The Role of the Alliance in the Pharmacologic Treatment of Depression

1997 ◽  
Vol 58 (5) ◽  
pp. 196-204 ◽  
Author(s):  
Margaret Weiss ◽  
Louise Gaston ◽  
Arthur Propst ◽  
Susan Wisebord ◽  
Vivian Zicherman
Keyword(s):  
Pharmacologic Treatment ◽  
Treatment Of Depression

scholarly journals Computerized Cognitive Behavioral Therapy for Treatment of Depression in Multiple Sclerosis

2019 ◽  
Vol 21 (3) ◽  
pp. 113-123
Author(s):  
Adrianna Ratajska ◽  
Jonathan Zurawski ◽  
Brian Healy ◽  
Bonnie I. Glanz
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Behavioral Therapy ◽  
Care Delivery ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Online Programs ◽  
Treatment Of Depression ◽  
Recent Developments ◽  
Considerable Work

Abstract Depression is common in multiple sclerosis (MS), affecting up to 50% of patients at some point in their lifetime. Although the rate of depression in MS is higher than that in the general population and that in patients with other chronic medical conditions, depression in MS is underdiagnosed and undertreated. Antidepressant agents are used empirically in the management of MS-related depression, but evidence specifically demonstrating the efficacy of these medications in patients with MS is sparse. Considerable work suggests that psychological interventions such as cognitive behavioral therapy (CBT) may be effective in the management of depression in MS. Recently there has been an expansion of computerized adaptations of CBT, allowing patients to complete therapy sessions remotely via online programs. This article reviews our current understanding of depression in MS and the role of CBT in its management, focusing on recent developments in computerized formats for CBT. Four computerized CBT programs that have been previously tested in patients with MS are described: Deprexis, MoodGYM, Beating the Blues, and MS Invigor8. We conclude that despite challenges inherent to computerized CBT interventions, such platforms have the potential to positively affect mental health care delivery to the MS patient population.

scholarly journals Women, ‘madness’ and exercise

2018 ◽  
Vol 44 (3) ◽  
pp. 181-192 ◽  
Author(s):  
Jennifer Jane Hardes
Keyword(s):  
Mental Health ◽  
Prima Facie ◽  
Health Condition ◽  
Significant Shift ◽  
Emotional States ◽  
Women’S Mental Health ◽  
Women's Mental Health ◽  
Treatment Of Depression ◽  
Exercise Promotion

The positive relationship between exercise and mental health is often taken for granted in today’s society, despite the lack of academic literature evidencing this symbiosis. Gender is considered a significant determinant in a number of mental health diagnoses. Indeed, women are considered twice as likely as men to experience the most pervasive mental health condition, depression. Exercise for women’s mental health is promoted through various macrolevel charity, as well as microlevel, campaigns that influence government healthcare policy and National Health Service guidelines. Indeed, ‘exercise prescriptions’ in the treatment of depression is not uncommon. Yet, this link between exercise as a treatment for women’s mental health has not always been so pervasive. In fact, an examination of asylum reports and medical journals from the late 19th century highlights a significant shift in attitude towards the role of exercise in the treatment of women’s emotional states and mental health. This paper specifically examines how this treatment of women’s mental health through exercise has moved from what might be regarded as a focus on exercise as a ‘cause’ of women’s mental ailments to exercise promoted as a ‘cure’. Unpacking the changing medical attitudes towards exercise for women in line with larger sociopolitical and historic contexts reveals that while this shift towards exercise promotion might prima facie appear as a less essentialist view of women and their mental and physical states, it inevitably remains tied to larger policy and governance agendas. New modes of exercise ‘treatment’ for women’s mental health are not politically neutral and, thus, what appear to emerge as forms of liberation are, in actuality, subtler forms of regulation.

