scholarly journals Hematological and Biochemical Profile of Sickle Cell Patients in Critical and Inter-Critical Periods in Brazzaville, Republic of Congo

2021 ◽  
Vol 11 (02) ◽  
pp. 57-65
Author(s):  
Edwige Paola Louanga Nanitelamio ◽  
Serge Oscar Mokono ◽  
Chaldam Jespère Mbani ◽  
Olivia Galiba Atipo-Tsiba ◽  
Fabien Roch Niama ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Biochemical Profile ◽  
Critical Periods ◽  
Republic Of Congo

scholarly journals Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Olivier Mukuku ◽  
Joseph K. Sungu ◽  
Augustin Mulangu Mutombo ◽  
Paul Makan Mawaw ◽  
Michel Ntetani Aloni ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Republic Of Congo ◽  
Copper Manganese

scholarly journals Improvement of SCD morbimortality in children: experience in a remote area of an African country

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Benoît Mukinayi Mbiya ◽  
Didier Kalenda Kalombo ◽  
Yannick Nkesu Mukendi ◽  
Valery Daubie ◽  
John Kalenda Mpoyi ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
African Country ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Public Health Problem ◽  
Cell Disease ◽  
Republic Of Congo ◽  
Reference Center

Abstract Background Sickle cell disease (SCD) is a public health problem in the Democratic Republic of Congo. While reference sickle cell centers have been implemented in capital cities of African countries and have proven to be beneficial for SCD patients. In the Democratic Republic of Congo, they have never been set up in remote areas for families with low or very low sources of income. Method A cohort of 143 children with SCD aged 10 years old (IQR (interquartile range): 6–15 years) (sex ratio male/female = 1.3) were clinically followed for 12 months without any specific intervention aside from the management of acute events, and then for 12 months with a monthly medical visit, biological follow-up, and chemoprophylaxis (folic acid/penicillin), adequate fluids and malaria prevention. Results The median age of patients at the diagnosis of SCD was 2 years (IQR: 1–5). The implementation of standardized and regular follow-ups in a new sickle cell reference center in a remote city showed an increase in the annual mean hemoglobin level from 50 to 70 g/L (p = 0.001), and a decrease in the lymphocyte count and spleen size (p < 0.001). A significant decrease (p < 0.001) in the average annual number of hospitalizations and episodes of vaso-occlusive crises, blood transfusions, infections, and acute chest syndromes were also observed. Conclusions The creation of a sickle cell reference center and the regular follow-up of children with sickle cell disease are possible and applicable in the context of a remote city of an African country and represent simple and accessible measures that can reduce the morbimortality of children with sickle cell disease.

Barriers to healthcare for sickle cell disease patients in the Democratic Republic of Congo

2017 ◽  
Vol 1 (1) ◽  
pp. 3-9
Author(s):  
Salomon Agasa Batina ◽  
◽  
Paul Kombi Kambale ◽  
Marcel Poyo Sabiti ◽  
Charles Tshilumba Kayembe ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Cell Disease ◽  
Republic Of Congo ◽  
Barriers To Healthcare

scholarly journals Seroprevalence Virus in Human Immunodeficiency Sickle Cell Anemia Duffy-46C/C in Democratic Republic of Congo—Case of the City of Kinshasa and Lubumbashi

OALib ◽  
2017 ◽  
Vol 04 (07) ◽  
pp. 1-7
Author(s):  
P. Lungu Anzwal ◽  
A. Kambote Kalumba ◽  
J. Kasali Mwamba ◽  
Saragosti S. Sentob ◽  
H. Situakibanza Nani Tuma ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Republic Of Congo ◽  
The City

scholarly journals Acute crises and complications of sickle cell anemia among patients attending a pediatric tertiary unit in Kinshasa, Democratic Republic of Congo

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Michel Ntetani Aloni ◽  
Bertin Tshimanga Kadima ◽  
Pépé Mfutu Ekulu ◽  
Aléine Nzazi Budiongo ◽  
René Makuala Ngiyulu ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Health Care Policy ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Delayed Diagnosis ◽  
Clinical Manifestations ◽  
Severe Infection ◽  
University Hospital ◽  
Republic Of Congo

In the Democratic Republic of Congo, the incidence of sickle cell anemia (SCA) is estimated to affect 30,000 to 40,000 neonates per year. However, there is paucity of data on acute clinical manifestations in sickle cell children. In these circumstances, it is difficult to develop a health care policy for an adequate management of sickle cell patients. This was a seven years’ retrospective study of children admitted with acute sickle cell crisis in the Department of Pediatrics in University Hospital of Kinshasa, Kinshasa, the Democratic Republic of Congo. A total of 108 patients were identified as having SCA. There were 56 (51%) girls and 52 (49%) boys. Median age was 10.5 years (range 1-24 years). No child was diagnosed by neonatal screening. The median age of diagnosis of sickle cell anemia was 90 months (range: 8-250 months). The median age at the first transfusion was 36 months (range 4-168). In this series, 61 (56.5%) patients were eligible for hydroxyurea. However, this treatment was only performed in 4 (6.6%) of them. Pain episodes, acute anemic crisis and severe infection represent respectively 38.2%, 34.3% and 21.9% of events. Altered sensorium and focal deficit were encountered occasionally and represented 3.4% of acute events. Acute renal manifestations, cholelithiasis and priapism were rarely reported, in this cohort. In Kinshasa, the care of patients suffering from sickle cell anemia is characterized by the delayed diagnosis and low detection of organ complications compared to reports of Western countries. This situation is due to resources deficiencies.

scholarly journals Establishing a national sickle cell disease program in the Republic of Congo

2018 ◽  
Vol 2 (Supplement_1) ◽  
pp. 17-18
Author(s):  
Alexis Elira Dokekias ◽  
Lydie Ngolet ◽  
Juan Salomon-Andonie ◽  
Sergei Nekhai ◽  
James G. Taylor
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Republic Of Congo ◽  
The Republic
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