Human Bone Derived Cell (HBDC) Behaviour of Sol-Gel Derived Carbonate Hydroxyapatite Coatings on Titanium Alloy Substrates

2005 ◽  
Vol 284-286 ◽  
pp. 541-544 ◽  
Author(s):  
Hala Zreiqat ◽  
R. Roest ◽  
Stella Valenzuela ◽  
Adriyan Milev ◽  
Besim Ben-Nissan
Keyword(s):  
Titanium Alloy ◽  
Surface Chemistry ◽  
Sol Gel ◽  
Surface Characteristics ◽  
Human Bone ◽  
Skeletal Tissue ◽  
Carbonate Hydroxyapatite ◽  
Hydroxyapatite Coatings ◽  
Coating Methods ◽  
Surface Chemistry Modification

Poor cell adhesion to orthopaedic and dental implants results in implant failure. Establishing and maintaining mature bone at the bone/device interface is critical to the long-term success of the prostheses. Considerable effort has been devoted to alter the surface characteristics of these biomaterials in order to improve the initial interlocking of device and skeleton in the noncemented joint prosthesis. Previously we demonstrated that surface chemistry modification of bioceramics induced osteogenesis. In the present work, we investigate the effect of surface chemistry modification of titanium alloy (Ti-6Al-4V) with alkoxide-derived carbonate hydroxyapatite (CHAp) using sol-gel coating methods on human bone derived cell (HBDC)behaviour. Western blotting demonstrated that sol gel coating of Ti-6Al-4V with CHAp upregulated the expression of key signalling protein Shc isoforms (p46, p52, p66) and phosphorylated Erk1/2. CHAp-modification of Ti-6Al-4V is associated with signal transduction pathways involving the key signalling protein Shc and ERK1/2 which may lead to enhanced gene expression of extracellular matrix proteins at the skeletal tissue/device interface.

Human Osteoclasts Behaviour on Sol-Gel Derived Carbonate Hydroxyapatite Coatings on Anodized Titanium Alloy Substrates

2006 ◽  
Vol 309-311 ◽  
pp. 709-712 ◽  
Author(s):  
Y. Ramaswamy ◽  
Besim Ben-Nissan ◽  
R. Roest ◽  
D. Haynes ◽  
Hala Zreiqat
Keyword(s):  
Titanium Alloy ◽  
Surface Modification ◽  
Sol Gel ◽  
Carbonate Hydroxyapatite ◽  
Hydroxyapatite Coatings ◽  
Coated Surface ◽  
Modified Surface ◽  
Anodized Titanium ◽  
Biological Performance ◽  
Human Osteoclasts

Titanium alloy has been used as a material for orthopaedic implants, however drawbacks still exist. Considerable efforts have been taken to modify the surface structure of the implant material and improve the biological performance. Previously we have demonstrated that biomaterials surface modification has a significant effect on the regulation of osteogenesis. We have investigated the behaviour of human osteoclasts on sol-gel coated carbonated hydroxyapatite on anodized titanium alloy. Osteoclasts cultured on the modified surface were able to attach and spread, exhibiting the characteristic peripheral brush border. Successful differentiation of the monocytes into osteoclasts and their attachment to the coated surface and the formation of resorption-like imprints indicated that carbonate hydroxyapatite (CHAP) coated titanium alloy play a significant role in regulating the functional activity of osteoclasts.

The effect of surface chemistry modification of titanium alloy on signalling pathways in human osteoblasts

Biomaterials ◽  
2005 ◽  
Vol 26 (36) ◽  
pp. 7579-7586 ◽  
Author(s):  
H. Zreiqat ◽  
Stella M. Valenzuela ◽  
Besim Ben Nissan ◽  
Richard Roest ◽  
Christine Knabe ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Surface Chemistry ◽  
Signalling Pathways ◽  
Human Osteoblasts ◽  
Surface Chemistry Modification ◽  
Modification Of Titanium ◽  
Effect Of Surface

