scholarly journals Gambaran D-Dimer Dan Limfosit Pada Pasien Terkonfirmasi Covid-19 Di RS Haji Jakarta

2021 ◽  
Vol 7 (1) ◽  
pp. 62-71
Author(s):  
Atna Permana ◽  
Cut Ervinar Yari ◽  
Alaika Kurnia Aditya
Keyword(s):  
Cross Sectional ◽  
D Dimer

Penyakit Virus Corona tahun 2020 merebak virus baru coronavirus jenis baru (SARS-CoV-2) yang penyakitnya disebut Coronavirus disease 2019 (Covid-19). Virus ini ditemukan di Wuhan, China pertama kali dan Lebih dari 30,6 juta kasus Covid 19 dan 950.000 kematian telah dilaporkan ke WHO per 2 Maret 2020.   Penelitian ini bertujuan untuk mengetahui gambaran D-dimer dan limfosit pada pasien terkonfirmasi Covid-19 di RS Haji Jakarta. Desain penelitian ini adalah cross sectional (potong lintang). Sebanyak tiga puluh pasien terkonfirmasi Covid-19 yang diambil menggunakan data sekunder berupa rekam medis di Laboratorium RS Haji Jakarta. Berdasarkan hasil pemeriksaan pada pasien terkonfirmasi Covid-19 terhadap 30 sampel pasien, didapatkan laki-laki sebanyak 17 orang (56,7%) dan perempuan sebanyak 13 orang (43,3%). Berdasarkan hasil pemeriksaan D-dimer didapatkan hasil nilai normal D-dimer sebanyak (40%) sedangkan hasil abnormal D-dimer sebanyak (60%). Berdasarkan hasil pemeriksaan limfosit didapatkan hasil nilai limfosit menurun sebanyak (43,4%), untuk hasil nilai limfosit normal sebanyak (50%), sedangkan nilai limfosit meningkat sebanyak (6,6%). Kata Kunci          : D-dimer, Limfosit, Covid-19

scholarly journals Preoperative prevalence of deep vein thrombosis in patients scheduled to have surgery for degenerative musculoskeletal disorders

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Keigo Sato ◽  
Hideki Date ◽  
Takehiro Michikawa ◽  
Mitsuhiro Morita ◽  
Kazue Hayakawa ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Musculoskeletal Disorders ◽  
Pulmonary Thromboembolism ◽  
Elective Surgery ◽  
Knee Surgery ◽  
Care Providers ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis ◽  
D Dimer

Abstract Background Although the incidence of symptomatic pulmonary thromboembolism after elective surgery for degenerative musculoskeletal disorders is comparatively low, it is extremely detrimental to both patients and health-care providers. Therefore, its prevention is mandatory. We aimed to perform a cross-sectional analysis of deep venous thrombosis (DVT) before elective surgery for degenerative musculoskeletal disorders, including total knee arthroplasty (TKA), total hip arthroplasty (THA), and spinal surgery, and identify the factors associated with the incidence of preoperative DVT. Methods The clinical data of patients aged ≥ 30 years who underwent TKA or THA, and spine surgery for lumbar or cervical degenerative disorders at our institution were retrospectively collected. D-dimer levels were measured preoperatively in all the patients scheduled for surgery. For the patients with D-dimer levels ≥ 1 µg/mL or who were determined by their physicians to be at high risk of DVT, the lower extremity vein was preoperatively examined for DVT on ultrasonography. Results Overall, we retrospectively evaluated 1236 consecutive patients, including 701 men and 535 women. Of the patients, 431 and 805 had D-dimer levels ≥ 1 and < 1 µg/mL, respectively. Of 683 patients who underwent lower extremity ultrasonography, 92 had proximal (n = 7) and distal types (n = 85) of DVT. The preoperative prevalence of DVT was 7.4 %. No patient had the incidence of postoperative symptomatic venous thromboembolism. A multivariate analysis revealed that age ≥ 80 years (odds ratio [OR], 95 % confidence interval [CI]: 2.8, 1.1–7.3), knee surgery (2.1, 1.1–4.0), American Society of Anesthesiologists (ASA) grade 2 (2.8, 1.2–6.8), ASA grades 3 or 4 (3.1, 1.0–9.4), and malignancy (1.9, 1.1–3.2) were significantly associated with DVT incidence. Conclusions This is the first study to conduct a cross-sectional analysis of preoperative DVT data of patients scheduled for elective surgery for degenerative musculoskeletal disorders. Although whether screening for preoperative DVT is needed to prevent postoperative symptomatic pulmonary thromboembolism remains to be clarified, our data suggested that DVT should be noted before surgery in the patients with advanced age, knee surgery, high ASA physical status, and malignancy.

