Blue Zone

2021 ◽  
pp. 1-17
Author(s):  
Michel Poulain ◽  
Anne Herm
Keyword(s):  
Blue Zone

Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics

2010 ◽  
Vol 113 (2) ◽  
pp. 240-248 ◽  
Author(s):  
Dali Yin ◽  
R. Mark Richardson ◽  
Massimo S. Fiandaca ◽  
John Bringas ◽  
John Forsayeth ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Nonhuman Primates ◽  
Target Volume ◽  
Convection Enhanced Delivery ◽  
Anatomical Structures ◽  
Green Zone ◽  
Optimal Target ◽  
Contrast Reagent ◽  
Cannula Placement ◽  
Blue Zone

Object The purpose of this study was to optimize stereotactic coordinates for delivery of therapeutic agents into the thalamus and brainstem, using convection-enhanced delivery (CED) to avoid leakage into surrounding anatomical structures while maximizing CED of therapeutics within the target volume. Methods The authors recently published targeting data for the nonhuman primate putamen in which they defined infusion parameters, referred to as “red,” “blue,” and “green” zones, that describe cannula placements resulting in poor, suboptimal, and optimal volumes of distribution, respectively. In the present study, the authors retrospectively analyzed 22 MR images with gadoteridol as a contrast reagent, which were obtained during CED infusions into the thalamus (14 cases) and brainstem (8 cases) of nonhuman primates. Results Excellent distribution of gadoteridol within the thalamus was obtained in 8 cases and these were used to define an optimal target locus (or green zone). Good distribution in the thalamus, with variable leakage into adjacent anatomical structures, was noted in 6 cases, defining a blue zone. Quantitative containment (99.7 ± 0.2%) of gadoteridol within the thalamus was obtained when the cannula was placed in the green zone, and less containment (85.4 ± 3.8%) was achieved with cannula placement in the blue zone. Similarly, a green zone was also defined in the brainstem, and quantitative containment of infused gadoteridol within the brainstem was 99.4 ± 0.6% when the cannula was placed in the green zone. These results were used to determine a set of 3D stereotactic coordinates that define an optimal site for infusions intended to cover the thalamus and brainstem of nonhuman primates. Conclusions The present study provides quantitative analysis of cannula placement and infusate distribution using real-time MR imaging and defines an optimal zone for infusion in the nonhuman primate thalamus and brainstem. Cannula placement recommendations developed from such translational nonhuman primate studies have significant implications for the design of anticipated clinical trials featuring CED therapy into the thalamus and brainstem for CNS diseases.

scholarly journals Psychological well-being in Italian families: An exploratory approach to the study of mental health across the adult life span in the blue zone

2017 ◽  
Vol 13 (3) ◽  
pp. 441-454 ◽  
Author(s):  
Paul Kenneth Hitchcott ◽  
Maria Chiara Fastame ◽  
Jessica Ferrai ◽  
Maria Pietronilla Penna
Keyword(s):  
Mental Health ◽  
Marital Status ◽  
Hierarchical Linear Modeling ◽  
Family Members ◽  
Depression Scale ◽  
Well Being ◽  
Personal Satisfaction ◽  
Psychological Well Being ◽  
The Impact ◽  
Blue Zone

Self-reported measures of psychological well-being and depressive symptoms were examined across differently aged family members, while controlling for the impact of marital status and personal satisfaction about family and non-family relations. Twenty-one grandchildren (i.e., ages 21-36 years) were recruited with their parents (i.e., 48-66 years old) and grandparents (i.e., 75-101 years of age) in the ‘blue zone’ of Ogliastra, an Italian area known for the longevity of its inhabitants. Each participant was individually presented a battery of questionnaires assessing their lifestyle and several perceived mental health indices, including the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS, Tennant et al., 2007), and the Center for Epidemiologic Studies Depression Scale (i.e., CES-D, Radloff, 1977). After assessing the level of concordance among adults sharing the same context, the Hierarchical Linear Modeling (HLM) approach was used to assess the nested dataset. It was found that family membership (i.e., grandchildren versus parents and grandparents) predicted the WEMWBS score but not the CES-D when the impact of marital status and personal satisfaction about social (i.e., family and non-family) ties was controlled for. Moreover, two separate repeated-measure Analyses of Variance (ANOVAs) documented similar level of personal satisfaction about social relationships across the three family groups. In conclusions, satisfying social ties with friends and family members together with an active socially oriented life style seems to contribute to the promotion of mental health in adult span.

