scholarly journals Mechanism of N-acetyl-cysteine inhibition on the cytotoxicity induced by titanium dioxide nanoparticles in JB6 cells transfected with activator protein-1

2017 ◽  
Vol 13 (6) ◽  
pp. 3549-3554
Author(s):  
Hongbo Shi ◽  
Yuanliang Gu ◽  
Zhenhua Xie ◽  
Qi Zhou ◽  
Guochuan Mao ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Jb6 Cells ◽  
Acetyl Cysteine

scholarly journals Induction of Activator Protein-1 through Reactive Oxygen Species by Crystalline Silica in JB6 Cells

2000 ◽  
Vol 276 (12) ◽  
pp. 9108-9114 ◽  
Author(s):  
Min Ding ◽  
Xianglin Shi ◽  
YongJu Lu ◽  
Chuanshu Huang ◽  
Stephen Leonard ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Crystalline Silica ◽  
Oxygen Species ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Jb6 Cells

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

Activator protein-1 is necessary for angiotensin-II stimulation of human adrenocorticotropin receptor gene transcription

2001 ◽  
Vol 268 (6) ◽  
pp. 1802-1810
Author(s):  
Danielle Naville ◽  
Estelle Bordet ◽  
Marie-Claude Berthelon ◽  
Philippe Durand ◽  
Martine Begeot
Keyword(s):  
Angiotensin Ii ◽  
Gene Transcription ◽  
Receptor Gene ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Stimulation Of
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