The Importance of Mitochondrial DNA in Aging and Cancer
Keyword(s):
Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue and tumors. This paper describes our contemporary view of mechanisms by which alterations of the mitochondrial genome contributes to the development of age- and tumor-related pathological conditions. The mechanisms described encompass altered production of mitochondrial ROS, altered regulation of the nuclear epigenome, affected initiation of apoptosis, and a limiting effect on the production of ribonucleotides and deoxyribonucleotides.
1994 ◽
Vol 269
(9)
◽
pp. 6878-6883
Keyword(s):
2009 ◽
Vol 297
(5)
◽
pp. E987-E998
◽
2007 ◽
Vol 226
(1-2)
◽
pp. 185-193
◽
2013 ◽
Vol 19
(14)
◽
pp. 1858-1866
◽
Keyword(s):
2020 ◽
Vol 21
(9)
◽
pp. 846-859