scholarly journals Effect of Exercise-Induced Lipolysis on Serum Vitamin D Level in Obese Children: A Clinical Controlled Trial

2021 ◽  
Vol 9 (B) ◽  
pp. 1596-1601
Author(s):  
Lamiaa K. Elsayyad ◽  
Alaa Shafie ◽  
Mazen Almehmadi ◽  
Amal F. Gharib ◽  
Ahmad El Askary ◽  
...  
Keyword(s):  
Vitamin D ◽  
Endurance Exercise ◽  
Vitamin D3 ◽  
Controlled Trial ◽  
Serum Vitamin ◽  
Exercise Program ◽  
Obese Children ◽  
Serum Vitamin D ◽  
Group I ◽  
Vitamin D Levels

BACKGROUND: Low Vitamin D levels associated with obesity have reached an epidemic level all over the world. It has been supposed that the low serum level of Vitamin D3 in obese subjects may be due to an increase in the uptake of Vitamin D3 by adipose tissue. AIM: The current study aimed to investigate the effect of a specially designed exercise program for boosting lipolysis on the Vitamin D level in obese children. METHODS: Thirty obese male children participated in the study. Their age was ranged from 9 to 11 years. The participants were assigned to two groups, Group I (GI) who received endurance exercise (ENE) only and Group II (GII) who received the specially designed exercise for increasing lipolysis (ENE preceded by resistance exercise). Free fatty acids (FFA), glycerol, and 25(OH)D were assessed before and immediately after exercise. RESULTS: FFA and glycerol showed a significant increase in both groups following exercise, while 25(OH)D showed a significant increase only in GII. GII showed significantly higher levels of FFA, glycerol, and 25(OH)D following exercise when it was compared to GI. CONCLUSION: The application of resistance training before ENE could improve the Vitamin D status through increasing the lipolytic activities more than the application of endurance exercise alone.

scholarly journals Systemic inflammation and alteration in vitamin D levels in pregnancy induced hypertension

2014 ◽  
Vol 5 (4) ◽  
pp. 11-15 ◽  
Author(s):  
Dilutpal Sharma ◽  
Rahul Saxena ◽  
Raj Saxena ◽  
Mousumi Sharma ◽  
Alok Milton Lal
Keyword(s):  
Vitamin D ◽  
Systemic Inflammation ◽  
Serum Vitamin ◽  
Pregnancy Induced Hypertension ◽  
Serum Vitamin D ◽  
Sodium Calcium ◽  
Group I ◽  
Vitamin D Levels ◽  
Induced Hypertension ◽  
Group Ii

Background: The increasing incidence of Pregnancy induced hypertension (PIH) or Pre-eclampsia in developed and developing countries are alarming. Systemic inflammation and disturbances in vitamin D and minerals (Sodium & Calcium) metabolism are almost invariable consequences of PIH; and variation in their levels can adversely affect the pregnancy leading to the development of PIH. Aim: In this context, a study was carried out to assess the level of serum vitamin D, sodium, calcium and inflammatory marker C-reactive protein (CRP) in non-pregnant (NP), normotensive pregnant (NTP) and PIH women and to determine their role in the etio-pathogenesis of PIH. Material and method: Serum vitamin D, sodium, calcium and CRP levels were estimated in 20 NTP women (Group I) and 20 PIH women (Group II) by using standard methods and statistically compared it with that of age matched 20 healthy non pregnant women (Control group) by using student’s t-test. Result: Serum Ca++ level were found to be significantly low in both Group I (p<0.05) and Group II (p<0.01) as compared to healthy controls. However, plasma vitamin D levels were decreased insignificantly in Group I (p < 0.1) and significantly (p < 0.05) in Group II patients. Similarly, serum sodium and CRP levels were increased significantly only in Group II patients. Conclusion: Thus, regular assessment of serum CRP, vitamin D, sodium and calcium levels and recommendation of diet low in sodium, rich in calcium and appropriate vitamin D should be increased during pregnancy to prevent PIH and its related complications. DOI: http://dx.doi.org/10.3126/ajms.v5i4.9809 Asian Journal of Medical Sciences 2014 Vol.5(4); 11-15