Development of Bioactive Hydroxyapatite Coatings on Titanium Alloys

2012 ◽  
Vol 533 ◽  
pp. 183-193 ◽  
Author(s):  
Adele Carradò
Keyword(s):  
Plasma Spraying ◽  
Sol Gel ◽  
Coating Properties ◽  
Bioactive Coatings ◽  
Bone Implant ◽  
Advantages And Disadvantages ◽  
Hydroxyapatite Coatings ◽  
Coating Methods ◽  
Plasma Sprayed ◽  
Plasma Spraying Process

Bioactive coatings are currently manufacturing using plasma-sprayed technique on metal implant surfaces in order to optimize bone-implant interactions. Nevertheless, some problems exist with coating process, e.g. poor interfacial adhesion, modification of coating properties, and the lack of an existing coating standard. In order to overcome some of the problems with the plasma-spraying process, researchers are investigating other experimental coating methods to enhance the adhesion and to control the coating properties. This paper will discuss the advantages and disadvantages of plasma spraying and the experimental coating processes as pulsed laser deposition as well as spin-coated sol-gel.

scholarly journals Surface Chemistry, Crystal Structure, Size and Topography Role in the Albumin Adsorption Process on TiO2 Anatase Crystallographic Faces and Its 3D-Nanocrystal: A Molecular Dynamics Study

Coatings ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 420
Author(s):  
Giuseppina Raffaini
Keyword(s):  
Crystal Structure ◽  
Molecular Dynamics ◽  
Surface Chemistry ◽  
Protein Adsorption ◽  
Adsorption Process ◽  
Sol Gel ◽  
Interaction Strength ◽  
Theoretical Work ◽  
Blood Protein ◽  
Tio2 Anatase

TiO2 is widely used in biomaterial implants. The topography, chemical and structural properties of titania surfaces are an important aspect to study. The size of TiO2 nanoparticles synthetized by sol–gel method can influence the responses in the biological environment, and by using appropriate heat treatments different contents of different polymorphs can be formed. Protein adsorption is a crucial step for the biological responses, involving, in particular, albumin, the most abundant blood protein. In this theoretical work, using molecular mechanics and molecular dynamics methods, the adsorption process of an albumin subdomain is reported both onto specific different crystallographic faces of TiO2 anatase and also on its ideal three-dimensional nanosized crystal, using the simulation protocol proposed in my previous theoretical studies about the adsorption process on hydrophobic ordered graphene-like or hydrophilic amorphous polymeric surfaces. The different surface chemistry of anatase crystalline faces and the nanocrystal topography influence the adsorption process, in particular the interaction strength and protein fragment conformation, then its biological activity. This theoretical study can be a useful tool to better understand how the surface chemistry, crystal structure, size and topography play a key role in protein adsorption process onto anatase surface so widely used as biomaterial.

scholarly journals Development of Novel Oral Formulations of Disulfide Antioxidants Based on Porous Silica for Controlled Release of the Drugs

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 963
Author(s):  
Ekaterina S. Dolinina ◽  
Elena V. Parfenyuk
Keyword(s):  
Antioxidant Activity ◽  
Surface Chemistry ◽  
Sol Gel ◽  
Porous Silica ◽  
The Body ◽  
Oral Drug ◽  
Therapeutic Concentration ◽  
Release Process ◽  
Zero Order Kinetics ◽  
Long Time

