scholarly journals Association between Bisphenol A Urine Level with Low-Grade Albuminuria in Egyptian Children and Adolescents

2021 ◽  
Vol 9 (B) ◽  
pp. 1092-1097
Author(s):  
Nermine Mahfouz ◽  
Ebtissam Salah ◽  
Ayman Armaneous ◽  
Mai M. Youssef ◽  
Mones Mahmoud Abu Shady ◽  
...  

 The glomerulus is the accessible window to visualize the endothelial status of the whole body. Minimal level of albuminuria even below the cutoff point of microalbuminuria might be a marker of endothelial dysfunction. Exposure to Bisphenol A may be a risk factor of developing low-grade albuminuria in pediatrics. Aim: This study investigated the association of exposure to Bisphenol A and the presence of low-grade albuminuria. Methods: A cross-sectional study enrolling 158 children; 91 boys and 67 girls. Children with hepatic disease, kidney disease and endocrinopathies were excluded from the study. Urinary albumin and creatinine were measured in a first morning urine specimen. Urinary albumin/creatinine ratio was calculated in mg/gm and was stratified into: macroalbuminuria of ˃300mg/gm, microalbuminuria of 30-300mg/gm and low grade albuminuria of ˂30mg/gm. Urinary Bisphenol A was measured by high performance liquid chromatography using florescent detector. Results: Low grade albuminuria was detected in 141 participants (89.24%), while microalbuminuria and macroalbuminuria were detected in 15 (9.5%) and 2 (1.26%) participants, respectively. The total urinary Bisphenol A in candidates with low grade albuminuria was categorized into four quartiles (<0.285, 0.285–0.599, 0.600–1.215, >1.215) ng/mL and similarly their low grade albuminuria into (<2.0404, 2.0404–4.0385, 4.0386–7.3870, >7.3870) mg/gm. Children with the highest compared to the lowest quartile of urinary Bisphenol A had comparable mean of low grade albuminuria with insignificant P value. Conclusion: low grade albuminuria was found in 141 out of 158 children. A direct cause effect of exposure to Bisphenol A could not be proved. Further studies are needed to investigate the pathophysiology of low grade   albuminuria and its significance                                                                                      

2021 ◽  
Author(s):  
Arabinda Mohan Bhattarai ◽  
Sulochana Parajuli ◽  
Salina Pradhananga

Abstract Background Measurement of Glycosylated Hemoglobin (HbA1c) is an established procedure in evaluating long-term glycemic control in diabetic patients. It is an index of glycemic control which is not affected by diurnal glucose fluctuations. Methods A retrospective cross sectional study was performed in the Biochemistry department of Shree Birendra Hospital, Kathmandu, Nepal involving 100 known cases of type 2 diabetes mellitus. This study was designed to study the variation of HbA1c with hemoglobin levels. HbA1c was measured by Bio-Rad D10 (HPLC method) and Nycocard (Immunochromatography method). Linear regressive analysis with correlation coefficient was used to compare HbA1c with hemoglobin levels and a p-value < 0.05 is considered statistically significant. Results There was a strong correlation of HbA1c values with Hemoglobin levels in HPLC methods p = 0.001, r = 0.6, however no such correlation was seen in Nycocard method p = 0.6, r = 0.08. Conclusion Cation-exchange high performance liquid chromatography (HPLC) is the latest method introduced in our country Nepal. Therefore, interference caused by Hemoglobin variants needs to be evaluated by methods such as HPLC. In such situations, we may consider fructosamine, glycated serum albumin or self-monitoring of blood glucose as an adjunct to HbA1C measurements.


Author(s):  
Shahid Iqbal ◽  
Anju Mittal ◽  
Sudeep Kumar ◽  
Sumesh Prasad Sah ◽  
Imran Mustafa ◽  
...  

