scholarly journals Evaluation of Bone Repair in the Mandible of Rabbits Using Biphasic Calcium Phosphate Micro-Macroporous Hydroxyapatite Bioceramics and Beta-Tricalcium Phosphate

2019 ◽  
Vol 19 (1) ◽  
pp. 1-12
Author(s):  
Francisco Franceschini Neto ◽  
Rudyard dos Santos Oliveira ◽  
Ana Paula Altheman Lopes ◽  
Carlos Eduardo Xavier dos Santos Ribeiro da Silva
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Repair ◽  
Beta Tricalcium Phosphate

Bimodal Porous Bi-Phasic Calcium Phosphate Ceramics and Its Dissolution in SBF Solution

2007 ◽  
Vol 330-332 ◽  
pp. 91-94 ◽  
Author(s):  
Y. Zhang ◽  
Yoshiyuki Yokogawa ◽  
Tetsuya Kameyama
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Reaction Rate ◽  
Ceramic Materials ◽  
Calcium Phosphate Ceramics ◽  
Fine Powders ◽  
Beta Tricalcium Phosphate ◽  
Sbf Solution ◽  
New Phase

Biphasic calcium phosphate (BCP) ceramics, a mixture of hydroxyapatite (HAp) and beta-tricalcium phosphate (β-TCP), of varying HAp/β-TCP ratios were prepared from fine powders. Porous BCP ceramic materials with HAp/β-TCP weight rations of 20/80, 40/60, and 80/20 were prepared. In this study, the bioactivity is reduced at a larger HAp content rate, which is likely related to the high driving pore for the formation of a new phase, and the reaction rate was proportional to the β-TCP. The porous BCP ceramics having a bigger porosity rate can easily under up dissolution. The powder having a larger β-TCP content rate can easily generate a new phase. The dissolution results confirmed that the biodegradation of calcium phosphate ceramics could be controlled by simply adjusting the amount of HAp or β-TCP in the ceramics and porosity rate.

scholarly journals Fabrication and Characterization of Biodegradable Gelatin Methacrylate/Biphasic Calcium Phosphate Composite Hydrogel for Bone Tissue Engineering

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 617
Author(s):  
Ji-Bong Choi ◽  
Yu-Kyoung Kim ◽  
Seon-Mi Byeon ◽  
Jung-Eun Park ◽  
Tae-Sung Bae ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Cell Viability ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Composite Hydrogel ◽  
Beta Tricalcium Phosphate ◽  
High Bone

In the field of bone tissue, maintaining adequate mechanical strength and tissue volume is an important part. Recently, biphasic calcium phosphate (BCP) was fabricated to solve the shortcomings of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP), and it is widely studied in the field of bone-tissue engineering. In this study, a composite hydrogel was fabricated by applying BCP to gelatin methacrylate (GelMA). It was tested by using a mechanical tester, to characterize the mechanical properties of the prepared composite hydrogel. The fabricated BCP was analyzed through FTIR and XRD. As a result, a different characteristic pattern from hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) was observed, and it was confirmed that it was successfully bound to the hydrogel. Then, the proliferation and differentiation of preosteoblasts were checked to evaluate cell viability. The analysis results showed high cell viability and relatively high bone differentiation ability in the composite hydrogel to which BCP was applied. These features have been shown to be beneficial for bone regeneration by maintaining the volume and shape of the hydrogel. In addition, hydrogels can be advantageous for clinical use, as they can shape the structure of the material for custom applications.

The Preparation and Morphology of Biphasic Calcium Phosphate Ceramics

2012 ◽  
Vol 506 ◽  
pp. 198-201
Author(s):  
P. Saiwanich ◽  
Kamonpan Pengpat ◽  
G. Rujijanagul ◽  
U. Intatha ◽  
Sukum Eitssayeam
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
X Ray Diffraction ◽  
Casting Method ◽  
X Ray ◽  
Gel Casting ◽  
Beta Tricalcium Phosphate ◽  
Ceramic Microstructure ◽  
Ball Milling Technique

In this work, thepreparation and morphology of biphasic calcium phosphate (BCP) have been studied. The biphasic calcium phosphate (BCP) ceramics were prepared by mixing between hydroxyapatite (HA) and Beta-tricalcium phosphate (β-TCP) powderby ball milling technique with different ratios (100:0,80:20,60:40,50:50,40:60, 20:80 and 0:100). After that the mixtures were forming by Gel casting method and then sintered at 1200°C, respectively. The phase formation of the biphasic calcium phosphateceramics were studied by X-ray diffraction (XRD) and their ceramic microstructure,shrinkage and density were investigated.

