Fewer LAG-3+ T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes

2022 ◽  
pp. ji2100850
Author(s):  
Britta E. Jones ◽  
Megan D. Maerz ◽  
Henry T. Bahnson ◽  
Ashwin Somasundaram ◽  
Lucas H. McCarthy ◽  
...  
PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0238070
Author(s):  
Sushmita Sinha ◽  
Pranav S. Renavikar ◽  
Michael P. Crawford ◽  
Scott M. Steward-Tharp ◽  
Ashley Brate ◽  
...  

BioDrugs ◽  
2021 ◽  
Author(s):  
Kamil Chwojnicki ◽  
Dorota Iwaszkiewicz-Grześ ◽  
Anna Jankowska ◽  
Maciej Zieliński ◽  
Paweł Łowiec ◽  
...  

2013 ◽  
Vol 19 (14) ◽  
pp. 1867-1877 ◽  
Author(s):  
Que Lan Quach ◽  
Luanne M Metz ◽  
Jenna C Thomas ◽  
Jonathan B Rothbard ◽  
Lawrence Steinman ◽  
...  

Background: Suppression of activation of pathogenic CD4+ T cells is a potential therapeutic intervention in multiple sclerosis (MS). We previously showed that a small heat shock protein, CRYAB, reduced T cell proliferation, pro-inflammatory cytokine production and clinical signs of experimental allergic encephalomyelitis, a model of MS. Objective: We assessed whether the ability of CRYAB to reduce the activation of T cells translated to the human disease. Methods: CD4+ T cells from healthy controls and volunteers with MS were activated in vitro in the presence or absence of a CRYAB peptide (residues 73–92). Parameters of activation (proliferation rate, cytokine secretion) and tolerance (anergy, activation-induced cell death, microRNAs) were evaluated. Results: The secretion of pro-inflammatory cytokines by CD4+ T cells was decreased in the presence of CRYAB in a subset of relapsing–remitting multiple sclerosis (RRMS) participants with mild disease severity while no changes were observed in healthy controls. Further, there was a correlation for higher levels of miR181a microRNA, a marker upregulated in tolerant CD8+ T cells, in CD4+ T cells of MS patients that displayed suppressed cytokine production (responders). Conclusion: CRYAB may be capable of suppressing the activation of CD4+ T cells from a subset of RRMS patients who appear to have less disability but similar age and disease duration.


2019 ◽  
Vol 337 ◽  
pp. 577046 ◽  
Author(s):  
Michał K. Zarobkiewicz ◽  
Wioleta Kowalska ◽  
Paweł Halczuk ◽  
Justyna Woś ◽  
Barbara Jodłowska-Jędrych ◽  
...  

2010 ◽  
Vol 71 (5) ◽  
pp. 437-441 ◽  
Author(s):  
Giovanni Frisullo ◽  
Viviana Nociti ◽  
Raffaele Iorio ◽  
Domenico Plantone ◽  
A. Katia Patanella ◽  
...  

2008 ◽  
Vol 22 (10) ◽  
pp. 3500-3508 ◽  
Author(s):  
Marina Saresella ◽  
Ivana Marventano ◽  
Renato Longhi ◽  
Francesca Lissoni ◽  
Daria Trabattoni ◽  
...  

2012 ◽  
Vol 46 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Łukasz Kraszula ◽  
Anna Jasińska ◽  
Makandjou-Ola Eusebio ◽  
Piotr Kuna ◽  
Andrzej Głąbiński ◽  
...  

2008 ◽  
Vol 127 ◽  
pp. S15
Author(s):  
Laure Michel ◽  
Laureline Berthelot ◽  
Ségolène Pettré ◽  
Sandrine Wiertlewski ◽  
Fabienne Le Frère ◽  
...  

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