Wat is verantwoord antibioticagebruik? Een zoektocht naar een definitie, kwaliteitsindicatoren, belemmerende en bevorderende factoren

2021 ◽  
Author(s):  
A.A. MONNIER
Keyword(s):  
Antibiotic Resistance ◽  
Healthcare Professionals ◽  
Antibiotic Use ◽  
The Body ◽  
Barriers And Facilitators ◽  
Societal Implications ◽  
Healthcare Facilities ◽  
Body Of Knowledge ◽  
Hospital Patients ◽  
Multi Stakeholder

What is responsible antibiotic use? A search for a multi-stakeholder definition, quality indicators, barriers and facilitators Antibiotic resistance leads to infections that are increasingly difficult to treat. Resistance can be partially curbed through responsible antibiotic use. In this thesis, responsible antibiotic use was explored by consulting different stakeholders: antibiotic prescribers, patients, public health organisations, manufacturers and regulators. Key results: Consensus on a definition and indicators for responsible antibiotic use: these can be applied by healthcare facilities for education and to improve their antibiotic use. Experiences of hospital patients with antibiotic use and their views on responsible antibiotic use: these can be utilized to improve the communication between healthcare professionals and patients. An inventory of barriers and facilitators for responsible antibiotic use: these can be utilized to guide multisectoral antibiotic policies. These results contribute to the body of knowledge regarding the complexity of using antibiotics responsibly. They are embedded in a context of increasing awareness of the societal implications of antibiotic resistance and of the need for multisectoral actions to address the issue.

Significant risk factors associated with facilities management (FM) outsourcing

2015 ◽  
Vol 22 (6) ◽  
pp. 771-796 ◽  
Author(s):  
Dubem I. Ikediashi ◽  
Stephen O. Ogunlana
Keyword(s):  
Risk Factors ◽  
Significant Risk ◽  
The Body ◽  
Healthcare Sector ◽  
Public Healthcare ◽  
Facilities Management ◽  
Content Type ◽  
Healthcare Facilities ◽  
Factors Associated ◽  
Body Of Knowledge

Purpose – The purpose of this paper is to extend the body of knowledge on healthcare facilities management (FM) by investigating the risks associated with outsourcing of FM services in hospitals. Design/methodology/approach – The paper relied on two strands of methodology common with pragmatic research. Questionnaire survey (QS) used data from 208 respondents representing ten hospitals while three out of the ten hospitals involved in the QS were selected based on their willingness to enter the case study (CS) interview. Data collected were analysed using descriptive and inferential statistics for QS and using narrative techniques by discussing themes, sub-themes for the CS. Findings – Findings established 24 out of the 35 risk factors as critical, four factors as somehow critical, and five factors as not critical. Besides, nine risk factors were found to be significantly loaded on the five risk categories. The rank analysis also revealed that the top five critical risk factors are: inexperience and lack of requisite skills; possibility of fraud by vendor; financial failure of chosen vendor; vendor opportunism; and fall in morale of employees. Originality/value – The study provides an unambiguous contribution to exiting body of knowledge on outsourcing risks as it relates to healthcare FM. It reinforces the theory that risks exist in any form of relationship but developed a distinct body of factors associated with outsourcing of FM services particularly from the context of Nigeria’s public healthcare sector.

Treatment protocol and effectiveness of cosmeceuticals in aesthetic practice

2020 ◽  
Vol 9 (4) ◽  
pp. 148-153
Author(s):  
Lucy Millar-Hume
Keyword(s):  
Antibiotic Resistance ◽  
Biological Effect ◽  
Treatment Protocol ◽  
Antibiotic Use ◽  
The Body ◽  
Level Of Evidence ◽  
Physiological Functions ◽  
Drug Products ◽  
Aesthetic Practice ◽  
Oral Isotretinoin

Pharmaceuticals are essentially drug products containing active ingredients that prevent, mitigate, treat disease and/or affect the anatomy or physiological functions of the body. Cosmeceuticals is a term blending the meaning and action of pharmaceuticals and cosmetics, resulting in a product that cannot exert a biological effect on cells, but can nonetheless improve the quality and condition of the skin. Traditional medical methods of treating acne centre around antibiotic use and oral isotretinoin. Antibiotic resistance is a growing problem, and it means aesthetic practitioners must find alternatives. Attention is turning to cosmeceuticals as a solution, but this raises the question of the level of evidence for their growing use.

