Encountering parents of a sick newborn child

SummarySerial quantitative immunoelectrophoretic (IE) measurements of antithrombin III heparin cofactor (AT III) were made in groups of well and sick newborn infants classified by gestational age. Collection methods (venous vs. capillary) did not influence the results; serum IE measurements were comparable to AT III activity by a clotting method. AT III is gestational age-dependent, increasing from 28.7% of normal adult values at 28-32 weeks to 50.9% at 37-40 weeks, and shows a gradual increase to term infant levels (57.4%) by 3-4 weeks of age. Infants with the respiratory distress syndrome (RDS) show lower levels of AT III in the 33-36 week group, 22% vs. 44% and in the 37-40 week group, 33.6% vs. 50.9%, than prematures without RDS. Infants of 28-32 week gestational age had only slight differences, RDS = 24%, non-RDS = 28.7%. The lowest levels of AT III were seen in patients with RDS complicated by disseminated intravascular coagulation and those with necrotizing enterocolitis. Crossed IE on representative infants displayed a consistent pattern which was identical to adult controls except for appropriate decreases in the amplitude of the peaks. The thrombotic complications seen in the sick preterm infant may be related to the low levels of AT III.

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Severe Homozygous Protein C Deficiency: Identification of a Splice Site Missense Mutation (184, Q → H) in Exon 7 of the Protein C Gene

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648812 ◽

1994 ◽

Vol 72 (01) ◽

pp. 065-069 ◽

Cited By ~ 2

Author(s):

J M Soria ◽

D Brito ◽

J Barceló ◽

J Fontcuberta ◽

L Botero ◽

...

Keyword(s):

Missense Mutation ◽

Gene Product ◽

Splice Site ◽

Protein C ◽

Purpura Fulminans ◽

Single Strand Conformation Polymorphism ◽

Donor Splice Site ◽

Protein C Deficiency ◽

Donor Splice ◽

Newborn Child

SummarySingle strand conformation polymorphism (SSCP) analysis of exon 7 of the protein C gene has identified a novel splice site missense mutation (184, Q → H), in a newborn child with purpura fulminans and undetectable protein C levels. The mutation, seen in the homozygous state in the child and in the heterozygous state in her mother, was characterized and found to be a G to C nucleotide substitution at the -1 position of the donor splice site of intron 7 of the protein C gene, which changes histidine 184 for glutamine (184, Q → H). According to analysis of the normal and mutated sequences, this mutation should also abolish the function of the donor splice site of intron 7 of the protein C gene. Since such a mutation is compatible with the absence of gene product in plasma and since DNA sequencing of all protein C gene exons in this patient did not reveal any other mutation, we postulate that mutation 184, Q → H results in the absence of protein C gene product in plasma, which could be the cause of the severe phenotype observed in this patient.

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EFFICACY OF A NOVEL DEVICE TO DETECT, ALERT AND RESOLVE NEONATAL APNEA - PILOT STUDY

Innovative Journal of Medical and Health Science ◽

10.15520/ijmhs.v9i9.2644 ◽

2019 ◽

Vol 9 (9) ◽

pp. 608-613

Author(s):

Dr. Swapna Lingaldinna,Dr. Himabindu Singh,Mona Sharma*

Keyword(s):

Newborn Care ◽

Standard Of Care ◽

The Novel ◽

Tertiary Referral ◽

Tertiary Referral Hospital ◽

Care Community ◽

Novel Device ◽

Sick Newborn ◽

Central Apneas ◽

Neonatal Apnea

Objective: To measure the accuracy of a novel device in detecting Bradycardia andDesaturation (B&D) events and to determine its efficacy in resolving apneas innewborns with comparison to standard monitor (which only detects B&D eventsand alerts).Design: This was a prospective observational study.Setting: Sick Newborn Care Unit of a large tertiary referral hospital in Hyderabad,India.Methods: 31 newborns were provided with a novel device, which monitored oxygensaturation and pulse rate and alarmed when values dropped below a set thresholdwhich is referred as an event, henceforth. The novel device also provided footstimulation in response to above-mentioned events. When the monitor alarmed, anurse attended to the baby to confirm whether the baby was breathing and whetherthe event had been resolved by the device. If the event had not resolved, appropriateaction as per the standard-of-care was performed.Results: The novel device “ApneBootTM” positively detected B&D events 94.03% oftimes as compared to the standard reference monitor. 56 of 67 observed B&D eventswere visually confirmed to be apneas, indicating that 83.6% of B&D eventscoincided with apneas. Of the 56 apneic events, 50 were central apneas, of which 35were resolved by the novel device, making the device’s efficacy of apnea resolution70%.Conclusion: The results of the study indicate that this novel device “ApneBootTM”is very effective in detecting and alarming B&D events, which coincides with theapnea, and resolving it by providing foot stimulation.Keywords: Novel Device, Neonatal Apnea, Low Birth Weight, Body Temperature,Kangaroo Mother Care, Community Health,

