Systemic Lycopene as an adjunct to Non-Surgical Periodontal Therapy in Generalized Chronic Periodontitis

Aim: To evaluate the potency of systemic anti-oxidants in the non-surgical treatment of generalised chronic periodontitis. Objective: Purpose of this short term clinical study is to ascertain whether or not daily systemic supplementation of antioxidants adjunctively used after scaling and root planing (SRP) would improve clinical condition in generalised chronic periodontitis using C-reactive protein (CRP) as inflammatory markers and chronic periodontitis treatment index needs (CPTIN Index) to evaluate reduction in periodontal pockets. Results: Each group involved 10 participants with age group 30-65 years. The test group was provided with treatment with 20 mg Lycopene once daily after 24 hours of completion of scaling and root planing. The CRP value at baseline ranged from 3- 6.2 with a mean value of 4.87± 1.09. After one month of treatment, the CRP value ranges between 1.1- 4.8 with a mean value of 3.10 ± 1.05. This clearly indicates a significant decrease in CRP with t value 10.83 and >0.00 p value. The CRP value of control group at baseline ranged from 3-5.9 with a mean value of 4.58± 1.08. After one month of treatment with scaling and root planing, the CRP value ranges to 2.2- 5.4 with a mean value of 3.96 ± 1.08. This clearly indicates a significant decrease in CRP with t value 13.29 and > 0.00 p value. Conclusion: Lycopene as an antioxidant is a promising treatment modality as an adjunct to full mouth scaling. It helps to modulate oxidative stress in periodontium during periodontitis. It also leads to maintenance of periodontal health.

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Laser Assisted Non-surgical Periodontal Therapy: A Double Blind, Randomized Clinical Trial

The Open Dentistry Journal ◽

10.2174/1874210601711010079 ◽

2017 ◽

Vol 11 (1) ◽

pp. 79-90 ◽

Cited By ~ 1

Author(s):

Joseph D. Everett ◽

Jeffrey A. Rossmann ◽

David G. Kerns ◽

Ibtisam Al-Hashimi

Keyword(s):

Laser Therapy ◽

Chronic Periodontitis ◽

Test Group ◽

Control Group ◽

Scaling And Root Planing ◽

Clinical Attachment Level ◽

Laboratory Parameters ◽

Root Planing ◽

Significant Difference ◽

Attachment Level

The objective of this study was to examine potential benefits of using laser therapy for secular decontamination in conjunction with scaling and root planing in the treatment of chronic periodontitis. The study was performed on 173 teeth in 14 patients in a split-mouth design, one side received scaling and root planing followed by laser therapy using a carbon dioxide (CO2) laser with an ablative handpiece (test group); the contralateral side received scaling and root planing without laser (control group). Clinical and laboratory parameters were evaluated prior to treatment and at 3 and 6 months following therapy; clinical measurements were performed by two blinded examiners. The clinical parameters included measurement of gingival recession (REC), bleeding on probing (BOP), clinical attachment level (CAL), pocket depth (PD), furcation involvement (FUR), and tooth mobility (MOB). Laboratory testing to determine the levels of periodontal pathogens was performed using PCR techniques. The results of the study revealed statistically significant differences in clinical and laboratory parameters at 3 and 6 months after therapy for both test and control groups, but no significant difference was observed between the two groups. However, sites receiving laser therapy tended to show a greater decrease in probing depths, gain in clinical attachment level, and reduced bacterial levels. In conclusion, the overall results of the study suggest a potential benefit of using laser therapy in conjunction with scaling and root planing for the treatment of chronic periodontitis.