Antibiotics

2019 ◽  
Author(s):  
Mary E. Wilson
Keyword(s):  
Antibiotic Resistance ◽  
Medical Care ◽  
Food System ◽  
Scientific Research ◽  
Antibiotic Use ◽  
Societal Implications ◽  
Collateral Damage ◽  
The Future ◽  
Globalized World ◽  
Answer Format

A STIRRING EXAMINATION OF A LOOMING CRISIS Virtually everyone has taken antibiotics. They can be lifesavers -- or they can be useless. But what are they? How are they used? And what happens as the effectiveness of antibiotics begins to decline? Antibiotics: What Everyone Needs to Know® examines the personal and societal implications of our planet's most important -- and arguably most overused -- medications. In a question-and-answer format, it unpacks the most complicated aspects of this issue, including: · How antibiotics are used (and overused) in humans, plants, and livestock · The consequences to date, and the potential crisis ahead, as overuse of existing antibiotics breeds new resistance in bacteria · How the globalized world enables antibiotic resistance more quickly · Collateral damage, individually and societally, of antibiotic use · The difficult decisions ahead related to medical care and the food system Grounded in the latest scientific research and translated for general readers, Antibiotics: What Everyone Needs to Know® offers a clear-eyed overview of where we are, and what the future holds, as antibiotics lose their might.

scholarly journals Evaluation of Knowledge and Risk Perception about Antibiotic Resistance in Biology and Mathematics Young Students in Nîmes University in France

2021 ◽  
Vol 18 (18) ◽  
pp. 9692
Author(s):  
Valentin Duvauchelle ◽  
Elsa Causse ◽  
Julien Michon ◽  
Patrick Rateau ◽  
Karine Weiss ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Risk Perception ◽  
Antibiotic Use ◽  
The Body ◽  
World Health ◽  
Resistance Risk ◽  
Similar Survey ◽  
Young Students ◽  
And Mathematics ◽  
Health Organization

In response to the antimicrobial resistance issue, the World Health Organization developed and conducted a survey in 2015 dealing with habits, antibiotic use, awareness of appropriate use and sensitization to the issue of antibacterial resistance. In France, we conducted a similar survey to investigate the use of antibiotics and students’ perceptions of the antibiotic resistance risk. Our results indicated that antibiotics are moderately taken (42% in the last six months), but mistakes remain in appropriate practices and knowledge. Many people still believe that the body develops resistance to antibiotics and 24% responded that antibiotics can be stopped before the end of the treatment if they feel better. Furthermore, only 14% said antibiotics could be used to treat gonorrhea while 57% indicated that influenza could be treated with antibiotics. We looked at risk perception as well, and noticed that students in biology were more aware of risk (mean score = 48.87) and health consequences (mean score = 40.33) than mathematics students (mean score = 44.11 and 37.44). They were more aware of the threat, had a better understanding of antibiotic resistance and their denial of this risk was less significant (mean score = 27.04 against 23.81). However, the importance of providing a minimum level of knowledge to young students has been emphasized, regardless of the field of expertise.

scholarly journals A Survey and Analysis of the American Public's Perceptions and Knowledge About Antibiotic Resistance

2016 ◽  
Vol 3 (3) ◽  
Author(s):  
Rebecca R. Carter ◽  
Jiayang Sun ◽  
Robin L. P. Jump
Keyword(s):  
Immune Response ◽  
Antibiotic Resistance ◽  
Antibiotic Use ◽  
Antibiotic Consumption ◽  
The Body ◽  
Amazon Mechanical Turk ◽  
Resistant Bacteria ◽  
Free Text ◽  
Bacterial Adaptation ◽  
Antibiotic Overuse