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Mapping the evidence on social, behavioural and community engagement for reproductive, maternal, newborn, child and adolescent health

10.23846/b/egm/20174 ◽

2017 ◽

Cited By ~ 1

Keyword(s):

Community Engagement ◽

Adolescent Health ◽

Child And Adolescent ◽

Child And Adolescent Health ◽

Newborn Child

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CLINICAL AND PARA-CLINICAL CHARACTERISTICS OF SICK NEWBORN BABIES TREATED AT PEDIATRIC DEPARTMENT OF HUE UNIVERSITY HOSPITAL

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2011.2.15 ◽

2011 ◽

pp. 112-117

Author(s):

Thi Kieu Nhi Nguyen

Keyword(s):

Respiratory Distress ◽

Congenital Malformation ◽

Clinical Characteristics ◽

Descriptive Study ◽

Neonatal Unit ◽

University Hospital ◽

Pediatric Department ◽

Sick Newborn ◽

Observational Descriptive Study

Objectives: 1. Describe neonatal classification of WHO. 2. Identify some principal clinical and paraclinical signs of term, preterm, post term babies. Patients and method: an observational descriptive study of 233 newborns hospitalized in neonatal unit at Hue university‘ s hospital was done during 12 months from 01/01/2009 to 31/12/2009 for describing neonatal classification and identifying principal clinical and paraclinical signs. Results: Premature (16.74%); Term babies (45.5%); Post term (37.76%); Premature: asphyxia (43.59%), hypothermia (25.64%), vomit (30.77%), jaundice (61.54%), congenital malformation (17.95%); CRP > 10mg/l (53.85%); anemia Hb < 15g/dl (12.82%). Term babies: poor feeding (21.7%); fever (24.53%); CRP > 10mg/l (53.77%); Hyperleucocytes/ Leucopenia (35.85%). Post term: respiratory distress (34%); lethargy (29.55%); vomit (26.14%); polycuthemia (1.14%); hypoglycemia (22.73%). Conclusion: each of neonatal type classified by WHO presente different clinical and paraclinical. Signs. The purpose of this research is to help to treat neonatal pathology more effectively.

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Factors Influencing Utilisation of Maternal Healthcare Services: Womens Perception

Social Work Chronicle ◽

10.21863/swc/2015.4.1and2.005 ◽

2015 ◽

Vol 4 (1and2) ◽

Author(s):

Gyanvati

Keyword(s):

Healthcare Services ◽

Maternal Healthcare ◽

Factors Affecting ◽

Factors Influencing ◽

Economic Background ◽

Newborn Child

This paper analyses the factors affecting for utilization of maternal healthcare services. Following is the section wise description of the paper. Firstly, the paper looks into socio-economic background of women. Secondly, the paper focuses on usage of maternal healthcare services by women. Thirdly, the paper also traces the factors affecting for usage of maternal healthcare services. Lastly, the paper concludes and suggests by emphasizing the significance of proper utilization of maternal healthcare services that it leads to better health of mother and their newborn child.

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The Newborn Child.

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1973.tb110737.x ◽

1973 ◽

Vol 1 (17) ◽

pp. 859-860

Keyword(s):

Newborn Child

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Should COVID-19 Mother Breastfeed her Newborn Child? A Literature Review on the Safety of Breastfeeding for Pregnant Women with COVID-19

Current Nutrition Reports ◽

10.1007/s13668-020-00343-z ◽

2021 ◽

Author(s):

Harshil Bhatt

Keyword(s):

Direct Contact ◽

Preventive Measures ◽

Case Reports ◽

Healthcare Providers ◽

Case Series ◽

Limited Evidence ◽

Her Family ◽

Viral Antibodies ◽

Newborn Child ◽

Droplet Transmission

Abstract Purpose of Review Breastfeeding is beneficial to both the newborn and the mother. During the COVID-19 pandemic, concerns have been raised on whether the SARS-CoV-2 virus could be transmitted from COVID-19 positive mother to the newborn through breastmilk. The purpose of this review is to examine the available evidence on the risks of transmission of infection from COVID-19 mothers to their newborns through breastfeeding. Recent Findings Data is very limited in this regard, with only a few smaller case series, and case reports have been published so far. In most of the studies, breastmilk samples from COVID-19 mothers tested negative for the virus. In the case reports where the virus was detected in breastmilk and the infants were diagnosed with COVID-19, it remained unclear whether the disease was transmitted through breastmilk or direct contact or through delivery. Another hypothesis is that the viral antibodies could pass to the newborn passively through breastmilk of COVID-19 positive mothers and give immunity to the child, but data is minimal. Summary Based on the currently available limited evidence and recognizing the benefits of breastfeeding, it may be concluded that if the health of the mother and her newborn allows, direct breastfeeding or extracted breastmilk should be encouraged by the healthcare providers after a careful discussion of the risks of vertical transmission to the mother and her family. Preventive measures should be taken by COVID-19 mothers to prevent droplet transmission of infection to the infants while breastfeeding.

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