scholarly journals IMPLANTATION OF AN INTRALUMINAL RINGED PROSTHESIS IN HIGH-RISK PATIENTS WITH ACUTE AORTIC DISSECTION TYPE I

1997 ◽  
Vol 58 (8) ◽  
pp. 1761-1764
Author(s):  
Masahiko KUINOSE ◽  
Kazuo TANEMOTO ◽  
Yuji KANAOKA
Keyword(s):  
High Risk ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Type I ◽  
High Risk Patients ◽  
Risk Patients

scholarly journals Single Stage Hybrid Repair for DeBakey Type I Aortic Dissection in High Risk Patients

2018 ◽  
Vol 56 (3) ◽  
pp. 363-372 ◽  
Author(s):  
Hao Lin ◽  
Yukui Du ◽  
Cuntao Yu ◽  
Xiangyang Qian ◽  
Xiaogang Sun ◽  
...  
Keyword(s):  
High Risk ◽  
Aortic Dissection ◽  
Single Stage ◽  
Type I ◽  
High Risk Patients ◽  
Hybrid Repair ◽  
Risk Patients

scholarly journals Single Stage Hybrid Repair for DeBakey Type I Aortic Dissection in High Risk Patients

2018 ◽  
Vol 68 (4) ◽  
pp. 1275
Author(s):  
H. Lin ◽  
Y. Du ◽  
C. Yu ◽  
X. Qian ◽  
X. Sun ◽  
...  
Keyword(s):  
High Risk ◽  
Aortic Dissection ◽  
Single Stage ◽  
Type I ◽  
High Risk Patients ◽  
Hybrid Repair ◽  
Risk Patients

Efficacy of ascending aortic banding technique concomitant with type I hybrid aortic arch repair in high-risk patients

2019 ◽  
Vol 34 (9) ◽  
pp. 1524-1532
Author(s):  
Hung-Lung Hsu ◽  
Chun-Yang Huang ◽  
Po-Lin Chen ◽  
Yin-Yin Chen ◽  
Chiao-Po Hsu ◽  
...  
Keyword(s):  
High Risk ◽  
Aortic Arch ◽  
Banding Technique ◽  
Type I ◽  
Aortic Banding ◽  
High Risk Patients ◽  
Risk Patients ◽  
Aortic Arch Repair

scholarly journals SARS-CoV-2 Spike Protein-Directed Monoclonal Antibodies May Ameliorate COVID-19 Complications in APECED Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Elise M. N. Ferré ◽  
Monica M. Schmitt ◽  
Sebastian Ochoa ◽  
Lindsey B. Rosen ◽  
Elana R. Shaw ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
High Risk ◽  
Severe Disease ◽  
Ventilatory Support ◽  
Host Cells ◽  
Spike Protein ◽  
Type I ◽  
Clinical Effects ◽  
High Risk Patients ◽  
Risk Patients

Patients with the monogenic immune dysregulatory syndrome autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), which is caused by loss-of-function mutations in the autoimmune regulator (AIRE) gene, uniformly carry neutralizing autoantibodies directed against type-I interferons (IFNs) and many develop autoimmune pneumonitis, both of which place them at high risk for life-threatening COVID-19 pneumonia. Bamlanivimab and etesevimab are monoclonal antibodies (mAbs) that target the SARS-CoV-2 spike protein and block entry of SARS-CoV-2 in host cells. The use of bamlanivimab and etesevimab early during infection was associated with reduced COVID-19–associated hospitalization and death in patients at high risk for progressing to severe disease, which led the US Food and Drug Administration to issue an emergency use authorization for their administration in non-hypoxemic, non-hospitalized high-risk patients. However, the safety and efficacy of these mAbs has not been evaluated in APECED patients. We enrolled two siblings with APECED on an IRB-approved protocol (NCT01386437) and admitted them prophylactically at the NIH Clinical Center for evaluation of mild-to-moderate COVID-19. We assessed the safety and clinical effects of early treatment with bamlanivimab and etesevimab. The administration of bamlanivimab and etesevimab was well tolerated and was associated with amelioration of COVID-19 symptoms and prevention of invasive ventilatory support, admission to the intensive care, and death in both patients without affecting the production of antibodies to the nucleocapsid protein of SARS-CoV-2. If given early in the course of COVID-19 infection, bamlanivimab and etesevimab may be beneficial in APECED and other high-risk patients with neutralizing autoantibodies directed against type-I IFNs.

