scholarly journals Letter to the Editor: Response to “Efficacy of oral iron therapy in geophagic women with iron deficiency anaemia residing in Botshabelo, South Africa”

2020 ◽  
pp. 114-115
Author(s):  
M Coetzee ◽  
A Van Marle
Keyword(s):  
South Africa ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Iron Status ◽  
Haemoglobin Concentration ◽  
Oral Iron ◽  
Iron Therapy ◽  
Iron Supplements ◽  
Deficiency Anaemia ◽  
Oral Iron Therapy

We read the recent paper by Mogongoa on efficacy of oral iron therapy in geophagic women with interest. The author must be congratulated on a detailed study. In summary, the study divided 84 geophagic women with iron deficiency anaemia into two groups, one which stopped geophagia, and one which continued with geophagia, while receiving oral iron supplements. After ten weeks of gradually escalating doses of oral iron the participants’ average iron status and haemoglobin had not improved significantly. Response to iron therapy was defined as a rise of the haemoglobin concentration by 2 g/dL within three weeks. In the group that had stopped geophagia 9.3% (4/43) participants had an increase of 2 g/dL in haemoglobin over the ten weeks, while in the group that continued with geophagia only one participant (2.9% = 1/35) had a similar improvement. The author concluded that “oral iron therapy was not effective in geophagia cases of iron deficiency anaemia” in the abstract and “in this study oral iron therapy was not effective for the correction of iron deficiency anaemia in geophagic Botshabelo females” in the conclusions. We wish to point out that this conclusion might not be entirely correct.

Su1994 ORAL IRON THERAPY PROMOTES A PROINFLAMMATORY GUT MICROBIOTA IN COLORECTAL CANCER PATIENTS WITH IRON DEFICIENCY ANAEMIA

2020 ◽  
Vol 158 (6) ◽  
pp. S-737-S-738
Author(s):  
Oliver Phipps ◽  
Mohammed Nabil Quraishi ◽  
Aditi Kumar ◽  
Edward Dickson ◽  
Oliver Ng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Gut Microbiota ◽  
Cancer Patients ◽  
Iron Deficiency Anaemia ◽  
Oral Iron ◽  
Iron Therapy ◽  
Deficiency Anaemia ◽  
Oral Iron Therapy ◽  
Colorectal Cancer Patients

scholarly journals Efficacy of oral iron therapy in geophagic women with iron deficiency anaemia residing in Botshabelo, South Africa

2020 ◽  
pp. 13-21 ◽  
Author(s):  
LF Mogongoa
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Iron Absorption ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Oral Iron ◽  
Iron Therapy ◽  
Deficiency Anaemia ◽  
Oral Iron Therapy ◽  
Soil Consumption

Background: Iron deficiency anaemia is the most commonly encountered form of anaemia in females worldwide. This form of anaemia is, amongst others, associated with geophagia that is defined as the consumption of soil. The two main reasons for the association of geophagia with anaemia are that soil is thought to supplement mineral deficiency and geophagia is seen as a symptom of the anaemia. However, it is hypothesised that soil consumption interferes with iron absorption instead of supplementing it. The first line of therapy for iron deficiency anaemia is oral iron. Therefore, if soil consumption interferes with iron absorption it could interfere with oral iron therapy leading to patients being burdened with symptoms of anaemia as treatment is not effective. The aim of the study was to evaluate the efficacy of oral iron therapy in female participants afflicted with iron deficiency anaemia associated with geophagia. Methods: In this prospective randomised intervention study, 84 geophagic women with iron deficiency anaemia were divided into two groups. One group continued with soil consumption while the other stopped consumption. Oral iron therapy was administered for ten weeks at increasing therapy doses for both groups. Red cell and iron study parameters were evaluated at different time intervals to ascertain the efficacy of iron replacement therapy. Results: The group that stopped soil consumption showed a statistically significant change in haemoglobin (9.4 to 10.0 g/dL, p = 0.029), mean corpuscular volume (73.6 to 75.7 fl), mean corpuscular haemoglobin (23.7 to 24.6 pg), serum iron (22.5 to 28 μg/dL, p < 0.001, transferrin saturation (4.8 to 6.9%, p < 0.001) and total iron-binding capacity (467 to 441 μg/L, p = 0.001). These findings were contrary to the group that continued with consumption, where the statistical changes were only observed for the iron study parameters (serum iron: 21 to 28 μg/dL, p = 0.038; transferrin saturation: 4.3 to 6.9%, p = 0.011; total iron-binding capacity: 496 to 421 μg/L, p = 0.002). Nevertheless, the changes for both groups were clinically insignificant. Oral iron therapy did not correct the anaemia in geophagic females of both groups, this could be explained by two hypotheses where soil affected the gastrointestinal lining and soil directly interfered with therapy iron absorption. This is evidenced by the group that continued with consumption showing fewer changes than the group that abstained from soil consumption. These results were consistent with a case study where oral iron therapy was implemented. Conclusion: Oral iron therapy was not effective in geophagia cases of iron deficiency anaemia.