Ruling out deep venous thrombosis in primary care

2005 ◽  
Vol 94 (07) ◽  
pp. 200-205 ◽  
Author(s):  
Karel G. M. Moons ◽  
Arno W. Hoes ◽  
Ruud Oudega
Keyword(s):  
Primary Care ◽  
Health Care ◽  
Decision Rule ◽  
Cross Sectional ◽  
Diagnostic Decision ◽  
Number Of Patients ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up ◽  
D Dimer

SummaryIn primary care, the physician has to decide which patients have to be referred for further diagnostic work-up. At present, only in 20% to 30% of the referred patients the diagnosis DVT is confirmed. This puts a burden on both patients and health care budgets. The question arises whether the diagnostic work-up and referral of patients suspected of DVT in primary care could be more efficient. A simple diagnostic decision rule developed in primary care is required to safely exclude the presence of DVT in patients suspected of DVT, without the need for referral. In a cross-sectional study, we investigated the data of 1295 consecutive patients consulting their primary care physician with symptoms suggestive of DVT, to develop and validate a simple diagnostic decision rule to safely exclude the presence of DVT. Independent diagnostic indicators of the presence of DVT were male gender, oral contraceptive use, presence of malignancy, recent surgery, absence of leg trauma, vein distension, calf difference and D-dimer test result. Application of this rule could reduce the number of referrals by at least 23% while only 0·7% of the patients with a DVT would not be referred. We conclude that by using eight simple diagnostic indicators from patient history, physical examination and the result of D-dimer testing, it is possible to safely rule out DVT in a large number of patients in primary care, reducing unnecessary patient burden and health care costs.

scholarly journals Profile of D-dimer in Uncomplicated Pregnancy

2019 ◽  
pp. 283-287
Author(s):  
Rahajuningsih Dharma ◽  
Mercy T. Panjaitan ◽  
Kanadi Sumapradja ◽  
Rianto Setiabudy
Keyword(s):  
Pregnant Women ◽  
Clinical Pathology ◽  
Cross Sectional Study ◽  
Control Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Uncomplicated Pregnancy ◽  
D Dimer

Abstract Objective: To obtain the profile of D-dimer in uncomplicated pregnancy. Methods: A cross sectional study was done on 90 uncomplicated pregnant women consisted of 30 women in each trimester and 30 healthy, nonpregnant women as control group from July to August 2012. D-dimer level was measured by particle enhanced immunoturbidimetry method using Innovance D-dimer and Sysmex CA 1500 in the Department of Clinical Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta. Results: All women in the control group showed normal D-dimer level (<0.,5 mg/L FEU). The median and range of D-dimer level in the 1st trimester, 2nd trimester, and 3rd trimester were 0.42 mg/L FEU and 0.1-1.07 mg/L FEU, 0.97 mg/L FEU and  0.6-3.34 mg/L FEU, and 1.56 mg/L FEU and  0.69-3.75 mg/L FEU, respectively.  Increased D-dimer level was found in 27% of pregnant women in 1st trimester, 87% in 2nd trimester, and 100% in 3rd trimester. Conclusion: Increased D-dimer level was found in  27% of pregnant women in 1st trimester, 87% in 2nd trimester, and  100% in 3rd trimester. The range of D-dimer level in the 1st trimester was 0.1-1.07 mg/L FEU, in the 2nd trimester was 0.6-3.34 mg/L FEU, and in the 3rd trimester was 0.69-3.75 mg/L FEU. Keywords: D-dimer, trimester, uncomplicated pregnancy   Abstrak Tujuan : Untuk mendapatkan profil  D-dimer pada kehamilan tanpa komplikasi. Metode : Penelitian potong lintang dilakukan pada 90 perempuan hamil tanpa komplikasi yang terdiri atas 30 perempuan pada tiap trimester dan 30 perempuan sehat yang tidak hamil, sebagai kelompok kontrol dari bulan Juli sampai Agustus 2012. Kadar D-dimer diukur dengan cara particle enhanced immunoturbidimetry  menggunakan reagen InnovanceÒ D-dimer dan koagulometer SysmexÒ CA 1500 di  Deparemen Patologi Klinik, Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, Jakarta. Hasil: Seluruh perempuan dalam kelompok kontrol mempunyai kadar D-dimer dalam batas normal (<0.,5 mg/L FEU). Median (rentang) kadar D-dimer  pada trimester pertama, kedua, dan ketiga berturut-turut  0.42 mg/L FEU  (0.1-1.07 mg/L FEU), 0.97 mg/L FEU (0.6-3.34 mg/L FEU), dan 1.56 mg/L FEU   (0.69-3.75 mg/L FEU).  Peningkatan kadar D-dimer ditemukan pada 27% perempuan hamil trimester pertama, 87%  trimester kedua, dan pada 100%  trimester ketiga.   Kesimpulan: Peningkatan kadar  D-dimer ditemukan pada  27% perempuan hamil trimester pertama,  87% trimester kedua dan   100% pada trimester ketiga.  Rentang kadar D-dimer level pada trimester pertama adalah 0.1-1.07 mg/L FEU, pada trimester kedua  0.6-3.34 mg/L FEU, dan pada trimester ketiga  0.69-3.75 mg/L FEU. Kata kunci: D-dimer, kehamilan tanpa komplikasi, trimester