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The effect of carbonate apatite membrane gelatin application on IL-1β level gingival crevicular fluid in chronic periodontitis patients

Padjadjaran Journal of Dentistry ◽

10.24198/pjd.vol31no3.23930 ◽

2019 ◽

Vol 31 (3) ◽

pp. 184

Author(s):

Indra Mustika Setia Pribadi ◽

Ina Hendiani ◽

Reynaldy Sartiono

Keyword(s):

Chronic Periodontitis ◽

Gingival Crevicular Fluid ◽

Test Group ◽

Wilcoxon Test ◽

Periodontal Pocket ◽

Control Group ◽

Carbonate Apatite ◽

Scaling And Root Planing ◽

Root Planing ◽

Crevicular Fluid

Introduction: Apatite carbonate material plays an important role in bone tissue regeneration. The use of this membrane is expected to achieve better treatment success than those without additional therapy. The antimicrobial content in the apatite carbonate membrane can be used to support periodontal treatment of chronic periodontitis after scaling and root planing. The purpose of this research was to analyse the effect of carbonate apatite membrane gelatin application on the IL-1β level of the gingival crevicular fluid in chronic periodontitis patients. Methods: This research was a double-blind, randomised controlled trial method, with purposive sampling, and split-mouth design. The parameter was the IL-1β level in the gingival crevicular fluid before and after scaling and root planing. Carbonate apatite membrane gelatin was applied to the periodontal pocket on the test group after scaling and root planing. Data were analysed by the Wilcoxon test with a p-value < 0.05. Results: The reduction of IL-1β level gingival crevicular fluid on day-0 and day-30 on both groups showed significant value (p < 0.001). However, it showed no significant differences statistically, between the test group and the control group. Conclusion: Carbonate apatite membrane gelatin application might reduce the IL-1β level of the gingival crevicular fluid, but not showing a better reduction from the control group.Keyword: Carbonate apatite membrane gelatin, IL-1β, periodontal therapy

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Efficacy of Oral Probiotics as an Adjunct to Scaling and Root Planing in Nonsurgical Treatment Outcome of Generalized Chronic Periodontitis Patients: A Clinico-Microbiological Study

International Journal of Experimental Dental Science ◽

10.5005/jp-journals-10029-1145 ◽

2017 ◽

Vol 6 (1) ◽

pp. 6-13 ◽

Cited By ~ 1

Author(s):

Ameet Mani ◽

Shubangi Mani ◽

Sugandha R Saini

Keyword(s):

Treatment Outcome ◽

Chronic Periodontitis ◽

Nonsurgical Treatment ◽

Control Group ◽

Scaling And Root Planing ◽

Once Daily ◽

Microbiological Study ◽

Root Planing ◽

Group I ◽

Group Ii

ABSTRACT Aim: This study aims to find out the effects of Probiotics, delivered with a lozenge for its effect on clinical and microbiological parameters in subjects with chronic periodontitis after scaling and root planing (SRP). Materials and methods: A total of 40 generalized mild to moderate chronic periodontitis subjects were finally enrolled in a double-blind, placebo-controlled, randomized clinical study. Selected subjects after SRP were randomly divided into two groups: Group I (test group) with 20 subjects receiving probiotic tablet once daily and group II (control group) receiving placebo tablets once daily. Clinical parameters and bacterial count for Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum were evaluated at baseline, 2, and 4 months after the medication. Results: On comparative evaluation between the two groups, results indicated that group I (probiotic group) exhibited statistically significant reduction in both clinical and microbiological levels than group II (control group) over the entire span of the study. Conclusion: Our results proved that daily oral supplementation of probiotics could be a useful adjunct to SRP in chronic periodontitis patients. How to cite this article Mani A, Saini R, Saini SR. Efficacy of Oral Probiotics as an Adjunct to Scaling and Root Planing in Nonsurgical Treatment Outcome of Generalized Chronic Periodontitis Patients: A Clinico-Microbiological Study. Int J Experiment Dent Sci 2017;6(1):6-13.

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Comparison of Clinical Attachment Level Gain Using Scaling Root Planing Versus Adjunctive Azithromycin on Chronic Periodontitis

10.53350/pjmhs211582054 ◽

2021 ◽

Vol 15 (8) ◽

pp. 2054-2056

Author(s):

Attique ur Rehman ◽

Marryam Riaz ◽

Moeez Ansari ◽

Saqib Naeem Sidiqui ◽

Adeel Ijaz Rana ◽

...

