scholarly journals Non-communicable respiratory disease in Malawi: a systematic review and meta-analysis

2020 ◽  
Vol 32 (2) ◽  
pp. 64-73
Author(s):  
Rebecca Nightingale
Keyword(s):  
Systematic Review ◽  
Respiratory Disease ◽  
Meta Analysis ◽  
Airflow Obstruction ◽  
Secondary Data ◽  
Chronic Respiratory Disease ◽  
African Countries ◽  
History Of ◽  
Sub Saharan ◽  
The Life Course

BackgroundNon-communicable respiratory diseases are important contributors to morbidity and mortality in sub-Saharan African countries such as Malawi. AimTo conduct a systematic review of the available literature relating to chronic respiratory disease in Malawi. MethodsWe conducted a systematic protocol-driven literature search of key scientific databases including Scopus and Medline. Papers were independently assessed for eligibility by two authors and included if they reported objective measures (including self-reported standard symptoms) of chronic respiratory disease and were conducted in Malawi. A meta-analysis of available estimates was then conducted. We re-analysed data from three of these studies in a secondary data analysis to allow for between-study comparisons. ResultsOur search identified 393 papers of which 17 (5 involving children and 12 involving adults) met the inclusion criteria. Wheeze was the symptom most frequently reported in children in the community (12.1%), hospital (11.2%) and HIV clinic (8.1%) settings. Cough was the symptom most frequently reported by adults in the community (3–18%). Spirometric abnormalities varied substantially between studies. For example, in adults, airflow obstruction varied between 2.3% and 20% and low forced vital capacity (FVC) varied between 2.7% and 52.8%. ConclusionWe identified a high burden of chronic respiratory symptoms and abnormal spirometry (particularly low FVC) within paediatric and adult populations in Malawi. The estimates for country-wide burden related to this disease were limited by the heterogeneity of the methods used to assess symptoms and spirometry. There is an urgent need to develop a better understanding of the determinants and natural history of non-communicable respiratory disease across the life-course in Malawi.

scholarly journals Effects of exercise training on physical and psychosocial health in children with chronic respiratory disease: a systematic review and meta-analysis

2018 ◽  
Vol 4 (1) ◽  
pp. e000409 ◽  
Author(s):  
Barbara Joschtel ◽  
Sjaan R Gomersall ◽  
Sean Tweedy ◽  
Helen Petsky ◽  
Anne B Chang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lung Function ◽  
Exercise Training ◽  
Respiratory Disease ◽  
Effect Size ◽  
Meta Analysis ◽  
Chronic Respiratory Disease ◽  
Cardiovascular Fitness ◽  
Standard Mean Difference ◽  
Children With Asthma

IntroductionChronic disease in children is increasing, including the prevalence of chronic respiratory diseases such as asthma, cystic fibrosis (CF), bronchiectasis and bronchopulmonary dysplasia (BPD). The aim of this systematic review and meta-analysis was to evaluate the effects of exercise training on health outcomes in children with chronic respiratory disease.MethodFive databases were searched for randomised controlled trials investigating the effects of exercise training on children with chronic respiratory disease. Following the PRISMA guidelines, eligible studies were identified and data were extracted. A meta-analysis was conducted for the outcomes cardiovascular fitness, lung function and quality of life (QoL).ResultsThe initial search returned 3688 papers. Twenty-seven (17 in children with asthma, 10 in children with CF) were included in the systematic review and 24 of these were included in the meta-analysis. No studies were identified in children with bronchiectasis or BPD. Included papers had a total of 1009 participants aged 8–20 years. In addition to cardiovascular fitness, lung function and QoL, studies also assessed pulmonary function, respiratory muscle strength, muscular strength and inflammation. Meta-analysis showed a large significant effect size in favour of exercise for cardiovascular fitness (peak VO2) (standard mean difference (SMD)=1.16, 95%  CI 0.61 to 1.70) and QoL (SMD=1.27, 95% CI 0.72 to 1.82) as well as a small, non-significant effect size for lung function (FEV1) (SMD=0.02, 95% CI -0.38 to 0.42).ConclusionExercise training significantly improves cardiovascular fitness and QoL in children with asthma and CF. Further research is needed, particularly in children with bronchiectasis and BPD.