scholarly journals Effect of Vitamin D3 (Cholecalciferol) Supplementation on Serum Vitamin D3 and 25-hydroxyvitamin D (25(OH)D) Concentrations Among Participants in the VITAL-DKD Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1779-1779
Author(s):  
Cora Best ◽  
Leila Zelnick ◽  
Simon Hsu ◽  
Christine Limonte ◽  
Ravi Thadhani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Weight ◽  
Vitamin D3 ◽  
Controlled Trial ◽  
Serum Vitamin ◽  
Threshold Effect ◽  
Omega 3 ◽  
Serum Vitamin D ◽  
Supplement Use ◽  
Effect Of Treatment

Abstract Objectives To compare the serum vitamin D3 and 25(OH)D responses to vitamin D3 supplementation in the VITAL-DKD study. Methods The Vitamin D and OmegA-3 TriaL (VITAL)-DKD was a 2 × 2 factorial, randomized, placebo-controlled trial of vitamin D3 (2000 IU/day) and omega-3 fatty acids (1 g/day) for prevention of chronic kidney disease among adults with type 2 diabetes. For the first 200 enrolled participants, we measured baseline and year 2 serum vitamin D3 concentration with a new validated liquid chromatography-tandem mass spectrometry method. Linear regression was used to test the effects of D3 treatment on changes in serum D3 and 25(OH)D concentrations and to examine possible effect modification by relevant clinical characteristics. Results Participants were 70 ± 6 years of age, 64% male, 70% non-Hispanic white, and 15% black. At baseline and year 2, serum D3 concentration and 25(OH)D3 concentration were positively related, with a threshold effect at a 25(OH)D3 concentration of 50 nmol/L. Below this threshold, serum D3 concentration rarely exceeded 5 nmol/L. Above it, serum D3 concentration was much more variable. Supplementation increased mean serum D3 concentration from 12 nmol/L at baseline to 41 nmol/L at year 2 (difference compared with placebo 30 nmol/L; 95% CI 25 to 35 nmol/L) and increased mean serum 25(OH)D concentration from 76 nmol/L to 102 nmol/L (difference compared with placebo 33 nmol/L; 95% CI 26 to 40 nmol/L). The effect of treatment on change in serum 25(OH)D was modified by body weight (−0.48 nmol/L per kg of weight; P &lt; 0.01), baseline 25(OH)D concentration (−0.30 nmol/L per nmol/L of baseline 25(OH)D; P &lt; 0.01), baseline D3 concentration (−5 nmol/L per 100% increase in baseline D3; P = 0.04), and non-study vitamin D supplement use (smaller effect as dose of non-study supplement increased). The effect of treatment on change in serum D3 concentration was modified only by body weight (−0.33 nmol/L per kg of weight; P = 0.01). Conclusions Among older adults, 2 years of 2000 IU/day vitamin D3 led to similar mean increases in serum D3 and 25(OH)D. Unlike the serum 25(OH)D response, the serum D3 response to supplementation did not depend on baseline vitamin D status. The serum vitamin D concentration may be an additional, valuable marker of exposure to vitamin D during supplementation. Funding Sources NIDDK NIH ODS NHLBI.

scholarly journals Simulation of Physicochemical and Pharmacokinetic Properties of Vitamin D3 and Its Natural Derivatives

2020 ◽  
Vol 13 (8) ◽  
pp. 160
Author(s):  
Subrata Deb ◽  
Anthony Allen Reeves ◽  
Suki Lafortune
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Water Solubility ◽  
Oral Absorption ◽  
Serum Vitamin ◽  
Log P ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Fraction Absorbed ◽  
Pharmacokinetic Behavior