Keyword(s):

Chronic Periodontitis ◽

P Value ◽

Scaling And Root Planing ◽

Test Results ◽

Once Daily ◽

Clinical Attachment Level ◽

Root Planing ◽

Effective Treatment Modality ◽

Periodontal Debridement ◽

Attachment Level

Objective: The objective of the study was to compare the mean clinical attachment gain in patients of chronic periodontitis after scaling and root alone versus Azithromycin as an adjunct to scaling and root. Study Design Comparative study Place and Duration: Conducted at Operative Dentistry Department, Azra Naheed Dental College, Lahore for a duration of 4 months from December 2019 to March 2020. Methodology: Total Sixty patients fulfilling the selection criteria were randomly allocated to SRP and SRP+Az groups. In both groups, conventional scaling and root planing was done. In the SRP group placebo capsules were prescribed, while in the SRP+Az group, Azithromycin (500mg) once daily was prescribed for 3 days. Clinical attachment level (CAL) was measured initially and after 5 weeks. Data was analyzed in SPSS version 19.0 using independent sample t-test. Results: Both groups showed gain in CAL compared to baseline. However, SRP+Az group showed significantly more gain in CAL in comparison to SRP group (P value < 0.05). Conclusion: Use of Azithromycin adjunctive to SRP is an effective treatment modality in chronic periodontitis patients. Keywords: Anti‐Bacterial Agents, Azithromycin, Chronic periodontitis, Clinical attachment level, Periodontal Debridement, Scaling and root planing,

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Evaluation of Subantimicrobial Dose Doxycycline as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients with Diabetes: A Randomized, Placebo-Controlled Clinical Trial

The Journal of Contemporary Dental Practice ◽

10.5005/jcdp-11-3-9 ◽

2010 ◽

Vol 11 (3) ◽

pp. 9-16 ◽

Cited By ~ 14

Author(s):

Satish Gupta ◽

Manohar L. Bhongade ◽

Vikas Deo ◽

Ritika Jaiswal

Keyword(s):

Clinical Trial ◽

Chronic Periodontitis ◽

Test Group ◽

Control Group ◽

Controlled Clinical Trial ◽

Diabetic Patients ◽

Scaling And Root Planing ◽

Pocket Depth ◽

Root Planing ◽

Patients With Diabetes

Abstract Aim Diabetic patients have more severe periodontal destruction, but periodontal therapy can improve metabolic control. Recently, interest has focused on the use of subantimicrobial dose doxycycline (SDD) as a treatment paradigm. Therefore, this study was undertaken to evaluate clinical efficacy of SDD with scaling and root planning (SRP) in chronic periodontitis patients with diabetes. Methods and Materials Twenty chronic periodontitis patients with diabetes mellitus were randomly allocated to either a test and a control group. Clinical measurements were recorded at baseline and at six months for probing pocket depth (PPD), clinical attachment level (CAL), and gingival recession (GR). After SRP, patients in the test group were instructed to take SDD 20-mg capsules twice a day while patients in the control group took a placebo twice a day. Both groups were on this regimen for a six-month period. Results A greater reduction in mean PPD was demonstrated in patients in the test group compared to the control group. The mean CAL increase observed in the test group was significantly greater (0.67 mm) than that in the control group. Conclusion It can be concluded that SRP, in conjunction with the SDD therapy described, is more effective then SRP alone in terms of CAL gain and PPD reduction in diabetic patients with severe periodontal disease. Clinical Significance Given the widespread prevalence of both chronic periodontitis and diabetes, the proposed treatment approach will prove to be of great value and contribute significantly to the overall health of the patients. Citation Deo V, Gupta S, Bhongade ML, Jaiswal R. Evaluation of Subantimicrobial Dose Doxycycline as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients with Diabetes: A Randomized, Placebo-Controlled Clinical Trial. J Contemp Dent Pract [Internet]. 2010 May; 11(3):009-016. Available from: http://www.thejcdp.com/journal/view/volume11- issue3-deo.

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Local Delivery of Hyaluronan as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis

Journal of Periodontology & Implant Dentistry ◽

10.15171/jpid.2016.003 ◽

2016 ◽

Vol 8 (1) ◽

pp. 12-18

Author(s):

Shyam Sunder Salavadhi ◽

Srikanth Chintalapani ◽

Chandra Mohan Pabolu ◽

Arpita Paul ◽

Ramesh Babu Mutthineni ◽

...

