scholarly journals Inhibitory Effects of Several Fluoroquinolones on Feline CYP1A and 3A in Hepatic Microsomes

2020 ◽  
Vol 10 (12) ◽  
pp. 219-237
Author(s):  
Syed Sher Shah Sadaat ◽  
Nasrin Stankzi ◽  
Mohammad Monir Tawfeeq ◽  
Farid Ahmad Tanin ◽  
Amanullah Aziz ◽  
...  
Keyword(s):  
Inhibitory Effects ◽  
Hepatic Microsomes

Inhibitory Effects of Propofol on Cytochrome P450 Activities in Rat Hepatic Microsomes

1993 ◽  
Vol 76 (4) ◽  
pp. 817???821 ◽  
Author(s):  
Max T. Baker ◽  
Maria V. Chadam ◽  
William C. Ronnenberg
Keyword(s):  
Cytochrome P450 ◽  
Inhibitory Effects ◽  
Hepatic Microsomes

Inhibitory effects of bioaccessible anthocyanins and procyanidins from apple, red grape, cinnamon on α-amylase, α-glucosidase and lipase

2020 ◽  
pp. 1-9
Author(s):  
Pınar Ercan ◽  
Sedef Nehir El
Keyword(s):  
Inhibitory Activity ◽  
Digestive Enzymes ◽  
Positive Control ◽  
Anthocyanin Content ◽  
Inhibitory Effects ◽  
Total Anthocyanin ◽  
Total Anthocyanin Content ◽  
Before And After ◽  
Red Grape

Abstract. The goals of this study were to determine and evaluate the bioaccessibility of total anthocyanin and procyanidin in apple (Amasya, Malus communis), red grape (Papazkarası, Vitis vinifera) and cinnamon (Cassia, Cinnamomum) using an in vitro static digestion system based on human gastrointestinal physiologically relevant conditions. Also, in vitro inhibitory effects of these foods on lipid (lipase) and carbohydrate digestive enzymes (α-amylase and α-glucosidase) were performed with before and after digested samples using acarbose and methylumbelliferyl oleate (4MUO) as the positive control. While the highest total anthocyanin content was found in red grape (164 ± 2.51 mg/100 g), the highest procyanidin content was found in cinnamon (6432 ± 177.31 mg/100 g) (p < 0.05). The anthocyanin bioaccessibilities were found as 10.2 ± 1%, 8.23 ± 0.64%, and 8.73 ± 0.70% in apple, red grape, and cinnamon, respectively. The procyanidin bioaccessibilities of apple, red grape, and cinnamon were found as 17.57 ± 0.71%, 14.08 ± 0.74% and 18.75 ± 1.49%, respectively. The analyzed apple, red grape and cinnamon showed the inhibitory activity against α-glucosidase (IC50 544 ± 21.94, 445 ± 15.67, 1592 ± 17.58 μg/mL, respectively), α-amylase (IC50 38.4 ± 7.26, 56.1 ± 3.60, 3.54 ± 0.86 μg/mL, respectively), and lipase (IC50 52.7 ± 2.05, 581 ± 54.14, 49.6 ± 2.72 μg/mL), respectively. According to our results apple, red grape and cinnamon have potential to inhibit of lipase, α-amylase and α-glucosidase digestive enzymes.

Inhibitory Effects of Transposed Letter Neighbours During Silent Sentence Reading

2014 ◽  
Author(s):  
Ascension Pagan ◽  
Hazel Blythe ◽  
Kevin Paterson ◽  
Simon Liversedge
Keyword(s):  
Inhibitory Effects ◽  
Sentence Reading
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