scholarly journals Frequency of Hepatotoxicity in Pulmonary Tuberculosis Patients taking Anti-Tuberculosis Therapy

2017 ◽  
Vol 1 (2) ◽  
pp. 3-10
Author(s):  
Farkhanda Noureen ◽  
Abdur Rehman ◽  
Asif Hanif
Keyword(s):  
Pulmonary Tuberculosis ◽  
Early Recognition ◽  
Cross Sectional Study ◽  
Common Side Effect ◽  
Real Problem ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Global Pandemic ◽  
Short Course Chemotherapy

Background: Tuberculosis is a global pandemic which affects millions of people every year. The treatment of tuberculosis consists of simultaneous use of several drugs for a prolonged period of time, therefore anti-tuberculosis treatment induced toxicity is a real problem. It is the most common side effect leading to interruption of therapy. Wide variations have been found in the reported incidence of hepatotoxicity during short-course chemotherapy. This study was conducted to determine the frequency of ATT induced hepatotoxicity in pulmonary TB patients.Methodology: This descriptive, cross-sectional study was conducted at Gulab Devi Chest Hospital Lahore from November 2015 to January 2016. Total 137 pulmonary TB patients were included in this study according to inclusion and exclusion criteria. Data of patients was collected by Questionnaire. Blood samples were taken and LFTs were done. Data was analyzed by using SPSS version 16.Results: Data of 137 patients was taken in the study. Out of which 60 (43.8%) were male and 77 (56.2%) were female. The mean age was 40.59±16.57. 45 (32.8%) patients out of 137, develop hepatotoxicity while 92 (67.2%) shows normal patterns of liver function. 22 (16.1%) patients out of 137 showed elevation of serum bilirubin levels.Conclusion: ATT induced hepatotoxicity is a frequent complication in Pulmonary Tuberculosis patients. So, all patients put on ATT must be followed up for at least the initial month. The patients and the treating physicians must be well-educated about the adverse effects of the ATT, its early recognition and management.

scholarly journals SEROPREVALENCE OF HIV INFECTION IN PULMONARY TUBERCULOSIS PATIENTS.

2020 ◽  
pp. 1-3
Author(s):  
K.G.R. Mallan ◽  
A. Fathahudeen ◽  
Manjula V.D.
Keyword(s):  
Pulmonary Tuberculosis ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Sputum Smear ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Medical College ◽  
Elimination Programme ◽  
Kerala State

Aim : To Determine the seroprevalence of Human immunodeficiency virus infection among Pulmonary Tuberculosis patients in a tertiary care teaching institution, in Ernakulam district of Kerala state in India. Methods : Study was conducted in Respiratory medicine department and integrated counselling and testing centre (ICTC) of Government Medical College, Ernakulam With approval of IEC after getting written informed consent , a cross sectional study was conducted among 384 pulmonary TB patients who were registered under the National TB elimination Programme (RNTCP). Result :The prevalence of HIV among study population was 1.3 %. There was no gender difference while the highest age group less than 30 followed by 30-60. The major respiratory pathology among study subjects was consolidation (42.7%) followed by fibrosis(25.3%).Consolidation was a predominant presenting pathology seen in female pulmonary TB patients.The sensitivity of sputum smear against CBNAAT was 60.4% and specificity was 83%. Conclusion : The prevalence is low compared with the national average of 3 to 3.4 % HIV co infection among Tuberculosis patients during the study period.

scholarly journals Prevalence of Antibiotic Resistance to Isonicotinylhydrazide and Rifampicin in Culture Positive Pulmonary Tuberculosis Patients From 2014 to 2016 in Zahedan City, Iran

2019 ◽  
Vol 4 (2) ◽  
pp. 57-61
Author(s):  
Seyed Mohammad Hashemi Shahri ◽  
Fatemeh Fardoust ◽  
Shokoufeh Mogharabi Ostad Kalayeh ◽  
Mohammad Ghenaatpisheh Sanani
Keyword(s):  
Antibiotic Resistance ◽  
Pulmonary Tuberculosis ◽  
Positive Culture ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
The World ◽  
Culture Positive

