotic Risk ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
Similar Incidence

Aim: Compare thrombotic risk in people with congenital hemophilia A (PwcHA) to the general non-hemophilia A (HA) population. Patients & methods: US claims databases were analyzed to identify PwcHA. Incidence rates of myocardial infarction, pulmonary embolism, ischemic stroke, deep vein thrombosis and device-related thrombosis were compared with a matched cohort without HA. Results: Over 3490 PwcHA were identified and 16,380 individuals matched. PwcHA had a similar incidence of myocardial infarction and pulmonary embolism compared with the non-HA population, but a slightly higher incidence of ischemic stroke and deep vein thrombosis. The incidence of device-related thrombosis was significantly higher in PwcHA. Conclusion: This analysis suggests that PwcHA are not protected against thrombosis, and provides context to evaluate thrombotic risk of HA treatments.

Postoperative Deep Vein Thrombosis, Pulmonary Embolism, and Myocardial Infarction

Spine ◽  
2018 ◽  
Vol 43 (13) ◽  
pp. E766-E772 ◽  
Author(s):  
Brian Shiu ◽  
Elizabeth Le ◽  
Ehsan Jazini ◽  
Tristan B. Weir ◽  
Timothy Costales ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Vein Thrombosis ◽  
Postoperative Deep Vein Thrombosis ◽  
Deep Vein

scholarly journals Retrospective Derivation and Validation of an Automated Electronic Search Algorithm to Identify Post operative Cardiovascular and Thromboembolic Complications

2015 ◽  
Vol 06 (03) ◽  
pp. 565-576 ◽  
Author(s):  
M. Tien ◽  
R. Kashyap ◽  
G. A. Wilson ◽  
V. Hernandez-Torres ◽  
A. K. Jacob ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Knee Arthroplasty ◽  
Search Algorithm ◽  
Cardiovascular Complications ◽  
Data Abstraction ◽  
Vein Thrombosis ◽  
Electronic Search ◽  
Deep Vein

Summary Background: With increasing numbers of hospitals adopting electronic medical records, electronic search algorithms for identifying postoperative complications can be invaluable tools to expedite data abstraction and clinical research to improve patient outcomes. Objectives: To derive and validate an electronic search algorithm to identify postoperative thromboembolic and cardiovascular complications such as deep venous thrombosis, pulmonary embolism, or myocardial infarction within 30 days of total hip or knee arthroplasty. Methods: A total of 34 517 patients undergoing total hip or knee arthroplasty between January 1, 1996 and December 31, 2013 were identified. Using a derivation cohort of 418 patients, several iterations of a free-text electronic search were developed and refined for each complication. Subsequently, the automated search algorithm was validated on an independent cohort of 2 857 patients, and the sensitivity and specificities were compared to the results of manual chart review. Results: In the final derivation subset, the automated search algorithm achieved a sensitivity of 91% and specificity of 85% for deep vein thrombosis, a sensitivity of 96% and specificity of 100% for pulmonary embolism, and a sensitivity of 100% and specificity of 95% for myocardial infarction. When applied to the validation cohort, the search algorithm achieved a sensitivity of 97% and specificity of 99% for deep vein thrombosis, a sensitivity of 97% and specificity of 100% for pulmonary embolism, and a sensitivity of 100% and specificity of 99% for myocardial infarction. Conclusions: The derivation and validation of an electronic search strategy can accelerate the data abstraction process for research, quality improvement, and enhancement of patient care, while maintaining superb reliability compared to manual review. Citation: Tien M, Kashyap R, Wilson GA, Hernandez-Torres V, Jacob AK, Schroeder DR, Mantilla CB. Retrospective Derivation and Validation of an Automated Electronic Search Algorithm to Identify Postoperative Thromboembolic and Cardiovascular Complications. Appl Clin Inform 2015; 6: 565–576http://dx.doi.org/10.4338/ACI-2015-03-RA-0026

Role of Obesity in the Etiology of Deep Vein Thrombosis and Pulmonary Embolism: Current Epidemiological Insights

2013 ◽  
Vol 39 (05) ◽  
pp. 533-540 ◽  
Author(s):  
Bob Siegerink ◽  
Willem Lijfering ◽  
John-Bjarne Hansen ◽  
Suzanne Cannegieter ◽  
Frits Rosendaal ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Vein Thrombosis ◽  
Deep Vein