scholarly journals Metabolic syndrome among type 2 diabetic patients in Sub-Saharan African countries: A systematic review and meta-analysis

2020 ◽  
Vol 14 (5) ◽  
pp. 1403-1411 ◽  
Author(s):  
Wondimeneh Shibabaw Shiferaw ◽  
Tadesse Yirga Akalu ◽  
Mihretie Gedefaw ◽  
Denis Anthony ◽  
Ayelign Mengesha Kassie ◽  
...  
Keyword(s):  
Systematic Review ◽  
Metabolic Syndrome ◽  
Meta Analysis ◽  
Diabetic Patients ◽  
African Countries ◽  
Type 2 Diabetic Patients ◽  
Sub Saharan ◽  
Type 2 Diabetic

scholarly journals Pooled molecular occurrence of Mycoplasma gallisepticum and Mycoplasma synoviae in poultry: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Miguel Angel Chaidez-Ibarra ◽  
Diana Zuleika Velazquez ◽  
Idalia Enriquez-Verdugo ◽  
Nohemi Castro del Campo ◽  
Miguel Angel Rodriguez-Gaxiola ◽  
...  
Keyword(s):  
Systematic Review ◽  
Molecular Detection ◽  
Meta Analysis ◽  
Ambient Air ◽  
Mycoplasma Gallisepticum ◽  
Chronic Respiratory Disease ◽  
Control Measures ◽  
Sub Saharan Africa ◽  
Ambient Air Pollution ◽  
Sub Saharan

Worldwide, Mycoplasma gallisepticum (MG) and M. synoviae (MS) are the main agents responsible for chronic respiratory disease in poultry. Therefore, we conducted a systematic review and meta-analysis to estimate their occurrence. We searched electronic databases to find peer-reviewed publications reporting the molecular detection of MG and MS in poultry and used meta-analysis to estimate their pooled occurrence (combined flock and individual), aggregating results at the regional and national levels. We performed a subgroup meta-analysis for subpopulations (broilers, layers, breeders, and diverse poultry including turkeys, ducks, and ostriches) and used meta-regression with categorical modifiers. We retrieved 2,294 publications from six electronic databases and included 85 publications from 33 countries that reported 62 studies with 22,162 samples for MG and 48 studies with 26,413 samples for MS. The pooled occurrence was 38.4% (95% CI: 23.5-54.5) for MS and 27.0% (20.4-34.2) for MG. Among regions, Europe and Central Asia had the lowest occurrence for both pathogens, while MG and MS were highly prevalent in South Asia and sub-Saharan Africa, respectively. MG occurrence was higher in Algeria, Saudi Arabia, and Sudan, whereas China, Egypt, and Ethiopia reported a higher occurrence of MS. MS and MG were more prevalent in the breeders and layers (62.6% and 31.2%, respectively) than in diverse poultry. The year of publication, the sample size, and the level of ambient air pollution (measured indirectly by PM2.5) were associated with the occurrence of both mycoplasmas. Our study revealed a high and heterogeneous occurrence of MG and MS and justifies the need for an early detection and improved control measures to reduce the spread of these pathogens.

scholarly journals Systematic review protocol examining sex differences in survival among low birthweight newborns and infants in sub-Saharan Africa

BMJ Open ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. e036645
Author(s):  
Akalewold T Gebremeskel ◽  
Arone W Fantaye ◽  
Lena E Faust ◽  
Sanni Yaya
Keyword(s):  
Systematic Review ◽  
Sex Differences ◽  
Low Birthweight ◽  
Data Extraction ◽  
Meta Analysis ◽  
Sub Saharan Africa ◽  
African Countries ◽  
Mortality And Morbidity ◽  
Qualitative And Quantitative ◽  
Sub Saharan

