Prospective Study of the Mastoid Plasties Using Resorbable Bioceramic MBCP® in Surgery of Cholesteatoma

2016 ◽  
Vol 720 ◽  
pp. 69-73
Author(s):  
Hugo Dercourt ◽  
Charles Henri A. Le Thuaut ◽  
Guillaume Michel ◽  
K Buquet ◽  
G. Daculsi ◽  
...  
Keyword(s):  
Pilot Study ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Ingrowth ◽  
High Rate ◽  
Mastoid Cavity ◽  
Histopathological Analysis ◽  
Sample Collection ◽  
Closed Technique ◽  
Nose And Throat

Tympanoplasty is the reference for cholesteatoma treatment in ear, nose, and throat (ENT surgery), with the realization of a closing technique, which preserves the external auditory canal. An insufficient pneumatisation is an element favoring the occurrence and recurrence of cholesteatoma. In a prospective clinical pilot study, we have realized the reconstruction of the mastoid cortical bone by a Micro Macroporous Biphasic Calcium Phosphate bioceramics disks (MBCPTM Biomatlante France) using the closed technique, in order to maintain or increase the mastoid pneumatisation. Eleven patients were used for this study, and some of them have a sample collection for histomorphometry and histopathological analysis. Bone regeneration at the expense of the bioceramic was observed. The size and shape of the disk was not preserved due to the large resorption and bone ingrowth at the expense of the implant. However 6 patients presented cholesteatoma recurrence. The MBCPTM disks are able to reconstruct the mastoid cortical and maintain the mastoid pneumatisation contrarily to the technique of filling the mastoid cavity. However, the high rate of cholesteatoma recurrence observed in our study, confirmed the interest to fill mastoid that suppress airspace posterior cavities.

Macro/Microporous Biphasic Calcium Phosphate Cylinders and Resorbable Collagen Membranes for Guided Bone Growth

2007 ◽  
Vol 361-363 ◽  
pp. 439-442
Author(s):  
Borhane H. Fellah ◽  
Said Kimakhe ◽  
G. Daculsi ◽  
Pierre Layrolle
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Growth ◽  
Bone Ingrowth ◽  
Collagen Membrane ◽  
Calcium Phosphate Ceramic ◽  
Collagen Membranes ◽  
Large Bone ◽  
Empty Control ◽  
Large Bone Defects

This study aims at evaluating bone growth in critical-sized femoral defects of rats filled with macro micro porous biphasic calcium phosphate ceramic (MBCP) cylinders surrounded or not by a resorbable collagen membrane. Femoral defects left empty (control) exhibited partial bone ingrowths after 3 and 6 weeks and were completely healed at 12 weeks. The defects filled with the collagen membranes appeared partially healed suggesting that the membranes constraint bone ingrowth. Bone formation occurred around the collagen membrane which partially degraded over time. In the MBCP/membrane group, bone has grown inside the macro pores of the MBCP cylinders. Bone ingrowth was more rapid and abundant in the defects filled with MBCP alone. The combination MBCP/collagen membrane may be beneficial for the reconstruction of large bone defects without using repetitive surgeries and autologous bone grafting.

Multicenter Pilot Study to Assess a Biphasic Calcium Phosphate Implant for Functional and Aesthetic Septorhinoplasty

2020 ◽  
Author(s):  
Ludovic de Gabory ◽  
Philippe Boudard ◽  
Jean-Pierre Bessède ◽  
Aline Maillard ◽  
Sabrina Lacomme ◽  
...  
Keyword(s):  
Pilot Study ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate

Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth

Biomaterials ◽  
1998 ◽  
Vol 19 (1-3) ◽  
pp. 133-139 ◽  
Author(s):  
Olivier Gauthier ◽  
Jean-Michel Bouler ◽  
Eric Aguado ◽  
Paul Pilet ◽  
Guy Daculsi
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Ingrowth ◽  
Calcium Phosphate Ceramics

Calcium Phosphate Ceramic Blasting on Titanium Surface Improve Bone Ingrowth

2007 ◽  
Vol 361-363 ◽  
pp. 1351-1354 ◽  
Author(s):  
Eric Goyenvalle ◽  
Eric Aguado ◽  
Ronan Cognet ◽  
Xavier Bourges ◽  
G. Daculsi
Keyword(s):  
Surface Roughness ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Titanium Surface ◽  
Bone Ingrowth ◽  
High Surface ◽  
Titanium Implants ◽  
Calcium Phosphate Ceramic ◽  
Abrasive Particles ◽  
Roughened Surface

Surface roughness modulates the osseointegration of orthopaedic and dental titanium implants. High surface roughness is currently obtained by blasting of titanium implants with silica or aluminium abrasive particles. This process includes into the surface abrasive particles and may cause the release of cytotoxic silica or aluminium ions in the peri implant tissue. To overcome this drawback, we currently develop an innovative gridblasting process using Biphasic Calcium Phosphate (BCP) particles (RBBM Resorbable and Biocompatible Blast Media) to generate biocompatible roughened titanium surface. This work present the technique of blasting using RBBM particles to provide a roughened surface which does not release cytotoxic elements and (ii) to assess the effects of such a roughened surface for bone osteointegration in critical size rabbit defect. Our results demonstrate that resorbable biphasic calcium phosphate abrasive particles can be used to create titanium surface roughness. This grid blasting process increases surface roughness of titanium implants and offers a non cytotoxic surface for rapid and efficient osteointegration.

