Ocular Penetration Enhancers

2021 ◽  
pp. 281-307
Author(s):  
Thomas Wai-Yip Lee ◽  
Joseph R. Robinson
Keyword(s):  
Penetration Enhancers ◽  
Ocular Penetration

Ocular Penetration Enhancers

2003 ◽  
pp. 281-307 ◽  
Author(s):  
Thomas Wai-Yip Lee ◽  
Joseph Robinson
Keyword(s):  
Penetration Enhancers ◽  
Ocular Penetration

scholarly journals Penetration Enhancers for Topical Drug Delivery to the Ocular Posterior Segment—A Systematic Review

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 276
Author(s):  
Abhinav Thareja ◽  
Helen Hughes ◽  
Carmen Alvarez-Lorenzo ◽  
Jenni J. Hakkarainen ◽  
Zubair Ahmed
Keyword(s):  
Drug Delivery ◽  
Experimental Studies ◽  
Topical Administration ◽  
Cell Penetrating Peptides ◽  
Posterior Segment ◽  
Penetration Enhancer ◽  
Penetration Enhancers ◽  
Qualitative Synthesis ◽  
Ocular Penetration ◽  
Ovid Medline

There is an unmet clinical need for eye drop formulations to efficiently treat the diseases of the posterior ocular segment by non-invasive topical administration. Here, we systematically reviewed the literature on ocular penetration enhancers and their ability to transfer drugs to the posterior segment of the eye in experimental studies. Our aim was to assess which penetration enhancer is the most efficient at delivering drugs to the posterior segment of the eye, when topically applied. We conducted a comprehensive search in three electronic databases (Ovid Embase, Ovid MEDLINE, and PubMed) to identify all the relevant manuscripts reported on ocular penetration enhancers based on the PRISMA guidelines. We identified 6540 records from our primary database search and filtered them per our inclusion/exclusion criteria to select a final list of 14 articles for qualitative synthesis. Of these, 11 studies used cell penetrating peptides (CPPs), 2 used chitosan, and 1 used benzalkonium chloride (BAC) as the penetration enhancer. Cationic and amphipathic CPPs, transactivator of transcription (TAT), and penetratin can be inferred to be the best among all the identified penetration enhancers for drug delivery to the fundus oculi via topical eye drop instillation. Further high-quality experimental studies are required to ascertain their quantitative efficacy.

Status of Fatty Acids as Skin Penetration Enhancers-A Review

2009 ◽  
Vol 6 (3) ◽  
pp. 274-279 ◽  
Author(s):  
Ashu Mittal ◽  
U. Sara ◽  
Asgar Ali ◽  
Mohd. Aqil
Keyword(s):  
Fatty Acids ◽  
Skin Penetration ◽  
Penetration Enhancers
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