IntroductionIn sub-Saharan African countries, low birthweight (LBW) accounts for three-quarters of under-five mortality and morbidity. However, there is no systematic evidence of sex differences in LBW survival risk. The aim of this protocol is to outline the methodological process of a systematic review that will gather qualitative and quantitative data on sex differences in survival among LBW newborns and infants in sub-Saharan Africa.MethodsThis protocol adheres to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols reporting guidelines. We will conduct a systematic review to retrieve all qualitative and quantitative studies. Electronic search strategies are being finalised on 24 February 2020 for Ovid Medline and EMBASE, and on 28 February 2020 for CINAHL, Scopus and Global Health in collaboration with a Health Sciences librarian. The primary outcome of interest is indicating sex differences in survival among LBW newborns and infants. Secondary outcomes are sex-disaggregated differences in morbidity among LBW newborns and infants. Screening, data extraction and assessments of risk of bias will be performed independently. Narrative synthesis and a meta-analysis will be conducted with studies that are compatible based on population and outcome. The systematic review is focused on the analysis of secondary data and does not require ethics approval.Ethics and disseminationAs it will be a systematic review, without human participants’ involvement, there will be no requirement for ethical approval. The systematic review will present key evidence of sex-disaggregated differences in mortality and morbidity among LBW newborns and infants in sub-Saharan Africa. Programme managers, policy-makers and researchers can use the findings to evaluate LBW health outcomes in different sexes. The final manuscript will be disseminated through a peer-reviewed journal and scientific conferences.PROSPERO registration numberCRD42020163470

scholarly journals Perinatal mortality and its determinants in Sub Saharan African countries: systematic review and meta-analysis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Dawit Tiruneh ◽  
Nega Assefa ◽  
Bezatu Mengiste
Keyword(s):  
Systematic Review ◽  
Perinatal Mortality ◽  
English Language ◽  
Meta Analysis ◽  
Random Effect ◽  
Rank Correlation ◽  
Preterm Births ◽  
Point Estimate ◽  
African Countries ◽  
Sub Saharan

Abstract Background Despite decreasing overall perinatal and maternal mortality in high-income countries, perinatal and maternal health inequalities are persisting in Sub Saharan African countries. Therefore, this study aimed to determine the effects size of rates and determinants for perinatal mortality in Sub-Saharan countries. Method The sources for electronic datasets were PubMed, Medline, EMBASE, SCOPUS, Google, Google Scholar, and WHO data Library. Observational studies published in the English language from January 01, 2000, to May 30, 2019 were included. STROBE and JBI tools were used to include relevant articles for this review. We used a Comberehensive Meta-Analysis version 2 software for this analysis. The I2 and Q- statistic values were used to detect the level of heterogeneity. The Kendall’s without continuity correction, Begg and Mazumdar rank correlation and Egger’s linear regression tests were used to detect the existence of significant publication bias (P <  0.10). The effects size were expressed in the form of point estimate and odds ratio with 95% CI (P <  0.05) in the random effect analysis using the trim and fill method. Result Twenty-one articles were included in this review. However, only fourteen studies reported the perinatal mortality rate. Among 14 studies, the observed and adjusted PMR was found to be 58.35 and 42.95 respectively. The odds of perinatal mortality among mothers who had no ANC visits was 2.04 (CI: 1.67, 2.49, P <  0.0001) as compared to those who had at least one ANC visit. The odds of perinatal mortality among preterm babies was 4.42 (CI: 2.83, 6.88, P <  0.0001). In most cases, heterogeneity was not evident when subgroup analyses were assessed by region, study design, and setting. Only perinatal mortality (P <  0.0001), antenatal care (P <  0.046) and preterm births (P <  0.034) showed a relationship between the standardized effect sizes and standard errors of these effects. Conclusion In general, engaging in systematic review and meta-analysis would potentially improve under-represented strategies and actions by informing policy makers and program implementers for minimizing the existing socioeconomic inequalities between regions and nations.