Abstract Background.  Little is known about the American public's perceptions or knowledge about antibiotic-resistant bacteria or antibiotic misuse. We hypothesized that although many people recognize antibiotic resistance as a problem, they may not understand the relationship between antibiotic consumption and selection of resistant bacteria. Methods.  We developed and tested a survey asking respondents about their perceptions and knowledge regarding appropriate antibiotic use. Respondents were recruited with the Amazon Mechanical Turk crowdsourcing platform. The survey, carefully designed to assess a crowd-sourced population, asked respondents to explain “antibiotic resistance” in their own words. Subsequent questions were multiple choice. Results.  Of 215 respondents, the vast majority agreed that inappropriate antibiotic use contributes to antibiotic resistance (92%), whereas a notable proportion (70%) responded neutrally or disagreed with the statement that antibiotic resistance is a problem. Over 40% of respondents indicated that antibiotics were the best choice to treat a fever or a runny nose and sore throat. Major themes from the free-text responses included that antibiotic resistance develops by bacteria, or by the infection, or the body (ie, an immune response). Minor themes included antibiotic overuse and antibiotic resistance caused by bacterial adaptation or an immune response. Conclusions.  Our findings indicate that the public is aware that antibiotic misuse contributes to antibiotic resistance, but many do not consider it to be an important problem. The free-text responses suggest specific educational targets, including the difference between an immune response and bacterial adaptation, to increase awareness and understanding of antibiotic resistance.

scholarly journals Antimicrobial stewardship: Assessment of knowledge, awareness of antimicrobial resistance and appropriate antibiotic use among healthcare students in a Nigerian University

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wuraola Akande-Sholabi ◽  
Amen T. Ajamu
Keyword(s):  
Antimicrobial Resistance ◽  
Antimicrobial Stewardship ◽  
Healthcare Professionals ◽  
Antibiotic Use ◽  
The Body ◽  
Healthcare Students ◽  
Inappropriate Use ◽  
The Past ◽  
Inadequate Knowledge ◽  
Nigerian University

Abstract Background Inappropriate use of antibiotics is a major cause of antimicrobial resistance (AMR). Inadequate knowledge about AMR among healthcare students could affect their practice of antimicrobial stewardship as future healthcare professionals. This study aims to assess the use of antibiotics and knowledge of AMR among future healthcare professionals of a Nigerian University. Methods Respondents’ knowledge of antimicrobial resistance, use of antibiotics, and source of antibiotics in the past 12 months was explored using a self-administered questionnaire. Multivariate analyses were used to evaluate the relationship between specific variables and respondents’ knowledge. Results Of the 939 questionnaires administered to the students, 866 were filled given a response rate of 92.2 %. A total of (765; 88.3 %) of the respondents were aware that antimicrobial resistance makes it harder to eliminate the infection from the body as existing drugs become less effective. In all 824, (95.2 %) of the respondents had use antibiotics in the past 12 months. The use of antibiotics to treat malaria was self-reported by (175; 21.2 %). About half (432; 52.4 %) purchased the antibiotics from community pharmacies, while others obtained their antibiotics from the hospitals (192; 23.3 %), patent medicine stores (150; 18.2 %), and friends and family (50; 6.1 %) in the last 12 months. In all 506, (58.4 %) had good knowledge of antimicrobial resistance. Logistic regression shows that students in 3rd to 6th year 9.29 [AOR = 9.29, 95 % CI: (3.7–22.96)], had greater knowledge of antimicrobial resistance. Conclusions The healthcare students demonstrated a moderate knowledge of AMR. This underscores the need to adopt several educational tactics to introduce the concepts of AMR to the students and ensure there are strict policies to regulate the flow of antibiotics.

scholarly journals Antibody-mediated cross-linking of gut bacteria hinders the spread of antibiotic resistance

2019 ◽  
Author(s):  
Florence Bansept ◽  
Loïc Marrec ◽  
Bitbol Anne-Florence ◽  
Claude Loverdo
Keyword(s):  
Antibiotic Resistance ◽  
Resistance Mutation ◽  
Multiscale Model ◽  
Antibiotic Use ◽  
Host Population ◽  
Host Immunity ◽  
The Body ◽  
Resistant Bacteria ◽  
Cost Of Resistance ◽  
Resistant Bacterial Strain