Introduction: Metabolic Syndrome (MetS) is a condition that increases the risk of cardiac disease, diabetes, hypertension and may be associated with microalbuminuria. Aim: To investigate the prevalence of metabolic syndrome and to determine albumin to creatinine ratio as a predictor of cardiovascular disease in metabolic syndrome. Materials and Methods: This was a hospital based cross-sectional study conducted from February 2019 to January 2020 in the Department of Biochemistry and Outpatient Department of Muzaffarnagar Medical College, Muzaffarnagar, Uttar Pradesh. Out of enrolled 795 subjects, 452 were male and 343 were female. The prevalence of metabolic syndrome was calculated on the basis of metabolic syndrome criteria. Anthropometric parameters like age, weight, height, blood pressure and the biochemical parameters including fasting blood sugar, triglyceride, Lipid Accumulation Product (LAP), urinary albumin, serum creatinine and urinary Albumin to Creatinine Ratio were measured in study population. SPSS version 16 was used for statistical analysis and student independent sample t-test was used for comparing differences amongst the variables. A p-value less than 0.05 was considered as statistically significant. Results: Out of 795 subjects, 152 patients (19.12%) were hypertensive, 85 patients (10.69%) were diabetic and 29 patients (3.65%) were hypertensive with diabetic. The prevalence of metabolic syndrome was around 18.11% (144 subjects), out of which 52.78% were female and 47.22% were male. Out of 144 Metabolic Syndrome subjects, 23 subjects were diabetic, 32 were hypertensive, 14 were diabetic with hypertensive and 75 were others. The mean levels of urinary albumin creatinine ratio were increased significantly in metabolic syndrome subjects and the increase in urine Albumin to Creatinine Ratio (uACR) was more in metabolic syndrome subjects having Diabetes and Hypertension both. Conclusion: The present study concluded that the microalbuminuria is associated with metabolic syndrome. The microalbuminuria was found to be more significant in metabolic syndrome subjects who were diabetic with hypertensive as compared to diabetic or hypertensive alone.


2020 ◽  
Vol 6 (2) ◽  
pp. 74-77
Author(s):  
Mohammad Enayet Hussain ◽  
Bithi Debnath ◽  
AFM Al Masum Khan ◽  
Md Ferdous Mian ◽  
Md Nahidul Islam ◽  
...  

Background: The visual evoked potentials (VEP) is a valuable tool to document occult lesions of the central visual channels especially within the optic nerve. Objectives: The purpose of the present study was to observe the findings of first few cases of VEP done in the neurophysiology department of the National Institute of Neurosciences (NINS), Dhaka, Bangladesh. Methodology: This cross-sectional study was conducted in the Department of Neurophysiology at the National Institute of Neurosciences and Hospital, Dhaka, Bangladesh from September 2017 to March 2020. All patients referred to the Neurophysiology Department of NINS for VEP were included. Pattern reversal VEPs were done using standard protocol set by International Federation of Clinical Neurophysiology (IFCN). Results: The mean age of the study population was 30.70 (±12.11) years (6-68 years) with 31 (46.3%) male and 36 (53.7%) female patients. The mean duration of illness was 8.71 (±1.78) months (3 days- 120 months). Most common presenting symptom was blurring of vision (37.3%) and dimness of vision (32.8%). Patterned VEP revealed mixed type (both demyelinating and axonal) of abnormality in most cases [29(43.35)]. The most common clinical diagnosis was multiple sclerosis (29.85%) and optic neuropathy (26.87%). In the clinically suspected cases of multiple sclerosis, optic neuropathy and optic neuritis most of the cases of VEP were abnormal and the p value is 0.04 in optic neuropathy and optic neuritis. Conclusion: The commonest presentation of the patients in this series were blurring of vision and dimness of vision. The most common clinical diagnosis for which VEP was asked for, was optic neuritis and multiple sclerosis. Most abnormalities were of mixed pattern (demyelinating and axonal). Journal of National Institute of Neurosciences Bangladesh, 2020;6(2): 74-77


Author(s):  
Sri Burhani Putri

Breast cancer is one of the most common illness that killed woman. One of the therapy to cure breast cancer is chemotherapy. Chemotherapy has side effect either physical and psychology, that caused people who’s in chemo therapy, prone to stress. Stress effected by many factors, such as characteristic and chopping strategy that patient has been using. The aim of this research is to get a perspective about the relation of characteristic and chopping strategy with breast cancer patient stress, whose in chemo therapy. This research using cross sectional study and taking sample by using accidental sampling method. The data analyzed by using bavariat and multivariat with variable result shows that breast cancer patient stress who has chemo therapy realted to age characteristic (p value = 0.00) the time since they diagnosed with cancer (pvalue = 0.03), how long they have chemo therapy (pvalue = 0.00) and chopping strategyby looking social support (pvalue = 0.00) looking for spiritual (pvalue = 0.00) with dominan variable which related to stress is chopping strategy to looking spiritual support (coeffecients B = -1.139).   Key words : Breast cancer, chemotherapy, stress  