Keyword(s):

Chronic Periodontitis ◽

Test Group ◽

Local Application ◽

Control Group ◽

Scaling And Root Planing ◽

Plaque Score ◽

Treatment Comparison ◽

Root Planing ◽

Probing Depth ◽

The Difference

Background and aims. The present study was carried out to evaluate the adjunctive effect of local application of hyaluronan gel with scaling and root planing in the treatment of chronic periodontitis. Materials and methods. Twelve patients with chronic periodontitis participated in the study with a split-mouth design. Plaque formation and bleeding on probing (BOP) were evaluated at baseline and at 1st, 4th and 12th weeks postoperatively. Probing depth (PD) and clinical attachment levels (CAL) were evaluated at baseline and at 12-week postoperative interval. 0.2 mL of 0.8% hyaluronan gel was administered subgingivally in the test sites at baseline and after 1 week. Results. The test group exhibited a significantly lower mean plaque score and mean BOP as compared to the control group at 1st, 4th and 12th weeks (P < 0.05). Between the two groups, post-treatment comparison at 12th week showed lower PD value in the test group as compared to the control group and higher gain in CAL in the test group as compared to the control group. The difference between the two groups was statistically significant (P < 0.05). Conclusion. Local application of hyaluronan gel in conjunction with SRP might have a beneficial effect in patients with chronic periodontitis.

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Evaluation of non-surgical therapy on glutathione levels in chronic periodontitis

European Journal of Dentistry ◽

10.4103/1305-7456.163226 ◽

2015 ◽

Vol 09 (03) ◽

pp. 415-422 ◽

Cited By ~ 8

Author(s):

Pooja Palwankar ◽

Minakshi Rana ◽

Kapil Arora ◽

C. Deepthy

Keyword(s):

Chronic Periodontitis ◽

Gingival Crevicular Fluid ◽

Test Group ◽

Redox Balance ◽

Control Group ◽

Scaling And Root Planing ◽

Root Planing ◽

Nonsurgical Periodontal Therapy ◽

Student’S T ◽

Crevicular Fluid

ABSTRACT Objective: To compare the levels of glutathione (GSH), both oxidized and reduced forms in patients with and without chronic periodontitis in gingival crevicular fluid (GCF). Materials and Methods: Twenty GCF samples from maxillary quadrants were collected using capillary micropipettes from the chronic periodontitis patients (test group) at baseline before treatment, at 1-month, 3 months, and 6 months after scaling and root planing and samples from 20 patients without chronic periodontitis (control group) from maxillary quadrants were also collected. GSH, oxidized glutathione (GSSG) levels and GSH: GSSG ratios were determined using the spectrophotometric method. Statistical Analysis: Results were concluded for the test over control groups using paired Student's t-test. Results: Lower concentrations of GSH (P < 0.001) and GSSG (P < 0.001) were detected in GCF in patients with chronic periodontitis (test group) than patients without chronic periodontitis (control group) at baseline. Treatment had a significant effect in improving the GSH and reducing GSSG levels postscaling and root planing at 1-month and 3 months but not significant effect at 6 months. Scaling and root planing increased the GSH: GSSG ratio (P < 0.001) in the test group as compared to the control group (P < 0.001). Conclusions: The concentrations of GSH within GCF are reduced in chronic periodontitis patients. Scaling and root planing (nonsurgical therapy) restores GSH concentration in GCF post 1-month and 3 months along with redox balance (GSH: GSSG ratio), but at 6 months the balance is not maintained. Adjunctive use of micronutritional supplements to boost antioxidant concentration in tissues by preserving GSH or by elevating its level at the inflamed sites is recommended, as nonsurgical periodontal therapy alone is not able to maintain redox balance for longer duration.

