scholarly journals Assessment of the current D-dimer cutoff point in pulmonary embolism workup at a single institution: Retrospective study

2018 ◽  
Vol 64 (3) ◽  
pp. 150
Author(s):  
S Alhassan ◽  
E Bihler ◽  
K Patel ◽  
S Lavudi ◽  
M Young ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Retrospective Study ◽  
Cutoff Point ◽  
Single Institution ◽  
D Dimer

Pulmonary Embolism Rule-out Criteria vs D-dimer testing in low-risk patients for pulmonary embolism: a retrospective study

2014 ◽  
Vol 32 (6) ◽  
pp. 609-613 ◽  
Author(s):  
J. Bokobza ◽  
A. Aubry ◽  
N. Nakle ◽  
C. Vincent-Cassy ◽  
D. Pateron ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Retrospective Study ◽  
Low Risk ◽  
Risk Patients ◽  
D Dimer ◽  
Rule Out

Use of clinical probability scores and D-dimer in suspected pulmonary embolism. Results from a Spanish retrospective study

2020 ◽  
Vol 27 (6) ◽  
pp. 468-469
Author(s):  
Antonio Jesús Láinez-Ramos-Bossini ◽  
Sara Moreno-Suárez ◽  
María del Carmen Pérez-García ◽  
Regina Gálvez-López ◽  
Francisco Garrido-Sanz ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Retrospective Study ◽  
Suspected Pulmonary Embolism ◽  
Clinical Probability ◽  
D Dimer

scholarly journals Age-adjusted D-dimer excludes pulmonary embolism and reduces unnecessary radiation exposure in older adults: retrospective study

2016 ◽  
Vol 93 (1101) ◽  
pp. 420-424 ◽  
Author(s):  
Jennifer Nobes ◽  
Claudia-Martina Messow ◽  
Mohammed Khan ◽  
Petr Hrobar ◽  
Chris Isles
Keyword(s):  
Older Adults ◽  
Pulmonary Embolism ◽  
Retrospective Study ◽  
Radiation Exposure ◽  
Unnecessary Radiation ◽  
D Dimer

scholarly journals Predicting pulmonary embolism in patients infected with COVID-19 based on D-dimer levels and days between diagnosis of the infection and D-dimer determination

2021 ◽  
Author(s):  
Ignasi Garcia-Olivé ◽  
Helena Sintes ◽  
Joaquim Radua ◽  
Jordi Deportos ◽  
Isabel Nogueira ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Retrospective Study ◽  
Hospital Admission ◽  
Cross Validation ◽  
Area Under The Curve ◽  
Subsequent Development ◽  
Tertiary Hospital ◽  
The Subject ◽  
D Dimer ◽  
Over Time

This was an observational, retrospective study, conducted at a tertiary hospital. All subjects with PCR-confirmed COVID-19 infection requiring hospital admission at our institution between the months of March and April 2020 were included in the study. We compared D-dimer levels in subjects who went on to develop a PE and those who did not. We then created a model to predict the subsequent development of a PE with the current D-dimer levels of the subject. D-dimer levels changed over time from COVID-19 diagnosis, but were always higher in subjects who went on to develop a PE. Regarding the predictive model created, the area under the curve of the ROC analyses of the cross-validation predictions was 0.72. The risk of pulmonary embolism for the same D-dimer levels varied depending on the number of days elapsed since COVID-19 diagnosis and D-dimer determination. To conclude, D-dimer levels were elevated in subjects with a COVID-19 infection, especially in those with PE. D-dimer levels increased during the first 10 days after the diagnosis of the infection and can be used to predict the risk of PE in COVID-19 subjects.

scholarly journals Elderly Population with COVID-19 and the Accuracy of Clinical Scales and D-Dimer for Pulmonary Embolism: The OCTA-COVID Study

2021 ◽  
Vol 10 (22) ◽  
pp. 5433
Author(s):  
Maribel Quezada-Feijoo ◽  
Mónica Ramos ◽  
Isabel Lozano-Montoya ◽  
Mónica Sarró ◽  
Verónica Cabo Muiños ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Area Under The Curve ◽  
Scoring Systems ◽  
Cutoff Point ◽  
Study Cohort ◽  
Clinical Scales ◽  
Clinical Probability ◽  
Wells Score ◽  
Revised Geneva Score ◽  
D Dimer

Background: Elderly COVID-19 patients have a high risk of pulmonary embolism (PE), but factors that predict PE are unknown in this population. This study assessed the Wells and revised Geneva scoring systems as predictors of PE and their relationships with D-dimer (DD) in this population. Methods: This was a longitudinal, observational study that included patients ≥75 years old with COVID-19 and suspected PE. The performances of the Wells score, revised Geneva score and DD levels were assessed. The combinations of the DD level and the clinical scales were evaluated using positive rules for higher specificity. Results: Among 305 patients included in the OCTA-COVID study cohort, 50 had suspected PE based on computed tomography pulmonary arteriography (CTPA), and the prevalence was 5.6%. The frequencies of PE in the low-, intermediate- and high-probability categories were 5.9%, 88.2% and 5.9% for the Geneva model and 35.3%, 58.8% and 5.9% for the Wells model, respectively. The DD median was higher in the PE group (4.33 mg/L; interquartile range (IQR) 2.40–7.17) than in the no PE group (1.39 mg/L; IQR 1.01–2.75) (p < 0.001). The area under the curve (AUC) for DD was 0.789 (0.652–0.927). After changing the cutoff point for DD to 4.33 mg/L, the specificity increased from 42.5% to 93.9%. Conclusions: The cutoff point DD > 4.33 mg/L has an increased specificity, which can discriminate false positives. The addition of the DD and the clinical probability scales increases the specificity and negative predictive value, which helps to avoid unnecessary invasive tests in this population.

