scholarly journals Structural adaptation in the density model

2021 ◽  
Vol 3 (3) ◽  
pp. 345-386
Author(s):  
Oleg V. Lepski ◽  
Gilles Rebelles
Author(s):  
Igor Tkach ◽  
Ulf Diederichsen ◽  
Marina Bennati

AbstractElectron paramagnetic resonance (EPR)-based pulsed dipolar spectroscopy measures the dipolar interaction between paramagnetic centers that are separated by distances in the range of about 1.5–10 nm. Its application to transmembrane (TM) peptides in combination with modern spin labelling techniques provides a valuable tool to study peptide-to-lipid interactions at a molecular level, which permits access to key parameters characterizing the structural adaptation of model peptides incorporated in natural membranes. In this mini-review, we summarize our approach for distance and orientation measurements in lipid environment using novel semi-rigid TOPP [4-(3,3,5,5-tetramethyl-2,6-dioxo-4-oxylpiperazin-1-yl)-L-phenylglycine] labels specifically designed for incorporation in TM peptides. TOPP labels can report single peak distance distributions with sub-angstrom resolution, thus offering new capabilities for a variety of TM peptide investigations, such as monitoring of various helix conformations or measuring of tilt angles in membranes. Graphical Abstract


2021 ◽  
Author(s):  
Daniel R Weimer ◽  
W. Kent Tobiska ◽  
Piyush M Mehta ◽  
Richard Joseph Licata ◽  
Douglas Drob

2010 ◽  
Vol 28 (3) ◽  
pp. 271-286 ◽  
Author(s):  
I. Shafer ◽  
R. Nancollas ◽  
M. Boes ◽  
A. L. Sieminski ◽  
J. B. Geddes

Author(s):  
Lina Fu ◽  
Jie Fang ◽  
Yunjie Lyu ◽  
Huahui Xie

Freeway control has been increasingly used as an innovative approach to ease traffic congestion, improve traffic safety and reduce exhaust emissions. As an important predictive model involved in freeway control, the predictive performance of METANET greatly influences the effect of freeway control. This paper focuses on modifying the METANET model by modeling the critical density. Firstly, the critical density model is deduced based on the catastrophe theory. Then, the perturbation wave and traveling wave that are obtained using the macro and micro data, respectively, have been developed to modify the above proposed critical density model. Finally, the numerical simulation is established to evaluate the effectiveness of the modified METANET model based on the field data from the realistic motorway network. The results show that overall, the predicted data from the modified METANET model are closer to the field data than those obtained from the original model.


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