scholarly journals Arthritis in Idiopathic Inflammatory Myopathy: Clinical Features and Autoantibody Associations

2014 ◽  
Vol 41 (6) ◽  
pp. 1133-1139 ◽  
Author(s):  
Martin Klein ◽  
Heřman Mann ◽  
Lenka Pleštilová ◽  
Zoe Betteridge ◽  
Neil McHugh ◽  
...  
Keyword(s):  
Physical Examination ◽  
Clinical Features ◽  
Strong Association ◽  
Inflammatory Myopathy ◽  
Clinical Manifestations ◽  
Idiopathic Inflammatory Myopathy ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Autoantibody Status

Objective.To determine the prevalence, distribution, and clinical manifestations of arthritis in a cohort of patients with idiopathic inflammatory myopathies (IIM). Associations with autoantibody status and HLA genetic background were also explored.Methods.Consecutive patients with IIM treated in a single center were included in this cross-sectional study (n = 106). History of arthritis, 68-joint and 66-joint tender and swollen joint index, clinical features of IIM, and autoantibody profiles were obtained by clinical examination, personal interview, and review of patient records. High-resolution genotyping in HLA-DRB1 and HLA-DQB1 loci was performed in 71 and 73 patients, respectively.Results.A combination of patients’ medical history and cross-sectional physical examination revealed that arthritis at any time during the disease course had occurred in 56 patients (53%). It was present at the beginning of the disease in 39 patients (37%) including 23 cases (22%) with arthritis preceding the onset of muscle weakness. On physical examination, 29% of patients had at least 1 swollen joint. The most frequently affected areas were wrists, and metacarpophalangeal and proximal interphalangeal joints. Twenty-seven out of the 29 anti-Jo1-positive patients had arthritis at any time during the course of their illness; this prevalence was significantly higher compared to patients without the anti-Jo1 autoantibody (p < 0.0001). No association of arthritis with individual HLA alleles was found.Conclusion.Our data suggest that arthritis is a common feature of myositis. It is frequently present at the onset of disease and it may even precede muscular manifestations of IIM. The most common presentation is a symmetrical, nonerosive polyarthritis affecting particularly the wrists, shoulders, and small joints of the hands. We have confirmed a strong association of arthritis with the presence of the anti-Jo1 antibody.

scholarly journals Diagnosis Based on Detection of CXCL10 in Urine as Biomarker for The Determining Diagnosis of Active Lung Tuberculosis

2021 ◽  
Vol 9 (1) ◽  
pp. 57
Author(s):  
Ni Made Mertaniasih ◽  
I Gede Yogi Prema Ananda ◽  
Soedarsono Soedarsono ◽  
Deby Kusumaningrum
Keyword(s):  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Urine Samples ◽  
Laboratory Research ◽  
Future Research ◽  
Cross Sectional ◽  
Pulmonary Tb ◽  
Lung Tuberculosis ◽  
History Of ◽  
Tuberculosis Diagnosis

Tuberculosis diagnosis is an important component in decreasing TB incidence and prevalence. Because of the difficulty to collect sputum in some cases, urine specimens are used as it is easier to garner. One of the biomarkers in urine that can be used to diagnose pulmonary TB is IP-10, which can be represented by the CXCL10 gene. The study aims to determine the accuracy of diagnosis based on detection of the CXCL10 gene in urine as a biomarker for the patients with suspected pulmonary TB in Dr. Soetomo Hospital in Surabaya from November 2019 until March 2020. Thus, this is an observative laboratory research with a cross-sectional study. CXCL10 gene was examined using PCR for 36 urine samples, and then, the data, together with the medical records of clinical manifestations of pulmonary TB, GeneXpert MTB /RIF, blood count, and thorax radiograph, were processed using IBM SPSS Statistics 26. The results of the GeneXpert MTB/RIF and thorax radiograph criteria show positive results of pulmonary TB, which were 44.4% and 69.4% respectively. CXCL10 gene was not found in all urine of healthy people (negative), while 2.8% (1/36 samples) positive CXCL10 gene was found in a patient with positive GeneXpert, also with negative clinical manifestations and urine culture. In this study, the accuracy of diagnosis based on detection of the CXCL10 gene in urine for diagnosis of active pulmonary TB was 2.8%. Future research is needed to improve the methods, among them are bigger size of urine samples and clearer medical history of patients. 