2017 ◽  
Vol 6 (2) ◽  
pp. 129
Author(s):  
Entia Nopa ◽  
Ranissa Dwi Imansari ◽  
Irwandi Rachman

Faktor Risiko Kejadian Penyakit Kulit Pada Pekerja Pengangkut Sampah Di Kota Jambi 1Entianopa, 2Ranissa Dwi Imansari, 3Irwandi Rachman       123Program Studi Kesehatan Masyarakat STIKES Harapan Ibu, Jambi   Abstrak Latar Belakang: Kulit merupakan organ terbesar pada tubuh manusia yang membungkus otot-otot dan organ-organ dalam serta merupakan jalinan jaringan pembuluh darah, saraf, dan kelenjar yang tidak berujung, semuanya memiliki potensi untuk terserang penyakit yang salah satunya adalah penyakit kulit. Penyakit kulit merupakan salah satu gangguan kesehatan yang sering dialami oleh pekerja pengangkut sampah. Berdasarkan komposisi sampah yang diangkut serta waktu paparan kerja. Tujuan penelitian ini untuk mengetahui hubungan antara masa kerja, pemakaian Alat Pelindung Diri (APD), dan personal hygiene dengan kejadian penyakit kulit pada pekerja pengangkut sampah di Kota Jambi. Metode: Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian cross sectional study. Sampel penelitian yaitu sebanyak 62 pekerja pengangkut sampah yang berada di Kantor Pekerjaan Umum dan Penata Ruang, yang mana seluruh populasi dijadikan sampel. Data dikumpulkan berdasarkan pemeriksaan kesehatan oleh dokter dan dengan kuesioner, kemudian dianalisa menggunakan uji statistik chi-square. Hasil: Hasil menunjukan bahwa pekerja yang mengalami penyakit kulit sebanyak 35 pekerja (56,5%). Berdasarkan hasil analisis chi-square didapatkan bahwa ada hubungan yang bermakna antara masa kerja dengan kejadian penyakit kulit pada pekerja pengangkut sampah dimana nilai (p-value= 0,006), Pemakaian Alat Pelindung Diri (APD) nilai (p-value= 0,008), personal hygiene nilai (p-value= 0,008). Kesimpulan: Untuk meminimalisir risiko terjadinya penyakit kulit pada pekerja pengangkut sampah disarankan perlunya disusun standar operasional prosedur yang aman, penyediaan sarana sanitasi agar dapat mengurangi resiko terkena penyakit kulit. Pentingnya pemakaian APD dan perilaku hidup bersih dan sehat selama bekerja, serta diharapkan pekerja menggunakan APD pada saat bekerja dan lebih memperhatikan personal hygiene.   Kata kunci      : Masa Kerja, APD, Personal Hygiene


Background: The most common benign pathological lesion in women of reproductive age is uterine leiomyoma. Gestational trophoblastic disease includes tumors and tumor like lesions originating from trophoblastic tissue. The aim of this study was to find the spectrum of molar pregnancy and uterine pathologies focusing on gestational trophoblastic disease as no study has been done in the past few years. Methods: Endometrial and uterine specimens of patients (n=436) between the ages of 15-65 years were collected from a private hospital in Karachi from December 2018 to December 2019. This cross-sectional study was carried out by pathological diagnosis of patients’ samples under light microscopy using hematoxylin and eosin staining. Stratification was done about age and nature of specimen to control the effect modifiers. The post stratification Chi square test was applied and p value <0.05 was considered significant. Results: Mean age of the patients was 36.1 years ±7.8. Total 436 uterine biopsies included 260(59.6%) hysterectomies, 56(12.8%) endometrial curetting’s, 117(26.8%) evacuation specimens and 3(0.7%) polypectomies. Common pathologies included 124(28.4%) leiomyomas, 61(14%) proliferative endometrium, 52(11.9%) adenomyosis and 32(7.3%) endometrial polyps. Gestational trophoblastic disease was seen in 9(2.06%). Seven (87.5%) were partial hydatidiform moles, one (12.5%) exaggerated placental site reaction and one choriocarcinoma. Mole was common between 26-30 years with mean age of 27.2 years and prevalence was 6/100 abortions. Conclusion: Leiomyoma was the commonest (28.4%) uterine pathology followed by proliferative endometrium (14.5%). However, endometrial stromal sarcoma and endometriosis were found 0.2% each. High prevalence of mole was seen in this study. Partial mole was most common and choriocarcinoma was least common. Keywords: Hydatidiform Mole; Pathology; Prevalence.


