Geographically Distinct Expression Profile of Host Defense Peptides in the Skin of the Chinese Odorous Frog, Odorrana margaretae

2014 ◽  
Vol 4 (4) ◽  
pp. 288-297
Author(s):  
LING Guiying ◽  
LI Li ◽  
GAO Jiuxiang ◽  
YU Haining ◽  
WANG Yipeng ◽  
...  
Keyword(s):  
Host Defense ◽  
Expression Profile ◽  
Host Defense Peptides ◽  
Defense Peptides

Human Host Defense Peptides - Role in Maintaining Human Homeostasis and Pathological Processes

2017 ◽  
Vol 24 (7) ◽  
pp. 654-672 ◽  
Author(s):  
Malgorzata Anna Dawgul ◽  
Katarzyna E. Greber ◽  
Wieslaw Sawicki ◽  
Wojciech Kamysz
Keyword(s):  
Host Defense ◽  
Host Defense Peptides ◽  
Human Host ◽  
Defense Peptides

scholarly journals Mechanistic Fingerprinting Reveals Kinetic Signatures of Resistance to Daptomycin and Host Defense Peptides in Streptococcus mitis-oralis

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 404
Author(s):  
Michael R. Yeaman ◽  
Liana C. Chan ◽  
Nagendra N. Mishra ◽  
Arnold S. Bayer
Keyword(s):  
Flow Cytometry ◽  
Host Defense ◽  
Durable Resistance ◽  
Cross Resistance ◽  
Streptococcus Mitis ◽  
Host Defense Peptides ◽  
Strain Pair ◽  
Defense Peptides

Streptococcus mitis-oralis (S. mitis-oralis) infections are increasingly prevalent in specific populations, including neutropenic cancer and endocarditis patients. S. mitis-oralis strains have a propensity to evolve rapid, high-level and durable resistance to daptomycin (DAP-R) in vitro and in vivo, although the mechanism(s) involved remain incompletely defined. We examined mechanisms of DAP-R versus cross-resistance to cationic host defense peptides (HDPs), using an isogenic S. mitis-oralis strain-pair: (i) DAP-susceptible (DAP-S) parental 351-WT (DAP MIC = 0.5 µg/mL), and its (ii) DAP-R variant 351-D10 (DAP MIC > 256 µg/mL). DAP binding was quantified by flow cytometry, in-parallel with temporal (1–4 h) killing by either DAP or comparative prototypic cationic HDPs (hNP-1; LL-37). Multicolor flow cytometry was used to determine kinetic cell responses associated with resistance or susceptibility to these molecules. While overall DAP binding was similar between strains, a significant subpopulation of 351-D10 cells hyper-accumulated DAP (>2–4-fold vs. 351-WT). Further, both DAP and hNP-1 induced cell membrane (CM) hyper-polarization in 351-WT, corresponding to significantly greater temporal DAP-killing (vs. 351-D10). No strain-specific differences in CM permeabilization, lipid turnover or regulated cell death were observed post-exposure to DAP, hNP-1 or LL-37. Thus, the adaptive energetics of the CM appear coupled to the outcomes of interactions of S. mitis-oralis with DAP and selected HDPs. In contrast, altered CM permeabilization, proposed as a major mechanism of action of both DAP and HDPs, did not differentiate DAP-S vs. DAP-R phenotypes in this S. mitis-oralis strain-pair.

scholarly journals Nano-mechanical in-process monitoring of antimicrobial poration in model phospholipid bilayers

RSC Advances ◽  
2017 ◽  
Vol 7 (31) ◽  
pp. 19081-19084
Author(s):  
Andrea Valsesia ◽  
Patrizia Iavicoli ◽  
Helen Lewis ◽  
Cloé Desmet ◽  
Dora Mehn ◽  
...  
Keyword(s):  
Process Monitoring ◽  
Host Defense ◽  
Phospholipid Bilayers ◽  
Host Defense Peptides ◽  
Defense Peptides ◽  
Membrane Poration

Nanomechanical monitoring of known mechanisms of membrane poration mediated by host defense peptides is reported.

A comparison of host-defense peptides in skin secretions of female Xenopus laevis×Xenopus borealis and X. borealis×X. laevis F1 hybrids

Peptides ◽  
2013 ◽  
Vol 45 ◽  
pp. 1-8 ◽  
Author(s):  
Milena Mechkarska ◽  
Manju Prajeep ◽  
Jérôme Leprince ◽  
Hubert Vaudry ◽  
Mohammed A. Meetani ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Host Defense ◽  
F1 Hybrids ◽  
Host Defense Peptides ◽  
Skin Secretions ◽  
Defense Peptides ◽  
Xenopus Borealis

scholarly journals Host-defense peptides

1996 ◽  
Vol 14 (7) ◽  
pp. 804-804
Author(s):  
Robert L. Erwin
Keyword(s):  
Host Defense ◽  
Host Defense Peptides ◽  
Defense Peptides

Host Defense Peptides as immunomodulators: the other side of the coin

Peptides ◽  
2021 ◽  
pp. 170644
Author(s):  
Ernesto M. Martell ◽  
Melaine González ◽  
Ludger Ständker ◽  
Anselmo J. Otero-González
Keyword(s):  
Host Defense ◽  
The Other ◽  
Host Defense Peptides ◽  
Defense Peptides

Host Defense Peptides in Fish

2009 ◽  
pp. 43-61
Author(s):  
Aleksander Patrzykat ◽  
Robert Hancock
Keyword(s):  
Host Defense ◽  
Host Defense Peptides ◽  
Defense Peptides

Host-Defense Peptides from the Secretion of the Skin Glands of Frogs and Toads

2009 ◽  
pp. 333-355 ◽  
Author(s):  
John Bowie ◽  
Rebecca Jackway ◽  
Frances Separovic ◽  
John Carver ◽  
Michael Tyler
Keyword(s):  
Host Defense ◽  
Host Defense Peptides ◽  
Skin Glands ◽  
Defense Peptides

Conformational Analysis of the Host-Defense Peptides Pseudhymenochirin-1Pb and -2Pa and Design of Analogues with Insulin-Releasing Activities and Reduced Toxicities

2015 ◽  
Vol 78 (12) ◽  
pp. 3041-3048 ◽  
Author(s):  
Giorgia Manzo ◽  
Mariano Andrea Scorciapino ◽  
Dinesh Srinivasan ◽  
Samir Attoub ◽  
Maria Luisa Mangoni ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Host Defense ◽  
Host Defense Peptides ◽  
Defense Peptides
Sign in / Sign up

Export Citation Format

Share Document