scholarly journals TOXICITY OF ZINC OXIDE NANOPARTICLES IN LUNG TISSUE AFTER REPEATED ORAL ADMINISTRATION

2013 ◽  
Vol 8 (4) ◽  
pp. 148-154 ◽  
Author(s):  
Shokouhian
Keyword(s):  
Zinc Oxide ◽  
Oral Administration ◽  
Lung Tissue ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration

2013 ◽  
Vol 10 (1) ◽  
pp. 9 ◽  
Author(s):  
Wan-Seob Cho ◽  
Byeong-Cheol Kang ◽  
Jong Kwon Lee ◽  
Jayoung Jeong ◽  
Jeong-Hwan Che ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Titanium Dioxide ◽  
Oral Administration ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles

Genotoxicity evaluation of zinc oxide nanoparticles in Swiss mice after oral administration using chromosomal aberration, micronuclei, semen analysis, and RAPD profile

2017 ◽  
Vol 33 (11) ◽  
pp. 821-834 ◽  
Author(s):  
Anurag Kumar Srivastav ◽  
Akhilesh Kumar ◽  
Jyoti Prakash ◽  
Dhirendra Singh ◽  
Pankaj Jagdale ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Oral Administration ◽  
Chromosomal Aberration ◽  
Zinc Oxide Nanoparticles ◽  
Dose Group ◽  
High Dose Group ◽  
Oxide Nanoparticles ◽  
High Dose ◽  
Zno Nps ◽  
Swiss Mice

The expanded uses of zinc oxide nanoparticles (ZnO NPs) have grown rapidly in the field of nanotechnology. Thus, rising production of nanoparticles (NPs) increases the possible risks to the environment and occupationally exposed humans. Hence, it is indispensable to appraise the safety toxicity including genotoxicity for these NPs. In the present study, we have evaluated the genotoxic effect of ZnO NPs after oral administration to Swiss mice at dose levels of 300 and 2000 mg/kg body weight. These doses were administered for 2 days at 24 h apart. Chromosomal aberration (CA) and micronucleus tests were conducted following Organization for Economic Co-operation and Development guidelines. DNA damage was evaluated at 0, 24, 48, and 72 h posttreatment using a randomly amplified polymorphic DNA (RAPD) assay; additionally, semen analyses were also performed at 34.5 days post oral exposure. The reactive oxygen species (ROS), 8-oxo-2′-deoxyguanosine and CAs were increased ( p < 0.05) at the highest dosage (2000 mg/kg) of ZnO NPs compared to controls. Aberrant sperm morphology with reduced sperm count and motility were also present ( p < 0.05) in the high-dose group. Based on the RAPD assay, the genomic template stability within the high-dose group (<90%) was less than the controls (100%). The results suggested that ZnO NPs are mildly genotoxic in a dose-related manner and this toxicity were induced by generation of ROS.

The effect of fluorination of zinc oxide nanoparticles on evaluation of their biodistribution after oral administration

2012 ◽  
Vol 23 (20) ◽  
pp. 205102 ◽  
Author(s):  
Chang-Moon Lee ◽  
Hwan-Jeong Jeong ◽  
Dong Wook Kim ◽  
Myung-Hee Sohn ◽  
Seok Tae Lim
Keyword(s):  
Zinc Oxide ◽  
Oral Administration ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles

A Histological and Immunohistochemical Study on the Effect of Zinc Oxide Nanoparticles on Rat Lung Tissue

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Nagwa Elshakaa ◽  
Nevine Bahaa ◽  
Asmaa Abo Zeid ◽  
Heba Abdel Latif
Keyword(s):  
Zinc Oxide ◽  
Lung Tissue ◽  
Zinc Oxide Nanoparticles ◽  
Control Group ◽  
Histological Structure ◽  
Oxide Nanoparticles ◽  
Rat Lung ◽  
Zno Nps ◽  
Group I ◽  
Group Ii

Abstract Background Nanoparticles (NPs) have unique and novel properties that lead to a diverse array of products with applications in diagnosis, drug delivery, food industry, paints, electronics, environmental cleanup, cosmetics and sunscreens. Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used engineered nanoparticles in consumer products. They are utilized in many commercial products including cosmetics, paints, textiles, and personal hygiene products. The study aimed to assess the effects of zinc oxide nanoparticles administered Intranasal or intravenous on lung tissue. Materials & methods twenty-five male Wistar rats were divided into Group I; control group, group II (Intranasal administered group) group II (Intravenous administered group). The animals were injected with 4 mg/kg of ZnO NPs. Rat Lungs were processed for histological, immunohistochemical. Results ZnO NPs caused thickening of interalveolar septa. Mononuclear cells were seen infiltrating the interalveolar septa. Many dilated blood vessels exhibited focal disruption and focal thickening of their wall. Tumor necrosis factor-alpha (TNF-α) immune reactivity was significantly increased. These findings increased mainly in the intranasal administered group when compared with the intravenous group. Conclusion ZnO NPs administration caused toxic effects on the histological structure of albino rat lung.

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