scholarly journals E-cigarettes: A novel therapy or a looming catastrophe

2021 ◽  
Vol 16 (1) ◽  
pp. 73
Author(s):  
Shahzad Hussain ◽  
Zainab Shahid ◽  
MahtabB Foroozesh ◽  
UmarF Sofi
Keyword(s):  
Novel Therapy

Effective novel therapy in the use of managing refractory hypoglycaemia in a patient with metastatic insulinoma

2019 ◽  
Author(s):  
Samantha Anandappa ◽  
Barbara McGowan ◽  
Andreas Prachalias ◽  
Debashis Sarker ◽  
Rosa Miquel ◽  
...  
Keyword(s):  
Novel Therapy

1172-P: GLUT4-Overexpressing Engineered Muscle Tissue Implants as a Potential Novel Therapy for Type 2 Diabetes: Lessons from Diabetic Mice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1172-P
Author(s):  
MARGARITA BECKERMAN ◽  
EDDY KARNIELI ◽  
CHAVA HAREL ◽  
AMIRA KLIP ◽  
PHILIP J. BILAN ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Muscle Tissue ◽  
Diabetic Mice ◽  
Novel Therapy

Heart Failure Models: Traditional and Novel Therapy

2015 ◽  
Vol 13 (5) ◽  
pp. 658-669 ◽  
Author(s):  
Mohamed Haidara ◽  
Abdullah Assiri ◽  
Hanaa Yassin ◽  
Hania Ammar ◽  
Milan Obradovic ◽  
...  
Keyword(s):  
Heart Failure ◽  
Novel Therapy ◽  
Failure Models

scholarly journals Targeting Notch signaling as a novel therapy for retinoblastoma

Oncotarget ◽  
2016 ◽  
Vol 7 (43) ◽  
pp. 70028-70044 ◽  
Author(s):  
Laura Asnaghi ◽  
Arushi Tripathy ◽  
Qian Yang ◽  
Harpreet Kaur ◽  
Allison Hanaford ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Novel Therapy

Pilot Study of Iodine-131–Metaiodobenzylguanidine in Combination With Myeloablative Chemotherapy and Autologous Stem-Cell Support for the Treatment of Neuroblastoma

2002 ◽  
Vol 20 (8) ◽  
pp. 2142-2149 ◽  
Author(s):  
Gregory A. Yanik ◽  
John E. Levine ◽  
Katherine K. Matthay ◽  
James C. Sisson ◽  
Barry L. Shulkin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Pilot Study ◽  
Neuroblastoma Cells ◽  
Complete Response ◽  
Novel Therapy ◽  
Peripheral Blood Stem Cells ◽  
Hematopoietic Stem ◽  
Stem Cell Rescue ◽  
Myeloablative Chemotherapy ◽  
Iodine 131

PURPOSE: The survival for children with relapsed or metastatic neuroblastoma remains poor. More effective regimens with acceptable toxicity are required to improve prognosis. Iodine-131–metaiodobenzylguanidine (131I-MIBG) selectively targets radiation to catecholamine-producing cells, including neuroblastoma cells. A pilot study was performed to examine the feasibility of a novel regimen combining 131I-MIBG and myeloablative chemotherapy with autologous stem-cell rescue. PATIENTS AND METHODS: Twelve patients with neuroblastoma were treated after relapse (five patients) or after induction therapy (seven patients). Eight patients had metastatic and four had localized disease at the time of therapy. All patients received 131I-MIBG 12 mCi/kg on day −21, followed by carboplatin (1,500 mg/m2), etoposide (800 mg/m2), and melphalan (210 mg/m2) administered from day −7 to day −4. Autologous peripheral-blood stem cells or bone marrow were infused on day 0. Engraftment, toxicity, and response rates were evaluated. RESULTS: The 131I-MIBG infusion and myeloablative chemotherapy were both well tolerated. Grade 2 to 3 oral mucositis was the predominant nonhematopoietic toxicity, occurring in all patients. The median times to neutrophil (≥ 0.5 × 103/μL) and platelet (≥ 20 × 103/μL) engraftment were 10 and 28 days, respectively. For the eight patients treated with metastatic disease, three achieved complete response and two had partial responses by day 100 after transplantation. CONCLUSION: Treatment with 131I-MIBG in combination with myeloablative chemotherapy and hematopoietic stem-cell rescue is feasible with acceptable toxicity. Future study is warranted to examine the efficacy of this novel therapy.

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