scholarly journals Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sijia Wang ◽  
Mei Lu ◽  
Zijun Zhao ◽  
Xueting Peng ◽  
Liang Li ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Degradation Products ◽  
Eosinophil Cationic Protein ◽  
Control Group ◽  
Cationic Protein ◽  
Glucocorticoid Treatment ◽  
Cross Sectional ◽  
Fibrin Degradation Products ◽  
Eosinophil Counts ◽  
D Dimer

AbstractBullous pemphigoid (BP), the most frequent blistering dermatosis in the elderly, is associated with increased mortality. The severity of BP can be assessed by detecting the anti-BP180 immunoglobulin G (IgG) concentration, but the lab test is not available in many community clinics. BP patients are usually in a hypercoagulable state with increased levels of D-dimer and fibrin degradation products (FDPs). We aimed to evaluate the use of D-dimer and FDPs in assessing BP severity. We compared the levels of plasma D-dimer, plasma FDPs, eosinophil counts, eosinophil cationic protein, and serum anti-BP180 IgG concentration between 48 typical BP patients and 33 Herpes zoster (HZ) patients (control group). Correlational analyses were conducted to determine the relationships between the lab values and common BP severity markers. The plasma D-dimer and FDP levels were higher in BP patients than in HZ controls (D-dimer: 3297 ± 2517 µg/L vs. 569.70 ± 412.40 µg/L; FDP: 9.74 ± 5.88 mg/L vs. 2.02 ± 1.69 mg/L, respectively, P < 0.0001). Significant positive correlations were found between D-dimer/FDP levels and BP severity markers (i.e. anti-BP180 IgG concentration [D-dimer: r = 0.3928, P = 0.0058; FDP: r = 0.4379, P = 0.0019] and eosinophil counts [D-dimer: r = 0.3625, P = 0.0013; FDP: r = 0.2880, P = 0.0472]) in BP patients. We also found an association between FDP and urticaria/erythema lesions (r = 0.3016, P = 0.0372), but no other BPDAI components. In 19 BP patients with complete remission after systemic glucocorticoid treatment, D-dimer and FDP levels decreased post-therapy (D-dimer: 5559 ± 7492 µg/L vs. 1738 ± 1478 µg/L; P < 0.0001; FDP: 11.20 ± 5.88 mg/L vs. 5.13 ± 3.44 mg/L; P = 0.0003), whereas they did not in BP patients with treatment resistant. Plasma D-dimer and FDP are convenient markers to evaluate BP severity assistant on BPDAI and eosinophil counts. FDP is also helpful for inflammatory lesions in BP patients.