Five Years Clinical Follow Up Bone Regeneration with CaP Bioceramics

2007 ◽  
Vol 361-363 ◽  
pp. 1339-1342 ◽  
Author(s):  
Clemencia Rodríguez ◽  
Alain Jean ◽  
Sylvia Mitja ◽  
G. Daculsi
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Bone Ingrowth ◽  
X Ray ◽  
Dental Implantation ◽  
Preventive Method

To overcome autograft use for dental implantation, it is important to prevent bone loss after tooth extraction or to restore alveolar bone level after pathological diseases. Biphasic calcium phosphate (BCP), mixture of HA and ß-TCP, have proven its performance in orthopaedic, while few studies have been reported in dentistry. We reported 5 years clinical follow up on bone regeneration after immediate dental root filling. MBCP 60/40 and MBCP 20/80 are biphasic CaP intimate mixture of HA/TCP 60/40 and 20/80; with interconnected macroporosity and microporosity. Forty cases have been distributed in two groups for alveolar pocket filling. Seven cases without filling are used as control. X-Ray at 0, 3, 6, 12 months and 5 years follow up for some patients were performed. In all the 40 cases, radio-opacity of the implantation area decreases on time, indicating resorption and bone ingrowths at the expense of the two bioceramics. No difference in the resorption kinetics appeared on X-Ray. After 1 year, the implantation area looks as physiological bone and is maintained on time. The newly formed bone is preserved after 5 years contrarily to the controls cases (without filling)where we observed decrease of 2 to 5 mm. This study demonstrated that immediate filling of alveolar pocket after tooth extraction is a preventive method of the jaw bone resorption. After long term (other one year) resorption and bone ingrowth were demonstrated for both micro and macroporous biphasic calcium phosphate with two different HA/TCP ratio.

Macroporous Biphasic Calcium Phosphate Efficiency in Mastoid Cavity Obliteration: Experimental and Clinical Findings

1992 ◽  
Vol 101 (8) ◽  
pp. 669-674 ◽  
Author(s):  
Guy Daculsi ◽  
Pascal Corlieu ◽  
Maurice Bagot D'Arc ◽  
Michel Gersdorff
Keyword(s):  
Calcium Phosphate ◽  
Biopsy Specimen ◽  
Biphasic Calcium Phosphate ◽  
Surgical Intervention ◽  
Experimental Studies ◽  
Clinical Findings ◽  
Mastoid Cavity ◽  
Lamellar Bone ◽  
Bone Graft Substitutes ◽  
Cavity Obliteration

Following our previous experimental studies on the performance of macroporous biphasic calcium phosphate (MBCP) in canine mastoid cavities, we used this material in patients requiring surgical intervention. Twenty-two cases were selected, and in eight specific cases a biopsy specimen was taken. Histologic, ultrastructural, and microanalysis studies were performed. This study demonstrates the effectiveness of MBCP implants as bone graft substitutes for mastoid cavity obliteration. Clinical evaluation of the series and histologic and ultrastructural results demonstrated the bioactivity and osteoconduction of this material, with partial transformation of MBCP granules into lamellar bone after several months.

In Vivo Performance of an Injectable Biphasic Calcium Phosphate Bone Filler

2008 ◽  
Vol 396-398 ◽  
pp. 583-586
Author(s):  
Pierre Layrolle ◽  
Serge Baroth ◽  
Eric Goyenvalle ◽  
Eric Aguado ◽  
Françoise Moreau ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Healing ◽  
Biphasic Calcium Phosphate ◽  
Bone Ingrowth ◽  
Submicron Particles ◽  
Bone Filler ◽  
Osteoclastic Resorption ◽  
Tcp Phases

An hydrated putty was prepared by mixing submicron particles, rounded particles and granules of Biphasic Calcium Phosphate (BCP) ceramics composed of HA and β-TCP phases. The material filled entirely critical sized defects in the femoral epiphysis of NZW rabbits. After 3, 6 and 12 weeks, histology revealed that submicron particles were rapidly degraded by multinucleated TRAP-positive cells. This osteoclastic resorption stimulated bone ingrowth while the large BCP particles served as scaffold supporting bone healing by osteoconduction.

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