Anti-Inflammatory and Analgesic Activities of Ethanol Extract of Aerial Parts of Justicia gendarussa Burm.

2010 ◽  
Vol 6 (3) ◽  
pp. 278-283 ◽  
Author(s):  
C. Jothimaniv ◽  
R.S. Kumar ◽  
N. Subramania
Keyword(s):  
Ethanol Extract ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
Analgesic Activities

scholarly journals Investigation of the Anti-Inflammatory and Analgesic Activities of Ethanol Extract of Stem Bark of SonapathaOroxylum indicum In Vivo

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
K. Lalrinzuali ◽  
M. Vabeiryureilai ◽  
Ganesh Chandra Jagetia
Keyword(s):  
Inflammatory Diseases ◽  
Ethanol Extract ◽  
Stem Bark ◽  
The Body ◽  
Protective Measure ◽  
Analgesic Effects ◽  
Oroxylum Indicum ◽  
Anti Inflammatory ◽  
Analgesic Activities

Inflammation is all a pervasive phenomenon, which is elicited by the body in response to obnoxious stimuli as a protective measure. However, sustained inflammation leads to several diseases including cancer. Therefore it is necessary to neutralize inflammation. Sonapatha (Oroxylum indicum), a medicinal plant, is traditionally used as a medicine in Ayurveda and other folk systems of medicine. It is commonly used to treat inflammatory diseases including rheumatoid arthritis and asthma. Despite this fact its anti-inflammatory and analgesic effects are not evaluated scientifically. Therefore, the anti-inflammatory and analgesic activities of Sonapatha (Oroxylum indicum) were studied in Swiss albino mice by different methods. The hot plate, acetic acid, and tail immersion tests were used to evaluate the analgesic activity whereas xylene-induced ear edema and formalin induced paw edema tests were used to study the anti-inflammatory activity of Sonapatha. The administration of mice with 250 and 300 mg/kg b.wt. ofO. indicumreduced pain and inflammation indicating that Sonapatha possesses analgesic and anti-inflammatory activities. The maximum analgesic and anti-inflammatory activities were observed in mice receiving 300 mg/kg b.wt. ofO. indicumethanol extract.Our study indicates thatO. indicumpossesses both anti-inflammatory and analgesic activities and it may be useful as an anti-inflammatory agent in the inflammation related disorders.

In vitro and in vivo anti-inflammatory effects of an ethanol extract from the aerial parts of Eryngium carlinae F. Delaroche (Apiaceae)

2021 ◽  
Vol 266 ◽  
pp. 113406
Author(s):  
Victor Arana-Argáez ◽  
Angel Josabad Alonso-Castro ◽  
Eunice Yáñez-Barrientos ◽  
Antonio Euan-Canto ◽  
Julio Cesar Torres-Romero ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Aerial Parts ◽  
Anti Inflammatory

Evaluation of Analgesic, Antipyretic and Anti-Inflammatory Effects of Ethanol Extract from a Fern Species Macrothelypteris Torresiana (Gaudich) Aerial Parts

2016 ◽  
Vol 6 (2) ◽  
pp. 57-63 ◽  
Author(s):  
Sumanta Mondal ◽  
Debjit Ghosh ◽  
Ganapaty Seru ◽  
Onkar Manna ◽  
Mora Venkata Reddy ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Aerial Parts ◽  
Fern Species ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory and analgesic activities of Clerodendrum capitatum (Willd) Schum. & Thonn. (Verbenaceae) leaves

2020 ◽  
Vol 17 (1) ◽  
pp. 1-7
Author(s):  
Abdulrahman Adamu ◽  
Abdulmumin Z. Abubakar ◽  
Adamu A. Ambi ◽  
Ibrahim M. Aliyu ◽  
Hamza Mohammed ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Ethyl Acetate ◽  
Aqueous Ethanol ◽  
Lethal Dose ◽  
Ethanol Extract ◽  
Perennial Herb ◽  
North East ◽  
South Central ◽  
Anti Inflammatory ◽  
Analgesic Activities