Powerful antioxidant α-lipoic acid (LA) exhibits limited therapeutic efficiency due to its pharmacokinetic properties. Therefore, the purpose of this work was to evaluate the ability of silica-based composites of LA as well as its amide (lipoamide, LM), as new oral drug formulations, to control their release and maintain their therapeutic concentration and antioxidant activity in the body over a long time. The composites synthesized at different sol–gel synthesis pH and based on silica matrixes with various surface chemistry were investigated. The release behavior of the composites in media mimicking pH of digestive fluids (pH 1.6, 6.8, and 7.4) was revealed. The effects of chemical structure of the antioxidants, synthesis pH, surface chemistry of the silica matrixes in the composites as well as the pH of release medium on kinetic parameters of the drug release and mechanisms of the process were discussed. The comparative analysis of the obtained data allowed the determination of the most promising composites. Using these composites, modeling of the release process of the antioxidants in accordance with transit conditions of the drugs in stomach, proximal, and distal parts of small intestine and colon was carried out. The composites exhibited the release close to the zero order kinetics and maintained the therapeutic concentration of the drugs and antioxidant effect in all parts of the intestine for up to 24 h. The obtained results showed that encapsulation of LA and LM in the silica matrixes is a promising way to improve their bioavailability and antioxidant activity.

In-Depth Investigation of Copper Surface Chemistry Modification by Ultrashort Pulsed Direct Laser Interference Patterning

Langmuir ◽  
2020 ◽  
Vol 36 (45) ◽  
pp. 13415-13425 ◽  
Author(s):  
Daniel W. Müller ◽  
Anne Holtsch ◽  
Sarah Lößlein ◽  
Christoph Pauly ◽  
Christian Spengler ◽  
...  
Keyword(s):  
Surface Chemistry ◽  
Copper Surface ◽  
Laser Interference ◽  
Direct Laser ◽  
Surface Chemistry Modification ◽  
Direct Laser Interference Patterning

Phases Transformations in Laser Treated Hydroxyapatite Coatings

1998 ◽  
Author(s):  
X. Ranz ◽  
T. Aslanian ◽  
L. Pawlowski ◽  
L. Sabatier ◽  
R. Fabbro
Keyword(s):  
Titanium Alloy ◽  
Sample Surface ◽  
Optical Microscope ◽  
Thermal Fields ◽  
Hydroxyapatite Coatings ◽  
Titanium Alloy Substrate ◽  
Plasma Sprayed ◽  
Different Content ◽  
Kinetics Of ◽  
Xrd Method

Abstract The hydroxyapatite Ca10(PO4)6OH2 (HAP) was plasma sprayed onto titanium alloy substrate. The samples having thickness of about 150 µm ware sprayed in a way to obtain two different content of crystalline HAP: 25 an 30 %. The coatings ware subsequently submitted to laser treatment with the CO2 laser. The treatment was carried out with different laser powers and scanning velocities and resulting thereof sample surface temperatures and the kinetics of the thermal fields ware monitored with a pyrometer. The XRD method enabled verification of the crystallinity state of HAP, content of amorphous calcium phosphate and the content of foreign phases. Optical microscope was used to check the microstructure and the depth of laser modified zone.

The Effect of Lithium Molybdate in Tungsten Trioxide Electrochromic Film

2017 ◽  
Vol 873 ◽  
pp. 32-36
Author(s):  
Thitinun Inmae ◽  
Lek Sikong ◽  
Kalayanee Kooptarnond
Keyword(s):  
Tungsten Trioxide ◽  
Sol Gel ◽  
Dip Coating ◽  
Amorphous Structure ◽  
Oxide Glass ◽  
Cyclic Voltammogram ◽  
Colored State ◽  
Coating Methods ◽  
Diffraction Patterns ◽  
Lithium Molybdate

Lithium molybdate doped tungsten trioxide electrochromic films were prepared from tungsten trioxide precursor and lithium molybdate powder by sol-gel and dip coating methods on fluorine doped tin oxide glass. The films, which synthesized were flat and amorphous structure, which confirmed by x-ray diffraction patterns. From UV-vis transmittance spectra within the wavelength from 400 to 800 nm. and cyclic voltammogram at the applying a potential of 1.0 V (bleached state) to -1.0 V (colored state) in sulfuric acid 0.5 M solution. The doping lithium molybdate 10 mol% films showed good result in terms of transmittance modulation, high diffusion coefficient and optimal surface area. Therefore, doping lithium molybdate 10 mol% has better outcome when compared to undoped lithium molybdate.

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