Vitamin D3 is an endogenous fat-soluble secosteroid, either biosynthesized in human skin or absorbed from diet and health supplements. Multiple hydroxylation reactions in several tissues including liver and small intestine produce different forms of vitamin D3. Low serum vitamin D levels is a global problem which may origin from differential absorption following supplementation. The objective of the present study was to estimate the physicochemical properties, metabolism, transport and pharmacokinetic behavior of vitamin D3 derivatives following oral ingestion. GastroPlus software, which is an in silico mechanistically-constructed simulation tool, was used to simulate the physicochemical and pharmacokinetic behavior for twelve vitamin D3 derivatives. The Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) Predictor and PKPlus modules were employed to derive the relevant parameters from the structural features of the compounds. The majority of the vitamin D3 derivatives are lipophilic (log P values >5) with poor water solubility which are reflected in the poor predicted bioavailability. The fraction absorbed values for the vitamin D3 derivatives were low except for calcitroic acid, 1,23S,25-trihydroxy-24-oxo-vitamin D3, and (23S,25R)-1,25-dihydroxyvitamin D3-26,23-lactone each being greater than 90% fraction absorbed. Cytochrome P450 3A4 (CYP3A4) is the primary hepatic enzyme along with P-glycoprotein involved in the disposition of the vitamin D derivatives. Lipophilicity and solubility appear to be strongly associated with the oral absorption of the vitamin D3 derivatives. Understanding the ADME properties of vitamin D3 derivatives with the knowledge of pharmacological potency could influence the identification of pharmacokinetically most acceptable vitamin D3 derivative for routine supplementation.

scholarly journals EFFECT OF MATERNAL VITAMIN D SUPPLEMENTATION DURING LACTATION EFFECT ON INFANTS' PROPENSITY TO INFECTION : AN EVIDENCE-BASED CASE REPORT

2021 ◽  
Vol 4 (2) ◽  
pp. 112-117
Author(s):  
Raphael Kosasih ◽  
Diana Sunardi
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Controlled Trial ◽  
Relevant Literature ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Oral Supplementation ◽  
Serum Vitamin D ◽  
Advanced Search ◽  
Lactating Mothers

Abstract Introduction: Vitamin D deficiency has become more prevalent around the world along with a sedentary lifestyle and limited exposure to sunlight. Deficiencies of vitamin D in lactating mothers could cause deficiencies in their infants and vitamin D deficient infants are at higher risk of having infectious diseases. Supplementation of Vitamin D to lactating mothers may benefit both mothers and infants to reduce infection morbidity. Methods: Relevant literature research was conducted in PubMed, Cochrane, and SciELO using relevant keywords and advanced search methods. Relevant literature was then screened for duplication, relevance, and eligibility. Results: A randomized-controlled trial was selected. The study showed that supplementation of 3000µg oral vitamin D3 to lactating mothers significantly raise their infants' serum vitamin D (p<0.01) and reduce infection morbidity (p<0.01) Conclusions: Oral supplementation of vitamin D3 could be given to lactating mothers to improve their infants' serum vitamin D and reduce infection morbidity. Keywords: vitamin D, lactation, infants' infection

scholarly journals Effect of vitamin D on women’s somatic and reproductive health

2020 ◽  
pp. 268-273
Author(s):  
I. G. Zhoukovskaya ◽  
I. R. Yakupova
Keyword(s):  
Vitamin D ◽  
Reproductive Health ◽  
Women’S Health ◽  
Women's Health ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Group I ◽  
Vitamin D Levels ◽  
Group Ii