AbstractThe body is home to a diverse microbiota, mainly in the gut. Resistant bacteria are selected for by antibiotic treatments, and once resistance becomes widespread in a population of hosts, antibiotics become useless. Here, we develop a multiscale model of the interaction between antibiotic use and resistance spread in a host population, focusing on an important aspect of within-host immunity. Antibodies secreted in the gut enchain bacteria upon division, yielding clonal clusters of bacteria. We demonstrate that immunity-driven bacteria clustering can hinder the spread of a novel resistant bacterial strain in a host population. We quantify this effect both in the case where resistance pre-exists and in the case where acquiring a new resistance mutation is necessary for the bacteria to spread. We further show that the reduction of spread by clustering can be countered when immune hosts are silent carriers, and are less likely to get treated, and/or have more contacts. We demonstrate the robustness of our findings to including stochastic within-host bacterial growth, a fitness cost of resistance, and its compensation. Our results highlight the importance of interactions between immunity and the spread of antibiotic resistance, and argue in the favor of vaccine-based strategies to combat antibiotic resistance.

scholarly journals Antibiotic Consumption and Knowledge of Antimicrobial Resistance: Online Survey

2020 ◽  
Author(s):  
Nurul Shaheera Shahpawee ◽  
Li Ling Chaw ◽  
Siti Hanna Muharram ◽  
Poh Hui Goh ◽  
Zahid Hussain ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Antimicrobial Resistance ◽  
Internal Consistency ◽  
Online Survey ◽  
Public Awareness ◽  
Antibiotic Use ◽  
Antibiotic Usage ◽  
The Body ◽  
World Health ◽  
Brunei Darussalam

Background: Public misconception and demand for the indication of antibiotics could lead to inappropriate prescribing and consumption. Successful treatment can only be achieved when the public and industrial users have knowledge on antibiotic use and resistance. This survey is aimed to assess antibiotic usage and knowledge regarding antibiotics and antimicrobial resistance (AMR) among undergraduate students of Universiti Brunei Darussalam (UBD), public university located in Brunei Darussalam. Methods: A cross-sectional study was performed using a self-administered questionnaire. The questionnaire was adapted from the World Health Organization (WHO) Antibiotic Resistance, Multi-country public awareness survey distributed online. Students at UBD were invited to participate in the online survey through internal email. The questionnaire consisted of 5 sections: demographic information, antibiotic usage, knowledge on antibiotics, antibiotic resistance (AMR) and use of antibiotics in agriculture. Data were analyzed descriptively and appropriate inferential statistics was used accordingly. Cronbach’s alpha was also done to determine the internal consistency. The section on antibiotic use and knowledge showed good internal consistency of Cronbach’s alpha 0.66 and 0.86 respectively. Research ethics approval was obtained from the PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam (UBD). Results: A total of 145 students returned the complete questionnaire. The result of the study found that 50% of the students had good level of knowledge of antibiotic and antimicrobial resistance with a mean total knowledge score of 11.4 out of 14. Respondents reported the use of antibiotic in the past (69%). Many of the students could identify the use of antibiotics for the treatment of bacterial infection. However, there were also students who incorrectly thought that antibiotics can be used for cold and flu (43%) and fever (41%). Moreover, 76% of the respondents mistakenly believed that antibiotic resistance is the result of the body becoming resistant to antibiotics. Only 12% of the respondents were found to have poor knowledge in the study. Conclusions: Misconceptions in regards to the use of antibiotics for conditions related to viral illnesses was noticed among the respondents in our study. Thus, improving knowledge on antibiotics is crucial to address those beliefs.

scholarly journals 190. Which antibiotic are you? Evaluation of a global antibiotic awareness personality quiz

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S101-S101
Author(s):  
Bradley J Langford ◽  
Maryrose R Laguio-Vila
Keyword(s):  
Public Health ◽  
Infectious Disease ◽  
Social Media ◽  
Antibiotic Resistance ◽  
Healthcare Professionals ◽  
Action Plan ◽  
Antibiotic Use ◽  
Public Health Campaign ◽  
Antibiotic Overuse ◽  
The Impact

