scholarly journals Lymphotoxin Pathway-Directed, Autoimmune Regulator-Independent Central Tolerance to Arthritogenic Collagen

2006 ◽  
Vol 177 (1) ◽  
pp. 290-297 ◽  
Author(s):  
Robert K. Chin ◽  
Mingzhao Zhu ◽  
Peter A. Christiansen ◽  
Wenhua Liu ◽  
Carl Ware ◽  
...  
Keyword(s):  
Central Tolerance ◽  
Autoimmune Regulator

scholarly journals Expression of the Autoimmune Regulator Gene and Its Relevance to the Mechanisms of Central and Peripheral Tolerance

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Roberto Perniola
Keyword(s):  
Peripheral Tolerance ◽  
Thymic Epithelial Cells ◽  
Monogenic Disease ◽  
Central Tolerance ◽  
Autoimmune Regulator ◽  
Pathogenic Variants ◽  
Autoimmune Polyendocrine Syndrome ◽  
Murine Homolog ◽  
Genes Encoding ◽  
Medullary Thymic Epithelial Cells

The autoimmune polyendocrine syndrome type 1 (APS-1) is a monogenic disease due to pathogenic variants occurring in the autoimmune regulator (AIRE) gene. Its related protein, AIRE, activates the transcription of genes encoding for tissue-specific antigens (TsAgs) in a subset of medullary thymic epithelial cells: the presentation of TsAgs to the maturating thymocytes induces the apoptosis of the autoreactive clones and constitutes the main form of central tolerance. Dysregulation of thymicAIREexpression in genetically transmitted and acquired diseases other than APS-1 may contribute to further forms of autoimmunity. AsAIREand its murine homolog are also expressed in the secondary lymphoid organs, the extent and relevance of AIRE participation in the mechanisms of peripheral tolerance need to be thoroughly defined.

scholarly journals Central tolerance to self revealed by the autoimmune regulator

2015 ◽  
Vol 1356 (1) ◽  
pp. 80-89 ◽  
Author(s):  
Alice Y. Chan ◽  
Mark S. Anderson
Keyword(s):  
Central Tolerance ◽  
Autoimmune Regulator

scholarly journals Defective Autoimmune Regulator-Dependent Central Tolerance to Myelin Protein Zero Is Linked to Autoimmune Peripheral Neuropathy

2012 ◽  
Vol 188 (10) ◽  
pp. 4906-4912 ◽  
Author(s):  
Maureen A. Su ◽  
Dan Davini ◽  
Philip Cheng ◽  
Karen Giang ◽  
Una Fan ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Myelin Protein ◽  
Myelin Protein Zero ◽  
Central Tolerance ◽  
Autoimmune Regulator ◽  
Protein Zero

Alterations of the autoimmune regulator transcription factor and failure of central tolerance: APECED as a model

2013 ◽  
Vol 9 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Vera Gallo ◽  
Giuliana Giardino ◽  
Donatella Capalbo ◽  
Loredana Palamaro ◽  
Rosa Romano ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Central Tolerance ◽  
Autoimmune Regulator
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