The article presents the results of a study of the effect of vitamin D deficiency on women’s health.The study aimed to determine the prevalence of vitamin D deficiency and its relationship with the somatic and reproductive health of women.Methods: observation group I included 31 women with a reduced serum vitamin D levels (20.4 ± 1.0 ng/ml), comparison group II included 31 patients with normal vitamin D levels (39.0 ± 1.4 ng/ml). Results: the negative effect of vitamin D deficiency on women’s health is also practically assured, i.e. the incidence of somatic pathology is significantly higher in group I compared with group II: obesity (62.5 ± 12.1% and 18.8 ± 9.8%; p <0.5), insulin resistance (55.0 ± 9.0% and 1.0 ± 6.0%; p <0.001); arterial hypertension (42.0 ± 8.8% and 13.0 ± 6.0%; p <0.01); hypertrophic myocardiopathy (25.8 ± 7.8% and 6.4 ± 4.4%; p <0.05); chronic colitis (29.0 ± 8.1% and 6.4 ± 4.4%; p <0.05), gastric ulcer (22.5 ± 7.5% and 3.2 ± 3.2%; p <0.05), chronic pancreatitis (22.5 ± 7.5% and 3.2 ± 3.2%; p <0.05), chronic gastritis (25.8 ± 7.8% and 9.7 ± 5.3%; p <0.1). The interaction between reduced vitamin D levels and reproductive system diseases is confirmed by significant increase in the prevalence of secondary amenorrhea (80.0 ± 9.0% and 16.0 ± 7.3%; p <0.001), secondary oligomenorrhea (75.0 ± 9.7% and 20.0 ± 8.0%; p <0.001), hyperplastic processes – uterine fibroids (48.4 ± 9.0% and 13.3 ± 6.1%; p <0.001) and adenomyosis (26.6 ± 7.9% and 6.7 ± 4.5%; p <0.05), polycystic ovary syndrome (29.0 ± 8.2% and 6.7 ± 4.5%; p <0.05), vaginal microbiocenosis disorders (aerobic vaginitis – 42.0 ± 8.9% and 16.1 ± 6.6%; p <0.05; bacterial vaginosis – 29.0 ± 8.2% and 9.7 ± 5.3%; p <0.05).Conclusion: management of vitamin D level is one of the priorities in the formation of therapeutic and preventive measures to improve the women’s health.

scholarly journals Seasonal Antimicrobial Activity of the Airway: Post-Hoc Analysis of a Randomized Placebo-Controlled Double-Blind Trial

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2602
Author(s):  
Luis G. Vargas Buonfiglio ◽  
Oriana G. Vanegas Calderon ◽  
Marlene Cano ◽  
Jacob E. Simmering ◽  
Philip M. Polgreen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Antimicrobial Activity ◽  
Antimicrobial Peptides ◽  
Vitamin D3 ◽  
Seasonal Pattern ◽  
Serum Vitamin ◽  
Neutralizing Antibody ◽  
Ultraviolet B ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: It is widely unknown why respiratory infections follow a seasonal pattern. Variations in ultraviolet B (UVB) light during seasons affects cutaneous synthesis of vitamin D3. Serum vitamin D concentration influences the expression of airway surface liquid (ASL) antimicrobial peptides such as LL-37. Objective: We sought to determine the effect of seasons on serum vitamin D levels and ASL antimicrobial activity. Methods: Forty participants, 18–60 years old, were randomized 1:1 to receive 90 days of 1000 IU vitamin D3 or placebo. We collected ASL via bronchoscopy and measured serum 25(OH) vitamin D from participants before and after intervention across seasons. We measured ASL antimicrobial activity by challenging samples with bioluminescent Staphylococcus aureus and measured relative light units (RLUs) after four minutes. We also investigated the role of LL-37 using a monoclonal neutralizing antibody. Results: We found that participants, prior to any intervention, during summer–fall (n = 20) compared to winter–spring (n = 20) had (1) decreased live bacteria after challenge (5542 ± 175.2 vs. 6585 ± 279 RLU, p = 0.003) and (2) higher serum vitamin D (88.25 ± 24.25 vs. 67.5 ± 45.25 nmol/L, p = 0.026). Supplementation with vitamin D3 increased vitamin D levels and restored ASL antimicrobial activity only during the winter–spring. The increased ASL antimicrobial activity seen during the summer–fall was abrogated by adding the LL-37 neutralizing antibody. Conclusion: ASL kills bacteria more effectively during the summer–fall compared to the winter–spring. Supplementation of vitamin D during winter–spring restores ASL antimicrobial activity by increasing the expression of antimicrobial peptides including LL-37.

