Association between handgrip strength and maximum expiratory flow with site-specific bone mineral density of healthy young adults

Author(s):  
Rimsha Tahir ◽  
Faateh Ahmad Rauf ◽  
Shafaq Ismail ◽  
Huma Saeed Khan ◽  
Shahid Hasan

Abstract Objective: To explore the association of handgrip strength and peak expiratory flow rate with site-specific bone mineral density T scores, and to study the correlation of body mass index and physical activity with the three parameters. Methods: The cross-sectional study was conducted in November 2018 at the Combined Military Hospital, Lahore Medical College and Institute of Dentistry, Lahore, Pakistan, and comprised healthy young adults. Data was collected using the international physical activity questionnaire. The subjects were grouped into low, moderate and high categories. Handgrip strength, peak expiratory flow rate, bone mineral density T scores and body mass index were measured for each subject. Data was analysed using SPSS 24. Results: Of the 102 subjects, 52(50.9%) were males and 50(49%) were females. There was a significant difference between the median values for all parameters of males and females (p<0.05). Bone mineral density and physical activity were moderately associated with handgrip strength and peak expiratory flow rate (p<0.05). Body mass index showed a moderate association with bone mineral density (p<0.05). Conclusion: Healthy young adults with better respiratory function and handgrip strength were found to have higher values of site-specific calcaneal bone mineral density. Subjects with higher reported levels of physical activity and a higher body mass index within a healthy range presented with improved values of bone mineral density, handgrip strength and peak expiratory flow rate. Key Words: Bone mineral density, Handgrip strength, Peak expiratory flow rate, Body mass index, Physical activity. Continuous...

Author(s):  
K. Subramanyam ◽  
Dr. P. Subhash Babu

Obesity has become one of the major health issues in India. WHO defines obesity as “A condition with excessive fat accumulation in the body to the extent that the health and wellbeing are adversely affected”. Obesity results from a complex interaction of genetic, behavioral, environmental and socioeconomic factors causing an imbalance in energy production and expenditure. Peak expiratory flow rate is the maximum rate of airflow that can be generated during forced expiratory manoeuvre starting from total lung capacity. The simplicity of the method is its main advantage. It is measured by using a standard Wright Peak Flow Meter or mini Wright Meter. The aim of the study is to see the effect of body mass index on Peak Expiratory Flow Rate values in young adults. The place of a study was done tertiary health care centre, in India for the period of 6 months. Study was performed on 80 subjects age group 20 -30 years, categorised as normal weight BMI =18.5 -24.99 kg/m2 and overweight BMI =25-29.99 kg/m2. There were 40 normal weight BMI (Group A) and 40 over weight BMI (Group B). BMI affects PEFR. Increase in BMI decreases PEFR. Early identification of risk individuals prior to the onset of disease is imperative in our developing country. Keywords: BMI, PEFR.


Author(s):  
Seema Gupta ◽  
Varun Malhotra ◽  
Yogesh Tripathi ◽  
Pratibha Dev

Background: Textile industries play a significant role in economical growth of the country. Health concern of these textile mill workers is the biggest challenge. Respiratory alterations were found in these workers with long term exposure of cotton dust. Effect of cotton dust on peak expiratory flow rate is not very well documented in the past.Aim/objective: The main objective of this study was the assessment of respiratory functions in textile mill workers along with the effect on peak expiratory flow rate in these workers.Material & Methods: 130 male textile mill workers were recruited for this study from the different sections of a textile mill. In which, 80 workers were present from exposed and remaining 50 were from non exposed area of a textile mill. 30 to 40 year of age workers with the working history of not more than 5 years, were included for the part of the study. Their Body mass index and respiratory functions were evaluated. Body mass index was calculated by using weight and height of an individual. Respiratory functions including Forced vital capacity and forced expiratory volume in 1 second was estimated by using spirometer and peak expiratory flow rate was measured by means of Wright’s peak flow meter.Results: the mean values of FVC, FEV1 and PEFR were found to be significantly (<0.01) lower in exposed group of textile mill when compared non exposed groups. When these values were compared on the basis of BMI, workers with BMI>25kg/m2 were found with lower mean values of FVC, FEV1 and PEFR when compared with workers with BMI<25kg/m2. Also there was significant (<0.05) negative correlation between BMI and PEFR in both exposed group and non exposed group of a textile mill.Conclusion: Workers in textile mill, with short term exposure of cotton dust may also present with respiratory alterations which may increase with long term exposure. Safety controls such as ventilation, etc and routine health check are very much required in textile industries.Keywords: Peak expiratory flow rate, Body mass index, Textile mill.   