Clerodendrum capitatum (Willd) Schumach and Thonn. (Verbenaceae) is a perennial herb, which grows up to 0.5 m to 2 m high. It is widespread over North-East, East, and South Central Africa. It is known as “bambaro or maashayi” by the Hausas of Northern Nigeria. The leaves are used traditionally to treat intercostal pain, headaches and toothaches. The aim of this study is to evaluate the anti-inflammatory and analgesic activities of the aqueous ethanol extract and fractions of C. capitatum. The anti-inflammatory activity was investigated using carrageenan induced rat paw oedema model, while acetic acid induced mice writhing model was used to evaluate the anti-nociceptive property. The oral median lethal dose values were found to be greater than 5,000 mg/kg for the aqueous ethanol extract, ethyl acetate and n-butanol fractions, while that of dichloromethane fraction was less than 2000 mg/kg using OECD method. The acetic acid induced writhing was significantly (P<0.05-0.001) reduced particularly for the EF and NF fractions at 200 mg/kg (93.12% and 98.79%). DF showed percentage inhibition of 87.59% and 81.75% at 50 and 100 mg/kg respectively. The extracts and fractions also caused a significant (P<0.05-0.001) dose dependent reduction of inflammation induced by carrageenan when compared with the negative control with the maximum inhibitory effect of 43.69% observed in Ethyl acetate fraction at 50 mg/kg dose at the 3rd hour. It can be concluded that the leaf extracts of C. capitatum possess anti-inflammatory and analgesic effects in animal models, which may be mediated through the phytochemical constituents present in the extract and fractions of the plant. Keywords: Clerodendrum capitatum; Anti-inflammatory; Analgesic; OECD

Pharmacological Studies on Aerial Parts of Calotropis Procera

1991 ◽  
Vol 19 (03n04) ◽  
pp. 223-231 ◽  
Author(s):  
J. S. Mossa ◽  
M. Tariq ◽  
A. Mohsin ◽  
A. M. Ageel ◽  
M. A. Al-Yahya ◽  
...  
Keyword(s):  
Traditional Medicine ◽  
Chemical Constituents ◽  
Evaluation Studies ◽  
Ethanol Extract ◽  
Neuromuscular Blocking ◽  
Laboratory Animals ◽  
Calotropis Procera ◽  
Control Group ◽  
Aerial Parts ◽  
Anti Inflammatory

The decoction of the aerial part of Calotropis procera is commonly used in Saudi Arabian traditional medicine for the treatment of variety of diseases including fever, joint pain, muscular spasm and constipation. The present investigation was undertaken to confirm its claimed activity in traditional medicine. The ethanol extract of the plant was tested on laboratory animals for its antipyretic, analgesic, anti-inflammatory, antibacterial, purgative and muscle relaxant activities. The results of this study showed a significant antipyretic, analgesic and neuromuscular blocking activity. On smooth muscle of guinea pig ileum, the extract produced contractions which was blocked by atropine supporting its use in constipation. The extract failed to produce significant anti-inflammatory and antibacterial activities. Our phytochemical studies on the aerial parts of C. procera showed the presence of alkaloids, cardiac glycosides, tannins, flavonoids, sterols and/or triterpenes. However, the chemical constituents responsible for the pharmacological activities remains to be investigated. The safety evaluation studies revealed that the use of extract in single high doses (up to 3g/kg) does not produce any visible toxic symptoms or mortality. However, prolong treatment (90 days) causes significantly higher mortality as compared to control group.

scholarly journals Anti-inflammatory and Analgesic Activities of Asteracantha longifolia Nees

