Growth Performance, Fasting Plasma Glucose and Lipid Profile of Sprague-Dawley Rats Fed Different Levels of Omani Halwa

2015 ◽  
Vol 14 (8) ◽  
pp. 503-510
Author(s):  
Amanat Ali ◽  
Khalid M. Al-Zuhaibi ◽  
Mostafa I. Waly ◽  
D. Sankar ◽  
Eugene H. Johnson
Keyword(s):  
Lipid Profile ◽  
Growth Performance ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Sprague Dawley ◽  
Fasting Plasma ◽  
Sprague Dawley Rats ◽  
Different Levels

scholarly journals Fasting Plasma Glucose and Coronary Heart Disease in a Rural Population of North Henan, China

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Quan Guo ◽  
Fei Lin ◽  
Yi Liu ◽  
Yang Li ◽  
Xue-Hui Wang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Rural Areas ◽  
Odds Ratio ◽  
Coronary Artery Lesions ◽  
Fasting Plasma ◽  
The Relationship ◽  
Different Levels

Even in individuals without diabetes, the incidence of coronary heart disease (CHD) increases with the rise in fasting plasma glucose (FPG); however, the threshold of FPG for CHD in rural areas of China is unclear. We retrospectively examined 2,987 people. Coronary angiography records were used to determine the presence of CHD as well as its severity. Risk factors for CHD and the relationship between different levels of FPG and CHD were analyzed. After adjusting for age, hypertension, dyslipidemia, smoking, drinking, chronic kidney disease, and previous ischemic stroke, the incidence of CHD in nondiabetic women began to increase when FPG exceeded 5.2 mmol/L (odds ratio (OR) = 1.438, 95% confidence interval (CI) = 1.099–1.880, p=0.008), and the degree of coronary artery lesions also became more severe (OR = 1.406, 95% CI = 1.107–1.788, p=0.005). However, no such correlations were found in nondiabetic men. In conclusion, among the nondiabetic women in rural areas of northern Henan, both the incidence of CHD and the severity of lesions increased when FPG levels were greater than 5.2 mmol/L, while no significant correlation between FPG and CHD was observed in diabetes-free men.

scholarly journals Effects of Recombinant Human Growth Hormone Therapy in Obesity in Adults: A Metaanalysis

2009 ◽  
Vol 94 (1) ◽  
pp. 130-137 ◽  
Author(s):  
Kavya C. Mekala ◽  
Nicholas A. Tritos
Keyword(s):  
Confidence Interval ◽  
Lipid Profile ◽  
Lean Body Mass ◽  
Body Mass ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Recombinant Human Growth Hormone ◽  
Rhgh Therapy ◽  
Fasting Plasma ◽  
Cardiovascular Morbidity And Mortality

Abstract Objective: To conduct a metaanalysis of human studies examining the efficacy and safety of recombinant human GH (rhGH) as therapy for obesity in adults. Design: A thorough search of the literature (including MEDLINE, EMBASE, and the Cochrane Register) was performed for pertinent studies, which were analyzed and subsequently synthesized in a comprehensive metaanalysis. Results: Administration of rhGH led to significant changes in body composition [weighted mean difference (95% confidence interval)], including fat mass [−0.9 kg (−1.3 to −0.4)], percent body fat [−1% (−1.3 to −0.7)], lean body mass [1.8 kg (0.6–2.9)], visceral adipose area [−22.8 cm2 (−39.8 to −5.7)], and lipid profile, including total cholesterol [−7 mg/dl (−11 to −3)] and low-density lipoprotein-cholesterol [−9 mg/dl (−13 to −5)]. There were increases in fasting plasma glucose [3 mg/dl (1–6)] and insulin [1.9 μU/ml (0.2–3.7)]. The latter finding was found only in shorter-term studies. Adverse effects included [odds ratio (95% confidence interval)] arthralgias [6 (1.9–18.6)], peripheral edema [5 (2.4–10.5)], and paresthesias [6.5 (1.5–27.3)]. Conclusions: Our metaanalysis suggests that rhGH therapy leads to decrease in visceral adiposity and increase in lean body mass as well as beneficial changes in lipid profile in obese adults, without inducing weight loss. Administration of rhGH was associated with increases in fasting plasma glucose and insulinemia. Because the rhGH doses used in many studies were supraphysiological, future studies of longer duration, using carefully titrated rhGH protocols, will be needed to fully establish the effects of rhGH therapy in obesity, including effects on cardiovascular morbidity and mortality.

scholarly journals The association between hypertension and other cardiovascular risk factors among non-diabetic Saudis adults–A cross sectional study

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246568
Author(s):  
Ghada M. A. Ajabnoor ◽  
Suhad Bahijri ◽  
Aliaa Amr Alamoudi ◽  
Rajaa Al Raddadi ◽  
Jawaher Al-Ahmadi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Fasting Plasma

Population specific associations between cardiovascular disease with various risk factors including pre-hypertension and hypertension were reported. We aimed to investigate the association of higher than optimal blood pressure with measures of dysglycemia, dyslipidemia, and markers of inflammation in non-diabetic Saudi adults hoping to improve current Saudi guidelines to prevent cardiovascular disease. Volunteers were recruited randomly from public healthcare centers in Jeddah. Demographic information, blood pressure (BP), and anthropometric measurements were taken. Fasting blood samples were drawn, then again following 1-hour oral glucose tolerance test. Glycated hemoglobin, fasting plasma glucose (FPG), lipid profile, highly sensitive C- reactive protein, gamma glutamyl transferase, and 1-hour plasma glucose were measured. Complete data was found for 742 men and 592 women. Pre-hypertension was found in 47.2% of men, and 24.7% of women, while 15.1% of men, and 14.6% of women were hypertensive. Means of measured variables differed significantly between normotensive, pre-hypertensive, and hypertensive groups of men and women in gender specific manner. Association between measured variables and elevated BP, and hypertension were assessed using logistic regression models. After adjustment for age, body mass index and waist circumference, elevated blood pressure was associated with elevated triglycerides in men, while hypertension was significantly associated with elevated fasting plasma glucose, total cholesterol, triglycerides, low density lipoprotein- cholesterol, and low high density lipoprotein- cholesterol in men, and elevated triglycerides, and total cholesterol in women. Therefore, it is strongly recommended to measure lipid profile, specifically TG, for all diagnosed pre-hypertensive and hypertensive patients in addition to FPG for men.

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