scholarly journals Molecular iodine-catalyzed one-pot multicomponent synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles

2018 ◽  
Vol 14 ◽  
pp. 2789-2798 ◽  
Author(s):  
Camila S Pires ◽  
Daniela H de Oliveira ◽  
Maria R B Pontel ◽  
Jean C Kazmierczak ◽  
Roberta Cargnelutti ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Functional Group ◽  
Diazo Compound ◽  
Molecular Iodine ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
X Ray ◽  
Dehydrogenative Coupling ◽  
Reflux Temperature

A one-pot iodine-catalyzed multicomponent reaction has been developed for the selective preparation of 5-amino-4-(arylselanyl)-1H-pyrazoles from a diverse array of benzoylacetonitriles, arylhydrazines and diaryl diselenides. The reactions were conducted in MeCN as solvent at reflux temperature under air. The methodology presents a large functional group tolerance to electron-deficient, electron-rich, and bulky substituents and gave the expected products in good to excellent yields. The synthesized 1,3-diphenyl-4-(phenylselanyl)-1H-pyrazol-5-amine was submitted to an oxidative dehydrogenative coupling to produce a diazo compound confirmed by X-ray analysis.

Iodine-Mediated Multicomponent Synthesis of 3-Sulfenylimidazo[1,2-a]pyridines from 2-Aminopyridines, Ketones, and Sulfonyl Hydrazides

Synlett ◽  
2019 ◽  
Vol 30 (05) ◽  
pp. 625-629 ◽  
Author(s):  
Hongjun Ren ◽  
Zhengkai Chen ◽  
Sipei Hu ◽  
Shiying Du ◽  
Yunjie Yao ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
High Efficiency ◽  
Molecular Iodine ◽  
Multicomponent Synthesis ◽  
One Pot

A one-pot multicomponent reaction for the synthesis of 3-sulfenylimidazo[1,2-a]pyridines from readily available 2-aminopyridines, ketones, and sulfonyl hydrazides, mediated by molecular iodine, has been developed. The transformations proceed smoothly with high efficiency and a broad substrate scope, affording the desired heterocyclic products in moderate to excellent yields.

scholarly journals One-pot multicomponent synthesis of thieno[2,3-b]indoles catalyzed by a magnetic nanoparticle-supported [Urea]4[ZnCl2] deep eutectic solvent

RSC Advances ◽  
2020 ◽  
Vol 10 (16) ◽  
pp. 9663-9671 ◽  
Author(s):  
The Thai Nguyen ◽  
Phuong Hoang Tran
Keyword(s):  
Multicomponent Reaction ◽  
Magnetic Nanoparticle ◽  
Deep Eutectic Solvent ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Green Catalyst

We have developed the synthesis of thieno[2,3-b]indole dyes via a multicomponent reaction of cheap and available reagents using a magnetic nanoparticle-supported [Urea]4[ZnCl2] deep eutectic solvent as a green catalyst.

One-pot multicomponent synthesis of β-acetamidoketones catalysed by pTSA1

2007 ◽  
Vol 85 (7-8) ◽  
pp. 479-482 ◽  
Author(s):  
Biswanath Das ◽  
Kongara Ravinder Reddy ◽  
Yallamalla Srinivas ◽  
Rathod Aravind Kumar
Keyword(s):  
Multicomponent Reaction ◽  
Acetyl Chloride ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
High Yields ◽  
Three Component Coupling

A catalytic amount of pTSA has been found to be effective to carry out a one-pot three-component coupling of aromatic aldehydes, enolizable ketones or ketoesters, and acetonitrile in the presence of acetyl chloride to afford β-acetamidoketones in high yields. Short reaction times and inexpensive catalyst are main advantages of this protocol.Key words: β-acetamidoketone, pTSA, multicomponent reaction, diastereoselectivity.

scholarly journals One-pot multicomponent synthesis of highly substituted pyridines using hydrotalcite as a solid base and reusable catalyst

2021 ◽  
pp. 169-174
Author(s):  
Sandip R. Kale ◽  
Santosh Kumar Surve
Keyword(s):  
Catalytic Activity ◽  
Multicomponent Reaction ◽  
Aromatic Aldehydes ◽  
Significant Loss ◽  
Solid Base ◽  
Reusable Catalyst ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Substituted Pyridines

One-pot synthesis of highly substituted pyridines has been demonstrated via multicomponent reaction of aldehydes, malononitrile and thiophenol using Mg-Al hydrotalcite as a solid base and reusable catalyst. The catalytic activity is intimately connected to the basicity of the catalyst. The best activities were observed with the Mg/Al: 5 catalyst. The catalyst could be reused for further run without a significant loss in activity. The protocol was also applicable for various aromatic aldehydes which affords desired product in good to excellent yield.

scholarly journals Application of One-Pot Three-Component Condensation Reaction for the Synthesis of New Organophosphorus–Sulfur Macrocycles