Reticulocyte haemoglobin as a diagnostic marker and its response towards oral iron therapy in paediatric iron deficiency anaemia: A feasibility study

2021 ◽  
Vol 11 (2) ◽  
pp. 78
Author(s):  
ManojKumar Patro ◽  
Bodhisatwa Behera ◽  
Sarmistha Subhadarshini ◽  
JagatShreya Satapathy ◽  
Niranjan Mohanty ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Feasibility Study ◽  
Iron Deficiency Anaemia ◽  
Diagnostic Marker ◽  
Oral Iron ◽  
Iron Therapy ◽  
Deficiency Anaemia ◽  
Oral Iron Therapy

Iron Therapy in Maintenance Haemodialysis

1975 ◽  
Vol 48 (6) ◽  
pp. 529-532 ◽  
Author(s):  
L. R. I. Baker ◽  
W. R. Cattell ◽  
J. A. Child ◽  
E. Savdie
Keyword(s):  
Iron Deficiency ◽  
Haemoglobin Concentration ◽  
Oral Iron ◽  
Iron Therapy ◽  
Iron Stores ◽  
Maintenance Haemodialysis ◽  
Oral Iron Therapy ◽  
Group I ◽  
Group Ii ◽  
Change In Mean

1. Marrow-iron stores were absent or reduced in twenty-three of thirty-nine patients studied within 52 months of starting maintenance haemodialysis. 2. Oral iron was given to twelve patients (group I) with absent or reduced, and to eleven patients (group II) with normal or increased marrow-iron stores. 3. A significant increase in mean haemoglobin concentration and marrow iron was observed in group I. No significant change in mean haemoglobin concentration or marrow iron occurred in group II. Mean haemoglobin concentration after treatment was significantly higher in group I than in group II. 4. The four patients who had normal or increased marrow iron and who received no oral iron all suffered a fall in haemoglobin concentration, and three of them showed a reduction in marrow iron. 5. These findings indicate that continuous oral iron therapy should be given to all patients on maintenance dialysis to correct or prevent iron deficiency.

scholarly journals Association between consumption of black tea and iron status in adult Africans in the North West Province: the THUSA study

2008 ◽  
Vol 100 (2) ◽  
pp. 430-437 ◽  
Author(s):  
P. S. Hogenkamp ◽  
J. C. Jerling ◽  
T. Hoekstra ◽  
A. Melse-Boonstra ◽  
U. E. MacIntyre
Keyword(s):  
South Africa ◽  
Iron Deficiency ◽  
Serum Ferritin ◽  
Iron Deficiency Anaemia ◽  
Iron Status ◽  
Black Tea ◽  
Tea Consumption ◽  
Deficiency Anaemia ◽  
North West ◽  
The North

The association between black tea consumption and iron status was investigated in a sample of African adults participating in the cross-sectional THUSA (Transition and Health during Urbanization of South Africans) study in the North West Province, South Africa. Data were analysed from 1605 apparently healthy adults aged 15–65 years by demographic and FFQ, anthropometric measurements and biochemical analyses. The main outcome measures were Hb and serum ferritin concentrations. No associations were seen between black tea consumption and concentrations of serum ferritin (menP = 0·059; womenP = 0·49) or Hb (menP = 0·33; womenP = 0·49). Logistic regression showed that tea consumption did not significantly increase risk for iron deficiency (men: OR 1·36; 95 % CI 0·99, 1·87; women: OR 0·98; 95 % CI 0·84, 1·13) nor for iron deficiency anaemia (men: OR 1·28; 95 % CI 0·84, 1·96; women: OR 0·93; 95 % CI 0·78, 1·11). Prevalence of iron deficiency and iron deficiency anaemia was especially high in women: 21·6 and 14·6 %, respectively. However, the likelihood of iron deficiency and iron deficiency anaemia was not significantly explained by tea consumption in sub-populations which were assumed to be at risk for iron deficiency. Regression of serum ferritin levels on tea consumption in women ≤ 40 years, adults with a daily iron intake ≤ 5·80 mg and adults with ferritin levels ≤ 26·60 μg/l, respectively, showedPvalues in the range of 0·28–0·88. Our findings demonstrate that iron deficiency and iron deficiency anaemia is not significantly explained by black tea consumption in a black adult population in South Africa. Tea intake was also not shown to be related to iron status in several sub-populations at risk for iron deficiency.

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