Gestation-specific D-dimer reference ranges: a cross-sectional study

2014 ◽  
Vol 122 (3) ◽  
pp. 395-400 ◽  
Author(s):  
N Murphy ◽  
DI Broadhurst ◽  
AS Khashan ◽  
O Gilligan ◽  
LC Kenny ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Reference Ranges ◽  
Sectional Study ◽  
Cross Sectional ◽  
D Dimer

A cross-sectional study comparing D-Dimer levels from first trimester to day 2 post partum in low risk pregnancies

2010 ◽  
Vol 95 (Supplement 1) ◽  
pp. Fa39-Fa39
Author(s):  
N. Murphy ◽  
B. Wallace ◽  
D. Broadhurst ◽  
A. Khashan ◽  
O. Gilligan ◽  
...  
Keyword(s):  
Post Partum ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Low Risk ◽  
Sectional Study ◽  
Cross Sectional ◽  
D Dimer

scholarly journals KORELASI ANTARA PROFIL HEMATOLOGI DENGAN PROCALCITONIN PADA PASIEN TERKONFIRMASI COVID-19

2021 ◽  
Vol 4 (1) ◽  
pp. 66
Author(s):  
Puspitasari Puspitasari ◽  
Andika Aliviameita ◽  
Evi Rinata
Keyword(s):  
Infectious Disease ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Test Results ◽  
Cross Sectional ◽  
Regression Test ◽  
Laboratory Examinations ◽  
Cross Sectional Design ◽  
The Relationship ◽  
D Dimer

Covid-19 is an infectious disease caused by SARS-CoV 2 and has spread very quickly. Several laboratory examinations were carried out on Covid-19 patients including molecular examinations, hematological profiles, and serology. This study aims to determine the relationship between leucocyte, d-dimer, hemoglobin and thrombocyte against procalcitonin in patients with Covid-19. This was an observational analytic study with cross sectional design. A sample of 50 was taken selectively at Aisyiyah Siti Fatimah Tulangan Hospital in November 2020 - January 2021. Multiple linear regression test results showed relationship between leucocyte with procalcitonin (b = -0.64; p = 0.426), d-dimer with procalcitonin (b = 2.702; p = 0.010), hemoglobin with procalcitonin (b = 0.656; p = 0.255), and thrombocyte with procalcitonin (b = 0.037; p = 0.002) . Based on the results, it is found that there is relationship between leucocyte, d-dimer, hemoglobin, and thrombocyte againts procalcitonin in Covid-19 patients.

scholarly journals Plasma Levels of D-dimer and Fibrin Degradation Products Correlate with Bullous Pemphigoid Severity: a Cross-sectional Study

2021 ◽  
Author(s):  
Sijia Wang ◽  
Mei Lu ◽  
Zijun Zhao ◽  
Xueting Peng ◽  
Liang Li ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Degradation Products ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Control Group ◽  
Glucocorticoid Treatment ◽  
Cross Sectional ◽  
Fibrin Degradation Products ◽  
Positive Correlations ◽  
D Dimer

Abstract Background Bullous pemphigoid (BP), the most frequent blistering dermatosis in the elderly, is associated with increased mortality. The severity of BP can be assessed by detecting the anti-BP180 immunoglobulin G (IgG) titer, but the lab test is not available in many community clinics. BP patients are usually in a hypercoagulable state with increased levels of D-dimer and fibrin degradation products (FDPs). ObjectivesTo evaluate the use of D-dimer and FDPs in assessing BP severity. Methods We compared the levels of plasma D-dimer, FDPs, eosinophils, and anti-BP180 IgG titer between 48 BP patients and 33 Herpes zoster (HZ) patients (control group). Correlational analyses were conducted to determine the relationships between the lab values and BP.ResultsThe plasma D-dimer and FDP levels were higher in BP patients than in HZ controls (D-dimer: 3297 ±2517 µg/L vs. 569.70 ±412.40 µg/L; FDP: 9.74 ±5.88 mg/L vs. 2.02 ±1.69 mg/L, respectively, P<0.0001). Significant positive correlations were found between D-dimer/FDP levels and BP severity markers (anti-BP180 IgG titer [D-dimer: r=0.3928, P=0.0058; FDP: r=0.4379, P=0.0019] and eosinophil counts [D-dimer: r=0.3625, P=0.0013; FDP: r=0.2880, P=0.0472]) in BP patients. We also found an association between FDP and urticaria/erythema lesions (r=0.3016, P=0.0372), but no other BPDAI components. In 19 BP patients with complete remission after systemic glucocorticoid treatment, D-dimer and FDP levels decreased post-therapy (D-dimer: 5559 ±7492µg/L vs. 1738 ±1478 µg/L; P<0.0001; FDP: 11.20 ±5.88 mg/L vs. 5.13 ±3.44 mg/L; P=0.0003), where as they did not in BP patients with treatment resistant.Conclusion Plasma D-dimer and FDP are convenient markers to evaluate BP severity.