Synlett ◽  
2018 ◽  
Vol 29 (11) ◽  
pp. 1496-1501 ◽  
Author(s):  
J. Woollins ◽  
Guoxiong Hua ◽  
David Cordes ◽  
Alexandra Slawin
Keyword(s):  
Multicomponent Reaction ◽  
Room Temperature ◽  
Condensation Reaction ◽  
Synthesis Method ◽  
Membered Ring ◽  
One Pot ◽  
X Ray ◽  
Efficient Approach ◽  
Mild Conditions ◽  
Sulfur Heterocycles

An efficient approach has been developed for the synthesis of new phosphorus–sulfur heterocycles by a one-pot three-component condensation reaction of a four-membered-ring thionation reagent [Lawesson’s reagent or its ferrocene analogue (2,4-diferrocenyl-1,3,2,4-diathiadiphosphetane 2,4-disulfide)], an alkane- or arenedithiol, and a dihaloalkane at room temperature in the presence of triethylamine. The simple synthesis method with mild conditions (room temperature and normal reactant concentrations) enhances further the application of the multicomponent reaction in the preparation of novel phosphorus–sulfur heterocycles. Six representative X-ray structures confirmed the formation of these macrocycles.

scholarly journals Ecofriendly and Facile One-Pot Multicomponent Synthesis of Thiopyrimidines under Microwave Irradiation

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Biswa Mohan Sahoo ◽  
B. V. V. Ravi Kumar ◽  
Jnyanaranjan Panda ◽  
S. C. Dinda
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Spectral Data ◽  
Multicomponent Reaction ◽  
Multicomponent Reactions ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Heating Method ◽  
Green Protocol ◽  
Drug Molecules

A rapid, improved, and ecofriendly synthesis of thiopyrimidines is carried out via one-pot multicomponent reaction of ethylcyanoacetate, substituted benzaldehydes, and thiourea in presence of ethanolic K2CO3 using microwave irradiation heating method. Excellent yields, shorter reaction time, and easy workup are the major advantageous features of this green protocol. So the application of multicomponent reactions involves the combination of multiple starting materials with different functional groups leading to the highly efficient and environmentally friendly construction of multifunctional drug molecules. The structures of the newly synthesized products were assigned on the basis of IR and 1HNMR spectral data.

scholarly journals Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Shivanand Merugu ◽  
Vijaya Kumar Ponnamaneni ◽  
Ravi Varala ◽  
Syed Farooq Adil ◽  
Mujeeb Khan ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
Multicomponent Reaction ◽  
Biological Evaluation ◽  
Anhydrous Ethanol ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Metal Free ◽  
Substituted Benzaldehydes

A series of (E)-3-(2-((5-(benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) acetyl)-2H-chromen-2-one and its derivatives (4a-h) have been obtained using a one-pot multicomponent reaction with good yields. The compounds have been synthesized from 3-(2-bromoacetyl)chromen-2-ones (1), 5-amino-1,3,4-thiadiazole-2-thiol (2), and substituted benzaldehydes (3) in anhydrous ethanol and conc. H2SO4. Subsequently, all the synthesized compounds have been screened for their antimicrobial activity and characterized by analytical and spectral data.

scholarly journals Graphene Oxide: A Carbocatalyst for the One-Pot Multicomponent Synthesis of 5-Aryl-1H-Indeno[2’,1’:5,6]Pyrido[2,3-d]Pyrimidine-2,4,6(3H)-Trione

2018 ◽  
Vol 42 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Hamid Reza Dehghanpour ◽  
Mohammad H. Mosslemin ◽  
Razieh Mohebat
Keyword(s):  
Graphene Oxide ◽  
Multicomponent Reaction ◽  
Catalytic Amount ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Pyrimidine Synthesis ◽  
Key Features ◽  
The One ◽  
Work Up ◽  
Operational Simplicity

A simple, straightforward and efficient method is described for the synthesis of 5-aryl-1H-indeno[2’,1’:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione via one-pot multicomponent reaction of indane-1,3-dione, arylaldehydes and 6-aminopyrimidin-2,4(1H,3H)-dione in presence of catalytic amount of graphene oxide in water. Graphene oxide is a versatile carbocatalyst and this is the first report on its application in a pyrido[2,3-d]pyrimidine synthesis. Good yield, use of readily available starting materials, operational simplicity, easy work-up and eco-friendly re-usable catalyst are the key features of this protocol.

scholarly journals Multicomponent Synthesis of Luminescent Iminoboronates

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 6039
Author(s):  
Samuel Guieu ◽  
Cátia I. C. Esteves ◽  
João Rocha ◽  
Artur M. S. Silva
Keyword(s):  
Crystal Structures ◽  
Multicomponent Reaction ◽  
Anthranilic Acid ◽  
Boronic Acid ◽  
Photophysical Properties ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Aggregation Induced Emission ◽  
Emission Enhancement ◽  
Diluted Solution

A family of iminoboronates was prepared through a one-pot multicomponent reaction, starting from boronic acid, anthranilic acid, and different salicylaldehydes. Their synthesis was straightforward and the complexes were obtained in good to excellent yields. Their photophysical properties were assessed in a diluted solution, and the complexes proved to be faintly luminescent. These chelates demonstrated remarkable Aggregation-Induced Emission Enhancement, which was rationalized using crystal structures.

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