Cardiovascular Autonomic Neuropathy and Early Atherosclerosis in Adolescent Type 1 Diabetic Patient

AIM: To evaluate cardiovascular autonomic neuropathy (CAN) in type 1 Diabetics and to detect its relation to coronary artery calcification.PATIENTS AND METHODS: It is a cross sectional study included 62 diabetics and 30 controls. Clinical, laboratory assessment and 24 Hr holter were done for all patients and controls and coronary artery calcium (CAC) scoring by multisclice CT was done for all patients only. T-test, Mann Whitney U test, and stepwise multiple regression were used for statistical analyses.RESULTS: CAC score was positive in 8.1 % of patients. Heart rate variability (HRV) was significantly lower in diabetics. All parameters of HRV were insignificantly lower in diabetics with positive CAC score. Patients with microalbuminuria had a significantly lower HRV. HRV had a significant correlation with age of patients, duration of disease, HbA1, and Qtc in diabetics.CONCLUSION: Percentage of arrhythmia and early atherosclerosis is high in adolescent type 1 diabetic patients. CAN is associated with early atherosclerosis. Cardiac autonomic neuropathy is associated with older age, longer duration, and poor glycemic control and microalbuminuria.

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Predictors of Cardiovascular Autonomic Neuropathy Onset and Progression in a Cohort of Type 1 Diabetic Patients

Journal of Diabetes Research ◽

10.1155/2018/5601351 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

M. Matta ◽

A. Pavy-Le Traon ◽

S. Perez-Lloret ◽

C. Laporte ◽

I. Berdugo ◽

...

Keyword(s):

Autonomic Neuropathy ◽

Selective Serotonin Reuptake Inhibitors ◽

Valsalva Maneuver ◽

Cardiovascular Autonomic Neuropathy ◽

Bivariate Analysis ◽

Diabetic Patients ◽

Laboratory Assessment ◽

Low Bmi ◽

Type 1 Diabetic Patients

Aim. The prevalence of cardiovascular autonomic neuropathy (CAN) in diabetes mellitus is well documented. However, the rate and predictors of both the development and progression of CAN have been less studied. Hereby, we assessed the rate and the major risk factors for CAN initiation and progression in a cohort of type 1 diabetic patients followed over a three-year period. Methods. 175 type 1 diabetic patients (mean age: 50 ± 11 years; female/male: 76/99) with positive bedside screening for CAN were included and underwent 2 standardized autonomic testings using 4 standardized tests (deep breathing, Valsalva maneuver, 30/15 ratio, and changes in blood pressure during standing), separated by 3 ± 1 years. CAN staging was achieved according to the Toronto Consensus Panel on Diabetic Autonomic Neuropathy into 4 categories: absent, possible, confirmed, or severe CAN. Results. Out of the 175 patients included, 31.4% were free of CAN, 34.2% had possible CAN, 24.6% had confirmed CAN, and 9.7% exhibited severe CAN at the first assessment. Among the 103 patients with nonsevere CAN at inclusion, forty-one (39.8%) had an increase of at least one category when reassessed and 62 (60.2%) remained stable. A bivariate analysis indicated that only BMI and exposure to selective serotonin reuptake inhibitors (SSRIs) were significantly different in both groups. A multivariate analysis indicated that lower BMI (OR: 0.15, CI 95%: 0.05–0.48, p=0.003) and SSRI exposure (OR: 4.18, CI 95%: 1.03–16.97, p=0.04) were the sole predictors of CAN deterioration. In the 55 patients negative for CAN at the first laboratory assessment, 12 became positive at the second assessment. Conclusion. No clear predictive factor for CAN onset was identified. However, once present, CAN progression was related to low BMI and SSRI exposure.