scholarly journals Aortic Dissection: Novel Surgical Hybrid Procedures

2017 ◽  
Vol 12 (01) ◽  
pp. 56
Author(s):  
Alessandro Cannavale ◽  
Mariangela Santoni ◽  
Fabrizio Fanelli ◽  
Gerard O’sullivan ◽  
◽  
...  
Keyword(s):  
High Risk ◽  
Aortic Dissection ◽  
Surgical Techniques ◽  
Thoracic Endovascular Aortic Repair ◽  
Endovascular Aortic Repair ◽  
Hybrid Procedures ◽  
Mortality And Morbidity ◽  
High Risk Patients ◽  
Early Results ◽  
Risk Patients

The management of patients with aortic dissection is challenging and its treatment is an area of development and innovation. Conventional surgical techniques are associated with significant risks in terms of mortality and morbidity in such high-risk patients. As a result of cumulative advances in technology, classical surgical techniques have been improved and enhanced by the newer endovascular approaches, leading to novel surgical hybrid procedures. Impressive early results have been seen with frozen elephant techniques, revascularisation of the supra-aortic branches and branched/fenestrated thoracic endovascular aortic repair-alone procedures. This review describes the techniques involved in the latest hybrid procedures for aortic dissection and their outcomes.

Catheter-based treatment of the dissected ascending aorta: a systematic review

2020 ◽  
Vol 59 (1) ◽  
pp. 80-91
Author(s):  
Changtian Wang ◽  
Ludwig Karl von Segesser ◽  
Francesco Maisano ◽  
Enrico Ferrari
Keyword(s):  
High Risk ◽  
Aortic Dissection ◽  
Endovascular Treatment ◽  
Open Surgery ◽  
Type A ◽  
Ascending Aorta ◽  
Type A Aortic Dissection ◽  
High Risk Patients ◽  
Risk Patients

Summary OBJECTIVES Type A aortic dissection requires immediate surgical repair. Despite improvements in surgery and anaesthesia, there is still a considerable risk when high-risk patients are concerned. Less invasive endovascular treatments are under evaluation. We investigated the current status of catheter-based treatment for type A aortic dissection with the entry tear located in the ascending aorta. METHODS A PubMed search was supplemented by searching through bibliographies and key articles. Demographics, risk score, stent graft detail, access route, mortality, cause of death, complications, reinterventions and follow-up data were extracted and analysed. RESULTS Thirty-one articles (7 retrospective reports; 24 case reports/series) were included in the study. In total, 104 patients (mean age 71 ± 14 years) received endovascular treatment for acute (63) or chronic (41) type A dissection. A history of a major cardiac or aortic operation was present in 29 patients. The mean EuroSCORE II was 30 ± 20 in 4 reports. A total of 114 stent grafts were implanted: ‘off-the-shelf’, 65/114; custom made, 12/114; and modified, 7/114. Hospital complications included intraprocedural conversion to open surgery (2/104), stroke (2/104), coronary stenting (2/104), early endoleak (9/104) and repeat aortic endovascular treatment for endoleak (5/104). Hospital mortality was 10% (intraoperative death 2/104). Mean duration of follow-up time was 21 ± 21 months (range 1–81 months); follow-up data were available for 86 patients: 10 patients died of non-aortic-related causes; reintervention for aortic disease (endovascular repair or open surgery) was performed in 8 patients. CONCLUSIONS Catheter-based ascending aorta repair for type A aortic dissection with the entry tear in the ascending aorta can be considered in carefully selected high-risk patients. Further analysis and specifically designed devices are required.

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