2015 ◽  
Vol 2 (3) ◽  
pp. 193
Author(s):  
Riris Lindiawati Puspitasari ◽  
Dewi Elfidasari ◽  
Kun Mardiwati Rahayu

<p><em>Abstrak –<strong> </strong></em><strong>Tahap perkembangan r</strong><strong>emaja ditandai </strong><strong>dengan</strong><strong> perubahan fisik umum </strong><strong>yang di</strong><strong>serta</strong><strong>i</strong><strong> perkembangan kognitif</strong><strong> maupun</strong><strong> sosial.<em> </em>Menstruasi merupakan </strong><strong>proses alamiah organ reproduksi wanita dengan </strong><strong>peng</strong><strong>e</strong><strong>ndalian hormon</strong><strong>. S</strong><strong>alah satu gangguan menstruasi adalah <em>Premenstrual Syndrome</em> </strong><strong>atau</strong><strong> sindrom sebelum haid</strong><strong> atau dikenal juga sebagai </strong><strong>ketegangan sebelum haid</strong><strong>.</strong><strong> </strong><strong>Siklus menstruasi yang tidak teratur, penurunan </strong><strong>level</strong><strong> progesteron dan peningkatan </strong><strong>level</strong><strong> estrogen, stres, usia <em>menarche</em> yang terlalu cepat, dan status gizi</strong><strong> merupakan beberapa faktor penyebab PMS. Penelitian ini bertujuan u</strong><strong>ntuk mengetahui pengetahuan mahasiswi Universitas Al Azhar Indonesia terhadap PMS<em>. </em></strong><strong>Metodologi yang digunakan yaitu studi <em>Cross Sectiona</em></strong><strong><em>l.</em></strong><strong> Populasi sampel penelitian adalah mahasiswi Universitas Al Azhar Indonesia. Variabel independen yang dipilih yaitu pengetahuan, usia <em>menarche</em>, siklus haid, olahraga, nutrisi, produktivitas, dan indeks massa tubuh (IMT). Berdasarkan uji </strong><strong>bivariat dan multivariat regresi logistik tidak ditemukan hubungan yang signifikan antara pengetahuan dengan premenstrual syndrome pada mahasiswi UAI yaitu pengetahuan dengan p value 0,169; OR 0,473; 95% CI 0,163-1,374</strong><strong>. Responden yang memiliki pengetahuan 0,473 kali lebih baik dalam penatalaksanaan <em>premenstrual syndrome</em> daripada responden yang memiliki pengetahuan kurang.</strong><strong></strong></p><p><strong> </strong></p><p><em>Abstract </em><strong>– Adolescent developmental</strong><strong> stage characterized by common physical changes that accompanied the cognitive and social development. Menstruation was known as a natural process of hormonal control in the female reproductive organs. One of menstrual disorders was premenstrual syndrome or syndrome before menstruation or also known as tension before menstruation. Irregular menstrual cycles, decreased levels of progesterone, increased level of estrogen, stress, menarche age, and nutritional status were informed as factors that cause premenstrual syndrome. This study aimed to determine student’s knowledge to premenstrual syndrome. The methodology used was a cross sectional study. The population sample was a student of University Al Azhar Indonesia. The independent variables were selected, namely knowledge, age of menarche, menstrual cycle, exercise, nutrition, productivity, and body mass index (BMI). Based on the test bivariate and multivariate logistic regression found no significant relationship between knowledge with premenstrual syndrome in UAI student that knowledge with p value 0.169; OR 0.473; 95% CI 0.163 to 1.374. Respondents who had knowledge 0.473 times better than others in treatment of premenstrual syndrome.</strong><strong></strong></p><p><strong><em> </em></strong></p><p><strong><em>Keywords</em></strong><em>: Premenstrual Syndrome</em><em>, </em><em>knowlwdge, menstruation, menarche.</em><em></em></p>