scholarly journals Prevalence and Clinical Features of Atopic Dermatitis in China

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Xin Wang ◽  
Lin-Feng Li ◽  
Da-yu Zhao ◽  
Yi-wei Shen
Keyword(s):  
Atopic Dermatitis ◽  
Bacterial Infection ◽  
Clinical Features ◽  
Population Based ◽  
Cross Sectional Study ◽  
Morbidity Rate ◽  
Cross Sectional ◽  
Increased Risk ◽  
Tertiary Hospitals ◽  
History Of

Background. The epidemiology of atopic dermatitis (AD) in Chinese outpatients is yet to be clarified.Objectives. To investigate population-based prevalence and clinical features of AD in Chinese outpatients.Methods. A multicenter cross-sectional study was conducted in outpatients with eczema or dermatitis from 39 tertiary hospitals in 15 provinces.Results. This study included 682 patients diagnosed with AD, with the mean age of28.8±20.1years and the median course of5.3±6.9years. AD patients had more severe itching (30.4% versus 13.8%,p<0.001) and clinically suspected bacterial infection (21.7% versus 16.1%,p<0.001) than those of other types of dermatitis. Older patients were more susceptible to have a history of flexion dermatitis (p<0.001), bacterial infection (p=0.005), and severe itching (p<0.001). Outpatients with clinically suspected bacterial infection had 3.53-fold increased risk of AD than those without it (p<0.001). The morbidity rate of AD in the (20–25°N) region is 2.86 times higher than that in the (40–45°N) region [OR (95% CI): 0.352 (0.241–0.514),p<0.001].Conclusions. AD is characterized by unique clinical/demographic features. Bacterial infection and latitude region may have an impact on the incidence of AD in China.

scholarly journals COVID-19 and Cognitive Impairment: A Cross-Sectional Clinic Based Study

2021 ◽  
Author(s):  
Amira Siddig ◽  
Khabab Abbasher Hussien Mohamed Ahmed ◽  
Ahmed Abdelrahman ◽  
AlHussien Abbasher ◽  
Abubaker Alsedig Abbasher ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Functions ◽  
Age Distribution ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Senior Consultant ◽  
Presenting Symptoms ◽  
Phonemic Fluency ◽  
History Of

Abstract Background: Patients with dementia are more prone to acquire COVID-19 infection. Patients with COVID-19 showed a tendency to develop cognitive impairment. Objectives: We aimed to study the clinical manifestations of COVID-19 infection among adult Sudanese demented patients and the prevalence of cognitive impairment among adult Sudanese non demented patients. Methodology: This is a descriptive cross-sectional study which took place in Sudan, Khartoum state in the period (September-December 2021) in a private neurology/psychiatry clinic. 135 adult Sudanese patients were included in this study and were divided into two groups. The first group consists of 100 patients with a known history of dementia that got infected recently with COVID-19, while the second group consists of 35 patients who developed some sort of cognitive impairment after recovering from COVID-19 infection. Regarding the second group, cognitive functions were assessed by senior consultant neurologist and senior consultant psychiatrist using a well validated neuropsychological measure. Results: Out of 100 patients in the first group, females were 60 and males were 40. Age distribution is between 63 -98. The common presenting symptoms of COVID-19 among this group were: Cough and fever (90 patients), diarrhea and vomiting (5 patients), breathlessness (4 patients), coughing of blood (5 patients), convulsions (1 patient), paraplegia (1 patient) and hemiplegia (1 patient). Regarding the second group, Age distribution varied from 30 to 80 years. Cognitive functions impairment was noticed as follows: Memory recall (22%), memory recognition (23%), memory encoding (24%), processing speed (16%), executive functioning (19%), phonemic fluency (17%) and category fluency (17%). Conclusion: Patients with dementia are more susceptible to develop COVID-19 infection. Patients with COVID-19 Infection are at risk of developing some sort of cognitive impairment after recovery.

scholarly journals STUDI KARAKTERISTIK PASIEN TUBERKULOSIS DI PUSKESMAS SEBERANG ULU 1 PALEMBANG

2017 ◽  
Vol 6 (4) ◽  
pp. 218-224
Author(s):  
Zata Ismah ◽  
Emma Novita
Keyword(s):  
Health Status ◽  
Family History ◽  
Physical Examination ◽  
Cross Sectional Study ◽  
Male Gender ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Low Socioeconomic ◽  
History Of