scholarly journals Potret Fraud pada Penyusunan Anggaran Perangkat Daerah

2019 ◽  
Vol 22 (1) ◽  
Author(s):  
Nova Indriani ◽  
Moh Nizarul Alim ◽  
Bambang Haryadi
Keyword(s):  
Participant Observation ◽  
Supervision System ◽  
Executive Staff ◽  
Observation Method ◽  
Effective Supervision ◽  
Blue Zone

This study aims to identify the existence of fraud that appears in the practice of budget preparation. The design of the study used case study in Blue Zone Regional Device by using participant observation method. Informan is the financial manager. The results of this study indicate that fraud on budgeting involves all parties ranging from planners, PPTKs, executive staff and exchequer. Fraud on budgeting occurs in the form of commitments (fees), separation of funds for non-budgetary activities (pressure), the use of legal gaps that are less effective supervision system (opportunity) and assume reasonable what is done and all the Regional Tools do the things (rationalization)

scholarly journals The Development of Situ Rawalumbu Tourism Area Use To Create Green and Blue Zone In Bekasi City

2021 ◽  
Vol 3 (1) ◽  
pp. 490-498
Author(s):  
Margareta Maria Sudarwani ◽  
Sri Pare Eni ◽  
Sahala Simatupang ◽  
Galuh Widati
Keyword(s):  
Area Use ◽  
Blue Zone

Situ adalah wadah genangan air di atas permukaan tanah yang terbentuk secara alami maupun buatan yang sumber airnya berasal dari mata air, air hujan, dan/atau limpasan air permukaan. Situ dapat dimanfaatkan secara ekologis dan ekonomis yaitu sebagai habitat berbagai jenis hewan, tumbuhan, daerah resapan air, sumber air bagi kehidupan, pengendali banjir dan pengatur iklim, sebagai lahan perikanan, penghasil sumber daya alam, serta sarana wisata dan olahraga (Puspita et al, 2005). Situ Rawa Lumbu terletak di Kecamatan Rawa Lumbu, Kota Bekasi, Jawa Barat. Kondisi Situ Rawa Lumbu saat ini mengalami pendangkalan akibat pembuangan sampah/limbah dari pemukiman sehingga air mengalami pencemaran. Dengan demikian, kawasan di sekitar situ mengalami krisis air bersih. Hal ini berdampak kepada pengaruh lingkungan alam khususnya dalam konservasi Kawasan Situ. Sebagai solusi dari permasalahan tersebut, maka diperlukan usaha pelestarian kawasan situ Rawa Lumbu, perlunya penataan pada Kawasan Situ Rawa Lumbu yang ramah lingkungan dengan tujuan melestarikan Kawasan konservasi dan meningkatkan sumber daya manusia sekitar. Oleh karena itu Program Studi Arsitektur Universitas Kristen Indonesia merencanakan Kegiatan Usulan Desain Kawasan Wisata Situ Rawa Lumbu Kota Bekasi yang diharapkan dapat ikut berpartisipasi dalam pembangunan kota Jakarta dan sekitarnya, dengan memperhatikan prinsip Pembangunan Yang Berkelanjutan. Kata kunci: kawasan wisata, pengembangan, situ rawalumbu, zona biru, zona hijau.

Potret Fraud Pada Penyusunan Anggaran Perangkat Daerah

2019 ◽  
Vol 2 (1) ◽  
pp. 19-31
Author(s):  
Nova Indriani ◽  
Moh. Nizarul Alim ◽  
Bambang Haryadi
Keyword(s):  
Blue Zone

Penelitian ini bertujuan untuk mengidentifikasi adanya kecurangan yang muncul dalam praktik penyusunan anggaran. Desain penelitian ini menggunakan studi kasus pada Blue Zone Regional Device dengan menggunakan metode observasi partisipan. Informan adalah manajer keuangan. Hasil penelitian ini menunjukkan bahwa kecurangan dalam penganggaran melibatkan semua pihak mulai dari perencana, PPTK, staf eksekutif dan menteri keuangan. Penipuan dalam penganggaran terjadi dalam bentuk komitmen (biaya), pemisahan dana untuk kegiatan non-anggaran (tekanan), penggunaan celah hukum yang kurang efektif dalam sistem pengawasan (peluang) dan menganggap wajar apa yang dilakukan dan semua Alat Regional melakukan hal-hal (rasionalisasi).

The Blue Zone ¿ Mobile Bluetooth Network Expansion

2008 ◽  
Author(s):  
A F R Shafie ◽  
M M M Ikram ◽  
C S Liyanage ◽  
A E Alahakoon ◽  
N M Liyanage ◽  
...  
Keyword(s):  
Network Expansion ◽  
Blue Zone
Sign in / Sign up

Export Citation Format

Share Document