Abstract Background Improving understanding of the impact of antibiotic overuse is a key component of the global action plan to address antibiotic resistance. Play is an underutilized opportunity to engage adults in learning about antibiotic resistance and the importance of appropriate antibiotic use in mitigating this public health threat. Our objective was to evaluate the reach of a web-based antibiotic awareness personality quiz. Figure 1. Antibiotic Personality Quiz Participants Methods A personality quiz (http://www.tiny.cc/antibioticquiz) was developed using an online platform (Tryinteract.com). The quiz included a series of short personality-based questions. Once complete, based on the responses provided, the respondent was automatically assigned an antibiotic that best matched their personality. This result was accompanied by key teaching points about the assigned antibiotic, a statement about the importance of appropriate antibiotic use and links to find more information. The quiz was launched in November 2017 to coincide with World Antibiotic Awareness Week and disseminated via social media. It was updated iteratively each year. We evaluated usage statistics from November 7 2017 to June 7 2020. Results During the 31-month evaluation period, there were 287,868 views of the quiz, and it was completed 207,148 times. The quiz was shared extensively on social media (Facebook 1667 shares, Twitter 1390 clicks). From a subset of 37,825 recent participants who were asked about their profession, most identified as non-infectious diseases healthcare professionals (n= 18,235, 48.2%), followed by infectious disease healthcare professionals (n=8,119, 21.8%), and healthcare students (n=6,986, 18.5%) (Figure 1). Respondents were well-represented globally, including US, Canada, Spain, France, India, United Kingdom, and Indonesia. Conclusion This exploratory analysis suggests incorporation of play into social media campaigns may augment the size of the receiving audience. An antibiotic awareness personality quiz engaged a high volume and broad range of non-infectious disease experts in learning more about antibiotic resistance. Antimicrobial stewards and public health campaign leaders should incorporate play into awareness opportunities and evaluate their impact. Disclosures All Authors: No reported disclosures

scholarly journals Barriers and facilitators to prudent antibiotic prescribing for acute respiratory tract infections: A qualitative study with general practitioners in Malta

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246782
Author(s):  
Erika A. Saliba-Gustafsson ◽  
Anna Nyberg ◽  
Michael A. Borg ◽  
Senia Rosales-Klintz ◽  
Cecilia Stålsby Lundborg
Keyword(s):  
Public Policy ◽  
Antibiotic Resistance ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Antibiotic Use ◽  
Barriers And Facilitators ◽  
Antibiotic Prescribing ◽  
Socioecological Model ◽  
Policy Level ◽  
Tract Infections

Background Antibiotic resistance is a leading global public health concern and antibiotic use is a key driver. Effective interventions are needed to target key stakeholders, including general practitioners (GPs). In Malta, little is known about factors that influence GPs’ antibiotic prescribing, making it challenging to implement targeted interventions. We therefore aimed to explore GPs’ understanding of antibiotic use and resistance, and describe their perceived barriers and facilitators to prudent antibiotic prescribing for acute respiratory tract infections in Malta. Methods Face-to-face individual semi-structured interviews were held with a quota sample of 20 GPs in 2014. Interviews were audio recorded and transcribed verbatim, and later analysed iteratively using manifest and latent content analysis. Findings were collated in a socioecological model to depict how GPs as individuals are embedded within larger social systems and contexts, and how each component within this system impacts their prescribing behaviour. Findings We found that GPs’ antibiotic prescribing decisions are complex and impacted by numerous barriers and facilitators at the individual, interpersonal, organisational, community, and public policy level. Predominant factors found to impact GPs’ antibiotic prescribing included not only intrinsic GP factors such as knowledge, awareness, experience, and misconceptions, but also several external factors. At the interpersonal level, GPs’ perceived patient demand and behaviour to be a persistent issue that impacts their prescribing decisions. Similarly, some GPs found pressure from drug reps to be concerning despite being considered an important source of information. Organisational and public policy-level issues such as lack of access to relevant antibiotic prescribing guidelines and current antibiotic resistance data from the community, were also considered major barriers to appropriate antibiotic prescribing. Utilisation of diagnostic testing was found to be low and GPs’ perceptions on the introduction of rapid point-of-care tests to support antibiotic prescription decisions, were mixed. Conclusion This study revealed the complexity of the antibiotic prescribing decision and the numerous barriers and facilitators that impact it, visualised through a socioecological model. Addressing GPs’ antibiotic prescribing practices will require targeted and coordinated implementation activities at all levels to change behaviour and address misconceptions, whilst also improving the physical and social environment. Trial registration number NCT03218930; https://clinicaltrials.gov/ct2/show/NCT03218930.

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