Abstrak Analisis karakteristik penderita TB selain berguna untuk pengobatan juga berguna dalam memudahkan penemukan tersangka TB. Penelitian ini bertujuan untuk menganalisis karakteristik penderita TB. Desain studi yang digunakan adalah crossectional dengan sampel sebanyak 40 pasien TB yang berobat 3 bulan terakhir di Puskesmas Seberang Ulu 1 Palembang. Pengumpulan data dilakukan dengan kunjungan rumah ke pasien lalu dilakukan wawancara serta pemeriksaan fisik dan status kesehatan.  Hasil penelitian didapatkan bahwa karakteristik penderita TB paling banyak pada kelompok : usia produktif usia 12 – 35 tahun  dan  rentang usia dewasa 49 -  61 tahun; jenis kelamin laki-laki; pendidikan sekolah tingkat dasar; pekerjaan buruh; sosial ekonomi rendah; perokok aktif. Ditemukan 13.2% pasien TB dengan DM, 45% pasien TB dengan hipertensi, 47.5% pasien TB dengan anemia, 55% pasien TB dengan gizi kurang, 17.5% pasien memiliki riwayat keluarga menderita TB. Pasien kambuh sebanyak 12.5%; pasien yang putus OAT 17.5%; serta ditemukan tidak minum OAT sebanyak 15%.   Kata kunci: Karakteristik, Deskriptif, Tuberkulosis,                            Abstracts Analysis of characteristics TB disease besides useful for treatment is also useful to finding TB cases. This study aims to analyze characteristic of TB patients. This research used cross sectional study design with 40 TB patients treated last 3 months at Puskesmas Seberang Ulu 1 Palembang. Data collection was done with patient home visits, interview, physical examination health status. The results was most of characteristic TB patients in productive age group, maximum age 35 years, male gender, primary education, occupation was coolie, low socioeconomic, active smokers. TB Patients was founded 13.2% with DM; 45% TB patients with hypertension; 47.5% TB patients with anemia; 55% TB patients with malnutrition; 17.5% of patients had a family history of TB. Patients relapsed were 12.5%; OAT dropout patients were founded 17.5%; 15% patients were not OAT.   Keywords: Characteristics, Descriptive, Tuberculosis

Clinical and paraclinical characteristics of Chlamydia trachomatis pneumonia in infants less than 6 months of age at National Children’s Hospital

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Hien Pham Thu
Keyword(s):  
Chlamydia Trachomatis ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Children's Hospital ◽  
Persistent Cough ◽  
Children’S Hospital ◽  
History Of ◽  
Eosinophil Counts

SUMMARY Objectives: The study aim was to describe clinical and paraclinical characteristics of Chlamydia trachomatis pneumonia in children under 6 months of age at National Children’s Hospital. Methods: This cross-sectional study included 71 cases of C. trachomatis pneumonia in Respiratory Department, National Children’s Hospital between 1 September 2017 and 31 August 2018. Results: Important features of C. trachomatis pneumonia in children under 6 months of age include persistent cough, nasopharyngitis, conjunctivitis, history of vaginal birth, mother’s history of vaginosis during pregnancy. Absolute eosinophil counts greater than 300/mm3 may suggest C. trachomatis pneumonia. Conclusion: Clinical manifestations of pneumonia due to C. trachomatis pneumonia are persistent cough, nasopharyngitis, conjunctivitis, mother’s history of vaginosis during pregnancy. A higher than 300 eosinophils/mm3 is strongly associated with C. trachomatis pneumonia.

scholarly journals Multimorbidity, polypharmacy and primary prevention in community-dwelling adults in Quebec: a cross-sectional study

2019 ◽  
Vol 36 (6) ◽  
pp. 706-712 ◽  
Author(s):  
Tu N Nguyen ◽  
Patrice Ngangue ◽  
Jeannie Haggerty ◽  
Tarek Bouhali ◽  
Martin Fortin
Keyword(s):  
Chronic Disease ◽  
Primary Prevention ◽  
Chronic Diseases ◽  
Strong Association ◽  
Renin Angiotensin System ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Concurrent Use ◽  
History Of