The Effect of Postpartum Depression on Infant Feeding Practice in Sub-Saharan African Countries: Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Demelash Woldeyohannes Handiso ◽  
Yohannes Tekalegn ◽  
Biniyam Sahiledengle ◽  
Dejene Ermias
Keyword(s):  
Systematic Review ◽  
Postpartum Depression ◽  
Infant Feeding ◽  
Meta Analysis ◽  
Infant Feeding Practice ◽  
Sufficient Evidence ◽  
Cochrane Library ◽  
Feeding Practice ◽  
African Countries ◽  
Sub Saharan

Abstract Background: Postpartum depression (PND) is a type of mood disorder that affects women after childbirth. Despite the detailed research related to these maternal and infant health outcomes, the relationship between postpartum depression and infant breastfeeding remains ambiguous. Hence, the aim of this study was to assess the effect of maternal postpartum depression on infant feeding practice in Sub-Saharan African Countries.Method: This systematic review and meta-analysis was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. PubMed, Google Scholar, Science Direct and Cochrane Library were systematically searched for relevant articles. STATA version 14 was used to calculate the pooled effect size with 95% confidence intervals (95% CI) of postpartum depression on infant feeding practice using the DerSimonian and Laird random effects meta-analysis. The heterogeneity and publication bias was assessed by using I2 test statistics and Egger’s test respectively.Result: Total of 1058 published and unpublished article were retrieved from different data bases. Finally four studies fulfilled the inclusion criteria for this systematic review and meta- analysis. This meta-analysis found that postpartum depression has no significant effect on the infant feeding practices (OR = 0.46, 95% CI: 0.18, 1.14).Conclusion: We did not find sufficient evidence to conclude the effect of postpartum depression on infant feeding practice. Thus, the investigators strongly recommend the researchers to conducted randomised control trail studies in Sub-Sahara African countries.

scholarly journals Risk Factors for Severe Illness and Death in COVID-19: A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Abraham Degarege ◽  
Zaeema Naveed ◽  
Josiane Kabayundo ◽  
David Brett-Major
Keyword(s):  
Systematic Review ◽  
Cardiovascular Diseases ◽  
Respiratory Disease ◽  
Meta Analysis ◽  
Chronic Respiratory Disease ◽  
Cerebrovascular Diseases ◽  
Cochrane Library ◽  
Severe Illness ◽  
Male Sex ◽  
The Impact

Abstract Objectives This systematic review and meta-analysis synthesized the evidence on the impact of demographics and comorbidities with clinical outcomes of COVID-19, including severe illness, admission to the intensive care unit (ICU), and death.MethodsThe PRISMA guidelines were followed to conduct and report this meta-analysis. The protocol is registered in PROSPERO International prospective register of systematic reviews (ID=CRD42020184440). Two authors independently searched literature from PubMed, Embase, Cochrane library and CINHAL on May 6, 2020; removed duplicates; screened titles, abstracts and full text using criteria; and extracted data from eligible articles. A random-effects model was used to estimate the summary odds ratio (OR). Variations among studies were examined using Cochrane Q and I2.ResultsOut of 4,275 articles obtained from the databases and screened, 71 studies that involved 216,843 patients were abstracted and then, where appropriate, analyzed by meta-analysis. The COVID-19 related outcomes reported were death in 26 studies, severe illness in 41 studies, and admission to ICU in 11 studies. Death was significantly correlated with hypertension (OR 2.60, 95% CI 1.95–3.25, I2 = 52.6%, n= 13 studies), cardiovascular disease (5.16, 4.10–6.22, 0.0%, 6), diabetes (2.11, 1.35–2.87, 67.4%, 12), chronic respiratory disease (2.83, 2.14–3.51, 0.0%, 9), cerebrovascular diseases (5.14, 1.08–9.19, 0.0%, 2), male sex (1.34, 1.18 – 1.50, 38.7%, 16), age older than 60 (6.09, 3.53 – 8.66, 95.5%, 6) or 65 years (3.56, 1.21 – 5.90, 18.2%, 6). Severe illness was also significantly associated with hypertension (1.70, 1.30 –2.10, 47.8%, 21), cardiovascular diseases (2.04, 1.01–3.08, 30.6%, 10), diabetes (1.65, 1.23–2.08, 24.9%, 18), male sex (1.35, 1.23 – 1.47, 0.0%, 32) and age at least 60 (4.91, 1.35 – 8.47, 0.0%, 4) or 65 (2.55,1.94 – 3.17, 24.5%, 9) years. Among hospitalized patients, the odds of admission to ICU was greater in individuals who had cardiovascular diseases (1.36,1.04–1.69, 0.0%, 4), diabetes (1.55, 1.20–1.90, 0.0%, 5) and chronic respiratory disease (1.52, 1.09–1.94, 0.0%, 5) than those who were not having these comorbidities. ConclusionsOlder age and chronic diseases increase the risk of developing severe illness, admission to ICU and death among COVID-19 patients. Special strategies are warranted to prevent SARS-CoV-2 infection and manage COVID-19 cases in those with vulnerabilities.