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Evaluation of Grape Seed Formulation as an Adjunct to Scaling and Root Planing on Oxidative Stress, Inflammatory Status and Glycaemic Control in Type 2 Diabetic Patients with Chronic Periodontitis: A Randomised Controlled Trial

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/45235.14792 ◽

2021 ◽

Author(s):

Sameekshya Acharya ◽

Sheela Kumar Gujjari ◽

KA Sudarshan Murthy ◽

Rishika Battula

Keyword(s):

Oxidative Stress ◽

Glycaemic Control ◽

Chronic Periodontitis ◽

Grape Seed ◽

Control Group ◽

P Value ◽

Diabetic Patients ◽

Scaling And Root Planing ◽

Root Planing ◽

And Control

Introduction: Nutraceuticals are food derived products that provide health benefits, in addition to basic nutritional value of the food. Grape Seed Extracts (GSE) contain a high concentration of proanthocyanidin which is known to possess strongest antioxidant property. Control and modulation of Reactive Oxygen Species (ROS) activity is normally achieved by synthesis and accumulation of antioxidants. Increased ROS production due to oxidative stress results in hyperinflammatory state and worsens the glycaemic status in diabetic patients with chronic periodontitis. Aim: The aim of the present study was to evaluate the effect of grape seed formulation as an adjunct to scaling and root planing (SRP) on oxidative stress, inflammatory status and glycaemic control in type 2 diabetic patients with chronic periodontitis. Materials and Methods: This was a double blind randomised clinical trial where 48 diabetic patients with chronic periodontitis were selected from the Outpatient Department of Periodontology, JSS Dental College, Mysore, Karnataka, India. The duration of the study was 10 months. Patients were randomly divided into two groups of 24 each: test group (SRP+grape seed formulation) and control group (SRP+placebo) which was given once daily for two months. Clinical parameters such as Plaque Index (PI), Gingival Index (GI), Pocket Probing Depth (PPD) and Clinical Attachment Level (CAL); metabolic parameters such as glycated Hb (HbA1c), Fasting Blood Sugar (FBS) was carried out at baseline, 3 months and 6 months. Also, inflammatory marker i.e., Myeloperoxidase (MPO) was estimated from Gingival Crevicular Fluid (GCF) and Total Antioxidant Capacity (TAOC) were recorded at baseline, 3 months and 6 months. Statistical Package for the Social Sciences (SPSS) version 16 was used for all statistical analysis. Intergroup and intragroup comparisons for both test and control group were analysed by paired t-test and independent t-test, respectively. A p-value ≤0.05 was considered as statistically significant. Results: Intergroup comparison showed that there was no significant difference in PI, Sulcular Bleeding Index (SBI), CAL, PD between the test and control group at baseline, 3 months and 6 months except SBI scores at 3 months with p-value=0.017 and PI scores with p-value=0.014. The test group (SRP+GSE) as well as control group (SRP+placebo) showed statistically significant improvement from baseline to 3 months and baseline to 6 months in PI, SBI, CAL and PD (p≤0.05). FBS showed significant improvement from baseline to 3 months in both test and the control group.At 3 months statistically significant results was seen in SBI, FBS, TAOC, MPO and PI scores between the test and the control group (p≤0.05). Conclusion: This study shows a promising result in using grape seed formulation as an adjunct to scaling and root planing to reduce the oxidative stress, decreasing the inflammation and achieving the glycaemic control in diabetic patients with chronic periodontitis. Further studies are needed to prove its efficacy as an adjunct to conventional therapy.

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Short-term results in evaluating a gingiva-adhesive hydrophobic-chlorhexidine-gel for chronic periodontitis

Medicine and Pharmacy Reports ◽

10.15386/cjmed-312 ◽

2014 ◽

Vol 87 (3) ◽

pp. 186-191

Author(s):

Ciprian Sarbu ◽

Darian Rusu ◽

Horia Călniceanu ◽

Adrian Kasaj ◽

Stefan Adrian Petrutiu ◽

...