Abstract Background Polypharmacy carries the risk of adverse events, especially in people with multimorbidity. Objective To investigate the prevalence of polypharmacy in community-dwelling adults, the association of multimorbidity with polypharmacy and the use of medications for primary prevention. Methods Cross-sectional analysis of the follow-up data from the Program of Research on the Evolution of a Cohort Investigating Health System Effects (PRECISE) in Quebec, Canada. Multimorbidity was defined as the presence of three or more chronic diseases and polypharmacy as self-reported concurrent use of five or more medications. Primary prevention was conceptualized as the use of statin or low-dose antiplatelets without a reported diagnostic of cardiovascular disease. Results Mean age 56.7 ± 11.6, 62.5% female, 30.3% had multimorbidity, 31.9% had polypharmacy (n = 971). The most common drugs used were statins, renin–angiotensin system inhibitors and psychotropics. Compared to participants without any chronic disease, the adjusted odds ratios (ORs) for having polypharmacy were 2.78 [95% confidence interval (CI): 1.23–6.28] in those with one chronic disease, 8.88 (95% CI: 4.06–19.20) in those with two chronic diseases and 25.31 (95% CI: 11.77–54.41) in those with three or more chronic diseases, P < 0.001. In participants without history of cardiovascular diseases, 16.2% were using antiplatelets and 28.5% were using statins. Multimorbidity was associated with increased likelihood of using antiplatelets (adjusted OR: 2.98, 95% CI: 1.98–4.48, P < 0.001) and statins (adjusted OR: 3.76, 95% CI: 2.63–5.37, P < 0.001) for primary prevention. Conclusion There was a high prevalence of polypharmacy in community-dwelling adults in Quebec and a strong association with multimorbidity. The use of medications for primary prevention may contribute to polypharmacy and raise questions about safety.

scholarly journals Frequency of Cataract and its Association with Tobacco Use in Subjects of an Eye Camp

2019 ◽  
Vol 34 (2) ◽  
Author(s):  
Saba Alkhairy Farnaz Siddiqui Mazhar-ul-Hassan, Arif Nayani
Keyword(s):  
Tobacco Use ◽  
Smokeless Tobacco ◽  
Strong Association ◽  
Tobacco Consumption ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Study Results ◽  
History Of ◽  
Cataract Development

Purpose: To find the frequency of cataract and to study the relationship between cataract development and tobacco use. Study Design: Cross sectional study. Place and Duration of Study: Single day eye camp at Dow University Hospital Karachi in August 2016. Material and Methods: All patients presenting to the camp were screened through standard eye examination including refraction and fundoscopy. After dilatation of pupil these patients were examined with a slit lamp by a consultant ophthalmologist for confirmation of the presence of cataract and its type. Participants were then questioned regarding the type of tobacco use and its duration and frequency with which it was consumed. Those patients with a history of tobacco consumption for more than ten years were included in the study. Results: A total of 550 patients presented to the eye camp of which 120 (21.81%) subjects were found to have a cataract. The mean age of the subjects was 58.02 ± 8.3 years. There were 67 (55.8%) males and 53 (44.2%) females. Among the patients diagnosed with cataract 89 (74.2%) had no history of tobacco usage while 31 (25.8%) gave a positive response regarding tobacco consumption. In nonsmokers the most common cataract was cortical where as in cigarette smokers it was nuclear 8 (57.1%) and in users of smokeless tobacco it was posterior subcapsular 5 (38.5%). There were no pseudophakic patients seen as almost all came from remote areas where there was lack of surgical facility. Conclusion: Tobacco consumption has a strong association with cataract development. Cigarette Smoking as well as chewing smokeless tobacco should be curtailed or avoided altogether. Keywords: Cataract, tobacco, visual acuity.

scholarly journals Clinical manifestations of hepatitis a virus infection in Kyrgyzstan children

KYAMC Journal ◽  
2018 ◽  
Vol 9 (2) ◽  
pp. 73-75
Author(s):  
Mohammed Khorshed Alam ◽  
Mamasaidov At ◽  
Mohammad Sultan Akbar ◽  
Mohammad Billal Hossain
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Clinical Manifestations ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Public Health Issue ◽  
Cross Sectional ◽  
History Of ◽  
Study Population ◽  
Southern City