Is Deep-Vein Thrombosis Always the Origin of Pulmonary Embolism? Imaging of Veins with a Total-Body Direct Thrombus MRI Technique

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 2297-2297
Author(s):  
Kirsten van Langevelde ◽  
Alexandr Srámek ◽  
Patrice W.J. Vincken ◽  
Jan-Kees van Rooden ◽  
Frits R. Rosendaal ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Conflicts Of Interest ◽  
Clinical Manifestations ◽  
Factor V Leiden ◽  
The Body ◽  
Prothrombin G20210a ◽  
Vein Thrombosis ◽  
Total Body ◽  
Deep Vein

Abstract Abstract 2297 Introduction Pulmonary embolism (PE) is thought to originate from embolisation of a deep-vein thrombosis (DVT), resulting in two clinical manifestations of one disease: venous thrombosis. However, in up to 50% of patients with PE, no DVT is found with ultrasound. A new technique in diagnosing DVT is ‘MR Direct Thrombus Imaging’ (MRDTI), using methaemoglobin in the thrombus as endogenous contrast. We performed total body MRIs to visualize thrombi from calf veins to subclavian veins, to assess the origin of PE. Methods Consecutive patients with a first PE diagnosed by Multi Detector CT scan are included. All patients undergo a 1.5 T MRDTI scan. In addition, blood is sampled for determination of genetic risk factors: the Factor V Leiden (FVL) and prothrombin G20210A (FII) mutations. Results 99 patients have been enrolled in the study. In 44/99 (44%) a thrombus was identified on MR images. Most thrombi originated from the left side of the body (27/44). The upper leg was involved most often (22/44), with thrombi extending into the calf in 16 of these patients. Other thrombi were present in the pelvic veins (4/44), and deep calf veins alone (12/44). 6 patients had merely thrombophlebitis. The FVL mutation was present in 14% (95% CI 6–27) of patients with a thrombus on MRI, and in 7% (95% CI 3–18) of patients without a thrombus. For FII, the prevalence in the group with a DVT on MRI was 2% (95% CI 0.4–12) and without a DVT 4% (95% CI 1–13). Conclusion In less than half of PE patients a thrombus can be found with total body MRI. When thrombi were present, they were mainly found in the upper leg, extending into the calf veins. Interestingly, 27% of PEs with a thrombus on MRI was related to isolated calf vein thrombosis and 14% to thrombophlebitis. In PE patients with no thrombus on MRI, a local origin of PE, a thrombus from cardiac origin or complete embolisation needs to be considered. Supported by Netherlands Heart Foundation grant number 2009B050 Disclosures: No relevant conflicts of interest to declare.

The incidence of pulmonary embolism during deep vein thrombosis

2013 ◽  
Vol 28 (1_suppl) ◽  
pp. 29-33 ◽  
Author(s):  
J D Nielsen
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Heart Failure ◽  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Major Trauma ◽  
Major Surgery ◽  
Vein Thrombosis ◽  
High Age ◽  
Deep Vein

Among life-threatening cardiovascular diseases, pulmonary embolism (PE) is the third most common after myocardial infarction and stroke. PE is a manifestation of venous thromboembolism (VTE). PE shares risk factors with deep vein thrombosis (DVT) and is regarded as a consequence of DVT rather than a separate clinical entity. Risk factors for VTE include major surgery, major trauma, high age, myocardial infarction, chronic heart failure, prolonged immobility, malignancy, thrombophilia and prior VTE. It is, however, important to recognize that these factors are not equally important and not equally common in patients with PE and DVT, respectively. Compared with DVT, PE is more often associated with major surgery, major trauma, high age, myocardial infarction and chronic heart failure, whereas malignancy and thrombophilia primarily are clinical predictors of DVT. In patients with prior VTE the initial clinical manifestation strongly predicts the manifestation of recurrent episodes, i.e. patients with previous PE are more likely to develop recurrent PE than DVT while patients with DVT predominantly are at risk of recurrent DVT.

Sign in / Sign up

Export Citation Format

Share Document