scholarly journals Production and Characterization of a 316L Stainless Steel/β-TCP Biocomposite Using the Functionally Graded Materials (FGMs) Technique for Dental and Orthopedic Applications

Metals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1923
Author(s):  
Bruna Horta Bastos Kuffner ◽  
Patricia Capellato ◽  
Larissa Mayra Silva Ribeiro ◽  
Daniela Sachs ◽  
Gilbert Silva
Keyword(s):  
Mechanical Properties ◽  
Stainless Steel ◽  
Calcium Phosphate ◽  
Functionally Graded Materials ◽  
Tricalcium Phosphate ◽  
316L Stainless Steel ◽  
Functionally Graded ◽  
Graded Materials ◽  
Beta Tricalcium Phosphate ◽  
Orthopedic Applications

Metallic biomaterials are widely used for implants and dental and orthopedic applications due to their good mechanical properties. Among all these materials, 316L stainless steel has gained special attention, because of its good characteristics as an implantable biomaterial. However, the Young’s modulus of this metal is much higher than that of human bone (~193 GPa compared to 5–30 GPa). Thus, a stress shielding effect can occur, leading the implant to fail. In addition, due to this difference, the bond between implant and surrounding tissue is weak. Already, calcium phosphate ceramics, such as beta-tricalcium phosphate, have shown excellent osteoconductive and osteoinductive properties. However, they present low mechanical strength. For this reason, this study aimed to combine 316L stainless steel with the beta-tricalcium phosphate ceramic (β-TCP), with the objective of improving the steel’s biological performance and the ceramic’s mechanical strength. The 316L stainless steel/β-TCP biocomposites were produced using powder metallurgy and functionally graded materials (FGMs) techniques. Initially, β-TCP was obtained by solid-state reaction using powders of calcium carbonate and calcium phosphate. The forerunner materials were analyzed microstructurally. Pure 316L stainless steel and β-TCP were individually submitted to temperature tests (1000 and 1100 °C) to determine the best condition. Blended compositions used to obtain the FGMs were defined as 20% to 20%. They were homogenized in a high-energy ball mill, uniaxially pressed, sintered and analyzed microstructurally and mechanically. The results indicated that 1100 °C/2 h was the best sintering condition, for both 316L stainless steel and β-TCP. For all individual compositions and the FGM composite, the parameters used for pressing and sintering were appropriate to produce samples with good microstructural and mechanical properties. Wettability and hemocompatibility were also achieved efficiently, with no presence of contaminants. All results indicated that the production of 316L stainless steel/β-TCP FGMs through PM is viable for dental and orthopedic purposes.

Fabrication and biological evaluation of porous β-TCP bioceramics produced using digital light processing

2021 ◽  
pp. 095441192110411
Author(s):  
SongFeng Xu ◽  
Hang Zhang ◽  
Xiang Li ◽  
XinXin Zhang ◽  
HuanMei Liu ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Femoral Condyle ◽  
Biological Evaluation ◽  
Mechanical Tests ◽  
Digital Light Processing ◽  
Beta Tricalcium Phosphate ◽  
Ectopic Bone ◽  
Good Biocompatibility ◽  
Mouse Osteoblast

Beta-tricalcium phosphate ( β-TCP) refers to one ideal bone repair substance with good biocompatibility and osteogenicity. A digital light processing (DLP)-system used in this study creates bioceramic green part by stacking up layers of photocurable tricalcium phosphate-filled slurry with various β-TCP weight fractions. Results show that the sintering shrinkage is anisotropic and the shrinkage vertically reaches over that horizontally. The obtained porous β-TCP parts have both macroporous outer structure and microporous inner structure, the macropore size is 400–600 μm and the micropore size is 500–1500 nm. The mechanical tests show that the porous β-TCP bioceramic’s compressive strength reaches 16.53 MPa. The cell culture confirmed that the porous β-TCP bioceramic is capable of achieving the effective attaching, growing, and proliferating pertained to mouse osteoblast cells. This study identified considerable blood vessels and significant ectopic bone forming obviously based on the histologically-related assessment when implanting to rabbit femoral condyle deficiency for 3 months. Thus, under high bioactive property and osteoinductivity, and large precision and mechanical strength that can be adjusted, the DLP printed porous β-TCP ceramics is capable of being promising for special uses of bones repairing.

scholarly journals Histological Evaluation of a New Beta-Tricalcium Phosphate/Hydroxyapatite/Poly (1-Lactide-Co-Caprolactone) Composite Biomaterial in the Inflammatory Process and Repair of Critical Bone Defects