Background: Acute hepatitis is one of the more common causes of hepatitis A virus (HAV). Humans appear to be the only reservoir for this virus. Clinical manifestations, and natural history of hepatitis A virus. The relative frequency of hepatitis A virus in Western country.Objectives: Hepatitis A infection developing countries where sanitation is still a public health issue. In Kyrgyzstan, there is no epidemiological data on children for this infection.Materials & Methods: A community based cross sectional study was carried in occurs around the southern city of Osh (Osh region) state in Kyrgyzstan in one of the smaller country central Asia. Total 260 children aged 1-18 years. Blood samples were analysed for anti-HAV total antibody (IgM and IgG) using a ELISA.Results: One hundred and forty four subjects tested positive for anti-HAV total antibody giving a prevalence rate of 55.4%. The median age for those positive was 9 years and for those without evidence of HAV infection was 4 years. 65 (45.1%) males and 79 (54.9) females were positive. The study population was mainly of the low social class with 94.1%.Conclusion: In the study population was HAV infection. Educational campaign is imperative and vaccine provision is advocated to further curb the spread of this infection.KYAMC Journal Vol. 9, No.-2, July 2018, Page 73-75

scholarly journals Assessment of the Association between Hypertention & Body Mass Index in Patients Visiting at Department of Medicine Pmch Nawabshah

2021 ◽  
pp. 80-88
Author(s):  
Sikander Ali Sial ◽  
Jagdesh Kumar ◽  
Attia Ayoob ◽  
Anwar Ali Jamali ◽  
Amir Hamzo Dahri ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Strong Association ◽  
Cross Sectional Study ◽  
Endocrine Disorders ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ethical Approval ◽  
History Of ◽  
The Relationship

Background: Hypertension is a common health issue all over the world; increased Body Mass Index (BMI) is alone one strong risk factor for the HTN. Objective: To assess the relationship between HTN & BMI in patients visited at department of Medicine PMCH Nawabshah. Methodology: This cross sectional study was conducted at PMC Hospital Nawabshah during March 2019 to February 2020. Sample size was 385. This study was conducted after ethical approval of institutional committee and willing male and female subjects with hypertension were included in present study after consent. Age ranges from 15 years and above. Those having other co morbidities like, DM, IHD, stroke and other metabolic and endocrine disorders were excluded from the study. Patients with history of drugs causing weight gain were also excluded. Results: there were total 385 subjects included, 130 were females and 245 were males1:2 ratio of female and male. Mean age of patients was 46.50 sd ± 8.65 years, mean BMI was 26.18 sd ± 4.73, mean systolic HTN was158.35sd ± 30.40 and mean diastolic blood pressure was 95.75 sd ± 12.91 mmHg. Conclusion: There is strong association between hypertension and BMI, as the BMI will increase the risk of HTN will increase.

scholarly journals Awareness and knowledge about glaucoma among patients visiting the screening clinic in Jeddah Eye Hospital, Saudi Arabia

2021 ◽  
Vol 14 (6) ◽  
pp. 887-895
Author(s):  
Saleh M. Alqahtani ◽  
◽  
Ahmed Almanjoumi ◽  
Sami H. Alzahrani ◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Features ◽  
Disease Risk ◽  
Knowledge Score ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
History Of ◽  
Screening Clinic ◽  
University Degree

AIM: To explore levels and determinants of awareness and knowledge about glaucoma among patients. METHODS: This was a cross-sectional study that included adult patients from October to the end of December 2018. A semi-structured questionnaire was designed by the researchers to measure the levels of awareness and knowledge about 18 basic information about glaucoma. The sheet was divided into 4 domains: types of glaucoma, risk factors, clinical features, and management. A knowledge score (KS, range=0-18) was calculated, with higher scores indicating higher levels. RESULTS: A total of 383 patients responded to the questionnaire, 61.9% males, mean±SD age was 38.5±12.94 years old, and 61.6% had a university degree or higher. Of them, 6.3% and 23.2% reported personal and family history of glaucoma, respectively. The most frequently reported source of information about glaucoma was another person with glaucoma (28.2%), followed by physicians (24.8%) and TV (19.6%). Knowledge by item ranged from 3.1% to 82.5% correctness rate, while KS showed mean=5.91 and median=5; and reliability testing of the knowledge scale showed Cronbach’s alpha=0.782. Higher KS were found among respondents with higher educational level (P=0.036), diabetes history (P=0.025), and personal (P<0.001) and family (P<0.001) history of glaucoma. CONCLUSION: This study reveals low awareness and knowledge levels about glaucoma among the attendees of a local eye care hospital, where several misconceptions about disease risk factors, clinical features, and management are identified.

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