Background: One third of the world’s population is infected with TB, and the disease is known as the second deadly global infection, even more severe than measles. The disease kills about 2 million people a year. Approximately 8 million people in the world are affected by advanced tuberculosis (TB). Objective: The current study aimed to determine the frequency of resistance to the antibiotics isoniazid and rifampin in positive culture pulmonary TB patients in Zahedan city during 2013-2016. Methods: This descriptive cross-sectional study studied 100 samples from patients who referred to Boo-Ali hospital of Zahedan city from 2014 to 2016. First, the isoniazid solution was prepared, and then the rifampin solution was prepared. After that, 200 μL of mycobacterium suspension was added to the antibiotic and antibiotic-free control. Results: Of 100 patients participating in the study, 50 (50%) were male and 50 (50%) were female. Participants had an average age of 51.69 ± 20.41 years (95-12 years), 79 (79%) were Iranians and 21 (21%) were Afghans. Of the 100 samples, 55 (55%) were from the year 2013, 21 (21%) were from 2014, 10 (10%) were from 2015, and 14 (14%) were from year 2016. The samples examined showed that 4 (4%) were resistant and 96% were sensitive. Conclusion: The results of the current study showed that out of 100 samples, 4 cases (4%) had resistance and 96% were sensitive; 2% were resistant to isoniazid, and 2% were resistant to isoniazid and rifampin.

scholarly journals Delay for First Consultation and Its Associated Factors among New Pulmonary Tuberculosis Patients of Central Nepal

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Wongsa Laohasiriwong ◽  
Roshan Kumar Mahato ◽  
Rajendra Koju ◽  
Kriangsak Vaeteewootacharn
Keyword(s):  
Pulmonary Tuberculosis ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Patient Delay ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Central Nepal ◽  
Delay Duration ◽  
Development Region ◽  
Public Health Challenge

Tuberculosis (TB) is still a major public health challenge in Nepal and worldwide. Most transmissions occur between the onset of symptoms and the consultation with formal health care centers. This study aimed to determine the duration of delay for the first consultation and its associated factors with unacceptable delay among the new sputum pulmonary tuberculosis cases in the central development region of Nepal. An analytical cross-sectional study was conducted in the central development region of Nepal between January and May 2015. New pulmonary sputum positive tuberculosis patients were interviewed by using a structured questionnaire and their medical records were reviewed. Among a total of 374 patients, the magnitude of patient delay was 53.21% (95% CI: 48.12–58.28%) with a median delay of 32 days and an interquartile range of 11–70 days. The factors associated with unacceptable patient delay (duration ≥ 30 days) were residence in the rural area (adj. OR = 3.10, 95% CI: 1.10–8.72;pvalue = 0.032) and DOTS center located more than 5 km away from their residences (adj. OR = 5.53, 95% CI: 2.18–13.99;pvalue < 0.001). Unemployed patients were more likely to have patient delay (adj. OR = 7.79, 95% CI: 1.64–37.00;pvalue = 0.010) when controlled for other variables.

scholarly journals Asymptomatic intestinal helminth co-infection among pulmonary tuberculosis patients in urban Surabaya: a preliminary study

2020 ◽  
Vol 3 (3) ◽  
pp. 112-118
Author(s):  
Rifat Nurwita Kusumaningtyas ◽  
Indah Setyawati Tantular ◽  
Deby Kusumaningrum ◽  
Rina K Kusumaratna
Keyword(s):  
Pulmonary Tuberculosis ◽  
Helminth Infection ◽  
Clinical Symptoms ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Intestinal Helminth ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Preliminary Study ◽  
Few Data

BACKGROUNDPulmonary tuberculosis (TB) is a leading cause of morbidity and mortality, and East Java province is the second largest contributor of co-infection in Indonesia. Asymptomatic helminth infection among pulmonary tuberculosis patients causes another public health problem. Few data relate to helminth infection based on clinical and immunological outcomes of pulmonary TB in highly endemic areas. METHODSThis study was designed as a preliminary study and aimed to determine helminth co-infection among TB patients with a macroscopic assessment. This cross-sectional study was conducted in June-August 2017. RESULTSAmong 16 treated active TB patients from TB cohort data of Tanakali Kedinding health center found that 56% were stool smear-positive for Trichuris trichiura eggs, but had no clinical symptoms. CONCLUSIONWhether or not the helminth infection may have an impact on the diagnosis and treatment of active TB remains to be further investigated. Co-infection could be inhibited by the host immune response and improve the prognosis of TB treatment.

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