Author(s):  
Hasnain Abbas Dharamshi ◽  
Ahmad Faraz ◽  
Erum Ashraf ◽  
Ali Abbas Mohsin Ali ◽  
Mansoor Ali Merchant Rameez ◽  
...  

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 947.2-947
Author(s):  
R. Elnemr ◽  
R. Bastawy ◽  
R. Ghazala ◽  
M. Abdelrazek ◽  
N. Elsawy

Background:Anti carbamylated protein anti carP are present in patients with Rheumatoid Arthritis RA and are associated with erosions. However their association with systemic or local bone loss in RA patients is still not confirmed.Objectives:The purpose of this study was to measure the serum level of anti carP in premenopausal women with RA and determine its relation to disease activity and bone loss.Methods:This case control study was conducted on forty eight RA premenopausal female patients diagnosed according to 2010 ACR/EULAR criteria and forty eight ages and body mass index matched healthy premenopausal females. RA patients with other autoimmune diseases, viral hepatitis malignancy or erosive joint disease and systemic diseases that affect bone quality were excluded from the study. All RA women were subjected to history taking, clinical examination, assessment of disease activity using disease activity score-28 DAS28 and clinical disease activity index CDAI functional assessment using health assessment questionnaire HAQ physical activity assessment using international physical activity questionnaire short form IPAQ fatigue assessment using modified fatigue impact scale MFIS, routine laboratory investigations, serological tests as well as Anti carP using ELISA kit. Moreover the bone mineral density was measured by a lunar Prodigy Advanced DEXA scanner system and plain x-ray of both hands and wrists in the anteroposterior view was done to assess the juxta articular osteopenia and erosions.Results:Anti carP level was significantly higher in RA patients than in healthy controls table 1. The serum level of anti carP had a significant positive correlation with RA DAS, CDAI, HAQ, IPAQ, MFIS and erosion and joint space narrowing in original sharp score. Also the anti carP had a significant negative correlation with the bone mineral density BMD of spine. The AUC of anti carP level showed a high level of accuracy AUC 0.857 figure 1 and the calculated cutoff value >65 can precisely discriminate subjects with RA from those without RA with 85.42% sensitivity and 85.11% specificity.Table 1.Comparison between the patient and healthy groups according to anti carp levelAnti-carpRA patientsHealthy controlUpMin – Max15.0 – 90.01.0 – 78.50322.0*<0.001*Mean ± SD71.24 ± 14.7045.99 ± 21.99Median (IQR)72.75 (70.5–78.3)55.0 (32.5–61.5)Figure 1.ROC curve for anti carP to diagnose RA patients from healthy subjectsConclusion:Anti carbamylated antibodies were higher in premenopausal RA women compared to ages and body mass index matched healthy women. Anti carP are associated with higher RA disease activity, increased disability and decreased physical activity. Moreover anti carP are associated with systemic trabecular bone loss manifested by decreased bone mineral density of the spine as well as local bone loss as manifested by increased number of joint erosions in premenopausal RA women.References:[1] Regueiro C, Ortiz AM, Boveda MD, Castañeda S, Gonzalez-Alvaro I, Gonzalez A. Association of high titers of anti-carbamylated protein antibodies with decreased bone mineral density in early arthritis patients. PLoS ONE 2018; 13(8):e0202583.Disclosure of Interests:None declared


Author(s):  
Tanuj Mathur ◽  
Dileep Kumar Verma ◽  
Sunita Tiwari ◽  
Narsingh Verma ◽  
Ranjana Singh

Introduction: Modern lifestyle has resulted in an increased prevalence of cardiovascular and respiratory diseases along with being overweight. An interaction between the three factors has also been demonstrated. Aim: The study aimed to assess the relationship of Body Mass Index (BMI), Mean Arterial Pressure (MAP) and Peak Expiratory Flow Rate (PEFR) in healthy individuals. Materials and Methods: This cross-sectional, observational study was done in the Department of Physiology, KGMU, Lucknow from 30 July 2019 to 30 July 2020. Forty healthy individuals, aged 18-35 years were assessed for height, weight, blood pressure and spirometric parameter of PEFR. PEFR was chosen as it was a reliable representative of airways functioning. PEFR reflects proximal airway calibre changes which might be due to effect of airway geometry. A correlation test was run to test the relation between BMI and PEFR and MAP and PEFR. Results: A weak correlation (r=-0.136) was noted between BMI and PEFR indicating that as BMI increased, PEFR compromised. A linear correlation was observed between MAP and PEFR. Conclusion: The present study confirms a weak association of BMI and MAP with PEFR.


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