Author(s):  
Dina Dewi Anggraini

ABSTRACT   The study aims todetermine the relationship between parenting style and the level of independence of Personal Hygiene Hand Wasting and Tooth Brush in Preschoolers in Kindergarten Negeri Pembina Blora in 2019. The study is a quantitative study, based on the research location including the type of field reseaerch, based on the ansence of the treatment of subjects including survey research, based on time is a cross sectional study, and based on objectives includin correlation analytics. The population in this study were all parents in Kindergarten Negeri Pembina Blora as many as 85 respondents. Based on the sample calculation, the sample obtained in this study that most parent in Kindergarten Negeri Pembina Blora amounted to 70 respondents. Srearmen’s rho test analysis results parenting parents with the level of independence of personal hygiene hand wasting result obtained p value = 0,000 < α (0,05), and parenting patters with the independence of personal hygiene tooth brush obtained results p value = 0,000 < α (0,05). So it can be concluded that were is a significant relationship between parenting parents with the level of independence of personal hygiene washing hands and brushing their tooth at preschoolers in Kindergarten Negeri Pembina Blora in 2019. Keywords: parenting; personal hygiene, preschool ABSTRAK   Penelitian ini bertujuan untuk mengetahui Hubungan Pola Asuh Orangtua Terhadap Tingkat Kemandirian Personal Hygiene Cuci Tangan dan Gogok Gigi pada Anak Prasekolah di TK Negeri Pembina Blora Tahun 2019. Penelitian ini adalah penelitian kuantitatif, berdasarkan tempat penelitian termasuk jenis penelitian lapangan, berdasarkan tidak adanya perlakuan terhadap subjek termasuk penelitian survey, berdasarkan waktu merupakan penelitian cross sectional, dan berdasarkan tujuan termasuk analitik korelasi. Populasi dalam penelitian ini adalah seluruh orangtua di TK Negeri Pembina Blora sebanyak 85 responden. Berdasarkan perhitungan sampel  maka diperoleh sampel pada penelitian ini adalah sebagian orangtua di TK Negeri Pembina Blora sebanyak 70 responden. Hasil analisis uji spearmen’s rho pola asuh orangtua dengan tingkat kemandirian personal hygiene cuci tangan didapatkan hasil p value = 0,000 < α (0,05), dan pola asuh orangtua dengan kemandirian personal hygiene gosok gigi didapatkan hasil p value = 0,000 < α (0,05). Sehingga dapat disimpulkan bahwa ada hubungan yang signifikan antara pola asuh orang tua dengan tingkat kemandirian personal hygiene cuci tangan dan gosok gigi pada anak prasekolah di TK Negeri Pembina Blora Tahun 2019. Kata kunci: pola asuh; personal hygiene; prasekolah


2017 ◽  
Vol 5 (1) ◽  
pp. 32-39
Author(s):  
Dedeh Husnaniyah

Tuberkulosis Paru merupakan penyakit menular yang disebabkan oleh Mycobacterium tuberculosis. Dampak TB Paru adalah penurunan daya tahan tubuh, kelemahan fisik, merugikan secara ekonomis dan dapat mengakibatkan isolasi sosial. Keadaan tersebut dapat mempengaruhi harga diri penderita TB Paru. Perubahan harga diri pada penderita TB Paru dapat mempengaruhi keberhasilan pengobatan, sehingga dibutuhkan adanya dukungan keluarga. Tujuan Penelitian ini adalah untuk mengidentifikasi pengaruh dukungan keluarga terhadap harga diri penderita TB Paru di Wilayah Puskesmas Eks Kawedanan Indramayu tahun 2015. Jenis penelitian ini adalah deskriptif analitik dengan rancangan penelitian cross sectional study. Pengambilan sampel dilakukan dengan tekhnik total sampling sebayak 45 responden. Hasil penelitian menunjukkan bahwa penderita TB Paru yang memiliki harga diri tinggi sebanyak 23 responden (51,1%) dan yang memiliki harga diri rendah sebanyak 22 responden (48,9%), penderita TB Paru yang mendapatkan dukungan keluarga sebanyak 26 responden (57,8 %) dan yang tidak mendapatkandukungan keluarga sebanyak 19 (42,2 %). Responden yang mendapatkan dukungan keluarga lebih banyak yang memiliki harga diri tinggi dibandingkan dengan responden yang tidak mendapatkan dukungan keluarga yaitu 69,6% dengan nilai p value = 0,047 (< 0,05). Simpulan dari penelitian ini adalah terdapat hubungandukungan keluarga denganharga diri penderita TB Paru. Hasil penelitian ini diharapkan dapat menjadi masukan bagi pemegang program TB untuk memberikan konseling terkait pentingnya dukungan keluarga bagi penderita TB Paru.


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