scholarly journals D-dimer-to-platelet Ratio as a Novel Marker of in-hospital Adverse Outcomes Among Patients With Acute Pulmonary Embolism: a Single-center Retrospective Study

2021 ◽  
Author(s):  
Xincheng Li ◽  
Yaowu He ◽  
Yu Shang ◽  
Yi Yang ◽  
Menghan Wang ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Retrospective Study ◽  
Adverse Events ◽  
Medical Records ◽  
Acute Pulmonary Embolism ◽  
Multivariate Analyses ◽  
Adverse Outcomes ◽  
Therapeutic Interventions ◽  
Serious Adverse Events ◽  
D Dimer

Abstract Background: This retrospective study aimed to evaluate the value of D-dimer to platelets ratio (DPR) in predicting the in-hospital prognosis of patients with acute pulmonary embolism (APE).Methods: We retrospectively reviewed the medical records of 237 patients with APE admitted from January 2016 to August 2020. The associations between the DPR and other predictors and serious adverse events were analyzed with univariate and multivariate analyses.Results: A total of 134 (56.5%) patients were categorized into the low DPR group (DPR <4.55) and 103 (43.5%) in the high DPR group (DPR ≥4.55) according to the cut-off value for the DPR of 4.55 with a sensitivity of 87.5% and a specificity of 62.0%, respectively. The model that included DPR revealed a significant improvement in the accuracy of the predictive value compared with the sPESI score alone (AUC: 0.721 [95% CI: 0.636-0.807]; P <0.001 vs AUC: 0.607 [95% CI: 0.496-0.718]; P=0.085; respectively. Multivariate analysis showed that DPR (P=0.001) and the pulmonary embolus position (P=0.011) were independent factors of serious adverse events (SAEs) of APE inpatients. The in-hospital SAEs rate was significantly higher in the high DPR group compared with the low DPR group.Conclusion: Our findings showed that DPR is seemed to be a novel marker of risk stratification in patients with APE. This parameter may be used to identify these patients at higher risk for clinical adverse events, and individualization of therapeutic interventions should be timely considered.

scholarly journals A higher D-dimer threshold for predicting pulmonary embolism in patients with COVID-19: a retrospective study

2020 ◽  
Vol 27 (6) ◽  
pp. 679-689
Author(s):  
Sofía Ventura-Díaz ◽  
Juan V. Quintana-Pérez ◽  
Almudena Gil-Boronat ◽  
Marina Herrero-Huertas ◽  
Luis Gorospe-Sarasúa ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Retrospective Study ◽  
D Dimer

D-Dimer and CT Rule Out Pulmonary Embolism

2008 ◽  
Vol 1 (2) ◽  
pp. 11
Author(s):  
DAMIAN MCNAMARA
Keyword(s):  
Pulmonary Embolism ◽  
D Dimer ◽  
Rule Out

Tissue plasminogen activator as a novel diagnostic aid in acute pulmonary embolism

VASA ◽  
2014 ◽  
Vol 43 (6) ◽  
pp. 450-458 ◽  
Author(s):  
Julio Flores ◽  
Ángel García-Avello ◽  
Esther Alonso ◽  
Antonio Ruíz ◽  
Olga Navarrete ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Negative Predictive Value ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Predictive Value ◽  
Acute Pulmonary Embolism ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diagnostic Utility ◽  
Tissue Plasminogen ◽  
D Dimer

Background: We evaluated the diagnostic efficacy of tissue plasminogen activator (tPA), using an enzyme-linked immunosorbent assay (ELISA) and compared it with an ELISA D-dimer (VIDAS D-dimer) in acute pulmonary embolism (PE). Patients and methods: We studied 127 consecutive outpatients with clinically suspected PE. The diagnosis of PE was based on a clinical probability pretest for PE and a strict protocol of imaging studies. A plasma sample to measure the levels of tPA and D-dimer was obtained at enrollment. Diagnostic accuracy for tPA and D-dimer was determined by the area under the receiver operating characteristic (ROC) curve. Sensitivity, specificity, predictive values, and the diagnostic utility of tPA with a cutoff of 8.5 ng/mL and D-dimer with a cutoff of 500 ng/mL, were calculated for PE diagnosis. Results: PE was confirmed in 41 patients (32 %). Areas under ROC curves were 0.86 for D-dimer and 0.71 for tPA. The sensitivity/negative predictive value for D-dimer using a cutoff of 500 ng/mL, and tPA using a cutoff of 8.5 ng/mL, were 95 % (95 % CI, 88–100 %)/95 % (95 % CI, 88–100 %) and 95 % (95 % CI, 88–100 %)/94 %), respectively. The diagnostic utility to exclude PE was 28.3 % (95 % CI, 21–37 %) for D-dimer and 24.4 % (95 % CI, 17–33 %) for tPA. Conclusions: The tPA with a cutoff of 8.5 ng/mL has a high sensitivity and negative predictive value for exclusion of PE, similar to those observed for the VIDAS D-dimer with a cutoff of 500 ng/mL, although the diagnostic utility was slightly higher for the D-dimer.

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