Keyword(s):

Oral Hygiene ◽

Chronic Periodontitis ◽

Test Group ◽

Study Groups ◽

Plaque Index ◽

Control Group ◽

Scaling And Root Planing ◽

Pocket Depth ◽

Root Planing ◽

Chlorhexidine Gel

Background and Aims: Oral mucosa and interproximal spaces of the teeth could favor the colonization of periodontopathogenic bacteria, which could be targeted by chemical antiplaque agents such as chlorhexidine, present in different oral hygiene products, thus improving the control of biofilm growth and delaying microbial accumulation. The study aimed to evaluate whether the use of a hydrophobic gel with good gingival adhesion for 14 days after the scaling and root planing of patients with chronic periodontitis would improve the treatment outcome, when compared with the use of a regular hydrophyllic gel.Material and Methods: Patients with moderate disease were included in two study groups. At baseline and 3 months after the treatment the following parameters were recorded: pocket depth, Approximal Plaque Index, Modified Gingival Index, Simplified Oral Hygiene Index, bleeding on probing. Patients received scaling and root planing in two sessions at 24 hours interval. After the treatment, patients in the test group applied the hydrophobic adhesive chlorhexidine gel once a day, every other day, while in the control group the gel was used twice daily.Results. Both treatments resulted in significant improvement in all clinical indices, except Approximal Plaque Index, which deteriorated significantly in both groups. Three months after mechanical treatment, the mean probing depth changed in the test group from 4.16±0.45 mm to 2.80±0.42 mm, and in the control group from 4.16±0.30 to 2.69±0.19.Conclusions: Both adjunctive anti-infective therapies induced clinical improvement 3 months from baseline. The differences between the two treatments were not statistically significant.

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Assessment of the Tissue Response to Modification of the Surface of Dental Implants with Carboxyethylphosphonic Acid and Basic Fibroblastic Growth Factor Immobilization (Fgf-2): An Experimental Study on Minipigs

Biology ◽

10.3390/biology10050358 ◽

2021 ◽

Vol 10 (5) ◽

pp. 358

Author(s):

Javier Aragoneses ◽

Ana Suárez ◽

Nansi López-Valverde ◽

Francisco Martínez-Martínez ◽

Juan Manuel Aragoneses

Keyword(s):

Surface Treatment ◽

Test Group ◽

Mean Value ◽

Control Group ◽

P Value ◽

Implant Surface ◽

Bone Contact ◽

Bone Implant ◽

Significant Difference ◽

The Mean

The aim of this study was to evaluate the effect of implant surface treatment with carboxyethylphosphonic acid and fibroblast growth factor 2 on the bone–implant interface during the osseointegration period in vivo using an animal model. The present research was carried out in six minipigs, in whose left tibia implants were inserted as follows: eight implants with a standard surface treatment, for the control group, and eight implants with a surface treatment of carboxyethylphosphonic acid and immobilization of FGF-2, for the test group. At 4 weeks after the insertion of the implants, the animals were sacrificed for the histomorphometric analysis of the samples. The means of the results for the implant–bone contact variable (BIC) were 46.39 ± 17.49% for the test group and 34.00 ± 9.92% for the control group; the difference was not statistically significant. For the corrected implant–bone contact variable (BICc), the mean value of the test group was 60.48 ± 18.11%, and that for the control group, 43.08 ± 10.77%; the difference was statistically significant (p-value = 0.035). The new bone formation (BV/TV) showed average results of 27.28 ± 3.88% for the test group and 26.63 ± 7.90% for the control group, meaning that the differences were not statistically significant (p-value = 0.839). Regarding the bone density at the interthread level (BAI/TA), the mean value of the test group was 32.27 ± 6.70%, and that of the control group was 32.91 ± 7.76%, with a p-value of 0.863, while for the peri-implant density (BAP/TA), the mean value of the test group was 44.96 ± 7.55%, and that for the control group was 44.80 ± 8.68%, without a significant difference between the groups. The current research only found a significant difference for the bone–implant contact at the cortical level; therefore, it could be considered that FGF-2 acts on the mineralization of bone tissue. The application of carboxyethylphosphonic acid on the surface of implants can be considered a promising alternative as a biomimetic coating for the immobilization of FGF-2. Despite no differences in the new bone formation around the implants or in the interthread or peri-implant bone density being detected, the biofunctionalization of the implant surface with FGF-2 accelerates the mineralization of the bone–implant interface at the cortical level, thereby reducing the osseointegration period.

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