scholarly journals Promoter identification and analysis of key glycosphingolipid biosynthesis-globo series pathway genes in piglets

2017 ◽  
Vol 16 (2) ◽  
Author(s):  
W.Y. Qin ◽  
L.N. Gan ◽  
R.W. Xia ◽  
W.H. Dong ◽  
S.Y. Sun ◽  
...  
Keyword(s):  
Globo Series ◽  
Glycosphingolipid Biosynthesis

Expression of key glycosphingolipid biosynthesis-globo series pathway genes inEscherichia coliF18-resistant andEscherichia coliF18-sensitive piglets

2016 ◽  
Vol 47 (4) ◽  
pp. 428-435 ◽  
Author(s):  
W. H. Dong ◽  
C. H. Dai ◽  
L. Sun ◽  
J. Wang ◽  
S. Y. Sun ◽  
...  
Keyword(s):  
Globo Series ◽  
Glycosphingolipid Biosynthesis

scholarly journals Different miRNA Profiles in Plasma Derived Small and Large Extracellular Vesicles from Patients with Neurodegenerative Diseases

2021 ◽  
Vol 22 (5) ◽  
pp. 2737
Author(s):  
Daisy Sproviero ◽  
Stella Gagliardi ◽  
Susanna Zucca ◽  
Maddalena Arigoni ◽  
Marta Giannini ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Extracellular Vesicles ◽  
Small Rnas ◽  
Biomarker Discovery ◽  
Toll Like Receptor ◽  
Neurotrophin Signaling ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing ◽  
Lateral Sclerosis ◽  
Glycosphingolipid Biosynthesis

Identifying biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are extracellular vesicles (EVs) of different sizes and biological functions transported in blood and they may be valid biomarkers for NDs. The aim of our study was to investigate common and different miRNA signatures in plasma derived LEVs and SEVs of Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic Lateral Sclerosis (ALS) and Fronto-Temporal Dementia (FTD) patients. LEVs and SEVs were isolated from plasma of patients and healthy volunteers (CTR) by filtration and differential centrifugation and RNA was extracted. Small RNAs libraries were carried out by Next Generation Sequencing (NGS). MiRNAs discriminate all NDs diseases from CTRs and they can provide a signature for each NDs. Common enriched pathways for SEVs were instead linked to ubiquitin mediated proteolysis and Toll-like receptor signaling pathways and for LEVs to neurotrophin signaling and Glycosphingolipid biosynthesis pathway. LEVs and SEVs are involved in different pathways and this might give a specificity to their role in the spreading of the disease. The study of common and different miRNAs transported by LEVs and SEVs can be of great interest for biomarker discovery and for pathogenesis studies in neurodegeneration.

scholarly journals Regulation of membrane-bound enzymes of glycosphingolipid biosynthesis

1984 ◽  
Vol 25 (13) ◽  
pp. 1541-1547
Author(s):  
J D Burczak ◽  
R M Soltysiak ◽  
C C Sweeley
Keyword(s):  
Membrane Bound ◽  
Membrane Bound Enzymes ◽  
Glycosphingolipid Biosynthesis

scholarly journals Accumulation of Unique Globo-series Glycolipids in PC 12h Pheochromocytoma Cells

1989 ◽  
Vol 264 (3) ◽  
pp. 1516-1521
Author(s):  
T Ariga ◽  
M Suzuki ◽  
R K Yu ◽  
Y Kuroda ◽  
I Shimada ◽  
...  
Keyword(s):  
Pheochromocytoma Cells ◽  
Globo Series

ChemInform Abstract: Inhibitors of Glycosphingolipid Biosynthesis

ChemInform ◽  
2010 ◽  
Vol 28 (25) ◽  
pp. no-no
Author(s):  
T. KOLTER ◽  
K. SANDHOFF
Keyword(s):  
Glycosphingolipid Biosynthesis

Chemoenzymatic Synthesis of DSGb5 and Sialylated Globo‐series Glycans

2019 ◽  
Vol 58 (33) ◽  
pp. 11273-11278 ◽  
Author(s):  
Pei‐Jhen Li ◽  
Szu‐Yu Huang ◽  
Pei‐Yun Chiang ◽  
Chen‐Yo Fan ◽  
Li‐Jhen Guo ◽  
...  
Keyword(s):  
Chemoenzymatic Synthesis ◽  
Globo Series

scholarly journals Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the β-Amyloid Precursor Protein and Amyloid β-Peptide

2005 ◽  
Vol 280 (30) ◽  
pp. 28110-28117 ◽  
Author(s):  
Irfan Y. Tamboli ◽  
Kai Prager ◽  
Esther Barth ◽  
Michael Heneka ◽  
Konrad Sandhoff ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Amyloid Β Peptide ◽  
Β Amyloid ◽  
Glycosphingolipid Biosynthesis
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