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Diabetic Cardiovascular Autonomic Neuropathy

10.21203/rs.3.rs-646618/v1 ◽

2021 ◽

Author(s):

Amira Siddig ◽

Abbasher Hussien Mohamed Ahmed ◽

Khabab Abbasher Hussien Mohamed Ahmed ◽

Mohammed Eltahier Abdalla Omer

Keyword(s):

Autonomic Neuropathy ◽

Diabetic Neuropathies ◽

Cardiovascular Autonomic Neuropathy ◽

Cardiac Autonomic Neuropathy ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Cross Sectional ◽

Coronary Syndrome ◽

Study Population

Abstract Introduction: Diabetic neuropathies are thought to result from diabetic microvascular injury involving small blood vessels that supply nerves. Cardiac autonomic neuropathy (CAN) represents a serious complication associated with Diabetic neuropathies. Objectives: The aim of the study is to investigate the presence of cardiovascular diabetic autonomic neuropathy in a group of adult diabetic Sudanese patients with ischemic heart disease. Methodology: This is a descriptive prospective cross sectional hospital based study. The study population included type 1 and type 2 diabetic patients admitted to the cardiac care unit in ELshaab Teaching Hospital with acute coronary syndrome over a period of two years, from April 2017to April 2019. Results: A total of 49 males (65.33%) and 26 females (34.67%) were included in the study. CAN was detected in 94.67% of the studied group Conclusion: An incidence of 94.67% cardiovascular autonomic neuropathy in our sample indicates a high occurrence of this syndrome among our diabetic patients. Poor glycemic control is a common feature among our studied group. Sub-clinical autonomic neuropathy can be detected early using autonomic function tests.

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Cardiac Affection in Type 1 Diabetic Patients in Relation to Omentin

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2015.132 ◽

2015 ◽

Vol 3 (4) ◽

pp. 699-704 ◽

Cited By ~ 3

Author(s):

Soha M. Abd El Dayem ◽

Ahmed A. Battah ◽

Amal El Shehaby

Keyword(s):

Type 1 Diabetes ◽

Regression Analysis ◽

Multiple Regression Analysis ◽

Multiple Regression ◽

Stepwise Multiple Regression ◽

Cardiac Autonomic Neuropathy ◽

Control Group ◽

Diabetic Patients ◽

Stepwise Multiple Regression Analysis

AIM: To evaluate cardiac affection in type 1 diabetes in relation to Omentin.PATIENTS AND METHODS: Sixty two diabetics and 30 volunteer of the same age and sex were included as a control group. Blood sample was taken for assessment of omentin and oxidized low density lipoprotein (OxLDL), glycosylated hemoglobin (HbA1) and lipid profile. Urine sample was taken for assessment of albumin/ creatinine ratio. 24 hour holter was also done. T-test, simple correlation followed by stepwise multiple regression analysis was used for analysis of data.RESULTS: Parameters of 24 hour holter were significantly lower in diabetics. Omentin was significantly lower, while OxLDL were significantly higher than controls. RMSSD, ST deviation and OxLDL were the parameters related to omentin by stepwise multiple regression analysis in diabetics.CONCLUSION: Diabetic patients had a cardiac autonomic neuropathy. A significant reduction of omentin and elevation OxLDL imply that they influence glucose metabolism in type 1 diabetes. Omentin had a significant relation to 24 hr holter which may reflect its role in cardiac affection. Omentin and OxLDL had a role in renal affection.

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Low prevalence of cardiac autonomic neuropathy in Type 1 diabetic patients without nephropathy

Diabetic Medicine ◽

10.1046/j.1464-5491.2001.00480.x ◽

2001 ◽

Vol 18 (8) ◽

pp. 607-613 ◽

Cited By ~ 12

Author(s):

J. A. Meinhold ◽

E. Maslowska-Wessel ◽

R. Bender ◽

P. T. Sawicki

Keyword(s):

Autonomic Neuropathy ◽

Cardiac Autonomic Neuropathy ◽

Diabetic Patients ◽

Low Prevalence ◽

Type 1 Diabetic Patients

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The influence of cardiovascular autonomic neuropathy on mortality in type 1 diabetic patients; 10-year follow-up

Biomedical Papers ◽

10.5507/bp.2015.063 ◽

2016 ◽

Vol 160 (1) ◽

pp. 111-117 ◽

Cited By ~ 6

Author(s):

Silvie Lacigova ◽

Jitka Brozova ◽

Daniela Cechurova ◽

Jitka Tomesova ◽

Michal Krcma ◽

...

