scholarly journals A Monte Carlo approach to lung dose calculation in small fields used in intensity modulated radiation therapy and stereotactic body radiation therapy

2014 ◽  
Vol 10 (4) ◽  
pp. 896 ◽  
Author(s):  
Asghar Mesbahi ◽  
Habib Dadgar ◽  
Nahideh Ghareh-Aghaji ◽  
Mohammad Mohammadzadeh
Keyword(s):  
Monte Carlo ◽  
Radiation Therapy ◽  
Stereotactic Body Radiation Therapy ◽  
Intensity Modulated Radiation Therapy ◽  
Dose Calculation ◽  
Lung Dose ◽  
Monte Carlo Approach ◽  
Stereotactic Body Radiation ◽  
Intensity Modulated ◽  
Small Fields

scholarly journals Stereotactic Body Radiation Therapy Versus Intensity-Modulated Radiation Therapy for Prostate Cancer: Comparison of Toxicity

2014 ◽  
Vol 32 (12) ◽  
pp. 1195-1201 ◽  
Author(s):  
James B. Yu ◽  
Laura D. Cramer ◽  
Jeph Herrin ◽  
Pamela R. Soulos ◽  
Arnold L. Potosky ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Treatment Cost ◽  
Treatment Initiation ◽  
Stereotactic Body Radiation Therapy ◽  
Intensity Modulated Radiation Therapy ◽  
Stereotactic Body Radiation ◽  
Intensity Modulated ◽  
Medicare Program ◽  
Gu Toxicity

Purpose Stereotactic body radiation therapy (SBRT) is a technically demanding prostate cancer treatment that may be less expensive than intensity-modulated radiation therapy (IMRT). Because SBRT may deliver a greater biologic dose of radiation than IMRT, toxicity could be increased. Studies comparing treatment cost to the Medicare program and toxicity are needed. Methods We performed a retrospective study by using a national sample of Medicare beneficiaries age ≥ 66 years who received SBRT or IMRT as primary treatment for prostate cancer from 2008 to 2011. Each SBRT patient was matched to two IMRT patients with similar follow-up (6, 12, or 24 months). We calculated the cost of radiation therapy treatment to the Medicare program and toxicity as measured by Medicare claims; we used a random effects model to compare genitourinary (GU), GI, and other toxicity between matched patients. Results The study sample consisted of 1,335 SBRT patients matched to 2,670 IMRT patients. The mean treatment cost was $13,645 for SBRT versus $21,023 for IMRT. In the 6 months after treatment initiation, 15.6% of SBRT versus 12.6% of IMRT patients experienced GU toxicity (odds ratio [OR], 1.29; 95% CI, 1.05 to 1.53; P = .009). At 24 months after treatment initiation, 43.9% of SBRT versus 36.3% of IMRT patients had GU toxicity (OR, 1.38; 95% CI, 1.12 to 1.63; P = .001). The increase in GU toxicity was due to claims indicative of urethritis, urinary incontinence, and/or obstruction. Conclusion Although SBRT was associated with lower treatment costs, there appears to be a greater rate of GU toxicity for patients undergoing SBRT compared with IMRT, and prospective correlation with randomized trials is needed.

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