scholarly journals Correlation between serum vitamin D3 levels and blood pressure in patients with essential hypertension and normotensive individuals

2020 ◽  
Vol 7 (6) ◽  
pp. 971
Author(s):  
Divya V. Patil ◽  
Tarun Kumar Dutta
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Essential Hypertension ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Sunlight Exposure ◽  
P Value ◽  
Lower Serum ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: Vitamin D, a fat-soluble vitamin is produced when ultraviolet rays from sunlight strike the skin. Literature data supports, there is a relationship between low vitamin D and pathogenesis of cardiovascular diseases and arterial hypertension. It had been seen that lower circulating 25(OH)D levels were associated with higher blood pressures. Aim was to study the correlation between serum vitamin D3 levels and blood pressure in patients with essential hypertension and normotensive individuals.Methods: An observational study was conducted on 60 individuals in the OPD at MGMCRI between January 2018 and December 2018. Based on history and blood pressure values (JNC 7), the population was divided into cases and controls in accordance with the age and sex. Serum Vitamin D levels were measured by chemiluminescence assay and classified into deficiency (<20ng/ml), insufficiency (20-30ng/ml) and sufficiency (30-100ng/ml). Statistical analysis was done using independent t test, one way ANOVA and correlation.Results: Among the hypertensive individuals, 90% were Vitamin D deficient and 10% had insufficiency. The mean Serum Vitamin D level in essential hypertension was 14.6±4.401 (p value <0.001). Serum Vitamin D levels were affected significantly by increasing BMI (p value <0.001) and less sunlight exposure (p value <0.001) among both cases and controls. There was also a significant negative correlation between serum vitamin D levels and systolic blood pressure (p <0.001).Conclusions: Isolated systolic hypertension was associated with lower serum Vitamin D levels. Obesity and reduced sunlight exposure are factors associated with lower serum Vitamin D levels.

Serum vitamin D levels in Czech overweight and obese children

2011 ◽  
Vol 44 (7) ◽  
pp. 541
Author(s):  
R. Prusa ◽  
J. Cepova ◽  
Z. Marinov ◽  
M. Pechova
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Obese Children ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Effect of serum vitamin D levels on weight loss in obese patients doing aerobic exercises: A retrospective study

2020 ◽  
Vol 7 (2) ◽  
pp. 400-404
Author(s):  
Ahmet Karadağ ◽  
Meryem Otu
Keyword(s):  
Vitamin D ◽  
Weight Loss ◽  
Serum Level ◽  
Aerobic Exercise ◽  
Body Fat ◽  
Serum Vitamin ◽  
Exercise Program ◽  
Obese Patients ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Objective:   This study evaluates the effect of serum vitamin D (Vit D) levels on weight loss in obese patients during an aerobic exercise program. Material and Methods: The study included 88 participants with body mass index (BMI) ≥25 kg/m2. A serum level of 25(OH)D3 >30 ng/ml was accepted as normal, 20–29 ng/ml as insufficient and <20 ng/ml as deficient. The obese patients were classified into three groups based on a serum level of 25(OH)D3. All participants enrolled on an eight-week aerobic exercise program. The BMI, body fat percentage (BF%) and body fat mass (BFM) of the participants were measured before and after aerobic exercise. Results: No statistically significant differences were identified between the groups in the first and last measured BMI, BF% and BFM values (p>0.05). The differences between the first and last measured weights, BMI, BF% and BFM were statistically significant within the groups (p<0.05). Conclusion: Aerobic exercise can lead to weight loss in obese patients, although the level of serum Vit D has no effect on weight loss in obese patients engaged in aerobic exercise.

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