The role of restricting access to potentially lethal medication in suicide prevention

2021 ◽  
pp. 709-712
Author(s):  
Cyril Höschl ◽  
Pavla Čermáková
Keyword(s):  
Suicide Prevention ◽  
Health Conditions ◽  
Suicide Methods ◽  
Suicide Rates ◽  
Life Saving ◽  
Health Strategy ◽  
Treatment Of Depression ◽  
Restrictive Measures ◽  
Lethal Means

Overdose with medications is a common method of suicide. Reviews of suicide prevention strategies confirmed that restricting access to lethal means is effective in preventing suicides. Nevertheless, there have not been any randomized controlled trials, proving that restriction of the access to toxic medications decreases suicide rates. Existing evidence is based mainly on observational, ecological, and cohort studies. Factors such as better mental health conditions, effective treatment of depression, and improvement in socioeconomic status, may also contribute to decreasing suicide rates. Restrictive measures will have a large effect if the respective method is frequent and lethal. Although there are some concerns about substitution of suicide methods if access to a specific drug is restricted, many studies suggest a life-saving potential. Restrictive measures represent an effective and feasible public health strategy for suicide prevention, particularly in individuals that carry out briefly planned impulsive acts, and in combination with other interventions.

Depression and risk of disability pension: A systematic review and meta-analysis

2019 ◽  
pp. 009121741983741 ◽  
Author(s):  
Sohrab Amiri ◽  
Sepideh Behnezhad
Keyword(s):  
Systematic Review ◽  
Confidence Interval ◽  
Publication Bias ◽  
Risk Ratio ◽  
Disability Pension ◽  
Common Mental Disorder ◽  
Meta Analysis ◽  
Psychological Consequences ◽  
Treatment Of Depression

Background and objective Depression is a common mental disorder that leads to undesirable consequences. The study of the role of depression in disability pension can provide valuable insights. This study was conducted with the goal of systematic review and meta-analysis of the relationship between depression and disability pension. Methods PubMed, Scopus, PsycInfo, and Google Scholar databases were systematically searched until March 2018. Fifteen prospective cohort studies were selected and included in the meta-analysis. The random-effects method was used to combine the studies. Subgroup analysis was performed, and publication bias was also examined. Results Depression was a risk factor for disability pension (pooled risk ratio =1.68 and 95% confidence interval = 1.50–1.88). In men, pooled risk ratio was 1.82 for the effect of depression on the risk of disability pension (95% confidence interval = 1.45–2.28). In women, pooled risk ratio was 1.62 (95% confidence interval = 1.31–2.02). The results showed that there is publication bias. Conclusions Depression is a factor for retirement due to disability. Therefore, the prevention and treatment of depression can reduce socioeconomic and psychological consequences imposed on society.

Glucocorticoids in the Physiological and Transcriptional Regulation of 5-HT1A Receptor and the Pathogenesis of Depression

2020 ◽  
pp. 107385842097571
Author(s):  
Darakhshan Jabeen Haleem
Keyword(s):  
Transcriptional Regulation ◽  
Critical Role ◽  
Treatment Strategies ◽  
Therapeutic Agents ◽  
Stressful Events ◽  
Antagonist Activity ◽  
Treatment Of Depression ◽  
Prevalence Of Depression ◽  
Circulating Levels

There is growing increase in the global prevalence of depression, but treatment outcome of this highly disabling disease is not satisfactory. Many patients are not benefitted by the currently prescribed antidepressants—together with this partial remission is very common. Improving treatment strategies and developing better therapeutic agents for treating depression is therefore highly needed. Stress-related epigenetic changes play a critical role in the pathogenesis as well as treatment of depression. Stressful events activate hypothalamic-pituitary-adrenal axis to increase circulating levels of glucocorticoids (GCs), and a greater sensitivity to this fright and flight response increases risk of depression. A role of serotonin (5-hydroxytryptamine; 5-HT) in responses to stress and in the pathogenesis and treatment of depression is well established. Substantial evidence supports a critical role of 5-HT1A receptors in these effects of 5-HT. The present article targets stress-induced higher and sustained increases of GCs and mediated influences on the physiological as well transcriptional regulation of 5-HT1A receptors to evaluate their causal role in the pathogenesis of depression. It is suggested that synthetic compounds with antagonist activity for GC receptors and agonist activity for 5-HT1A receptors may prove better therapeutic agents for treating depression.

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