Symmetry ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1356
Author(s):  
Elizabeth Ferreira Martinez ◽  
Ana Elisa Amaro Rodrigues ◽  
Lucas Novaes Teixeira ◽  
Andrea Rodrigues Esposito ◽  
Walter Israel Rojas Cabrera ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Inflammatory Process ◽  
Histological Evaluation ◽  
Alloplastic Material ◽  
Beta Tricalcium Phosphate ◽  
Evaluation Time ◽  
Synthetic Biomaterial ◽  
Critical Bone Defects

Background: The use of biomaterials is commonplace in dentistry for bone regeneration. The aim of this study was to evaluate the performance of a new alloplastic material for bone repair in critical defects and to evaluate the extent of the inflammatory process. Methods: Forty-five New Zealand rabbits were divided into five groups according to evaluation time (7, 14, 30, 60, 120 days), totaling 180 sites with six-millimeter diameter defects in their tibiae. The defects were filled with alloplastic material consisting of poly (lactide-co-caprolactone), beta-tricalcium phosphate, hydroxyapatite and nano-hydroxyapatite (BTPHP) in three different presentations: paste, block, and membrane. Comparisons were established with reference materials, such as Bio-ossTM, Bio-oss CollagenTM, and Bio-gideTM, respectively. The samples were HE-stained and evaluated for inflammatory infiltrate (scored for intensity from 0 to 3) and the presence of newly formed bone at the periphery of the defects. Results: Greater bone formation was observed for the alloplastic material and equivalent inflammatory intensity for both materials, regardless of evaluation time. At 30 days, part of the synthetic biomaterial, regardless of the presentation, was resorbed. Conclusions: We concluded that this novel alloplastic material showed osteoconductive potential, biocompatibility, low inflammatory response, and gradual resorption, thus an alternative strategy for guided bone regeneration.

scholarly journals Composite Bioceramics/Polymer Electrospun Scaffolds for Regenerative Medicine

2012 ◽  
Vol 529-530 ◽  
pp. 441-446
Author(s):  
Thomas Miramond ◽  
Pascal Borget ◽  
Caroline Colombeix ◽  
Serge Baroth ◽  
G. Daculsi
Keyword(s):  
Cell Adhesion ◽  
Calcium Phosphate ◽  
Regenerative Medicine ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Electrospun Scaffolds ◽  
Mineral Particles

The main goal of this study was to succeed in the relevant association of well-known osteoconductive biphasic calcium phosphate (BCP) made of Hydroxyapatite (20% HA) and β-Tricalcium Phosphate (80% β-TCP) crystallographic phases and resorbable poly (L-lactide-co-D,L-lactide)(PLDLLA) 3D matrices synthesized by electrospinning. Two types of mineral particles were obtained, BCP new hollow granules, and classical BCP particles. It appeared that hollow shells/PLDLLA composite 3D matrices allowed higher cell adhesionin vitro,thanks to internal concavities and are promising scaffolds in terms of cell carrying.

Repairing of Osteochondral Defects in Joint Using Beta-TCP/ Carboxymethyl Chitin Composite

2005 ◽  
Vol 284-286 ◽  
pp. 791-794 ◽  
Author(s):  
Shingo Masuda ◽  
Yusuke Yoshihara ◽  
Kazuaki Muramatsu ◽  
Izumi Wakebe
Keyword(s):  
Mechanical Properties ◽  
Articular Cartilage ◽  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Bone Defects ◽  
Promising Material ◽  
Osteochondral Defects ◽  
Repair Rate ◽  
Beta Tricalcium Phosphate

Beta-tricalcium phosphate/carboxymethyl chitin composites [TCP/CMCh] of various ratios of TCP granules and CMCh were made and their mechanical properties, handling properties and repair performance for bone defects and for osteochondral defects were investigated. Water pooling ratio of CMCh was approximately 40 times the weight itself. TCP/CMCh of a higher TCP ratio had higher stress at 50%-strain. The stress at 50%-strain of TCP/CMCh with 0, 2.5, 5.0, 7.5, 10 TCP ratios was 0.12, 0.51, 1.08, 1.46, 1.67 (MPa, n=5), respectively. The TCP/CMCh with 5.0 TCP ratios had the best total scores in handling tests. The bone repair rate of TCP/CMCh was TCP ratio 2.5< Blank= TCP ratio 7.5< TCP ratio 5.0. In the implantation test for osteochondral defects, TCP/CMCh was completely absorbed at four weeks after surgery. Regeneration of the articular cartilage was seen with TCP/CMCh and HA/CMCh but not with TCP granules, which remained eight weeks after implantation. The regenerated articular cartilage had remained 32 weeks after implantation. In conclusion, it was demonstrated that this TCP/CMCh composite was a promising material for repairing osteochondral defects.

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