scholarly journals Full genome sequencing to study the evolutionary characteristics of foot-and-mouth disease virus in southern Africa

2014 ◽  
Vol 81 (2) ◽  
Author(s):  
Christopher J. Kasanga ◽  
Begoña Valdazo-González ◽  
Rahana Dwarka ◽  
Jemma Wadsworth ◽  
Nick J. Knowles ◽  
...  
Keyword(s):  
Disease Virus ◽  
Genome Sequencing ◽  
Southern Africa ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Full Genome ◽  
Full Genome Sequencing ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Full Genome Sequencing Reveals New Southern African Territories Genotypes Bringing Us Closer to Understanding True Variability of Foot-and-Mouth Disease Virus in Africa

Viruses ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 192 ◽  
Author(s):  
Lidia Lasecka-Dykes ◽  
Caroline Wright ◽  
Antonello Di Nardo ◽  
Grace Logan ◽  
Valerie Mioulet ◽  
...  
Keyword(s):  
Disease Virus ◽  
Genome Sequencing ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Full Genome ◽  
Full Genome Sequencing ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Complete Genome Sequences of Three African Foot-and-Mouth Disease Viruses from Clinical Samples Isolated in 2009 and 2010

2016 ◽  
Vol 4 (3) ◽  
Author(s):  
Steven Van Borm ◽  
Toon Rosseel ◽  
Andy Haegeman ◽  
Mpolokang Elliot Fana ◽  
Latoa Seoke ◽  
...  
Keyword(s):  
Genome Sequencing ◽  
Complete Genome ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Clinical Samples ◽  
Full Genome ◽  
Full Genome Sequencing ◽  
Genome Sequences ◽  
Foot And Mouth

The complete genome sequences of three foot-and-mouth disease viruses (one virus of each serotype SAT1, SAT2 and O) were directly sequenced from RNA extracted from clinical bovine samples, demonstrating the feasibility of full-genome sequencing from strong positive samples taken from symptomatic animals.

scholarly journals Reconstruction of the Transmission History of RNA Virus Outbreaks Using Full Genome Sequences: Foot-and-Mouth Disease Virus in Bulgaria in 2011

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49650 ◽  
Author(s):  
Begoña Valdazo-González ◽  
Lilyana Polihronova ◽  
Tsviatko Alexandrov ◽  
Preben Normann ◽  
Nick J. Knowles ◽  
...  
Keyword(s):  
Disease Virus ◽  
Rna Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Full Genome ◽  
Genome Sequences ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
History Of

The first full genome characterization of an Iranian foot and mouth disease virus

2020 ◽  
Vol 279 ◽  
pp. 197888
Author(s):  
Hamideh Najafi ◽  
Mohammad Hossein FallahMehrabadi ◽  
Hossein Hosseini ◽  
Zahra Ziafati Kafi ◽  
Amir Modiri Hamdan ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Full Genome ◽  
Genome Characterization ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Molecular biological characteristics of foot-and-mouth disease virus in the African buffalo in southern Africa

2014 ◽  
Vol 81 (2) ◽  
Author(s):  
Christopher J. Kasanga ◽  
Rahana Dwarka ◽  
Gaothlele Thobokwe ◽  
Jemma Wadsworth ◽  
Nick J. Knowles ◽  
...  
Keyword(s):  
Disease Virus ◽  
Southern Africa ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Biological Characteristics ◽  
African Buffalo ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Accumulation of nucleotide substitutions occurring during experimental transmission of foot-and-mouth disease virus

2013 ◽  
Vol 94 (1) ◽  
pp. 108-119 ◽  
Author(s):  
Nicholas Juleff ◽  
Begoña Valdazo-González ◽  
Jemma Wadsworth ◽  
Caroline F. Wright ◽  
Bryan Charleston ◽  
...  
Keyword(s):  
Disease Virus ◽  
Genome Sequence ◽  
Heparan Sulphate ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Full Genome Sequence ◽  
Full Genome ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Transmission Pathways

Analysis of full-genome sequences was previously used to trace the origin and transmission pathways of foot-and-mouth disease virus (FMDV) outbreaks in the UK in 2001 and 2007. Interpretation of these data was sometimes at variance with conventional epidemiological tracing, and was also used to predict the presence of undisclosed infected premises that were later discovered during serological surveillance. Here we report the genome changes associated with sequential passage of a highly BHK-21-cell-adapted (heparan sulphate-binding) strain of FMDV arising from two independent transmission chains in cattle. In vivo virus replication rapidly selected for a wild-type variant with an amino acid substitution at VP356. Full-genome sequence analysis clearly demonstrated sequence divergence during parallel passage. The genetic diversity generated over the course of infection and the rate at which these changes became fixed and were transmitted between cattle occurred at a rate sufficient to enable reliable tracing of transmission pathways at the level of the individual animal. However, tracing of transmission pathways was only clear when sequences from epithelial lesions were compared. Sequences derived from oesophageal–pharyngeal scrapings were problematic to interpret, with a varying number of ambiguities suggestive of a more diverse virus population. These findings will help to correctly interpret full-genome sequence analyses to resolve transmission pathways within future FMDV epidemics.

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