2012 ◽  
Vol 15 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Md Al Amin ◽  
Ishtiaque A Chowdhury ◽  
KMM Mahbub ◽  
Mafruhi Sattar ◽  
Masum Shahriar ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Analgesic Activity ◽  
Ethanol Extract ◽  
Pharmaceutical Journal ◽  
Significant Inhibition ◽  
Leukocyte Migration ◽  
Croton Oil ◽  
Cotton Pellet ◽  
Anti Inflammatory ◽  
Analgesic Activities

The present study was designed to evaluate the analgesic and anti-inflammatory activities of the ethanol extract of whole plant of Asteracantha longifolia Nees (family Acanthaceae) in mice. The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate, formalin induced pain and acetic acid-induced writhing test in mice. Anti inflammatory effects were determined by ear swelling induced by croton oil, xyleneinduced ear edema, leukocyte migration induced by carrageenan, cotton pellet-induced granuloma formation. Tramadol (10 mg/kg) and Ibuprofen (100 mg/kg) were used as reference analgesic agents. The crude ethanol extract showed a significant inhibition of ear swelling caused by croton oil and xylene in mice. The crude extract decreased leukocyte migration induced by carrageenan, also moderately inhibited the weight of granuloma induced by a cotton pellet, as well as the formalin-induced pain. The extract given by p.o. route, produced significant inhibition of abdominal constrictions caused by acetic acid. Moreover, the extract also showed moderate analgesic activity on the hot plate pain threshold in mice. These data demonstrated that the plant may contain bioactive compounds possessing anti-inflammatory and analgesic activities. DOI: http://dx.doi.org/10.3329/bpj.v15i2.12586 Bangladesh Pharmaceutical Journal 15(2): 171-176, 2012

Diuretic, anti-inflammatory, and analgesic activities of the ethanol extract from Cynoglossum lanceolatum

2012 ◽  
Vol 139 (1) ◽  
pp. 149-154 ◽  
Author(s):  
Cheng-Hao Yu ◽  
Wei-Zhong Tang ◽  
Cheng Peng ◽  
Tao Sun ◽  
Bin Liu ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Anti Inflammatory ◽  
Analgesic Activities

scholarly journals Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae)

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Maria Christina dos Santos Verdam ◽  
Fernanda Guilhon-Simplicio ◽  
Kleyton Cardoso de Andrade ◽  
Karina Lorena Meira Fernandes ◽  
Tallita Marques Machado ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Antioxidant Activities ◽  
Ethanol Extract ◽  
Quinic Acid ◽  
Polyphenol Content ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Writhing Test ◽  
Anti Inflammatory ◽  
Analgesic Activities

Background. Byrsonima is a promising neotropical genus, rich in flavonoids and triterpenes, with several proven pharmacological properties. Nevertheless, Byrsonima duckeana W. R. Anderson is an Amazonian species almost not studied. Objective. To assess the antioxidant, anti-inflammatory, and analgesic activities of Byrsonima duckeana leaves. Materials and Methods. We analyzed an ethanol extract and its fractions for polyphenol content and UHPLC-MS/MS, phosphomolybdenum, DPPH, TBARS antioxidant tests, formalin-induced pain, carrageenan-induced peritonitis, acetic acid-induced abdominal writhings, and hot plate assays. Results. All the samples showed high polyphenol content and antioxidant capacity in the phosphomolybdenum, DPPH, and TBARS tests. We identified ethyl gallate, quinic acid, gallic acid, catechin, epicatechin, quercetrin, and quercetin in the samples. B. duckeana was able to reduce leukocyte migration in the carrageenan-induced peritonitis by 43% and the licking time in the formalin test by 57%. In the acetic acid-induced writhing test, the chloroform (FCL) and ethyl acetate (FEA) fractions were the most active samples. FEA was selected for the hot plate test, where all the dosages tested (5, 50, and 200 mg·kg−1) showed significant analgesic activity. Conclusion. B. duckeana has interesting analgesic and antioxidant activities, due to its high phenolic content, especially phenolic acids.

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