High prevalence of proteinuric nephropathy in Type 2 diabetes: Album, a community-based general practitioners screening study in French overseas territories

2014 ◽  
Vol S1 (01) ◽  
Author(s):  
Xavier Debussche
Keyword(s):  
Type 2 Diabetes ◽  
General Practitioners ◽  
Community Based ◽  
High Prevalence ◽  
Screening Study ◽  
French Overseas Territories ◽  
Overseas Territories

scholarly journals High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes

Diabetologia ◽  
2012 ◽  
Vol 55 (8) ◽  
pp. 2154-2162 ◽  
Author(s):  
L. J. M. Boonman-de Winter ◽  
F. H. Rutten ◽  
M. J. M. Cramer ◽  
M. J. Landman ◽  
A. H. Liem ◽  
...  
Keyword(s):  
Heart Failure ◽  
Type 2 Diabetes ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
High Prevalence

scholarly journals A Community-Based, Culturally Tailored Behavioral Intervention for Korean Americans With Type 2 Diabetes

2009 ◽  
Vol 35 (6) ◽  
pp. 986-994 ◽  
Author(s):  
Miyong T. Kim ◽  
Hae-Ra Han ◽  
Hee-Jung Song ◽  
Jong-Eun Lee ◽  
Jiyun Kim ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Behavioral Intervention ◽  
Korean Americans ◽  
Community Based ◽  
Culturally Tailored

The management of Type 2 diabetes: A survey of Australian general practitioners

2012 ◽  
Vol 95 (3) ◽  
pp. 326-332 ◽  
Author(s):  
M. Jiwa ◽  
X. Meng ◽  
D. Sriram ◽  
J. Hughes ◽  
S. Colagiuri ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
General Practitioners

scholarly journals Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees

2017 ◽  
Vol 115 (2) ◽  
pp. 379-384 ◽  
Author(s):  
Goo Jun ◽  
Alisa Manning ◽  
Marcio Almeida ◽  
Matthew Zawistowski ◽  
Andrew R. Wood ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mexican American ◽  
Complex Disease ◽  
Rare Variants ◽  
Whole Genome Analysis ◽  
Mexican American Families ◽  
Extended Pedigrees ◽  
High Prevalence ◽  
Study Designs

A major challenge in evaluating the contribution of rare variants to complex disease is identifying enough copies of the rare alleles to permit informative statistical analysis. To investigate the contribution of rare variants to the risk of type 2 diabetes (T2D) and related traits, we performed deep whole-genome analysis of 1,034 members of 20 large Mexican-American families with high prevalence of T2D. If rare variants of large effect accounted for much of the diabetes risk in these families, our experiment was powered to detect association. Using gene expression data on 21,677 transcripts for 643 pedigree members, we identified evidence for large-effect rare-variant cis-expression quantitative trait loci that could not be detected in population studies, validating our approach. However, we did not identify any rare variants of large effect associated with T2D, or the related traits of fasting glucose and insulin, suggesting that large-effect rare variants account for only a modest fraction of the genetic risk of these traits in this sample of families. Reliable identification of large-effect rare variants will require larger samples of extended pedigrees or different study designs that further enrich for such variants.

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