scholarly journals Risk factors for severe illness and death in COVID-19: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Abraham Degarege ◽  
Zaeema Naveed ◽  
Josiane Kabayundo ◽  
David Brett-Major
Keyword(s):  
Systematic Review ◽  
Cardiovascular Diseases ◽  
Respiratory Disease ◽  
Meta Analysis ◽  
Chronic Respiratory Disease ◽  
Cerebrovascular Diseases ◽  
Cochrane Library ◽  
Severe Illness ◽  
Male Sex ◽  
The Impact

AbstractObjectivesThis systematic review and meta-analysis synthesized the evidence on the impact of demographics and comorbidities with clinical outcomes of COVID-19, including severe illness, admission to the intensive care unit (ICU), and death.MethodsThe PRISMA guidelines were followed to conduct and report this meta-analysis. The protocol is registered in PROSPERO International prospective register of systematic reviews (ID=CRD42020184440). Two authors independently searched literature from PubMed, Embase, Cochrane library and CINHAL on May 6, 2020; removed duplicates; screened titles, abstracts and full text using criteria; and extracted data from eligible articles. A random-effects model was used to estimate the summary odds ratio (OR). Variations among studies were examined using Cochrane Q and I2.ResultsOut of 4,275 articles obtained from the databases and screened, 71 studies that involved 216,843 patients were abstracted and then, where appropriate, analyzed by meta-analysis. The COVID-19 related outcomes reported were death in 26 studies, severe illness in 41 studies, and admission to ICU in 11 studies. Death was significantly correlated with hypertension (OR 2.60, 95% CI 1.95–3.25, I2 = 52.6%, n= 13 studies), cardiovascular disease (5.16, 4.10–6.22, 0.0%, 6), diabetes (2.11, 1.35–2.87, 67.4%, 12), chronic respiratory disease (2.83, 2.14–3.51, 0.0%, 9), cerebrovascular diseases (5.14, 1.08–9.19, 0.0%, 2), male sex (1.34, 1.18 1.50, 38.7%, 16), age older than 60 (6.09, 3.53 8.66, 95.5%, 6) or 65 years (3.56, 1.21 5.90, 18.2%, 6). Severe illness was also significantly associated with hypertension (1.70, 1.30 –2.10, 47.8%, 21), cardiovascular diseases (2.04, 1.01–3.08, 30.6%, 10), diabetes (1.65, 1.23–2.08, 24.9%, 18), male sex (1.35, 1.23 1.47, 0.0%, 32) and age at least 60 (4.91, 1.35 8.47, 0.0%, 4) or 65 (2.55,1.94 3.17, 24.5%, 9) years. Among hospitalized patients, the odds of admission to ICU was greater in individuals who had cardiovascular diseases (1.36,1.04–1.69, 0.0%, 4), diabetes (1.55, 1.20–1.90, 0.0%, 5) and chronic respiratory disease (1.52, 1.09–1.94, 0.0%, 5) than those who were not having these comorbidities.ConclusionsOlder age and chronic diseases increase the risk of developing severe illness, admission to ICU and death among COVID-19 patients. Special strategies are warranted to prevent SARS-CoV-2 infection and manage COVID-19 cases in those with vulnerabilities.

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