Keyword(s):

Autonomic Neuropathy ◽

Cardiovascular Autonomic Neuropathy ◽

Diabetic Patients ◽

Type 1 Diabetic Patients

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Silent Coronary Artery Disease in Diabetic Patients With Cardiac Autonomic Neuropathy

Diabetes Care ◽

10.2337/diacare.17.10.1231 ◽

1994 ◽

Vol 17 (10) ◽

pp. 1231-1232 ◽

Cited By ~ 5

Author(s):

G. Ermendy ◽

Z. DaviDovits ◽

S. Khoor

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Autonomic Neuropathy ◽

Cardiac Autonomic Neuropathy ◽

Diabetic Patients ◽

Silent Coronary Artery Disease ◽

Artery Disease

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Evaluation of Post-Translation Control Mechanisms (Mirnas) In Type 1 Diabetic Patients with and Without Cardiac Autonomic Neuropathy

Scholarly Journal of Food and Nutrition ◽

10.32474/sjfn.2020.02.000150 ◽

2020 ◽

Vol 2 (5) ◽

Author(s):

Beata Kiec Wilk

Keyword(s):

Autonomic Neuropathy ◽

Cardiac Autonomic Neuropathy ◽

Diabetic Patients ◽

Control Mechanisms ◽

Translation Control ◽

Type 1 Diabetic Patients

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Sclerodactyly and Diabetic Complications among Egyptian Adolescent Type 1 Diabetic Patient

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2019.641 ◽

2019 ◽

Vol 7 (23) ◽

pp. 4004-4009

Author(s):

Soha M. El Dayem ◽

Abo El Magd El Bohy ◽

Ahmed A. Battah

Keyword(s):

Diabetic Complications ◽

Clinical Laboratory ◽

Microvascular Complications ◽

Glycosylated Hemoglobin ◽

Vascular Complications ◽

Diabetic Patients ◽

Skin Thickness ◽

Laboratory Assessment ◽

Limited Joint Mobility

BACKGROUND: One of the common complications of diabetic patients is sclerodactyly which is considered as a part of limited joint mobility. AIM: To assess sclerodactyly in adolescent type 1 diabetics and to detect its relation to other diabetic complications. METHODS: Sixty-three diabetics and 60 controls were studied. Clinical, laboratory assessment, ultrasonography of the skin, carotid artery intima-media thickness (cIMT) & renal colour duplex were done for all participants. RESULTS: Sclerodactyly was positive in 12 (19%) of diabetics. Patients with sclerodactyly had a significantly thickened skin compared to patients without sclerodactyly and controls, P = 0.0001. Male diabetics had significantly thickened skin (p = 0.0001). Diabetic patients with sclerodactyly had significant higher systolic blood pressure (p = 0.03), cholesterol (p = 0.05) and triglyceride (p = 0.004) and lower HDL-c (p = 0.04). Skin thickness had a significant positive correlation with age of diabetic patients (p = 0.02), waist/height ratio (p = 0.04), glycosylated hemoglobin (p = 0.03), albumin/creatinine ratio (p = 0.03), and cIMT (p = 0.03). CONCLUSION: Ultrasound easily diagnoses sclerodactyly. Diabetic patients had a high prevalence of sclerodactyly with increased macrovascular and microvascular complications. Sclerodactyly may be a marker for diabetic vascular complications. Frequent follow up of diabetic patients for early detection of sclerodactyly in uncontrolled diabetic patients is recommended. It could be an alarming sign for microalbuminuria, hypertension, hyperlipidaemia and atherosclerosis.

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