scholarly journals Clinical Profile and Outcome of COVID Positive Hematology Patients during the COVID-19 Pandemic - an Analytical Cross Sectional Study from a Tertiary Care Centre in India

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 4996-4996
Author(s):  
Faisal Kassim ◽  
Chirag Sunil Lalwani ◽  
Hamsini Movva ◽  
Sani Kodathumuriyil Sunny ◽  
Merlin Moni ◽  
...  
Keyword(s):  
Active Treatment ◽  
Conflicts Of Interest ◽  
Tertiary Care ◽  
Outcome Variable ◽  
Categorical Variables ◽  
Care Hospital ◽  
Cross Sectional ◽  
Hematological Diseases ◽  
Significant Difference ◽  
D Dimer

Abstract Introduction: The COVID-19 pandemic is a global public health challenge that has affected more than 30 million people and taken more than 4 lakh lives in India. The first and second COVID waves have greatly impacted the lives of a vast majority and vaccination of the masses remains a struggle. Although SARS -CoV-2 infections in patients with hematological diseases are expected to have an adverse outcomes, only limited reports are available from India. Hence, our study aims to identify the outcome in terms of severity and mortality in this group and the risk factors involved in developing severe COVID-19 and death. Methodology: This is a cross sectional analytical study done in a tertiary care hospital in Southern India for a period of 11 months. All hematological patients irrespective of age, who were infected with SARS-CoV-2 during the first wave (June -December 2020) and second wave (March - June 2021) were consecutively enrolled for the study after IRB approval. The patients were then categorized as neoplastic (acute and chronic leukemia, lymphoma, myeloma, MPN and MDS ) and non-neoplastic (ITP, aplastic anemia, hemolytic anemia, MGUS and TTP ) diseases. The clinical data was collected retrospectively from the electronic medical records and by direct telephonic contact. Patients were categorized as having mild (spO2 &gt; 94 % symptomatic /asymptomatic), moderate (spO2 90 - 94 %) and severe (spO2 &lt; 90 %) disease based on their severity of infection, each category of patients received appropriate clinical management. Treatment details, mortality and other outcomes were recorded for 30 days. The continuous variables were represented as mean (± SD)/median (IQR) and categorical variables as frequency and percentage. The association of the outcome variable with selected variables were calculated using Chi-square tests and kaplan meier survival analysis. The data sets were analyzed (SPSS version 21) and a p value of &lt; 0.05 was considered statistically significant. Results: The study was conducted with 70 patients (n=70). Demographic details of patients are summarized in Table 1.Seventeen (24.3%) out of 49 (70%) hospitalized patients required ICU care. There were 13 (18.6%)deaths. in the patients who survived, prolonged antigen positivity of COVID on testing after 21 days was seen in 9 patients (16.1%). In 35 patients (50%)hematological treatment was restarted with a mean delay of 9.2 +/- 10.72 days. Predictors of severity of the disease is summarized in Table 2. Age more than 50 years (P=0.002)(Figure 1a), severe COVID (P=&lt;0.001) and D dimer value of &gt;2 times normal (P=0.047) were associated with a 30-day mortality. Additionally, patients on active treatment for hematological disease were at greater risk of severe COVID (P=0.012). There was no significant difference in severity (P=0.197) or mortality (P=0.556)in patients with neoplastic vs. non-neoplastic disorders Conclusion: COVID-19 patients with malignant and non-malignant hematological diseases showed an increased mortality. Age &gt; 50 years and high D dimer values (&gt;2N) were identified as predictors of mortality. Active treatment for haematological disease predisposed to severe disease.The study needs to be validated further on a larger cohort of patients . Preventive strategies including vaccination is warranted in patients with hematological disorders. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

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