scholarly journals A Case of Hepatic Injury Following Shrapnel Injury to the Abdomen in a Paediatric Patient

2021 ◽  
Author(s):  
Sunita Sudama
Keyword(s):  
Hepatic Injury ◽  
Multiple Organ ◽  
Organ Injury ◽  
Solid Organ ◽  
Penetrating Injuries ◽  
Solid Organ Injury ◽  
Visceral Injury ◽  
Penetrating Abdominal Trauma ◽  
High Degree ◽  
Rule Out

In children, trauma is the leading cause of morbidity and mortality worldwide. Trauma can be a catalyst resulting in intra-abdominal solid organ injury in this population. The case report highlights a prepubescent male who presented with a penetrating abdominal wound resulting in hepatic injury. The mechanism of injury in this case is unusual and differs from previously reported causes of penetrating abdominal trauma in children. The case demonstrates that penetrating abdominal injuries may be more likely to require surgical intervention secondary to their association with a high percentage of multiple organ injuries. Penetrating injuries in children require a high degree of vigilance to rule out visceral injury.

scholarly journals The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury

2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Li Ning ◽  
Xiong Rui ◽  
Wang Bo ◽  
Geng Qing
Keyword(s):  
Histone Deacetylase ◽  
Chromatin Remodeling ◽  
Current Knowledge ◽  
Organ Injury ◽  
Solid Organ ◽  
Solid Organ Injury ◽  
Histone Deacetylase 3 ◽  
Physiological Conditions ◽  
Inflammatory Conditions ◽  
Therapeutic Value

AbstractHistone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.

scholarly journals Management for traumatic hepatic injury diagnosed by contrast-enhanced ultrasonography in a patient with an occluded coeliac axis: a case report

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110199
Author(s):  
Young Hoon Sul ◽  
Yook Kim
Keyword(s):  
Case Report ◽  
Hepatic Artery ◽  
Hepatic Injury ◽  
Active Bleeding ◽  
Organ Injury ◽  
Solid Organ ◽  
Median Arcuate Ligament ◽  
Contrast Enhanced ◽  
Arcuate Ligament ◽  
Contrast Enhanced Ultrasonography

Transcatheter arterial embolization (TAE) is the standard of care for haemodynamically-stable patients with blunt hepatic injury but it is sometimes impossible due to unfavourable vascular anatomies. This case report describes a 43-year-old male patient with abdominal pain following a motorcycle accident. Based on computed tomography (CT) findings, he was diagnosed with high-grade hepatic injury with coeliac axis stenosis (CAS) due to compression by the median arcuate ligament, and an aberrant right hepatic artery. Contrast-enhanced ultrasonography (CEUS) demonstrated multiple high echogenic tubular and ovoid structures suggestive of active bleeding within the injured liver area. Angiography revealed unique interlobar and intrahepatic collateral vessels between the right and left hepatic arteries. Liver haemorrhages were also identified. Catheterization of the feeding arteries through the collateral pathway was unsuccessful, so a decision was made to cannulate the stenotic portion of the coeliac trunk with a 5-Fr Yashiro catheter. After several attempts, the microcatheter was successfully advanced coaxially into the common hepatic artery. Embolization was performed with a 1:2 mixture of N-butyl cyanoacrylate and iodized oil. Successful haemostasis was confirmed following TAE. CEUS helped clinicians identify active bleeding following traumatic solid organ injury. TAE was a safe and effective treatment strategy. Before performing TAE, attention should be given to the presence of CAS associated with compression by the median arcuate ligament.

Embolization versus Surgery for Stabilized Patients with Solid Organ Injury

2021 ◽  
Author(s):  
Makoto Aoki ◽  
Toshikazu Abe ◽  
Shuichi Hagiwara ◽  
Daizoh Saitoh ◽  
Kiyohiro Oshima
Keyword(s):  
Organ Injury ◽  
Solid Organ ◽  
Solid Organ Injury

Defining the role of angioembolization in pediatric isolated blunt solid organ injury

2020 ◽  
Vol 55 (4) ◽  
pp. 688-692 ◽  
Author(s):  
Robert A. Swendiman ◽  
Matthew A. Goldshore ◽  
Stephen J. Fenton ◽  
Michael L. Nance
Keyword(s):  
Organ Injury ◽  
Solid Organ ◽  
Solid Organ Injury

scholarly journals Free abdominal fluid without obvious solid organ injury upon CT imaging: an actual problem or simply over-diagnosing?

2009 ◽  
Vol 3 (1) ◽  
Author(s):  
Vanessa M Banz ◽  
Muhammad U Butt ◽  
Heinz Zimmermann ◽  
Victor Jeger ◽  
Aristomenis K Exadaktylos
Keyword(s):  
Ct Imaging ◽  
Organ Injury ◽  
Solid Organ ◽  
Solid Organ Injury ◽  
Actual Problem

Serial Computed Tomographic Scans Document Healing of Solid Organ Injury in a Trauma Patient with Multiple Injuries

2006 ◽  
Vol 61 (3) ◽  
pp. 765
Author(s):  
Fulvio Tagliabue ◽  
Gianmaria Confalonieri ◽  
Antonio Romelli ◽  
Maria Emanuela Limonta ◽  
Sabina Terragni ◽  
...  
Keyword(s):  
Trauma Patient ◽  
Organ Injury ◽  
Multiple Injuries ◽  
Solid Organ ◽  
Solid Organ Injury ◽  
Computed Tomographic
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